125 results about "Cerebral tissue" patented technology

Methods for treating total and partial occlusions employ a perfusion conduit which is penetrated through the occlusive material. Oxygenated blood or other medium is then perfused through the conduit in a controlled manner, preferably at a controlled pressure below the arterial pressure, to maintain oxygenation and relieve ischemia in tissue distal to the occlusion. In another aspect, interventional devices, such as stents or balloon catheters, are passed through the perfusion catheter to remove obstructions. Optionally, the occlusion may be treated while perfusion is maintained, typically by introducing a thrombolytic or other agent into the occlusive material using the perfusion conduit or by employing mechanical means to remove the obstruction. Such methods are particularly suitable for treating acute stroke to prevent damage to the cerebral tissue.

Methods for treating total and partial occlusions employ a perfusion conduit which is penetrated through the occlusive material. Oxygenated blood or other medium is then perfused through the conduit to maintain oxygenation and relieve ischemia in tissue distal to the occlusion. Optionally, the occlusion may be treated while perfusion is maintained, typically by introducing a thrombolytic or other agent into the occlusive material using the perfusion conduit. Such methods are particularly suitable for treating acute stroke to prevent irreversible damage to the cerebral tissue.

A prosthetic hearing system is described that provides multi-path stimulation of the patient auditory system. A mechanical stimulation component applies mechanical stimulation signals to cerebral tissue such as the dura mater, cerebrospinal fluid, vestibular structures, etc. using multiple separate mechanical stimulation channels. And an electrical stimulation component provides electrical stimulation of auditory neural tissue of the patient user.

A method for delivering ultrasound energy to a patient's intracranial space includes the steps of forming a hole in a patient's skull, locating an ultrasound transmitter near or into the hole, and transmitting ultrasound from the transmitter into the intracranial space, wherein the Mechanical Index of ultrasound energy traveling through cerebral tissue in the intracranial space is less than 1.0, the power intensity delivered to a target tissue in the intracranial space is greater than 50 mW / cm2 and less than 200 mW / cm2, and the frequency of the transmitted ultrasound is within the range between 500 kHz and 2 MHz. Microbubbles, aspirin, both microbubbles and aspirin, and a mixture of microbubbles and aspirin, can also be delivered into the intracranial space.

Electrical stimulation is applied to the inferior colliculus or colliculi (IC), in order to diminish tinnitus by revising auditory pathway neuronal activity. This intervention diminishes tinnitus and treats other neurological and otological disorders. The locations and methods of electrode placement and anchoring and the structure of the electrodes are an advance over prior treatments. Other treatment locations in the nearby region of the IC, including the superior colliculi (SC) and Peri-aqueductal gray (PAG), provide treatments for other disorders and symptoms such as partial hearing loss and pain. The IC is a unique choice for the treatment of tinnitus and other disorders because an electrode placed in that region enables minimal invasiveness. The anchoring location also uniquely minimizes invasiveness by providing the option of residing in the meninges instead of the brain tissue. The shape of the electrode and its anchoring process uniquely match the brain's anatomy in order to provide greater specificity in diagnosis and treatment. Stimulation of areas near the IC, particularly the superior colliculus and peri-aqueductal gray, can be used to treat various neurological disorders. Customized feedback from the implantable system enables the creation of customized treatment programs.

A method predicting stroke evolution uses magnetic resonance diffusion and perfusion images obtained shortly after the onset of stroke symptoms to automatically estimate the eventual volume of dead cerebral tissue resulting from the stroke. The diffusion and perfusion images are processed to extract region(s) of interest presenting tissue at risk of infarction. A midplane algorithm is also used to calculate ratio and diffusion and perfusion measures for modelling infarct evolution. A parametric normal classifier algorithm is used to predict infarct growth using the calculated measures.

The invention discloses an acupuncture teaching model and particularly relates to a multifunctional acupuncture three-dimensional teaching model which comprises a transparent simulation body model and a base, wherein the transparent simulation body model is arranged on the base. All the body organs such as skin tissue, muscular tissue, skeleton tissue, viscera tissue, vascular tissue and brain tissue are arranged on the transparent simulation body model. Body meridian lines and acupuncture points are embedded in the tissue and among the tissue. Leads, light-emitting devices, pressure sensors and acupuncture sensors are arranged in the tissue, the meridian lines and the acupuncture points. A control circuit is arranged on the base. The leads, the light-emitting devices, the pressure sensors and the acupuncture sensors are electrically connected to the control circuit. A central processor is arranged on the control circuit which is connected with an outside computer through an interface. The acupuncture simulation body teaching model and the ordinary computer form a teaching system. A three-dimensional animation simulation body model corresponding to the teaching model and a body anatomical structure database are arranged on the computer, and positions and organs of the three-dimensional animation simulation body model and the body anatomical structure database and positions and organs of the simulation body teaching model are in one-to-one correspondence and form relevance.

