31 results about "Cerebral tissue" patented technology

The present invention provides an early intelligent screening and warning method and system for acute stroke based on deep learning, which relates to the field of medical imaging and artificial intelligence technology, including obtaining multi-phase angiography images of the patient's brain through a pulsed dynamic imaging scheme, extracting hemodynamic characteristics using a dual-stream feature extraction network, and constructing a vascular lesion risk distribution map in combination with a vascular structure analysis model to mark potential embolism risk areas. Further, combining tissue perfusion parameters obtained by multispectral imaging and brain tissue function parameters obtained by electroencephalogram signals, an adaptive threshold segmentation model is used to identify the ischemic penumbra area. Finally, based on the ischemic penumbra area, tissue perfusion parameters, and brain tissue function parameters, a hierarchical decision model with a spatiotemporal attention mechanism is used to calculate the risk level and generate a corresponding clinical intervention plan. The present invention can achieve early and accurate screening and risk warning of acute stroke, and improve the efficiency of clinical intervention.

The disclosed physiological feedback systems and methods assist with assessing, monitoring and / or treating a patient experiencing a cardiac arrest event. The systems and methods receive multiple inputs and are continuous and / or iterative during a treatment session to provide physiological state trends of the patient. An index of the physiological state of the patient can be derived and confounders, and / or their effects, can be identified, and / or removed, from the index. Additionally, the systems and methods can assist with determining ischemic injury in a patient based on cerebral tissue oxygenation and / or other physiological data.

Disclosed herein are methods and devices for transvascular placement of electrodes on a surface of a brain or in deep brain structures for the purpose of neuromodulation. The device can comprise a delivery catheter comprising a lumen. The device can comprise a piercing assembly extending through the delivery catheter, wherein the piercing assembly comprises a piercing assembly catheter and a needle. The device can comprise one or more electrodes configured to contact the brain tissue; and wherein the piercing assembly catheter comprises an opening in a wall thereof such that when the delivery catheter and the piercing assembly catheter are positioned within a vessel, the needle extends through the opening to puncture a vessel wall.

This invention discloses a data processing method and system based on the changing trends of image features, relating to the field of cerebral infarction early warning technology. The data processing method includes: feature extraction: processing image data and modal data separately using feature analysis methods to obtain image features, image feature change data, modal data features, modal data feature change data, and the regions where the features are located. In this invention, image data provides intuitive information about brain structure and lesions, while modal data supplements key features such as hemodynamics, brain tissue electrical activity, and electrical impedance from different physiological dimensions. TCD data can monitor blood flow velocity and vascular resistance in real time, BI data is sensitive to changes in pathological states such as cerebral edema, and EEG data reflects subtle changes in neuronal electrical activity. Through feature extraction and analysis, the combination of multi-source heterogeneous data achieves the correction of image feature changing trends, thereby ensuring the accuracy of data processing.

The invention discloses a cerebral infarction risk early warning method and system based on an image feature change trend, and relates to the technical field of cerebral infarction early warning. The cerebral infarction risk early warning method comprises the steps of feature extraction, wherein image data and modal data are processed through a feature analysis method, and image features, image feature change data, modal data features, modal data feature change data and regions where the features are located are obtained; the image data provides visual information of a brain structure and a focus, the modal data supplements key features such as hemodynamics, brain tissue electrical activity and electrical impedance from different physiological dimensions, the TCD data can monitor blood flow velocity and vascular resistance in real time, and the BI data is sensitive to change of pathological states such as encephaledema. The EEG data reflects the subtle change of the electrical activity of neurons, and the image feature change trend is corrected through feature extraction and analysis and combination of multi-source heterogeneous data, so that the accuracy of cerebral infarction risk early warning is ensured.

