61 results about "Keratoconus" patented technology

The disclosure concerns altering the mechanical and/or chemical property of a body tissue, particularly an ocular tissue. In specific cases, it concerns altering or stabilizing the shape of the cornea, such as in a subject suffering or at risk for ectasia or keratoconus. In other specific cases, it concerns strengthening the sclera in a subject suffering or at risk for myopia. The invention employs light irradiation of a photoactivatable compound, such as one that applies crosslinking to the tissue, for example.

A method for stabilizing collagenous eye tissues by nitrite and nitroalcohol treatment. The topical stiffening agent contains sodium nitrite or a nitroalcohol in a buffered balanced salt solution and can be applied to the surface of the eye on a daily basis for a prolonged period. Application of the solution results in progressive stabilization of the corneal and scleral tissues through non-enzymatic cross-linking of collagen fibers. The compounds can penetrate into the corneal stroma without the need to remove the corneal epithelium. In addition, ultraviolet light is not needed to activate the cross-linking process. The resulting stabilization of corneal and scleral tissues can prevent future alterations in corneal curvature and has utility in diseases such as keratoconus, keratectasia, progressive myopia, and glaucoma.

Examples of methods and apparatus for an accurate measurement of the anterior surface of the eye including the corneal and scleral regions are disclosed. The measurements provide a three-dimensional map of the surface which can be used for a variety of ophthalmic and optometric applications from astigmatism and keratoconus diagnostics to scleral lens fitting.

Methods of stabilizing collagen fibrils in a cornea are disclosed. The stabilization may be effected by treating the cornea with a protein that crosslinks collagen fibrils, such as decorin. The stablization methods include treatment of corneas before, during, or after a surgical procedure, treatment of keratectasia, and treatment of keratoconus.

The disclosure concerns altering the mechanical and/or chemical property of a body tissue, particularly an ocular tissue. In specific cases, it concerns altering or stabilizing the shape of the cornea, such as in a subject suffering or at risk for ectasia or keratoconus. In other specific cases, it concerns strengthening the sclera in a subject suffering or at risk for myopia. The invention employs light irradiation of a photoactivatable compound, such as one that applies crosslinking to the tissue, for example.

The invention provides a method for diagnosing a keratoconus case based on XGBoost+SVM hybrid machine learning. The method includes the following steps that: the corneal examination data of ophthalmicpatients are collected, each corneal sample is labeled with a category label keratoconus, suspected keratoconus and normal cornea by ophthalmologists, and the labeled corneal samples are adopted as training sample data; the feature values of the features of the corneal sample data are normalized and are mapped to an interval [0, 1]; the XKoost is used to expand the features of the sample data, and an expanded feature set is adopted as the training features of the samples; and based on the training features of the sample data, an SVM diagnosis model is trained and constructed; and the diagnosis model is adopted to diagnose and predict new cases. Tests have shown that the diagnostic effect of the method has met the requirements of clinical applications. The method can be used for screeningthe keratoconus, especially suspected keratoconus, can reduce dependence on the diagnosis of medical experts, and can basically improve diagnostic efficiency and accuracy.

A contact lens is fitted to a cornea of a patient's eye to gradually alter the patient's cornea during continued wear to reshape the altered cornea conditions such as the corneas of post refractive surgery, post previous Ortho-K. and keratoconus. The contact lens has a plurality of zones that comprise one optical zone, at least one conformation zone, a connecting zones complex, an alignment zone and a peripheral zone. The one or more conformation zones are utilized to conform the angle of the central optical zone, as well as the alignment zone, to compress on the central and mid-peripheral portion of the altered cornea for redistribute cornea tissue to reduce the residual refractive errors, after refractive surgery, or to smooth out the central cornea surface of the keratoconus for better bare or spectacle vision after contact lens are removed.