A method for delivering ultrasound energy to a patient's intracranial space includes the steps of forming a hole in a patient's skull, locating an ultrasound transmitter near or into the hole, and transmitting ultrasound from the transmitter into the intracranial space, wherein the Mechanical Index of ultrasound energy traveling through cerebral tissue in the intracranial space is less than 1.0, the power intensity delivered to a target tissue in the intracranial space is greater than 50 mW / cm2 and less than 200 mW / cm2, and the frequency of the transmitted ultrasound is within the range between 500 kHz and 2 MHz. Microbubbles, aspirin, both microbubbles and aspirin, and a mixture of microbubbles and aspirin, can also be delivered into the intracranial space.

Prior approaches have delivered O2 to a subject by inhalation, but the relationship between local signal changes and metabolism has been complicated by H217O created in non-cerebral tissues. During a brief pulse of 17O2 inhalation, this arterial input function for H217O is negligible due to convective transport delays. Additional delays in the arterial input function due to restricted diffusion of water makes pulsed inhalation of 17O2 even more effective. Accordingly, ventilator system are provided to deliver 17O2 as a brief pulse to a subject. Subsequent MR imaging demonstrates delayed appearance of H217O in the cerebral ventricles, suggesting that the arterial input function of H217O is delayed by restricted water diffusion in addition to convective transit delays. Delivery as a brief pulse therefore offers significant advantages in relating MR signal changes directly to metabolism.

The present invention relates to a method for the treatment of cerebral ischaemia and a drug for the treatment of cerebral ischaemia in particular in humans, as occurs for example in the case of stroke patients. It was found surprisingly that peripheral administering of erythropoietin to the cerebral tissue affected by the ischaemia has a distinctly protective effect. Erythropoietin has the effect thereby that the region of the cerebral tissue which is damaged permanently, in particular in the penumbra, is dramatically reduced relative to conventional measures in the case of cerebral ischaemia without erythropoietin administration.

The invention relates to a method for segmenting a sulus region on the surface of a pallium of a three-dimensional cerebral magnetic resonance image. The technical characteristics lie in that firstly, the 3D cerebral nuclear magnetic resonance image is pretreated and the surface of the pallium is reconstructed, including removing a braincase and non-cerebral tissues; carrying out cerebral tissue segmenting on a cerebral image and reconstructing the surface of the pallium of geometrical accuracy and correct topological structure in the segmented cerebral image; the surface of the pallium is shown by a series of vertexes and triangles; secondly, the maximum principle curvature and the minimum principle curvature of each vertex on the surface of the pallium are estimated; and finally, sulus and gyrus regions are segmented on the surface of the pallium according to the maximum principle curvature and Hidden Markov Random Field expectation maximization framework and each sulus region is marked by connectivity analysis. Compared with other methods, the method has the advantages of simple and effective algorithm and high segmentation accuracy.

An X-ray computed tomography apparatus calculates transfer functions h(t) using a time-concentration curve Ca(t) for pixels of a cerebral artery and a time-concentration curve Ci(t) for pixels of cerebral tissues including capillary vessels and then calculates a delay time for each pixel of an object region from a time when an artery curve rises on the basis of the transfer functions. Further, the apparatus differently produces a visual color map showing time differences of blood flow conditions and provide it in a predetermined form by coloring pixels with a time delay from the other pixels without a time delay on the basis of the calculated delay time.

The Chinese herbal medicine preparation for strengthening kidney-Yang is prepared with ginseng, dodder seed, schisandra, pilose antler, morinda root and other 24 kinds of Chinese medicinal materials. It has obvious functions of astringing vital energy, strengthening kidney-Yang, preventing and treating cardiac and cerebral tissue ischemia, regulating physiological function, raising immunity, etc. and is especially suitable for old people to take for prolonging life. Clinical application shows that it has determined curative effect and on allergic reaction and no toxic side effect.