The invention relates to the technical field of cerebrovascular analysis, and discloses a neurosurgery cerebrovascular analysis device, which is characterized in that an automatic tissue transfer mechanism is arranged in a detection table, and a microscopic photographing piece is arranged right above the automatic tissue transfer mechanism; the tissue automatic transferring mechanism comprises a transferring and overturning belt, two transparent glass sheets and an automatic washing assembly, two symmetrical disposal notches are formed in the transferring and overturning belt, the transparent glass sheets are rotationally arranged in the disposal notches, and when one transparent glass sheet moves to the position under the microscopic photographing piece, the automatic washing assembly is arranged in the disposal notches; the other transparent glass sheet synchronously moves to the central area of the lower wall of the transferring and overturning belt; by arranging the automatic tissue transferring mechanism, especially the alternate working mode of the transferring and overturning belt and the two transparent glass sheets, circulating treatment of automatic transferring, photographing and cleaning of brain tissue samples is achieved, the analysis efficiency is greatly improved, and manual intervention is reduced.

Provided is a structure composed of a cell population comprising endothelial cells, astrocytes and pericytes, and a 3D (three dimensional) cell growth material within which the cell population is located. The structure has a TEER value of at least 450 Ω / cm2. The cells of the structure may be derived from the brain. The cells may be human cells, and in particular may be primary derived non-immortalised cells. The structure is particularly suited for use in a model of the blood brain barrier, and the invention also provides such a model. The structure is located in a container, in which it separates a first chamber located on a first side of the structure and a second chamber located on a second side of the structure. The first and second chambers respectively contain first and second liquids in contact with first and second sides of the structure. The liquids mimic the brain extracellular fluid and the blood. The blood brain barrier model provided may be used in models of brain disease, and to investigate uptake of agents into the brain or diseased brain.

Disclosed is a non-invasive system and related methods to deliver electrical current to ischemic brain tissue rapidly with minimal set up, to treat acute ischemic stroke via direct cytoprotection and by collateral blood flow enhancement promoting recanalization of occluded vessel. In one embodiment, the system includes a cap with plurality of electrodes which are operable in combination to deliver an electrical current when in contact onto skin of the head region of the subject. In one embodiment, the electrical current delivery is individualized to target each individual's ischemic tissue only. In one embodiment, the electrode positioning can be selected from pre-determined electrode montages according to the location of the ischemia and vessel occlusion site. In one embodiment, the system can be applied as a standalone treatment or adjunct to reperfusion therapies to salvage the at-risk ischemic tissue (aka penumbra) and improve patient outcomes.

The invention discloses an experimental method for relieving ferroptosis of cerebral apoplexy rats through tVNS, and relates to the technical field of nerve regulation and control. Comprising the following steps: S1, constructing a rat MCAO model, and constructing an SD rat right cerebral ischemia reperfusion model by adopting a suture method; s2, experiment grouping: randomly dividing experimental animals into (1) a false operation group: an SHAM group; (2) a cerebral ischemia reperfusion group: an MCAO group; (3) an ear vagus nerve electrical stimulation group after cerebral ischemia reperfusion: a tVNS group; and S3, performing ear vagus nerve electrical stimulation intervention. Ferroptosis related proteins such as GPX4, ACSL4 and FTH1 are detected through Western blot, it is proved that tVNS can improve stroke rat brain tissue ferroptosis, and clear molecular mechanism support is provided for intervention; the content of reduced glutathione and the content of malondialdehyde are respectively detected by using a GSH and MDA content detection kit, and the effectiveness of tVNS in the aspect of relieving ferroptosis is further verified.

The invention provides traditional Chinese medicine compound essential oil and application thereof in preparation of anti-depression products, and relates to the technical field of traditional Chinese medicine essential oil pharmacy. The traditional Chinese medicine compound essential oil is prepared from 3-15 parts of benzoin essential oil, 2-10 parts of China rose essential oil, 2-10 parts of immature bitter orange essential oil, 1-8 parts of amomum cardamomum essential oil and 1-8 parts of fennel essential oil. The traditional Chinese medicine compound essential oil disclosed by the invention is administered in a sniffing manner, and improves cerebral depression symptoms by stimulating olfactory nerves and influencing cerebral cortex edges and neurotransmitters. After a CUMS depression animal model is treated by the traditional Chinese medicine compound essential oil disclosed by the invention, the symptom of pleasant sensation disappearance is well reversed and improved, and the state of animal movement reduction and the behavior state of despair and struggling abandoning of the depression animal model are obviously improved; meanwhile, the levels of DA, 5-HT and NE in brain tissues of the depression animal model are remarkably improved, and the pathological change of the brain-sea horse area of the depression animal model is remarkably improved. The traditional Chinese medicine compound essential oil disclosed by the invention can be used for preparing medicines for aromatherapy, has no adverse reaction and high acceptability, and provides a new way for treating depression.

