462 results about "Sodium nitrite" patented technology

The invention discloses a novel synthetic method for 5-phenyl tetrazole, which includes the following steps: firstly performing acid neutralization to hydrazine hydrate; then adding mixing solution formed by cyanobenzene, water and ethyl alcohol to generate phenyl aminoguanidine salt; adopting sodium nitrite for diazotization to obtain nitrine amidine under the acidic condition; obtaining 5-phenyl tetrazole crude product through closed loop under the alkaline condition; obtaining 5-phenyl tetrazole acceptable product through adopting ethyl alcohol for refining. The method has the advantages of simple technology, simplicity in operation and high product yield.

The invention relates to the technical field of cement mortar compositions, and particularly discloses a double-component anti-freezing early-strength slurry and a preparation method and application thereof. The double-component anti-freezing early-strength slurry provided by the invention is composed of a component A and a component B in a weight ratio of 25: (4-10), the component A is prepared from the following components in parts by weight: 250 to 280 parts of Portland cement, 90 to 100 parts of admixture, 145 to 165 parts of sand and 6.4 to 8.4 parts of water reducing agent; and the component B comprises the following components in parts by weight: 8-10 parts of a sodium nitrite antifreeze agent, 50-58 parts of a reinforcing aid, 32-40 parts of anhydrite, 240-270 parts of an admixture, 155-175 parts of sand and 4.1-6.1 parts of a water reducing agent. By utilizing the technical scheme, the prepared double-component anti-freezing early-strength slurry has the advantages of rapid development of early compressive strength and stable growth of later compressive strength under different ultralow temperature conditions.

The invention discloses a corrosion-resistant polypropylene edge band material and a preparation method thereof, and belongs to the technical field of preparation of edge band materials. The corrosion-resistant polypropylene edge sealing strip material is prepared from, by weight, 50-75 parts of polypropylene, 2-5 parts of an antioxidant, 3-6 parts of a corrosion-resistant agent, 2-4 parts of a composite flame retardant, 8-15 parts of calcium carbonate and 2-4 parts of dye, the corrosion-resistant agent is prepared from 2, 6-dichlorobenzonitrile, 1, 2, 4-triazole, a sulfuric acid solution, sodium nitrite and parachloroaniline, and the corrosion-resistant agent is prepared from 2, 6-dichlorobenzonitrile, 1, 2, 4-triazole, a sulfuric acid solution, sodium nitrite and parachloroaniline. The composite flame retardant is prepared from 3-glycidyl ether oxypropyl trimethoxy silane, diphenyl silanediol, barium hydroxide and boric acid. The edge band material prepared by the method has excellent corrosion resistance, flame retardance, heat resistance and mechanical properties.

The invention belongs to the field of lithium ion battery material preparation, and provides a preparation method of low-impurity battery grade iron phosphate, which comprises the following steps: dissolving titanium dioxide ferrous sulfate in water to obtain a solution A, adjusting the pH value of the solution A to 3.0-4.0, reacting, and carrying out solid-liquid separation to obtain a clear liquid; adjusting the pH value of the clear liquid, and then mixing the clear liquid with sodium nitrite to obtain a solution B; adding the solution B into a reaction kettle, introducing compressed oxygen until the pressure in the kettle body is 5-15 bar, reacting until the pressure in the kettle body is reduced to a constant value, and carrying out solid-liquid separation to obtain a purified iron source solution; preparing iron phosphate dihydrate by taking the purified iron source solution and a phosphorus source as raw materials through a precipitation method; and calcining the iron phosphate dihydrate to obtain the low-impurity battery-grade iron phosphate. The preparation method is simple and feasible in process, low in cost, wide in source of required raw materials, good in safety, low in cost, easy to realize large-scale production, good in impurity removal effect and low in iron loss, and the Mn content of the battery-grade iron phosphate prepared from the impurity-removed ferrous sulfate can be as low as 10 ppm or below.

