40 results about "Intraocular fluid" patented technology

The utility model discloses an aqueous humor quantitative collecting device capable of accurately controlling pressure, which is characterized in that a limiting device is arranged on an adjusting device; the control button is slidably arranged on the adjusting device in a sleeving mode and can rotate to a locking working position or a starting working position relative to the adjusting device. The piston assembly penetrates through the limiting device and the adjusting device and is fixedly installed on the control button. A plurality of scale marks are arranged on the outer wall of the suction cylinder, the suction cylinder is fixed to the adjusting device, and the suction cylinder is arranged outside the limiting device and the piston assembly in a sleeving mode; the liquid collecting assembly is installed at the end, away from the adjusting device, of the suction barrel and communicates with the suction barrel. By using the device, intraoperative side injury caused by movement of eyeballs of a patient in an operation can be effectively avoided, meanwhile, loss of intraocular fluid sample amount collected by an injector is avoided, the volume of the sampled intraocular fluid can be accurately controlled, the intraocular pressure level can be reduced, the operation process is convenient and rapid, and pain of the patient is obviously relieved.

A phacoemulsification system and a corresponding method are described. The system having a handpiece having a needle and a sleeve at a distal end to emulsify a lens of an eye; an irrigation module configured to supply irrigation fluid into the eye; an aspiration module configured for aspiring eye fluid; a priming cover for fitting over the distal end of the handpiece during a priming process; external pressure sensors coupled with the priming cover; one or more sensors for monitoring at least one of an irrigation pressure and an aspiration pressure; and a processor configured to operate in a priming process. The priming process includes operating the irrigation module to fill the irrigation channel with fluid and remove air bubbles. The one or more processors are configured for obtaining calibration pressure data from the external pressure sensors and for calibrating the sensors of the system.

Apparatus and methods are provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the device includes a housing shell defining a cavity between a first end and a second end of the housing shell, and an elastic membrane disposed within the cavity to divide the cavity into a fluidic channel that permits a flow of fluid from the first end to the second end and a sealed cavity. The elastic membrane deforms to change the volume of the sealed cavity responsive to pressure fluctuations between the first and second ends, thereby varying the fluidic resistance of the flow of fluid through the fluidic channel.

This invention belongs to the field of contact lens technology, specifically providing a method for designing scleral lenses based on ocular surface and scleral topography. Based on the topography of the anterior surface of the patient's cornea and sclera, the method divides the anterior surface of the cornea and sclera into meridians at equal angles, and designs the surface profile curves of the anterior and posterior surfaces of the scleral lens according to the morphology of the patient's cornea and sclera. Finally, 3D reconstruction is used to obtain the 3D surface profile data of the scleral lens. The optical zone of the scleral lens can be designed in various ways depending on the different shapes of the patient's eyeball; the transition zone can be designed in diverse ways to ensure the thickness of the intraocular fluid at certain locations based on the ocular surface morphology; and the landing zone smoothly conforms to the anterior surface of the sclera. This invention maximizes conformity to the patient's ocular surface morphology, ensures the uniformity of the intraocular fluid, and maintains a high degree of matching with the ocular surface, thereby achieving trial-free scleral lens fitting, improving clinical accuracy and efficiency, and enhancing patient safety and satisfaction.

A phacoemulsification system and a corresponding method are described. The system having a handpiece having a needle and a sleeve at a distal end to emulsify a lens of an eye; an irrigation module configured to supply irrigation fluid into the eye; an aspiration module configured for aspiring eye fluid; a priming cover for fitting over the distal end of the handpiece during a priming process; external pressure sensors coupled with the priming cover; one or more sensors for monitoring at least one of an irrigation pressure and an aspiration pressure; and a processor configured to operate in a priming process. The priming process includes operating the irrigation module to fill the irrigation channel with fluid and remove air bubbles. The one or more processors are configured for obtaining calibration pressure data from the external pressure sensors and for calibrating the sensors of the system.

The invention discloses an expandable vitreous cavity crystal shedding blocking device for cataract surgery, relates to the technical field of cataract surgery auxiliary instruments, and provides the following scheme that the expandable vitreous cavity crystal shedding blocking device comprises a blocking net injection mechanism, and the front end of the blocking net injection mechanism is connected with a crystalline lens blocking net; and the barrier net injection mechanism comprises an outer sleeve. A spiral transmission structure of the screwing pipe and the outer sleeve is combined with a linkage mechanism of the transmission rod and the traction block, control over the crystalline lens blocking net by the medical steel wire is achieved, the medical-grade polycarbonate oval outer ring and the medical-grade polycarbonate oval inner ring can be unfolded or folded according to needs, a stable bearing concave face can be formed in an operation to prevent a crystalline lens from falling off, and the use effect of the medical-grade polycarbonate oval outer ring and the medical-grade polycarbonate oval inner ring is improved. In addition, numerical value marks of the observation opening provide visual screwing depth reference for doctors, and the postoperative infection risk is reduced by combining tight sealing of liquid in the eyes through the sealing ring.