The invention discloses application of a gene editing virus interfering expression and secretion of enzyme prototype cathepsin D in brain trauma, belongs to the field of gene functions and application, and finds that brain injury is aggravated and nerve dysfunction is aggravated due to the fact that the level of the enzyme prototype cathepsin D in plasma is increased due to the brain trauma through detection. The mechanism is as follows: the enzyme prototype cathepsin D enhances the transendocytosis effect of cerebral vascular endothelial cells after brain trauma, so that plasma inflammatory factors are gathered in damaged brain tissues; meanwhile, the expression of cerebrovascular endothelial cells VCAM-1 is also up-regulated, and neutrophil infiltration in an injured brain region after brain trauma is intensified. Research finds that down-regulation of plasma enzyme prototype cathepsin D can alleviate inflammatory factor concentration and neutrophil density in a brain injury area after trauma, and alleviate neurological function impairment of mice. Aiming at the functions of the plasma prototype cathepsin D, a strategy for reducing the plasma level of the plasma prototype cathepsin D by a gene editing technology for interfering the prototype cathepsin D is provided for treating the cerebral trauma.

The invention discloses a non-invasive brain oxygen saturation monitoring method and system. The system is characterized in that a light source driving circuit drives a probe module to generate a light signal with a preset time sequence under the control of a main control unit; the probe module comprises a first light source and a second light source, the same sides of the first light source and the second light source are respectively provided with three detectors which are arranged along a radial direction and are arranged at different intervals, and the three detectors corresponding to the first light source and the three detectors corresponding to the second light source are arranged on the left side and the right side in mirror symmetry; the signal conditioning module is used for processing the detected optical signal to obtain a spectral signal; the analog-to-digital conversion circuit is used for converting the spectral signal into a corresponding digital signal, and then the digital signal is transmitted to the signal preprocessing module through the communication interface under the control of the main control unit; the signal preprocessing module is used for filtering and denoising the received signal and then transmitting the signal to the calculation module to quantitatively calculate the brain oxygen saturation. The brain tissue blood oxygen saturation monitoring efficiency, accuracy and convenience are improved.

The application discloses a kind of local brain tissue blood oxygen saturation near-infrared detection method and device, to solve the problem of the difference between the group average head model parameter and patient individual parameter in prior art, especially severe patients;Existing device also has the problems of positioning deviation, poor repeatability, insufficient accuracy and difficult to quantify indicators. Through the accurate and repeatable positioning of skin texture double-mode positioning sticker, the individual head three-dimensional anatomical model and individual multi-layer light transmission simulation model are constructed by querying the patient individual image data, and the light transmission loss is calculated layer by layer, combined with the patient individual skull density, based on the patient individual image head blood flow map analysis of cerebral blood perfusion process and individual neck arteriovenous biochemical blood gas detection, to complete the individualized detection of local brain tissue blood oxygen saturation. The application calls the existing multi-source detection data of the patient to improve the detection accuracy of local brain tissue oxygen saturation by algorithm calculation, without any additional examination and cost.

Disclosed herein are methods and devices for transvascular placement of electrodes on a surface of a brain or in deep brain structures for the purpose of neuromodulation. The device can comprise a delivery catheter comprising a lumen. The device can comprise a piercing assembly extending through the delivery catheter, wherein the piercing assembly comprises a piercing assembly catheter and a needle. The device can comprise one or more electrodes configured to contact the brain tissue; and wherein the piercing assembly catheter comprises an opening in a wall thereof such that when the delivery catheter and the piercing assembly catheter are positioned within a vessel, the needle extends through the opening to puncture a vessel wall.

