19 results about "Mechanical index" patented technology

Provided are methods for improving an expression of a nucleic acid construct in a cell or an organ of a subject using sonoporation and optimization of ultrasonic acoustic energy mechanical index.

The invention provides an ultrasonic plane wave multi-mode cooperative imaging method and system, and the method comprises the steps: controlling an ultrasonic probe to execute shear wave elastic imaging and sound attenuation imaging of which the mechanical index is equal to or greater than a first threshold value based on a multi-level voltage control scheme; and executing super-resolution imaging with the mechanical index smaller than or equal to a second threshold value after the super-resolution imaging is completed. The method comprises the following steps: acquiring a sound attenuation coefficient graph generated in a sound attenuation imaging process, and respectively acquiring a first super-resolution graph without contrast agent perfusion, a second super-resolution graph with contrast agent perfusion and a tissue elasticity graph generated in a shear wave elasticity imaging process based on an ultrafast plane wave technology; performing post-processing on the collected first super-resolution graph to generate a probability density graph of the tissue structure, and performing post-processing on the collected second super-resolution graph to generate a microbubble tracking speed graph; and carrying out cooperative imaging on the tissue elasticity map, the sound attenuation coefficient map, the probability density map and the velocity map. The imaging comprehensiveness and accuracy are improved, and early lesion diagnosis is facilitated.

The invention discloses a transcranial focused ultrasound stimulation thermal effect and mechanical effect simulation system and method, and relates to the technical field of biomedical engineering, and the system comprises a sound field effect simulation module which is used for calculating a brain sound field based on set ultrasonic parameters and a stimulation target in combination with a constructed human brain model; the biothermodynamic simulation is used for calculating the heat effect of different ultrasonic waves on the biological tissue on the main propagation path and the temperature change caused by the heat effect; the mechanical effect simulation is used for calculating the mechanical effect of the ultrasonic wave in the focusing area when the ultrasonic wave acts on the brain tissue, and calculating a mechanical index MI to evaluate the cavitation effect risk; evaluating the thermal injury of the soft tissue in the ultrasonic stimulation according to the cumulative energy model; according to the simulation system and method, sound field distribution and partial biological effects of transcranial focused ultrasound stimulation can be accurately analyzed.

The invention provides methods for enhancing the efficacy of a cancer treatment or treating cancer in a subject by administering a composition comprising an anti-cancer agent and a microbubble suspension. The microbubble suspension is characterized by a gas concentration range of 1.24 pL / kg to 30.57 pL / kg of the subj ect's body weight or a human equivalent dose (HED) range of 2x 108 to 4x 109 bubbles per kg body weight. Ultrasound with a setting of continuous non-thermal pulses with short cycle and sufficient time interval is applied to induce microbubble destruction in a targeted region using continuous non-thermal pulses with short cycles and sufficient time intervals, wherein the mechanical index (MI) value is between 0.4 and 1.2.

Methods and systems for improving medical conditions by delivering a focused ultrasound signal to target sites of the brain. The focused ultrasound signal can have a mechanical index of between about 1.0 to about 8.0 and / or an acoustic pressure of between about 1.0 MPa to about 3.0 MPa. The medical condition can comprise addiction (including binge eating), anxiety disorders and anxiety associated disorders, tinnitus, neurodegenerative disorders, neuropsychiatric disorders, cognitive disorders, neurodevelopmental disorders, post-traumatic stress disorder, stroke recovery, and combinations thereof.

The invention discloses an ultrasonic imaging method and an ultrasonic imaging device, and the method comprises the steps: in a gray-scale imaging mode, controlling an ultrasonic probe to emit a first ultrasonic wave to a target tissue which does not contain a contrast agent microbubble, receiving an echo of the first ultrasonic wave to obtain a first echo signal, and generating a first ultrasonic image according to the first echo signal; marking at least one first region of interest on the first ultrasonic image; and in other imaging modes except the gray-scale imaging mode, controlling the ultrasonic probe to emit second ultrasonic waves to the target tissue containing the contrast agent microbubbles, receiving echoes of the second ultrasonic waves to obtain second echo signals, and generating a second ultrasonic image according to the second echo signals, wherein the emission mechanical indexes of other imaging modes are smaller than the emission mechanical index of the gray-scale imaging mode; and based on the position of the first region of interest, automatically marking and displaying a second region of interest corresponding to the first region of interest on the second ultrasonic image. The method can simplify user operation and improve user experience.

