The invention discloses a medical rubbish harmless resource comprehensive utilization system. A comprehensive utilization method comprises the following steps of: sterilizing and disinfecting medical rubbish at high temperature and high pressure, sorting out disposable syringes, containers, trays and other medical hard plastics and disposable infusion tubes, infusion bags, blood bags, rubbish liquid bags and other medical soft plastics, collecting through splitting and classification, granulating, cleaning, drying and recycling; sorting out common waste plastics, recycling after cleaning, drying and granulating; sorting out paper plastic packaging materials, pulping, dewatering and recovering paper pulp; sorting out syringe needles, scalpels and other metal items and infusion bottles, smears and other glass items, and recycling at specialized rubbish recycling departments; and crushing, dewatering and drying the rest items, sending to produce RDF (Refuse Derived Fuel), and selling the RDF or using the RDF as a fuel of a steam boiler. Medical rubbish is completly recycled at high value. The medical rubbish resources do not emit pollutants during recycling and do not bring any harm to environment.