The present invention relates to iota-carrageenan for use as a main or sole active ingredient in an aqueous pharmaceutical composition for the prevention or treatment of non-viral non-allergic clinically relevant eye conditions affecting at least one of mucosal tissues at or around an individual's eye, an eye surface, corneal tissue, and fluid inside the eye, said clinically relevant eye conditions selected from the group consisting of increased intraocular pressure, non- allergic and non-viral conjunctivitis, irritations caused by airborne particulate matter other than allergens, and late complications of non-viral and non-allergic conjunctivitis selected from the group consisting of corneal opacities, subepithelial infiltrates, and formation of ocular pseudomembranes.

The invention belongs to the technical field of eye surgical instruments, and particularly relates to a surgical puncture knife capable of pumping and injecting intraocular fluid. Comprising a puncture tool bit, a grab handle and an air pump, and the bottom of the puncture tool bit is fixedly connected with the top end of the grab handle; one end of the hole channel is located at the position of the tool bit area, and the other end of the hole channel is located at the bottom of the puncture tool bit; an opening in one end of the flow channel is formed in the top end face of the grab handle and is in butt joint with the through hole channel of the puncture tool bit; an opening at the other end of the runner is formed in the side wall or the bottom end of the grab handle; the other end of the runner is connected with an air pump through a pipeline; the air pump can rotate forwards and backwards to perform liquid pumping and liquid injection operations. The disposable intramedullary nail has the advantages that the disposable intramedullary nail is simple in structure and convenient to operate, liquid suction / liquid injection can be directly performed after one-time puncture action, an extra liquid tube does not need to be inserted into a wound after the tool bit is pulled out, wound expansion is prevented, and surgical risks caused by secondary insertion into an eyeball are reduced.

The invention relates to the technical field of microbiological detection, in particular to a method for rapidly detecting nucleic acid of intraocular fluid or tear bacteria. On the basis of a constant-temperature nucleic acid amplification technology, multiple groups of amplification primers required by amplification of different pathogenic bacteria are designed, and detection primers with high detection sensitivity, strong specificity and good stability are obtained through screening; secondly, designing and optimizing efficient pathogen cracking conditions and preparation of related reagents according to biological characteristics of target pathogens; the primer group and the reagent obtained through optimization are used for detecting pathogenic bacteria, the sample size demand is low, the sensitivity and the specificity are high, and an effective technical means is provided for rapid detection of bacterial infection on site (outpatient service, ward or operating room) after cataract operation.

The application provides an ophthalmic minimally invasive drainage device, and relates to the technical field of medical devices.The device comprises a drainage tube, a dispersion tube and a release tube fixed as a whole, the longitudinal section shape of the drainage tube, the dispersion tube and the release tube is flat, the left end of the drainage tube is provided with a liquid inlet assembly for liquid inlet; the upper part of the drainage tube is provided with a fixing assembly for limiting surgical thread; the dispersion tube is fixedly connected with a fixing lug; the release tube is in the shape of a circular arc, the right end of the release tube is provided with a pressure stabilizing membrane, and a pressure stabilizing port is arranged between the pressure stabilizing membrane and the release tube.The fixing assembly can limit surgical thread, ensure the stability of the drainage tube, improve the operation quality and reduce operation complications; the pressure stabilizing membrane and the pressure stabilizing port can change the size of the pressure stabilizing port by using the pressure deformation characteristics of the pressure stabilizing membrane, thereby ensuring the stability of the intraocular fluid pressure in the anterior chamber and being beneficial to the treatment of glaucoma.

Methods of treating an eye for an ocular condition such as placing a composite depot comprising a xerogel with embedded degradable particles into an anterior chamber of an eye to deliver a therapeutic agent. The xerogel is a hydrogel after exposure to intraocular fluid and is degradable. The degradable particles comprise the therapeutic agent and hydrolytically degrade in the anterior chamber to provide a controlled release of the therapeutic agent into the eye. Materials and processes for making depots are provided as well as alternative methods of their use.