The present invention relates to the active general flavone components extracted from longbract cattail as one kind of Chinese medicinal materials. The extractive includes mainly isorhamnetin, quercetin, kaempferol and their glycoside derivatives, and also includes the degraded products of the said components, their metal salt derivatives, metal complexes, etc. The extractive may be obtained via solvent extraction process and other process. The extractive has the functions of lowering blood fat, resisting atherosclerosis, raising the tolerance of cardiac and cerebral tissues to deficiency of oxygen and blood, resisting platelet aggregation, etc. and may be used in preventing and treating cardiac and cerebral vascular diseases, traumatic injury, haemorrhages and other diseases.

The present invention is medicine composition for treating cerebral ischemia and its medicinal application. The medicine composition has ginsenoside and salvianolic acid as main components. It can reduce the cerebral infarction area obviously, reduce behavior disorder caused by cerebral tissue necrosis obviously, and reach the aim of treating cerebral blood supply insufficiency, cerebral thrombosis, cerebral embolism, cerebral vascular spasm, senile dementia, etc.

A skull replacing apparatus of 3D print and a manufacturing method thereof relate to a skull replacing apparatus and a manufacturing method thereof. In order to solve the problem of dysfunction due to the fact that the existing skull replacing object can't satisfy the refine requirement to a patent defect portion so that the cerebral tissue can't be fully protected and the skull replacing object usually doesn't match with the patent skull, the invention provides a skull replacing apparatus. The apparatus comprises a fixation piece, a compact substance layer 1, a compact substance layer 2 and a transitional layer, wherein the fixation piece and the compact substance layer 1 are located above the transitional layer; the compact substance layer 2 is located below the transitional layer and the compact substance layer 1 is connected to the compact substance layer 2 through the transitional layer; the compact substance layer 1, the transitional layer and the compact substance layer 2 have the same shape with the defect skull; and the transitional layer is a micro truss structure. The method comprises: a. imaging the damaged skull with 3D so as to determine the geometry size and parameter of the skull to acquire original datum of the skull needed to be replaced; b. designing a three-dimensional model of a skull replacing structure and printing the designed model; c. and improving the surface of a sample. The skull replacing apparatus and the manufacturing method thereof are suitable for skull replacement.

A health-care food for promoting growth and development, preventing arteriosclerosis, cerebral tissue sanility, osteoporosis, hyperlipemia, obesity, etc, improving immunity, blackening hair, etc is proportionally prepared from animal's embryo egg, black sesame, fleece flower root and / or walnut.

A method and system are provided which are useful for the non-invasive determination and monitoring of cerebral tissue oxygenation. The method comprises the steps of generating at least first and second jugular venous output signals against time based on the reflection of at least first and second wavelengths of light, respectively, from an external tissue site on the patient in the proximity of the internal jugular vein; obtaining corresponding first and second cardiac arterial output signals for the first and second wavelengths of light, respectively, from the patient, and separating the first and second cardiac arterial output signals from the first and second jugular venous output signals, respectively, to generate first and second cerebral venous output signals; and determining cerebral tissue oxygenation based on the first and second cerebral venous output signals. A system useful to monitor cerebral tissue oxygenation may comprise a first module for optically generating at least first and second jugular venous output signals against time at at least first and second wavelengths of light, respectively, from the patient; a second module for generating first and second cardiac arterial output signals at the first and second wavelengths of light, respectively, from the patient; and a signal processing means adapted to separate the first and second cardiac arterial output signals from the first and second jugular venous output signals, respectively, to yield first and second cerebral venous output signals, for the determination of cerebral tissue oxygenation.

The invention discloses application of curcumin to preparation of drugs for treating cerebral ischemia / reperfusion injuries, belonging to the technical field of drug preparation. A cerebral ischemia / reperfusion injury model is prepared and curcumin-PVP (polyvinylpyrrolidone) solid dispersions are used for treating the disease model after being dissolved with the saline for injection. Results show that curcumin can obviously improve the injuries of vital organs such as distant livers and kidneys caused by cerebral tissue injuries and cerebral ischemia / reperfusion injuries and can control the expression levels of several factors related to apoptosis, inflammations and oxidation, control further aggravation of the injuries and protect the vital organs such as cerebral tissues and livers and kidneys.

An application of the brasileiin in preparing the medicines for treating the cerebral ischemia, encephalorrhagia and the cerebral disfunction caused by excessive peroxide in cerebral tissue is disclosed.