The invention provides a preparation method of 4-fluoro-3, 5-dimethylphenylhydrazine hydrochloride, which comprises the following steps: salifying 4-fluoro-3, 5-dimethylaniline serving as a substrate with concentrated hydrochloric acid, reacting with sodium nitrite to prepare a diazo solution, reducing the diazo solution into corresponding phenylhydrazine by using alkaline sodium sulfite as a reducing agent system, and reacting the 4-fluoro-3, 5-dimethylphenylhydrazine hydrochloride with the diazo solution to prepare the 4-fluoro-3, 5-dimethylphenylhydrazine hydrochloride. And acidizing the 2, 5-dimethyl phenylhydrazine to obtain corresponding phenylhydrazine hydrochloride. According to the preparation method, sodium sulfite which is low in cost and easy to obtain is used as a reducing agent, the defects that metal residues are high, the environment is prone to being polluted and the raw material cost is high due to the fact that a metal reducing agent is adopted when phenylhydrazine hydrochloride is prepared in the prior art are overcome, the reaction is completed in a water phase, no organic solvent is adopted, and the concept of green chemistry is met; and the problems of complicated post-treatment and easy pollution caused by the adoption of an organic solvent can be effectively avoided.

The invention relates to the technical field of polyurethane coatings, and discloses a preparation method of an antibacterial wear-resistant waterborne polyurethane coating, which comprises the following steps: taking concentrated hydrochloric acid, p-phenylenediamine, sodium nitrite, paraformaldehyde, amino-modified nano silicon dioxide and hexamethylene diisocyanate as raw materials; the preparation method comprises the following steps: taking 9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide as a raw material, carrying out diazotization coupling reaction, substitution reaction, Mannich reaction and addition reaction to prepare modified polyisocyanate, then taking 9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide and ((2-aminoethyl) azadiyl) dimethanol as raw materials, carrying out substitution reaction to prepare DOPO-based dihydric alcohol, and carrying out reaction to prepare the DOPO-based dihydric alcohol. Finally, the modified polyisocyanate, DOPO-based dihydric alcohol and polyethylene glycol 400 are used as raw materials, an antibacterial wear-resistant polyurethane emulsion is prepared through a prepolymerization reaction and a chain extension reaction, and the prepared polyurethane coating has good antibacterial, anti-ultraviolet, flame-retardant and wear-resistant properties.

The invention relates to a pickling process of a cold-rolled strip, and belongs to the technical field of metal surface treatment. The acid pickling process comprises the steps of surface pretreatment, sand blasting treatment, acid pickling, water washing, passivation and the like. In the surface pretreatment, an oil removing agent and a rust removing agent are used for removing oil stains and rust stains on the surface of the cold-rolled strip, and then deionized water is used for cleaning. 200-mesh brown aluminum oxide and high-purity nitrogen are used for blowing and removing solid impurities in the sand blasting treatment. And pickling is carried out by using a 180-220g / L hydrochloric acid solution at 60-80 DEG C for 3-10 minutes. And after washing, drying at 110 DEG C in a nitrogen atmosphere. In the passivation step, a sodium nitrite passivation solution with the mass fraction of 30-50% is sprayed under the nitrogen atmosphere, and a laser drying method is used for drying. In addition, the invention further provides a preparation method of the oil removal agent and the rust removal agent and specific parameters of sand blasting treatment, nitrogen purging, acid pickling, spraying and laser drying.