A phacoemulsification system and a method are described. The system including: a handpiece having a needle and a sleeve at a distal end and an orientation detection unit; an irrigation module configured to supply irrigation fluid into the eye; an aspiration module configured for aspiring eye fluid; a priming cover for fitting over the distal end of the handpiece during a priming process; external pressure sensors coupled with the priming cover; one or more sensors for monitoring at irrigation and spiration pressure; and a processor configured to operate in a priming process. The priming process includes operating the irrigation module to fill the irrigation channel with fluid and remove air bubbles. The one or more processors are configured for obtaining calibration pressure data from the external pressure sensors and orientation data from the orientation detection unit and for calibrating the sensors of the system in accordance with orientation data.

A phacoemulsification system and a corresponding method are described. The system having a handpiece having a needle and a sleeve at a distal end to emulsify a lens of an eye; an irrigation module configured to supply irrigation fluid into the eye; an aspiration module configured for aspiring eye fluid; a priming cover for fitting over the distal end of the handpiece during a priming process; external pressure sensors coupled with the priming cover; one or more sensors for monitoring at least one of an irrigation pressure and an aspiration pressure; and a processor configured to operate in a priming process. The priming process includes operating the irrigation module to fill the irrigation channel with fluid and remove air bubbles. The one or more processors are configured for obtaining calibration pressure data from the external pressure sensors and for calibrating the sensors of the system.

The invention relates to the technical field of biological material detection, in particular to an intraocular fluid marker rapid detection method based on artificial intelligence. The method comprises the following steps: firstly, collecting an intraocular fluid sample to be detected; obtaining a physical interference factor according to the color characteristic, the turbid characteristic and the flow characteristic of the intraocular fluid sample; acquiring a nucleic acid quality factor according to the concentration, purity and dominant characteristics of nucleic acid in the intraocular fluid sample; acquiring a matrix inhibition factor according to dripping morphological characteristics and pipetting liquid level characteristics of the intraocular fluid sample; and inputting the physical interference factor, the nucleic acid quality factor and the matrix inhibition factor of the intraocular fluid sample into a pre-trained circulation parameter recommendation model, and carrying out rapid detection on the marker of the intraocular fluid sample according to recommended circulation parameters output by the model. According to the method, the sample characteristic factors which reflect the influence of the intraocular fluid sample on the detection are quantified from different angles, and then the loop parameters are recommended through the neural network model for rapid detection, so that the detection efficiency and effect of the intraocular fluid marker are improved.

The utility model discloses an intraocular liquid leading-out device, which belongs to the technical field of medical instruments and comprises a film bag, a connecting plate, a handle, a drain valve, a tube opening cover, a connecting body, an interface thread, a drainage tube, an external thread, a flow limiting buckle, a clamping component, a flushing hole and a wire outlet hole, a connecting plate is arranged on one side of a film bag, a handle is arranged on the connecting plate, a drain valve is arranged at one end of the film bag, a tube opening cover is arranged on the outer side of the drain valve, a connecting body is arranged at the other end of the film bag, connector threads are arranged in the connecting body, a drainage tube is arranged at the connector threads, and external threads are arranged at one end of the drainage tube. The drainage tube is sleeved with the flow limiting buckle, the clamping assembly is arranged at the end opening of the drainage tube, the flushing hole is formed in one end of the drainage tube, the intraocular liquid extraction device can effectively prevent the falling-off situation in the using process through the clamping assembly, redundant liquid in the intraocular conjunctival sac can be extracted conveniently, and therefore the treatment effect can be improved.

The present invention discloses a quantitative aqueous humor collection device capable of precisely controlling pressure, characterized in that it comprises: a limiting device installed on an adjusting device; a control button slidably sleeved on the adjusting device, and the control button can be rotated relative to the adjusting device to a locked working position or a start working position; a piston assembly passes through the limiting device and the adjusting device and is fixedly installed on the control button; a plurality of scale lines are provided on the outer wall of a suction cylinder, the suction cylinder is fixed to the adjusting device, and the suction cylinder is sleeved on the outside of the limiting device and the piston assembly; a liquid collecting assembly is installed on an end of the suction cylinder away from the adjusting device, and the liquid collecting assembly is connected to the suction cylinder. By using this device, intraoperative secondary injuries caused by movement of the patient's eyeball during surgery can be effectively avoided, while the loss of the amount of intraocular fluid sample collected by the syringe can be avoided. The volume of the sampled intraocular fluid and the reduced intraocular pressure level can also be precisely controlled. The operation process is convenient and quick, and the patient's pain is significantly reduced.