A device has a source for emitting near infrared radiation into cerebral tissue, a sensor for detecting radiation exiting from the tissue, and an evaluation unit which detects the exiting radiation as an input signal having pulsatile and non-pulsatile components and is programmed to determine the concentration of an injected indicator in the tissue from the non-pulsatile signal component, iteratively determine an inflow function characterizing cerebral blood flow by varying a mean transit time until reaching a stop criterion, determine indicator concentration relative to cerebral blood volume from the inflow function and the pulsatile signal component, calculate cerebral blood volume by dividing indicator concentration in the tissue by indicator concentration relative to cerebral blood volume, calculate cerebral blood flow by dividing the cerebral blood volume by the mean transit time when the stop criterion has been reached, and scale the inflow function using values determined from the pulsatile signal component.

The invention discloses a visible cerebral ventricle and subdural external drainage system. The visible cerebral ventricle and subdural external drainage system comprises a visible cerebral ventricle puncture system and a drainage system. The visible cerebral ventricle puncture system comprises a visible puncture guiding core, and LED light sources and a miniature camera are coaxially arranged at the intracranial end of the visible puncture guiding core. The wall of a puncture sheath is see-through, and millimeter scales are arranged on the outer wall of the puncture sheath. The visible cerebral ventricle and subdural external drainage system has the remarkable advantages that as the miniature camera can be connected to one end of the visible puncture guiding core, and a monitor is connected to the other end of the visible puncture guiding core, cerebral puncture is completely performed in a direct-viewing mode, precision is improved, and it is avoided that due to operation based on a rule of thumb, the cerebral tissue is damaged, or cerebral hemorrhage occurs. As miniature vanes (fixing clamps) are arranged at the position distant from the cerebral ventricle by 10 cm-15 cm and used for fixing a drainage tube at the incised skin, the defect that a drainage tube used for the current clinic is simply bound and fixed through threads is overcome.

The invention provides a composition containing EGCG and bamboo leaf flavonoid. The composition can be made into any pharmaceutically-acceptable dosage form, and the weight ratio of EGCG to bamboo leaf flavonoid is 0.05-2:1. The invention further discloses a preparation method of the composition and applications of the composition in preparation of drugs for protecting heart and cerebral vessels and tissues, relieving myocardial and cerebral ischemia, and reducing the happening rate of myocardial infarction, stroke, and cardiovascular diseases.

The invention provides a multi-functional cardiovascular and cerebrovascular rehabilitation exercise handstand device. The device comprises a base frame, a main balance rod and an upper limb support frame. The rear portion of the base frame is provided with a support rod. The rear end of the main balance rod is connected rotationally with the upper end of the support rod. The upper portion of the main balance rod rear end is provided with a seat device. The lower portion of the main balance rod front end is fixedly provided with a motor. The main balance rod front end is connected with the upper limb support frame in a hinge mode. The front end of the main balance rod is coupled with a lower limb transmission shaft. The upper end of the upper limb support frame is coupled with an upper limb transmission shaft. The center of the main balance rod is coupled with an eccentric wheel. The eccentric wheel is connected with the base frame through an eccentric wheel support rod. The motor is connected with the lower limb transmission shaft through a transmission device to drive the lower limb transmission shaft to rotate. The lower limb transmission shaft is connected with the upper limb transmission shaft through an upper limb transmission device. The lower limb transmission shaft is connected with the eccentric wheel through the speed reducing device. The multi-functional cardiovascular and cerebrovascular rehabilitation exercise handstand device can make the upper limbs, lower limbs and the whole body do exercise, make the blood gravity of the whole body to function on the head to dilate the blood vessel, modify the cardio-cerebral circulation, increase the nutritional supply to the cardio-cerebral tissues, and attain the goal of preventing and treating cardio-cerebral diseases.

This invention provides a method for determining the amount of blood in a volume of cerebral tissue (cerebral blood volume) in a mammalian subject comprising (a) acquiring a first magnetic resonance image of the volume of tissue in vivo; (b) administering intraperitoneally to the subject a gadolinium-containing contrast agent in an amount greater than about 1 mg per kg body weight and less than about 20 mg per kg body weight; (c) acquiring a second magnetic resonance image of the volume of tissue in vivo, which second image is acquired at least about 15 minutes after, but not more than about 2 hours after, administering the contrast agent; and (d) determining the amount of cerebral blood volume based on the first and second images.

A sensor is provided available for continuous monitoring of regional blood flow in a tissue, including cerebral tissue. Methods of monitoring regional blood flow using the sensor as well as systems and computer readable medium therefor are also provided.