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Mechanical index (MI) is an ultrasound metric. It is defined as MI=PNP/√(Fc), where PNP is the peak negative pressure of the ultrasound wave (MPa), derated by 0.3 dB cm⁻¹ MHz⁻¹ to account for the difference between in-water and in-tissue acoustic attenuation, and Fc is the center frequency of the ultrasound wave (MHz). MI is measured with a calibrated hydrophone in a tank of water. Derated (0.3 dB/cm/MHz) Pulse Pressure Squared Integral (ppsi) values are measured along the axis of the ultrasound beam.
Methods and systems of improving medical conditions via ultrasound neuromodulation of the brain
Methods and systems for improving medical conditions by delivering a focused ultrasound signal to target sites of the brain. The focused ultrasound signal can have a mechanical index of between about 1.0 to about 8.0 and / or an acoustic pressure of between about 1.0 MPa to about 3.0 MPa. The medical condition can comprise addiction (including binge eating), anxiety disorders and anxiety associated disorders, tinnitus, neurodegenerative disorders, neuropsychiatric disorders, cognitive disorders, neurodevelopmental disorders, post-traumatic stress disorder, stroke recovery, and combinations thereof.
Owner:WEST VIRGINIA UNIV BOARD OF GOVERNORS ON BEHALF OF WEST VIRGINIA UNIV