A weather resistant thick steel plate comprises, by weight, 0.06%-0.9% of C, not more than 0.30% of Si; 1.10%-1.50% of Mn, not more than 0.015% of P, not more than 0.003% of S, 0.035%-0.065% of Als, 0.25%-0.50% of Cu, 0.20%-0.50% of Ni, 0.40%-0.70% of Cr, 0.50%-0.15% of Mo, 0.008%-0.018% of Ti, 0.030%-0.060% of V, 0.015%-0.030% of Nb, not more than 0.0055% of N, 0.001%-0.004% of Ca, 0.0004%-0.0010% of selectively added B, and the balance of Fe and unavoidable impurities. The manufacturing method includes deep desulfurization of molten iron, converter smelting, LF, RH, continuous casting, on-line finishing of slabs, cut-to-length torch cutting of slabs, heating, TMCP, and slow cooling of steel plates. The obtained weather resistant thick steel plate has balanced strong toughness and strong plasticity, low yield ratio, atmospheric corrosion resistance, excellent weldability and fatigue resistance, and is especially applicable to non-coating high-rise building structures and bridge structures.