The invention relates to a brain-imitating model body for an ultrasonic system to calibrate craniocerebral imaging. The brain-imitating model body comprises a shell with an opening in the top, brain-imitating tissue filled in the shell, a skull-imitating sheet which is detachably arranged above the brain-imitating tissue and abuts against the brain-imitating tissue, and a circulation-imitating assembly which is composed of a blood-imitating vessel partially located in the brain-imitating tissue and a driving part used for driving fluid in the blood-imitating vessel to flow. The calibration assembly and the lesion imitation assembly are both arranged on the brain imitation tissue and used for reflecting ultrasonic signals sent by the ultrasonic system to calibrate the imaging performance of the ultrasonic system, the calibration assembly comprises a plurality of calibration lines parallel to the skull imitation sheet, and the lesion imitation assembly is parallel to the calibration lines. According to the invention, the obvious acoustic impedance difference between the skull and the brain tissue and the sound wave refraction effect of the skull are simulated, and the imaging performance of an ultrasonic system on craniocerebral imaging can be calibrated, so that image distortion caused by the skull is avoided.

An information processing apparatus for epilepsy diagnosis includes a reception unit that receives designation of a first site in a brain tissue of a test subject that is a detection target of an electrical signal, a wire information reception unit that receives wire information, a determination unit that determines a second site in a blood vessel in or near the brain tissue of the test subject based on the wire information, the second site being suitable for detection of the electrical signal from the first site using a device for epilepsy diagnosis disposed in the blood vessel, and a display control unit that displays the second site in the blood vessel in a prescribed display section.

The present disclosure discusses a devices, systems and methods for transvascular, transvenous and / or transdural access, to the brain parenchyma, subarachnoid or subdural spaces. In some embodiments, the disclosed systems and methods may be used for local drug delivery, tissue biopsy, nanofluidic or microelectronic device / component delivery / insertion / implantation, in situ imaging, ablation of abnormal brain tissue and the like. Embodiments of the present disclosure include an access catheter system for extravascular procedures in the brain having an elongate, flexible tubular body, with at least one lumen extending axially there through between a proximal end, and a distal end. The access catheter system may include a side exit port and a distal end port. Further, the access catheter system may include a selective deflector positioned within the lumen configured to deflect a procedure catheter and permit a guide catheter.

The application discloses sgRNA for knocking out a TMEM91 gene and application thereof, and relates to the technical field of biological medicines.The sequence of the sgRNA is shown in SEQ ID No.1 or SEQ ID No.2.A gene knockout mouse is constructed according to the TMEM91, and experimental results prove that the sequence can significantly silence the expression of TMEM91.Compared with wild-type mice, the TMEM91 mRNA of the knockout TMEM91 mouse is completely removed, and the TMEM91 gene knockout mouse provides new evidence for the biological function of TMEM91 at the in-vivo level.The application proves for the first time that inhibiting the expression of the TMEM91 gene can enhance kidney injury of the mouse, thereby proving that the TMEM91 is a new target for treating kidney injury, and the application is beneficial to further studying the mechanism of occurrence and development of kidney injury related diseases caused by low expression of the TMEM91.

The present disclosure discusses a devices, systems and methods for transvascular, transvenous and / or transdural access, to the brain parenchyma, subarachnoid or subdural spaces. In some embodiments, the disclosed systems and methods may be used for local drug delivery, tissue biopsy, nanofluidic or microelectronic device / component delivery / insertion / implantation, in situ imaging, ablation of abnormal brain tissue and the like. Embodiments of the present disclosure include an access catheter system for extravascular procedures in the brain having an elongate, flexible tubular body, with at least one lumen extending axially there through between a proximal end, and a distal end. The access catheter system may include a side exit port and a distal end port. Further, the access catheter system may include a selective deflector positioned within the lumen configured to deflect a procedure catheter and permit a guide catheter.

The present application relates to the technical field of intracranial blood vessel ultrasound training model, specifically to an intracranial blood vessel TCD simulation training model, comprising a peristaltic pump, the input end and the output end of the peristaltic pump are connected with conveying pipelines, the peristaltic pump is provided with a head model on one side, the head model comprises a head model body, the head model body has a simulated cranial cavity, the top of the simulated cranial cavity has a placing opening, the upper part of the placing opening has an openable cover; the outer side of the head model body has a temporal window, an occipital window and an eye window; the inside of the simulated cranial cavity is filled with a plurality of brain tissue simulation gels, the brain tissue simulation gels are embedded with adjustable simulation blood vessel network structures arranged according to the structure of Willis ring, the input end and the output end of the adjustable simulation blood vessel network structures are respectively connected with the output end and the input end of the peristaltic pump. The present application solves the problems that the existing clinical TCD doctor training relies on direct operation on patients, has many defects, lacks special simulation training model, cannot evaluate the accuracy of doctor operation and limits the application of TCD technology.