Provided herein methods for treating a subject suffering from a disease or a disorder associated with hyperproliferating cells, by irradiating the cells with low-frequency ultrasound at an intensity that is either below the cavitational threshold intensity for the ultrasound frequency, or is characterized by a low-frequency mechanical index below 2.5. The methods may further comprise determining an elasticity value of the cells, and adjusting the ultrasound intensity accordingly.

This application discloses an ultrasonic imaging method and apparatus. The method comprises: utilizing an external magnetic field to concentrate a magnetic ultrasonic contrast agent in a target area; emitting ultrasonic waves to the target area to activate the magnetic ultrasonic contrast agent, causing it to scintillate; detecting ultrasonic echoes from the target area; and generating an ultrasonic image of the target area using the ultrasonic echo signals. The above technical solution utilizes an external magnetic field to concentrate the magnetic ultrasonic contrast agent in the target area, thereby reducing the mechanical index of the ultrasonic wave used in ultrasonic scintillation imaging.

Methods are provided for improving expression of a nucleic acid construct in a cell or organ of a subject using sonoporosis and optimization of the ultrasonic acoustic energy mechanical index.

This invention relates to the field of ice mechanical performance testing technology and discloses a method for testing the dynamic compression mechanical properties of ice structures. The method includes simultaneously acquiring three-dimensional coordinates, time series, acoustic emission signals, and thermal infrared images of an ice structure during dynamic compression using multiple sensors to construct a multimodal dataset; extracting mechanical indices, acoustic features, and thermodynamic parameters after spatiotemporal alignment processing to generate an integrated feature set; automatically identifying consistent and abnormal regions based on spatial distance and feature similarity; simulating the evolution of mechanical properties under different working conditions using consistent region data; calculating anomaly risk indices by combining acoustic energy distribution and infrared temperature difference changes to form a high-risk point set; and finally generating a risk warning report through failure mode identification. This method achieves multi-dimensional automated evaluation of the mechanical properties of ice structures, accurately locating defective areas and quantifying risk levels, thus improving the accuracy of testing and analysis and the ability to provide early warnings.

The invention discloses an application of microbubbles in preparing a medicine for treating ischemic eye diseases by combining ultrasonic to generate small-amplitude resonance or steady-state cavitation, namely under the excitation of ultrasonic pulses with ultrasonic peak negative pressure lower than 300kPa (kPa) or ultrasonic mechanical index (MI) lower than 0.2, the microbubbles in blood circulation generate small-amplitude resonance or steady-state cavitation; the cavitation mechanical effect stimulates eyeball blood perfusion to be increased, and then the treatment effect of improving the visual function is achieved. The novel treatment application of the microbubbles is characterized in that after the microbubbles enter human blood circulation through intravenous injection, under the condition that pulse type ultrasonic energy directional irradiation is conducted, the emission frequency is 500 KHz to 10.0 MHz, the peak value negative pressure is 10 kPa to 300 kPa, and the pulse width is 1 to 20 cycles, the microbubbles in an eyeball blood vessel cavity are stimulated to generate small-amplitude resonance or steady-state cavitation; and then the treatment effects of eyeball blood perfusion increase and vision improvement are achieved. The new medicine application of the microvesicles is suitable for treating various ischemic eye diseases, and is a brand-new new treatment application with application prospects.

Methods and systems for improving medical conditions by delivering a focused ultrasound signal to target sites of the autonomic nervous system. The focused ultrasound signal can have a mechanical index of between about 0.1 to about 5.0 and / or an acoustic pressure of between about 0.1 MPa to about 2.5 MPa. The medical condition can comprise chronic or refractory rhinitis, chronic rhinosinusitis, autonomic instability / autonomic dysfunction, functional gastrointestinal disorders, inflammatory disorders, immune disorders (including improving cancer and infections by neuromodulation of immune function), complex regional pain syndrome, post-traumatic stress disorder (PTSD), anxiety and anxiety-associated disorders, autism, fibromyalgia, uterine function, metabolic disorder, urinary incontinence or binge eating.