The invention discloses a preparation method of a thidiazuron preparation, and relates to the technical field of thidiazuron preparation. The preparation method of the thidiazuron preparation comprises the following steps: adding 5-amino-1, 2, 3-thiadiazole, ethylene glycol dimethyl ether and triethylamine into a four-neck flask, heating and uniformly stirring, dropwise adding phenyl isocyanate into the mixed solution obtained in the step 1, heating to carry out catalytic synthesis reaction, cooling to room temperature, and carrying out suction filtration to obtain yellow solid thidiazuron. And further treating to obtain the thidiazuron preparation. Sodium nitrite is selected as a solvent in the preparation process of 5-amino-1, 2, 3-thiadiazole, and the amount of substance of another initial material aminoacetonitrile hydrochloride is controlled in the preparation reaction, so that the yield of thidiazuron is ensured to be optimal, the reaction temperature range and the dropwise adding amount are determined, the optimal reaction conditions are finally perfected, and the yield of 5-amino-1, 2, 3-thiadiazole is improved. A preparation mode which is simpler to operate, higher in yield and suitable for industrial production is provided for preparation of the thidiazuron preparation.

The invention relates to the field of medicine synthesis and preparation, in particular to a synthesis method of toxyanib phosphate. The use amount of acetic acid is greatly reduced in the preparation process, so that excessive acid does not need to be neutralized in the post-treatment process, and a large amount of wastewater is not generated; in addition, the use amount of sodium nitrite is reduced, and the environment and health are facilitated; the enamine reduction reaction does not use acetic acid as a solvent and a hydrogenation reaction catalyzed by heavy metal palladium, so that the safety of the reaction is improved, and the purity of the product is also improved; a decarboxylation reaction and a Vilsmeier-Haack reaction are carried out by a one-pot method, so that the reaction steps are reduced, and the product purity is improved; when aldol reaction is carried out in side chain splicing, side reaction and generation of isomer impurities are reduced. The method is short in route, mild in reaction condition, low in equipment requirement and convenient to operate, industrial production is easy to achieve, and a complex purification method is not needed.

The invention belongs to the technical field of wastewater treatment, and particularly relates to a treatment method of high-concentration ammonia-nitrogen wastewater. The treatment method comprises the following treatment steps: (1) pretreatment of high-ammonia-nitrogen wastewater: adding an acidic solution into to-be-treated high-ammonia-nitrogen wastewater, adjusting the pH value of the system to 3 or below, then adding a regulating agent NaNO2, and uniformly mixing; and (2) high-temperature hydrothermal treatment: putting the mixed wastewater pretreated in the step (1) into a closed hydrothermal reactor, heating to 120-180 DEG C, carrying out high-temperature hydrothermal reaction, cooling after the reaction is completed, obtaining treated produced water, and collecting produced nitrogen. According to the treatment method, the hydrothermal reaction is regulated and controlled based on cooperation of acid and sodium nitrite, the method is carried out under high-temperature and high-pressure conditions, the reaction rate can be increased, the treatment time can be shortened, and the treatment efficiency can be improved. The problems that in an existing high-ammonia-nitrogen wastewater treatment technology, the ammonia nitrogen treatment concentration is low, the process technology is complex, and secondary pollution is generated are solved.

The invention belongs to the technical field of food processing, and particularly relates to fermented beef jerky and a preparation method thereof. The preparation method of the beef jerky comprises the following steps: (1) removing fascia and fat from fresh cattle hind leg meat, washing with clear water, and cutting into meat slices; (2) adding table salt, glucose, white granulated sugar and sodium nitrite into the sliced meat, uniformly mixing, adding a fermentation inoculant which comprises staphylococcus calcaratus, pediococcus acidilactici, bifidobacterium bifidum and Witzia ciliaris, and fermenting; and (3) after fermentation, drying and cooling to obtain the fermented beef jerky. Specific strains are selected to form a fermentation inoculant for fermentation, and the prepared fermented beef jerky is high in free amino acid and soluble peptide content, low in nitrite residual quantity, uniform red brown in color and slightly bright in surface, and belongs to high-quality beef jerky.