Methods, kits, and devices for detecting open-globe eye injuries are described. A device including a target recognition element specific for intraocular fluid, appropriate for use in the field is described. A method for detecting an open-globe eye injury by detecting proteins found in intraocular fluid is also described. A device may include a soft absorbent swab for sample collection, a lateral flow assay device, and a blood filter to improve device performance.

An ophthalmic surgical instrument includes a handpiece configured to be held by a user, and a working tip coupled to a distal end of the handpiece that includes a proximal opening configured to be disposed outside an eye, a distal opening configured to be disposed inside the eye and expose a tool to the inside of the eye, and a channel between the openings. When the distal opening is disposed inside the eye and the proximal opening is uncovered the proximal opening permits the channel to be in fluid communication with ambient atmosphere, the channel is configured to enable passive aspiration of fluid from inside the eye, such that the fluid flows from the distal to the proximal opening and into the ambient atmosphere. The tool comprises forceps, scissors, a delamination spatula, a pick, an illumination fiber, or a laser fiber.

The present application relates to a primer set, a kit and its application for detecting intraocular bacterial infection, and belongs to the field of biological detection technology. The primer set for detecting intraocular bacterial infection in the present application includes a detection primer pair, a detection probe, an exogenous internal standard primer pair and an exogenous internal standard probe. The present application also discloses a kit for detecting intraocular bacterial infection, including the above-mentioned primer set for detecting intraocular bacterial infection, a PCR reaction premix, a negative quality control product, a positive quality control product, a nucleic acid releaser, a PCR decontamination reagent and an exogenous internal standard. The present application can specifically detect whether the sample contains bacteria by performing qPCR on the eye (intraocular fluid) sample, and can still complete the detection of the sample when the sample amount is small or the bacterial content is low. The minimum detection limit can reach 34CFU / mL, which has the advantages of rapid and simple detection of whether bacteria exist in a single sample, and high sensitivity, strong specificity and a wide detection range.

A glaucoma shunt for draining a fluid from an eye to a tissue surrounding the eye, the glaucoma shunt being implantable within tissue of the eye, the glaucoma shunt includes a shunt body that is formed from a microporous material that is arranged so as to form a reservoir within the shunt body; and a conduit in fluid communication with the reservoir, the conduit being insertable into the eye such that the fluid at a distal end of the conduit is allowed to flow through the conduit and accumulate within the reservoir, wherein the microporous material transitions from a hydrophobic state to a hydrophilic state as the fluid that is accumulated in the reservoir diffuses to the tissue surrounding the eye through the microporous material so as to provide a variable flow resistance as the microporous material transitions from the hydrophobic state to the hydrophilic state.

A stent implant for treating glaucoma by intraocular fluid drainage from the anterior chamber, for example into the suprachoroidal space. The stent implant is designed to change in shape after being inserted into the eye, during which change the width and / or thickness or the flow cross-section is increased by for example 20%, in another example more than 200%, and in a further example by more than 400%, at least one point of the stent implant. In the case of intraocular fluid drainage from the anterior chamber into the suprachoroidal space, a cyclodialysis cleft which may open can be largely or completely closed. With appropriate adjustments, the stent implant can also be applied in trabecular, uveoscleral, uveolymphatic and subconjunctival applications for intraocular fluid drainage from the anterior chamber. The implant can even be used for direct intraocular fluid discharge from the anterior chamber onto the surface of the eye.

A phakic intraocular lens for the correction of complex astigmatism in keratoconus, containing an optical zone of the lens located on the optical axis of the lens, holes located on it for the circulation of intraocular fluid, a fixation zone around the optical zone, differs in that it additionally has an absolutely opaque disk placed in the optical center, in the center of which there is a hole. In addition, the lens with these elements is made of various biologically compatible materials by simultaneous molding.

A precise pressure-controlled aqueous humor quantitative collection device and a use method therefor. The precise pressure-controlled aqueous humor quantitative collection device comprises a liquid collection assembly (6), a control knob (3), an adjustment device (2), a suction cylinder (5), a piston assembly (4), and a limiting device (1). The limiting device (1) is installed on the adjustment device (2). The control knob (3) is slidably sleeved on the adjustment device (2) and can rotate relative to the adjustment device (2) to a locked working position or a starting working position. The piston assembly (4) penetrates through the limiting device (1) and the adjustment device (2), and is fixedly installed on the control knob (3). An outer wall of the suction cylinder (5) is provided with several scale lines. The suction cylinder (5) is fixed to the adjustment device (2) and is sleeved outside the limiting device (1) and the piston assembly (4). The liquid collection assembly (6) is installed at the end of the suction cylinder (5) away from the adjustment device (2) and is in communication with the suction cylinder (5). By using the precise pressure-controlled aqueous humor quantitative collection device, secondary injuries caused by intraoperative movement of the patient's eyeball can be effectively avoided, and the volume of sampled intraocular fluid and the reduced intraocular pressure level can also be precisely controlled. The operation process is convenient and quick, significantly reducing patient discomfort.

