The present invention relates to the non-invasive optical measurement of glucose and other dissolved substances in human or animal
intraocular fluid. For this purpose, a method and devices for carrying out the method are proposed. The method according to the invention takes
advantage of the fact that the wave dependence of optical activity is fundamentally different from corneal
birefringence. The optical activity of substances dissolved in the
intraocular fluid, such as glucose, lactate,
ascorbic acid or amino acids, is scaled as a first approximation with the reciprocal value of the
wavelength square. Upon closer review, higher orders must be taken into consideration and effectively an exponent varying from a value of 2 may occur. For glucose, the exponent shall be denoted as 2+xG, with the value xG being approximately 0.2. Accordingly, the exponents for lactate are denoted as 2+xLak, for
ascorbic acid as 2+xAsc and for amino acids as 2+xAm. In contrast, corneal
birefringence is scaled with the reciprocal value of the
wavelength and therefore behaves considerably different from the optical activity. For the method according to the invention, a
physical model is used, which describes the influence on the polarization of measurement
radiation by the components of the eye, particularly by the
intraocular fluid and the
cornea.