The invention discloses a nano phase change heat storage material with high decomposition temperature as well as a preparation method and application thereof, and belongs to the technical field of mixed molten salt energy storage materials. The nanometer phase change heat storage material is composed of 99 wt% of low-melting-point mixed molten salt and 1 wt% of SiO2 nanometer particles. The low-melting-point mixed molten salt is composed of potassium nitrate, sodium nitrite and sodium nitrate according to the mass ratio of 53: (10-30): (17-37). The low-melting-point and high-decomposition-temperature nanometer phase change heat storage material with the melting point being 150-175 DEG C and the decomposition temperature being 660-723 DEG C is prepared by combining the mixed molten salt composed of potassium nitrate, sodium nitrite and sodium nitrate according to the specific dosage ratio with SiO2 nanoparticles, the melting point of the phase change material is low, energy consumption can be effectively reduced, and the energy consumption is reduced. And the composition has good decomposition temperature, melting latent heat and other thermophysical properties.

The invention discloses a continuous kettle type nitromethane production process, and relates to the technical field of basic chemical raw material synthesis and flow chemical reaction process control, which comprises the following steps: quantitatively and continuously pumping a temperature-regulated sodium nitrite mixed solution into a raw material mixer in a closed-loop automatic control mode through a variable-frequency feeding pump matched with a mass flow meter; synchronously, quantitatively and continuously pumping dimethyl sulfate into the raw material mixer in a closed-loop automatic control manner by matching a feeding pump with a stop valve and a mass flow meter, and uniformly mixing the two raw materials in the raw material mixer according to the stoichiometric molar ratio of the dimethyl sulfate to the sodium nitrite, according to the tandem type segmented design, each reaction kettle can be subjected to customized temperature field control and heat transfer design specially aiming at the special thermodynamic and dynamic requirements of the reaction stage where the reaction kettle is located, the heat transfer efficiency of the whole system is greatly improved, and due to the fact that reaction heat is taken away timely and accurately, the heat transfer efficiency is greatly improved. And a by-product generation path induced by local abnormal high temperature is effectively restrained.

The invention discloses a colloidal emulsion explosive with high storage stability and a preparation method thereof. The raw materials for preparing the emulsion explosive comprise ammonium nitrate, calcium nitrate, water, a compound emulsifier, compound wax and a special foaming agent. Wherein the composite emulsifier is a modified span-80 composite emulsifier obtained by carrying out esterification reaction on an anionic carboxylate emulsifier and multiple hydroxyl sites of span-80, and the composite emulsifier has high molecular weight, so that the space volume of a lipophilic group is increased, and an interfacial film is tighter; the special foaming agent is composed of sodium nitrite, zinc nitrate, gelatin peptone, Tween 80, phosphoric acid, urea and water, the gelatin peptone is a green pure natural raw material, the surface tension of an emulsion matrix is effectively reduced, the contact area of the foaming agent and the emulsion matrix is increased, the foaming efficiency is catalyzed by zinc nitrate, and bubbles are good in stability and not prone to escaping due to Tween 80. The use of the compound emulsifier and the special foaming agent improves the blasting performance and storage stability of the emulsion explosive.

The present invention discloses a high-purity photochlorination synthesis method of p-fluorobenzoyl chloride, wherein an aromatic nitro compound or its salt is selected to form an inhibition system with triethanolamine, which not only inhibits side reactions, but also inhibits the photochlorination process to inhibit fluorotoluene, the self-luminous defluorination of p-fluorotrichlorobenzyl, and the high-temperature defluorination of p-fluorobenzoyl chloride in the distillation process, thereby further improving the purity of the synthesized p-fluorobenzoyl chloride to above 99.5. The aromatic nitro compound or its salt is specifically any one or two of nitrobenzene, dinitrobenzene, nitrotoluene, sodium nitrite or potassium nitrite, preferably potassium nitrite; the dosage is 0.1‰ to 1‰ of the mass of p-fluorotoluene, and the addition amount and time are strictly controlled to ensure that the effect of inhibiting the defluorination is achieved while ensuring the safety of the reaction process and the product, and has good practical value and important economic value.