The application discloses a kind of local brain tissue blood oxygen saturation near-infrared detection method and device, to solve the problem of the difference between the group average head model parameter and patient individual parameter in prior art, especially severe patients;Existing device also has the problems of positioning deviation, poor repeatability, insufficient accuracy and difficult to quantify indicators. Through the accurate and repeatable positioning of skin texture double-mode positioning sticker, the individual head three-dimensional anatomical model and individual multi-layer light transmission simulation model are constructed by querying the patient individual image data, and the light transmission loss is calculated layer by layer, combined with the patient individual skull density, based on the patient individual image head blood flow map analysis of cerebral blood perfusion process and individual neck arteriovenous biochemical blood gas detection, to complete the individualized detection of local brain tissue blood oxygen saturation. The application calls the existing multi-source detection data of the patient to improve the detection accuracy of local brain tissue oxygen saturation by algorithm calculation, without any additional examination and cost.

The application relates to MSBI (Multiple Sclerosis Brain Isolate) nucleotide sequences as well as probes and primers comprising part of said nucleotide sequences and antibodies against polypeptides encoded by said nucleotide sequences. These compounds are useful as early markers for the future development of cancer and diseases of the CNS (Multiple sclerosis MS, Prion-linked diseases, amyotrophic lateral sclerosis, transmissible spongiforme encephalitis, Parkinson's disease, Alzheimer disease) and should represent targets for treatment and prevention.

To provide means and methods for extending the therapeutic window of pharmaceuticals that are locally delivered to the brain, preventing both export from the brain and systemic accumulation, thereby increasing the brain-to-serum ratio.SOLUTION: The present invention relates to a polypeptide comprising a crystallizable fragment (Fc) region of IgG for use in prevention or treatment of a disease, in particular a disease affecting a central nervous system. The polypeptide is administered locally to an affected compartment, in particular to the central nervous system. The Fc region bears a modification that results in reduced affinity to a neonatal Fc receptor (FcRn), thereby resulting in an increased brain-to-serum concentration of the polypeptide.SELECTED DRAWING: Figure 6A

The present disclosure discusses a devices, systems and methods for transvascular, transvenous and / or transdural access, to the brain parenchyma, subarachnoid or subdural spaces. In some embodiments, the disclosed systems and methods may be used for local drug delivery, tissue biopsy, nanofluidic or microelectronic device / component delivery / insertion / implantation, in situ imaging, ablation of abnormal brain tissue and the like. Embodiments of the present disclosure include an access catheter system for extravascular procedures in the brain having an elongate, flexible tubular body, with at least one lumen extending axially there through between a proximal end, and a distal end. The access catheter system may include a side exit port and a distal end port. Further, the access catheter system may include a selective deflector positioned within the lumen configured to deflect a procedure catheter and permit a guide catheter.

Disclosed is a flexible hybrid electronic system for intraoperative intracranial monitoring. The system includes a flexible front-end signal collection circuit, a back-end signal processing circuit and a computer system, wherein the front-end signal collection circuit includes a flexible substrate, an electroencephalogram layer, a flexible sensor array, a temperature-controlled hydrogel interface layer, and an electrothermal film. The flexible sensor array is used for collecting pressure, temperature, electroencephalographic and cerebral tissue oxygen saturation signals, and the electrothermal film regulating the adhesion and peeling of the temperature-controlled hydrogel interface layer and cerebral tissue. The signal processing circuit is electrically connected to the signal collection circuit, so as to receive signals collected by the flexible sensor array and the electroencephalographic layer, analyze then transmit to the computer system. When the pressure data exceed a preset normal threshold, the alarm module is triggered to alert the surgeon to the cranial status.