Methods and systems of improving tinnitus in a patient in need thereof is provided. The method can include delivering an ultrasound signal to a target site of the patient's brain. The target site can include the medial geniculate nucleus, the nucleus accumbens, the caudate nucleus, the pulvinar nucleus, the insula, the subcallosal anterior cingulate area, the cingulate cortex, the auditory cortex, or combinations thereof. The method can be performed without delivering microbubbles to open the blood brain barrier. The ultrasound signal can have a Mechanical Index of between about 1.5 and about 5.0 and / or an acoustic pressure of between about 0.55 MPa and about 2.5 MPa.

Methods and systems for improving medical conditions by delivering a focused ultrasound signal to target sites of the brain. The focused ultrasound signal can have a mechanical index of between about 1.0 to about 8.0 and / or an acoustic pressure of between about 1.0 MPa to about 3.0 MPa. The medical condition can comprise addiction (including binge eating), anxiety disorders and anxiety associated disorders, tinnitus, neurodegenerative disorders, neuropsychiatric disorders, cognitive disorders, neurodevelopmental disorders, post-traumatic stress disorder, stroke recovery, and combinations thereof.

Methods and systems of improving tinnitus in a patient in need thereof is provided. The method can include delivering an ultrasound signal to a target site of the patient's brain. The target site can include the medial geniculate nucleus, the nucleus accumbens, the caudate nucleus, the pulvinar nucleus, the insula, the subcallosal anterior cingulate area, the cingulate cortex, the auditory cortex, or combinations thereof. The method can be performed without delivering microbubbles to open the blood brain barrier. The ultrasound signal can have a Mechanical Index of between about 1.5 and about 5.0 and / or an acoustic pressure of between about 0.55 MPa and about 2.5 MPa.

The invention relates to the technical field of ice mechanical property testing, and discloses a dynamic compression mechanical property testing method based on an ice structure. The method comprises the following steps: synchronously acquiring a three-dimensional coordinate, a time sequence, an acoustic emission signal and a thermal infrared image of an ice structure in a dynamic compression process by utilizing multiple sensors, and constructing a multi-modal data set; after space-time alignment processing, mechanical indexes, acoustic features and thermodynamic parameters are extracted, and an integrated feature set is generated; a consistent region and an abnormal region are automatically identified based on the spatial distance and the feature similarity; simulating a mechanical property evolution rule under different working conditions by using consistent regional data; an abnormal point risk index is calculated by combining acoustic energy distribution and infrared temperature difference change, and a high-risk point set is formed; and finally, generating a risk early warning report through failure mode recognition. According to the method, multi-dimensional automatic evaluation of the mechanical properties of the ice structure is realized, the defect area can be accurately positioned, the risk level can be quantified, and the accuracy and early warning capability of test analysis are improved.

The invention discloses a construction method and application of a cerebral small vascular disease animal model, and relates to the technical field of cerebral small vascular diseases. Injecting the microbubble mixed liquid into the animal to be modeled, and then performing ultrasonic action on the upper part of the brain of the animal to be modeled by using an ultrasonic probe; during ultrasonic action, the center frequency of the ultrasonic probe is 3-5 MHz, the mechanical index is 1.2-1.5, and the ultrasonic irradiation time is 900-1200 s. The animal constructed by the method can simulate the pathology and image features of cerebral small vascular diseases, can simulate the features of micro-bleeding, micro-infarction and the like, shows the features of white matter high signal, iron-containing hemeroflavin deposition, encephalatrophy and the like in imaging examination, and is obviously superior to a laser-induced micro-bleeding model. Compared with a traditional method, the animal model building method is simple, multi-generation breeding does not need to be conducted on the animal to be modeled, and the modeling method has the technical advantages of being short in time consumption, free of craniotomy and additional injury and economical and practical.

Methods are provided for improving expression of a nucleic acid construct in a cell or organ of a subject using sonoporosis and optimization of the ultrasonic acoustic energy mechanical index.

Methods and systems for improving medical conditions by delivering a focused ultrasound signal to target sites of the autonomic nervous system. The focused ultrasound signal can have a mechanical index of between about 0.1 to about 5.0 and / or an acoustic pressure of between about 0.1 MPa to about 2.5 MPa. The medical condition can comprise chronic or refractory rhinitis, chronic rhinosinusitis, autonomic instability / autonomic dysfunction, functional gastrointestinal disorders, inflammatory disorders, immune disorders (including improving cancer and infections by neuromodulation of immune function), complex regional pain syndrome, post-traumatic stress disorder (PTSD), anxiety and anxiety-associated disorders, autism, fibromyalgia, uterine function, metabolic disorder, urinary incontinence or binge eating.