The invention discloses delayed coagulation type super-early-strength quick-hardening mortar and a preparation method thereof, and relates to the technical field of building materials, a shell-core structure targeted modified early strength agent is designed, a staged dry-wet mixing technology is adopted, seabed in-situ curing is combined, cooperation of mortar delayed coagulation construction and super-early-strength development is achieved, and the construction efficiency is improved. According to the present invention, with the design of the targeted modified early strength agent, the surface delayed coagulation shell and the core early strength core structure are formed through the grafting reaction of the sodium nitrite and the hydroxyl carboxylic acid monomer, and the 15-25% accurate grafting rate control is matched, such that the antagonism problem of the traditional early strength agent and the delayed coagulation agent can be solved, and the deep sea open caisson grouting temporary support requirement can be met; in the deep sea environment, the delayed coagulation shell can guarantee a construction window of 75-105 min, the requirement for long-distance grouting of the seabed is met, deep sea high pressure can trigger the delayed coagulation shell to be broken, the core early strength core rapidly activates cement to be hydrated, and the mortar can rapidly form the requirement for rapid bearing of the open caisson temporary support with enough strength.

The invention discloses a water-based compensation sodium source sodium ion battery positive pole piece and a preparation method thereof. Mixing a positive active material, a conductive agent, a water-based binder, a water-soluble sodium supplement agent and a solvent to obtain positive slurry; wherein the water-soluble sodium supplement comprises sodium nitrite, sodium oxalate and sodium citrate; the solvent is water; and coating the surface of a current collector with the positive electrode slurry to prepare the positive electrode plate. Deionized water is used for replacing a traditional organic solvent to serve as a pulping solvent, and dual-function optimization is achieved by adding a specific water-soluble sodium supplementing agent. The sodium supplementing agent is uniformly distributed in the pole piece through a dissolution-recrystallization mechanism, and an efficient sodium ion pre-compensation system is formed. According to the method, the production cost and the energy consumption are remarkably reduced, the structural degradation of the positive active material in a water system environment can be effectively inhibited, irreversible sodium loss caused by formation of a first-week solid electrolyte interface (SEI) of a negative electrode is counteracted through a sodium source compensation mechanism, and the method has remarkable environmental friendliness and industrial application value.

The invention discloses a synthesis method of 5-nitrotetrazole sodium salt, and solves the problem of relatively large potential safety hazard in the synthesis process of 5-nitrotetrazole sodium in the prior art. The method for safely preparing the high-energy compound 5-nitrotetrazole sodium salt based on DAT comprises the following steps: adding 1, 5-diamino tetrazole into a certain amount of ice water and acid to dissolve 1, 5-diamino tetrazole; slowly dropwise adding a sodium nitrite solution into the ice-water mixture solution, and uniformly stirring at a certain temperature; slowly heating the mixture to a certain temperature, and reacting for a period of time to obtain filtrate; removing filtrate to obtain white powder; and dissolving the obtained white powder in acetone, filtering to obtain a solution, and removing the solvent to obtain the 5-nitrotetrazole sodium salt. The preparation method provided by the invention is simple, safe and mild in reaction condition; water is used as a solvent, so that environmental pollution is avoided, and environmental protection requirements are completely met; and dangerous intermediates such as tetrazole-5 diazonium salt and 5nitrotetrazole acid copper salt are not generated.

The invention belongs to the field of textile dyeing and finishing, and relates to a dyeing method capable of regulating and controlling in-situ assembly of dye molecules through cellulose fiber graft modification. The dyeing method comprises the following steps: soaking a cellulosic fiber textile in a 4-beta-hydroxyethylsulfonyl sulfate aniline-2-sulfonic acid aqueous solution for reaction, washing with water, drying, soaking in a hydrochloric acid aqueous solution, adding a sodium nitrite aqueous solution for reaction, adding urea, washing with water, and drying to obtain the cellulosic fiber textile. Soaking in a coupling component aqueous solution containing a coupling component, sodium hydroxide and sodium carbonate for reaction, alternately washing with hot water and cold water, and drying to obtain the dyed textile. The dyeing method is mild in condition, dye hydrolysis is avoided, the dye uptake and the dyeing fastness are improved, and the dye utilization rate is high; high temperature and a large amount of inorganic salt or auxiliaries are not needed, the dye is directly generated and fixed in the fiber, energy consumption is remarkably reduced, and waste water treatment pressure is reduced.