The invention discloses a keratoconus recognition method and device based on multi-dimensional feature fusion, and the method comprises the steps: 1), carrying out the data processing through a designed standardized flow through the multi-dimensional data of a single patient, carrying out the grading of keratoconus, and dividing the keratoconus into a normal keratoconus, a subclinical keratoconusand a keratoconus; 2) constructing a multi-dimensional model, carrying out feature fusion in various modes, connecting an SE module to carry out feature recombination, and then carrying out model training; 3) carrying out interpretability operation of category judgment by utilizing gradient back propagation, and outputting a visual image; (4) comparing influences of one-dimensional convolution andtwo-dimensional convolution on the keratoconus data model for special consideration of the c keratoconus data model, and (5) selecting the category where the maximum score in the three scores is located as the discriminated category through the designed model to obtain a good classification effect, and optimizing the problem that the conic cornea recognition effect is poor in practical application.

The invention relates to a method for diagnosing keratoconus cases based on machine learning. According to the method, a support vector machines-recursive feature elimination (SVM-RFE) algorithm and agradient boosting regression tree (ABDT) algorithm are applied to accurate diagnosis of the keratoconus cases. Furthermore for aiming at specific application cases, effective overall plan designing,process designing and algorithm parameter setting are performed. Through test of a large number of clinic instances, the diagnosis accuracy of the method is effectively improved and basically satisfies the requirement for clinic applications.

An improved formulation of an ophthalmic composition contains riboflavin, as cross-linking agent of corneal collagen, administered by corneal iontophoresis, able to guarantee an increased capacity of permeation of riboflavin of the corneal stroma and therefore greater therapeutic efficacy in the treatment of keratoconus.

The invention discloses a method for expressing corneal irregularity structure changes based on change consistency parameters of an anterior segment tomography technology. According to the method, a method for establishing objective indexes of parameter change relative positions is provided, the positions, where morphological changes may occur, of the irregular corneas are comprehensively expressed, the early diagnosis performance of irregular corneal diseases such as the conic corneas can be theoretically improved, and meanwhile the complexity of combined interpretation of a large number of parameters in clinical actual work is reduced.

The invention aims at providing a medicine for treating keratoconus, which takes an Nrf2-ARE signal path as a target. The medicine can activate the signal path or improve the expression of downstream antioxidant genes NQO-1 and SOD2, so as to reduce the expression of matrix degrading enzymes; therefore, the medicine is suitable for the treatment of keratoconus. The medicine disclosed by the invention, which is used for treating the keratoconus by virtue of a methylation inhibitor 5-aza, can improve the expression of antioxidant genes of keratoconus matrix cells and can reduce the content of the matrix degrading enzymes as well.

The invention provides a keratoconus recognition method and device, and the method comprises the steps: taking various types of corneal morphological data as the input data of a neural network, extracting the high-dimensional features of the data for classification, obtaining a classification result related to various types of keratoconus, and converting the manual observation of corneal topographic map data into a machine recognition process. According to the method, the neural network is used for replacing manual work to subdivide the types of the keratoconus, reference information used fordiagnosis is rapidly and accurately provided, and therefore the working efficiency of doctors can be improved, and high accuracy is achieved.

The invention aims to provide a novel application of a KRT12 gene to preparation of diagnostic reagents for keratoconus detection, and accordingly provides an effective method for keratoconus disease gene diagnosis, prenatal gene screening and genetic counseling. Application effects indicate that SNP (single nucleotide polymorphism) sites and detection primers can be effectively used for rapidly detecting KRT12 gene mutation sites of clinical patients and fetal cotyledon or amniotic fluid.

The present invention relates generally to a medicinal solution, and more particularly to a medicinal solution which is to be continuously or pulse-delivered for the purpose of treating various ocular diseases, conditions, or maladies, such as keratoconus, infectious keratitis, severe inflammatory conditions, and ocular surface neoplasia. In particular, the medicinal solution comprises the combination of a medication for treating one of the aforenoted or similar diseases, conditions, or maladies, and an anesthetic for rendering the patient comfortable during the treatment procedure.