An ocular implant (10) for delivering intraocular fluid from a site of intraocular fluid excess in a patient, the implant (10) comprising: a body (12) including one or more drainage channels (20), each having an outlet (24), the outlets being in fluid communication with a drainage site located away from the site of intraocular fluid excess; and an elongated tubular component (30) in fluid communication with the body (12), the component (30) having a first end portion (32) providing an inlet (38), a second end portion (34) providing an end (40), and so on. and a lumen extending between the inlet (38) and the end (40), wherein the inlet (38) is in fluid communication with the portion of the intraocular fluid excess, such that the intraocular fluid can flow through the inlet (38) and through the lumen to the end (40), and wherein the second end portion (34) includes one or more openings (42), each opening being in fluid communication with a corresponding drainage channel in one or more drainage channels (20) to allow the intraocular fluid to flow from the second end portion (34) to each outlet in the outlet (24).

Methods of treating an eye for an ocular condition such as placing a composite depot comprising a xerogel with embedded degradable particles into an anterior chamber of an eye to deliver a therapeutic agent. The xerogel is a hydrogel after exposure to intraocular fluid and is degradable. The degradable particles comprise the therapeutic agent and hydrolytically degrade in the anterior chamber to provide a controlled release of the therapeutic agent into the eye. Materials and processes for making depots are provided as well as alternative methods of their use.

Spacer device 800 for implantation into an eye, comprising a flexible body configured to conform to an anatomical tissue surface of the eye, the body comprising an inner surface 825 and an outer surface 845, wherein the spacer device is configured to reversibly transition between a compressed configuration suitable for feeding through an application element 400 and an expanded configuration defining a convex, internal three-dimensional volume 370 for receiving fluid from an anterior chamber of the eye, wherein the spacer device comprises engagement elements 810, 830, each positioned along and extending along a longitudinal axis of the inner surface 825, and wherein the engagement elements are configured to: (i) engage with an application element 400 to stabilize the spacer device during implantation into the eye, and (ii) engage with the tissue surface after insertion, and wherein a central slot 865 arranged between the engagement elements 810, 830 forms a primary drainage path for the fluid circulation.

An ocular implant (10) for conveying intraocular fluid away from a site of excess intraocular fluid within a patient, the implant (10) including: a body (12) including one or more drainage channels (20) each having an outlet (24) fluidly communicable with drainage site located away from the site of excess intraocular fluid; and an elongated tubular member (30) fluidly communicable with the body (12), the member (30) having a first end portion (32) providing an inlet (38), a second end portion (34) providing an end (40), and a lumen extending between the inlet (38) and the end (40), wherein the inlet (38) is fluidly communicable with the site of excess intraocular fluid so that the intraocular fluid is able to flow past the inlet (38) and through the lumen towards the end (40), and wherein the second end portion (34) includes one or more openings (42) each fluidly communicable with a respective one of the one or more drainage channels (20) to permit the intraocular fluid to flow from the second end portion (34) to each of the outlets (24).

Glaucoma shunts for draining fluid from an eye to surrounding tissue and being implantable within eye tissue, the shunts include a shunt body formed from microporous materials arranged to form a reservoir within the shunt body, and a conduit having a proximal end in fluid communication with the reservoir and an opposing distal end, the distal end being insertable into the eye to facilitate drainage of fluid into the conduit via the distal end, wherein the conduit and the reservoir together define a flow passage along which drainage of fluid flows through the conduit, to the reservoir, and into surrounding tissue via the microporous material, wherein the flow passage presents a variable flow resistance along the conduit that has a plurality of sequential flow resistances with first and second flow resistances defined therein such that the first flow resistance is different from the second flow resistance.

Devices and methods for intraocular fluid injection are disclosed. A device can include a surgical instrument for an ophthalmic procedure. The surgical instrument can include a handle. A fluid compartment can be coupled to the handle and configured to hold a substance. A tool can be coupled to the distal end of the handle and have a lumen configured to convey the substance into an intraocular site of a patient. A piston can be in the handle and configured to reciprocate along the longitudinal axis of the handle to draw the substance from the fluid compartment and eject the substance through the lumen of the tool. A push button can be on the lateral side of the housing and configured to engage the piston via a sloped surface to actuate a forward stroke of the piston towards the distal end of the handle.