The invention relates to a part and an electrophoretic coating process and application thereof, and belongs to the technical field of electrophoretic coating. The zirconium treatment liquid provided by the invention comprises hexafluorozirconic acid, aluminum nitrate, nitric acid, hydrogen fluoride and sodium nitrite; wherein aluminum nitrate can reduce the concentration of free fluorine in the treating fluid and promote hydrolysis of hexafluorozirconic acid, so that the generation speed of a zirconium film is increased; and the sodium nitrite can prevent the part base material from rusting, so that the anti-rust treatment after zirconium treatment is omitted. A part only needs to be subjected to zirconium treatment in the zirconium treatment liquid for 120 s, a zirconium film with the film weight being 48 mg / m < 2 > can be obtained, anti-dry spraying or anti-rust agent spraying does not need to be carried out after zirconium treatment to prevent the part from being rusted, and compared with the prior art, the efficiency of the electrophoretic coating process is improved; the parts subjected to electrophoretic coating are still free of corrosion after being subjected to a salt spray test for 1000 hours, and compared with the prior art, the performance is greatly improved.

The invention relates to a titanium-based enamel coating resistant to cold and hot impact and suitable for low-temperature firing and a preparation method thereof.The titanium-based enamel coating comprises enamel frits and grinding additives, and the grinding additives comprise titanium powder, aluminum silicate fibers, sodium nitrite, clay and water; the preparation method comprises the following steps: firstly preparing the enamel frit, then mixing the enamel frit with a grinding additive to obtain enamel glaze slip, then pretreating the titanium substrate to remove surface dirt, then carrying out wet spraying on the enamel glaze slip on the surface of the pretreated titanium substrate, and finally, sequentially drying and sintering the titanium substrate sprayed with the enamel glaze slip to obtain the titanium-based composite material. The titanium-based enamel coating is prepared. The titanium-based enamel coating resistant to cold and hot impact and suitable for low-temperature firing can bear 700 DEG C water cooling circulation for 22-26 times without ceramic cracking or falling off, and has excellent cold and hot impact resistance; during preparation, the preparation process is simple, and the firing temperature is 835-845 DEG C and is reduced by more than 60 DEG C compared with the prior art.

The invention discloses a method for preparing 4-methoxycarbonyl-2-methylthiophene-3-sulfonamide, comprising the following steps: 1. preparing a sodium disulfide solution for standby; 2. reacting 4-amino-5-methylthiophene-3-methyl formate with sodium nitrite to obtain a diazo solution for standby; 3. reacting sodium disulfide with the diazo solution prepared in step 2 to obtain 3,3'-disulfide-bis[4-methoxycarbonyl-2-methylthiophene]; 4. reacting 3,3'-disulfide-bis[4-methoxycarbonyl-2-methylthiophene] with sulfonyl chloride; 5. adding water to separate layers, and treating the organic layer with ammonia to obtain 4-methoxycarbonyl-2-methylthiophene-3-sulfonamide. The invention provides a new preparation route for 4-methoxycarbonyl-2-methylthiophene-3-sulfonamide, wherein sulfur dioxide or chlorine is not used in the preparation process, thereby improving operational safety, reducing environmental pressure, reducing production costs, and being suitable for industrial production.