The present invention relates to an integrated apparatus for cerebral tissue biopsy or electrode placement by means of venous intervention via a superficial cerebral vein. The integrated apparatus comprises a catheter and a variable balloon. The catheter is connected to the proximal end of the balloon. At least three channels are formed in the catheter: a balloon filling channel, a guide channel, and a working channel. The balloon filling channel is in communication with an inner cavity of the balloon so as to inject a contrast agent into the balloon to expand the balloon. The guide channel penetrates through the inner cavity of the balloon from the proximal end of the balloon and exits from the distal end of the balloon to be sleeved with a microguide wire. The working channel extends out of a side wall of the catheter at a set distance from the proximal end of the balloon. The working channel is provided with a puncture needle in a penetrating manner. The puncture needle protrudes from the exit port of the working channel and is used for biopsy sampling of superficial or deep brain tissue or electrode placement. The integrated apparatus has rich functions, which can not only be used for biopsy, but also can be used for electrode placement, and has accurate positioning, simple operation, high success rate, and little environmental influence in the working process.

The invention belongs to the field of medical image data processing, and discloses a medical image data processing method and system for an interventional operation. Comprising the following steps: collecting brain magnetic resonance image data of a patient before an operation, and extracting brain structure information including ventricle, blood vessel trend and brain sulcus and brain return; local intracranial pressure data are monitored in real time in an operation, and an operation field area video stream collected by a binocular camera device is analyzed to obtain an invasion path of a surgical instrument and deformation information of brain tissue resection in real time; constructing a brain deformation prediction model based on the topological association graph, taking local intracranial pressure data, a surgical instrument invasion path and deformation information of brain tissue excision as input, and outputting deformation field distribution data; the method is applied to a preoperative brain three-dimensional model, a dynamic brain model is generated through geometric coherence constraint processing, the dynamic brain model is used for a surgical navigation system, and real-time accurate prediction of intra-operative brain tissue deformation is achieved.

The invention discloses an application of an agilawood extract in preparation of a medicine for resisting cerebral arterial thrombosis, and belongs to the technical field of traditional Chinese medicines. A cerebral arterial thrombosis rat model is constructed by utilizing a 2-VO method, the action mechanism of the agilawood extract on cerebral arterial thrombosis (IS) is researched by analyzing the physiological status, behavioral performance and brain tissue pathological change of rats, the treatment effect of agilawood on cerebral arterial thrombosis is further evaluated, and a theoretical basis is provided for the action mechanism of agilawood. Results show that the agilawood extract can improve physiological status, balance ability and neurological function damage of IS rats; hE staining results show that the agilawood extract can improve pathological states such as abnormal neuron arrangement and neuronal nucleus fixation and contraction of IS rat brain hippocampus. And a theoretical basis is laid for treating behavioral diseases of cerebral arterial thrombosis patients and improving the life quality of the cerebral arterial thrombosis patients.

Astrocytes are known to regulate the body responses to diseases and injuries in central nervous system (CNS). Embodiments of the instant disclosure relate to biomaterial for delivering extracellular vesicles derived from reactive cell populations for improving brain healing after injury. Also provided are methods of improving angiogenesis, axonogenesis, or inducing tissue repair using the disclosed biomaterials. Also provided are methods of making the biomaterials.

The present invention discloses a traditional Chinese medicine composition for promoting blood circulation and unblocking meridians, and its use in preparing a medicament for treating cerebral stroke. The traditional Chinese medicine composition is prepared from astragalus root, angelica root, earthworm, millettia reticulata, salvia miltiorrhiza, safflower, mulberry branch, earthworm, processed polygonum multiflorum, cornus officinalis, Morinda officinalis, and Eucommia bark. The present invention optimizes the compatibility based on a traditional old prescription to obtain a new traditional Chinese medicine formula, which has the effects of invigorating qi and promoting blood circulation, nourishing the liver and kidneys, and removing blood stasis and unblocking meridians. It repairs brain damage caused by cerebral stroke, alleviates neurological dysfunction and brain tissue inflammation, is safe, has no drug-induced liver damage toxicity, and cooperates with Western medicine precision medicine to significantly improve the therapeutic effect of cerebral stroke, improve patients' clinical symptoms, and promote the recovery of neurological function, providing a new integrated Chinese and Western medicine treatment strategy for clinical practice.