The invention discloses a polyfunctional group synergistic reverse osmosis membrane and a preparation method thereof, and relates to the technical field of new materials and membrane separation. The polysulfone porous base membrane is sequentially soaked in a water phase monomer solution and an oil phase monomer solution, the polyamide reverse osmosis membrane is prepared through interfacial polymerization, sulfonic acid groups are introduced in the process, and water transfer channels are increased; soaking in an aminobenzene sulfonic acid aqueous solution, and introducing a benzenesulfonic acid group to improve the hydrophilicity of the reverse osmosis membrane; then treating with a sodium nitrite aqueous solution, and carrying out diazotization coupling reaction on the surface, so as to improve the crosslinking degree of the polyamide separation functional layer. The reverse osmosis membrane is cleaned by using a sodium sulfite aqueous solution, and an unreacted diazo group is replaced by a sulfurous acid group, so that the surface stability of the reverse osmosis membrane is improved. The preparation method provided by the invention is easy to control and simple in process, and the reverse osmosis membrane obtained by the preparation method has a synergistic effect of polyfunctional groups, so that the desalination rate and the water permeation flux of the reverse osmosis membrane are both improved, and the reverse osmosis membrane can be applied to the fields of purified water preparation, industrial sewage and wastewater deep treatment, seawater desalination and the like.

The invention relates to the technical field of medical intermediate processing, and discloses a preparation method of polyfluoro substituted benzene series compounds based on diazonium salt, which comprises the following steps: 1) taking fluoroaniline substances, fluoboric acid and sodium nitrite as raw materials, reacting for 2-4 hours at the reaction temperature of lower than 10 DEG C, and performing suction filtration and purification to obtain a diazonium salt intermediate; 2) distilling the diazonium salt intermediate at 130-150 DEG C, and decomposing the diazonium salt intermediate to obtain a compound which is o-difluorobenzene, p-difluorobenzene or 1, 2, 4-trifluorobenzene; according to the method, a diazonium salt intermediate is prepared by taking a fluorine-containing aniline substance, fluoboric acid and sodium nitrite as raw materials, the yield of the step can reach 95% or above, the yield of pure o-difluorobenzene obtained by heating and decomposing diazonium salt can reach 80% or above, and the yield of p-difluorobenzene can also reach 85% or above; the yield of the obtained 1, 2, 4-trifluorobenzene can also reach 84% or above; the method is short in process, mild in reaction, simple in operation, high in product yield and simple in purification operation, and the product purity can reach 99% or above.

The invention discloses a method for preparing a bio-based disazo lake pigment, comprising the following steps: S1, aniline compound is diazotized with sodium nitrite under the action of acid solution, and then coupled with 2,5-hydroxyterephthalic acid to prepare disazo-2,5-hydroxyterephthalic acid dye; S2, the disazo-2,5-hydroxyterephthalic acid dye prepared in step S1 is reacted with a metal salt in an aqueous solution to prepare a bio-based disazo lake pigment. In the present invention, the main raw material of the bio-based disazo lake pigment comes from biological fermentation, the preparation method is simple, and the structure has two pairs of adjacent hydroxyl groups and carboxyl groups, which can have a good complexing effect on metal ions, and is easy to form an intermolecular association to stabilize the metal ions. The organic lake pigment prepared by the present invention can tolerate a wide pH range without the freeing of metal ions when used to prepare an aqueous color paste, and does not affect the viscosity and tinting power of the color paste.

The invention relates to a method for jointly determining plutonium 238, 239 + 240 and neptun-237 in aerosol by taking Pu-236 as a yield tracer agent, which comprises the following steps: step 1, sample pretreatment: cutting an aerosol sample into pieces, adding 236Pu, ashing, and leaching with a nitric acid solution A; step 2, valence state adjustment: adjusting the acidity of the leaching solution, and sequentially adding a hydroxylamine hydrochloride solution, a ferrous sulfamate solution and a sodium nitrite solution to adjust the valence state of nuclide; step 3, separation and purification: separating and purifying by adopting a TEVA resin column, leaching by using a nitric acid solution B and a hydrochloric acid solution, and desorbing by using an HCl-HF solution; and 4, the desorption solution is subjected to electro-deposition to prepare a source, and a low background alpha spectrometer is adopted for measurement of plutonium 238, 239 + 240 and neptun-237. The detection method is high in sensitivity, the recovery rate of the neptun-237 is high, and the blank of joint analysis of plutonium 238, 239 + 240 and neptun-237 is filled.

The invention provides a composite heat storage material and a preparation method thereof, and relates to the technical field of phase change heat storage materials. The composite heat storage material comprises the following raw materials in percentage by mole: 10-70% of sodium hydroxide, 1-5% of potassium hydroxide, 10-60% of sodium nitrate and 10-70% of sodium nitrite. The prepared composite heat storage material has the characteristics of stable thermal cycle performance, high phase change heat storage density and the like, and is suitable for the field of medium-temperature heat storage.

The invention discloses a phototherapy reagent and a preparation method and application thereof. The preparation method comprises the following steps: 1-[4-(diethylamino) phenyl]-ethane-1-ketone and 4-methoxybenzaldehyde are subjected to a condensation reaction in a NaOH ethanol solution, and a product and nitromethane are subjected to addition; performing condensation and addition on the other groups of raw materials by the same method; cyclizing the two addition products with ammonium acetate, and coordinating with boron trifluoride diethyl etherate to obtain NHM; carrying out substitution reaction on the NHM and sodium nitrite to obtain NOO; and oxidizing NOO by m-chloroperoxybenzoic acid to obtain NNOO. The reagent can target a tumor hypoxia microenvironment, hypoxia monitoring is achieved, NO is released through photostimulation for tumor gas therapy, meanwhile, the secondary amplification photo-thermal therapy effect is achieved, preparation is controllable, diagnosis and treatment are integrated, and the reagent is sensitive, safe and suitable for biomedical research and clinical diagnosis.

The present invention relates to a method for preparing a high-purity peramivir intermediate. The method comprises the following steps: Step 1: adding compound II to a reaction kettle, and dropwise adding a sodium borohydride methanol solution; after the dropwise addition is completed, the reaction is stirred at a controlled temperature; purified water and a sodium nitrite solution are added, and the reaction is stirred to prepare compound (III); Step 2: adding acetic anhydride dropwise to compound (III), and the reaction is stirred at a controlled temperature; Step 3: adding a sodium carbonate aqueous solution, stirring, separating the liquids, collecting the organic phase, concentrating under reduced pressure, adding a solvent, stirring and crystallizing, and centrifuging until no obvious liquid flows out; vacuum drying the filter cake to obtain an off-white crude peramivir acetylate (IV); Step 4: refining to obtain an off-white solid peramivir acetylate (IV). #imgabs0#

The present application relates to a kind of five-ring thiazole indole ketone piperazine amide derivatives and purposes thereof.The derivatives take ethyl cyanoacetate as starting material, generate hydroxylamine compound (A) under the action of sodium nitrite and phosphoric acid;Obtain 2-amino ethyl cyanoacetate (B) by reduction, in turn with acetic anhydride, lawson reagent is reacted, and 5-amino-4-carboxylate thiazole compound (D) is obtained;After bromination by NBS, under the catalysis of phosphorus oxychloride, react with tetrahydropyridine indole ketone, generate 2-bromo-6,7-dihydrothiazolo [5'',4'':4',5'] pyrimido [1',2':1,2] pyrindo [3,4-b] indole-4 (12H) -ketone (F), again under alkaline condition, first with Boc piperazine, then by Boc treatment and obtain compound (H);Finally, react with acyl chloride, and 28 different substitution structures of five-ring thiazole indole ketone piperazine amide compound (I1-I28) are synthesized.The 28 compounds are tested on three kinds of cancer cells, and the results show that: 28 compounds have significant inhibitory activity on Hela cervical cancer cells, HT-29 human colon cancer cells and HGC-27 human gastric cancer cells.