77 results about "Meninges" patented technology

An RNAi agent and composition for inhibiting the expression of transthyretin (TTR), which can be used for treating and / or preventing ATTR-related diseases comprising ATTR-PN (transthyretin amyloidosis polyneuropathy), ATTR-CM (transthyretin amyloidosis cardiomyopathy), senile systemic amyloidosis diseases, and leptomeningeal / central nervous system amyloidosis diseases.

The invention discloses a preparation method of a drug-loaded glycoprotein-like network hybridization tissue engineering valve material, which comprises the following steps: carrying out a one-pot hybridization cross-linking reaction on a decellularized biological material, oxidized hyaluronic acid, phenylboronic acid grafted silk fibroin and curcumin to construct and form a drug-loaded glycoprotein-like network on the biological material; the biological material is animal tissue, including but not limited to any one of pericardium, valve, intestinal membrane, meninx and the like. The method comprises the following steps: soaking a decellularized biological material in a solution A containing OHA, SF-PBA and curcumin, and continuously oscillating for 48 hours to carry out a cross-linking reaction; and then washing with phosphate buffer saline water and distilled water to obtain the drug-loaded glycoprotein-like network hybrid tissue engineering valve material. The prepared tissue engineering valve material overcomes the defects that traditional decellularized valve and glutaraldehyde cross-linked valve materials are easy to calcify, have toxicity and are poor in immunogenicity.

The invention discloses biological glue and a preparation method thereof.The preparation method comprises the steps that gel and activation liquid are prepared, and the gel is prepared by evenly mixing I-type collagen freeze-dried powder, chitosan and a fibrinogen solution; and mixing the freeze-dried thrombin with a calcium chloride solution to prepare an activation solution. The meninx suturing device has the advantages that sliding in the meninx suturing process is effectively reduced, an operation is easier to carry out, the risk that the meninx or a repairing material slides after the operation can be reduced, and a wound is evenly healed; most of the components are type I collagen which is beneficial to meninx injury repair, and the components contain chitosan which has antibacterial and hemostatic effects.

A quinazoline derivative (represented by the formula (I)) salt's crystal form, a preparation method and application are provided; specifically, the hydrochloride crystal form A, B, C, D, F, H, I, Sulphate crystal form A, Maleate crystal form A, Succinate crystal form A, Adipate crystal form A, Glycolate crystal form A, Malate crystal form A, Fumarate Salt crystal form A, besylate crystal form A, B, C, benzoate crystal form A, hippurate crystal form A and oxalate crystal form A of the quinazoline derivative represented by formula (I). The salt crystal form provided by the present invention has good stability, which can be used in the treatment of non-small cell lung cancer brain metastasis, meningeal metastasis, primary brain cancer or glioma, etc., and has good bioavailability, which is of great significance for further research on the efficacy of such solid drugs.

The invention discloses application of a biomarker in diagnosis of lung cancer soft meningeal metastasis. According to the present invention, it is found for the first time that the metabolites such as Indolastic acid, L-Glutic acid, N-Lactoylphenylalanine, cis-Acetic acid, Formiglumic acid and N-Acetylneomic acid in the cerebrospinal fluid have good diagnosis efficiency on the lung cancer soft meningeal metastasis, have high accuracy, high sensitivity and high specificity, can be used as the biological marker of the lung cancer soft meningeal metastasis, and can be used in the effective diagnosis of the lung cancer soft meningeal metastasis. The invention provides a brand-new thought and strategy for research and development of related diagnostic products for the lung cancer soft meningeal metastasis, and has wide application prospects and important transformation significance in the technical field of diagnosis of the lung cancer soft meningeal metastasis.

This invention provides a near-infrared therapy device for improving Alzheimer's disease, characterized by comprising: a frequency-modulated drive circuit 1, a near-infrared LD light source 2, an optical fiber coupler 3, a light source power monitoring photodetector (PD) 4, an optical power monitoring circuit 5, an optical fiber beam splitter 6, an MPO optical fiber cable 7, and an optical transmitter 8. The optical transmitter includes an optical transmitter housing 8-1, a fiber-end hemispherical emitting microlens 8-2, and a beam-shaping coupling lens 8-3. This invention can be used to regulate the metabolism and cellular function of meningeal lymphatic endothelial mitochondrial cells, promote meningeal lymphatic transport in the central nervous system, thereby alleviating the pathological symptoms of Alzheimer's patients and enhancing their cognitive function. The device has a simple and compact structure, is easy to plug and unplug, has low optical signal loss, and high coupling efficiency. It can be widely used in novel non-invasive optical brain-computer interface devices and belongs to the field of fiber optic sensing technology.

In some embodiments herein, methods, compositions, and uses for countering the effects of aberrant meningeal lymphatic drainage and / or modulating lymphatic vessels of the central nervous system are described. In some embodiments, methods, compositions, or uses for treating, preventing, or ameliorating symptoms of a neurodegenerative disease associated with aberrant meningeal lymphatic drainage are described. Modulating lymphatic vessels, or countering the effects of aberrant meningeal lymphatic drainage, in accordance with some embodiments, are used to diagnose, treat, prevent, or ameliorate symptoms of neurodegenerative diseases such as Alzheimer's disease (AD) and dementia. Methods of diagnosing and monitoring the progression of neurological diseases are also provided.

The application discloses a dural membrane scissors for neurosurgery, which is characterized by comprising a scissors provided with a first blade arm and a second blade arm, wherein the first blade arm and the second blade arm are rotationally connected through a first rotating disc and a second rotating disc connected thereto, and a shaft sleeve is arranged at the second rotating disc; through the proper resistance of the air bag, the doctor can exert force with his hand, which can improve the doctor's attention and hand feeling during the operation, and is beneficial to more accurate operation; when the first blade arm and the second blade arm are away from each other, the guide shaft gradually leaves the air bag, but the recovery of the air bag needs a certain reaction time, so that when the first blade arm and the second blade arm are opened outward, the air bag does not generate a counteracting pushing force on the first blade arm and the second blade arm, so that the doctor can slowly open the first blade arm and the second blade arm outward, avoids the interference of the counteracting force of the air bag, and makes the operation more accurate.

The present invention relates to an antibody or fragment thereof specifically binding to meningeosis carcinoma-specific antigen, such as DDX53, KIF3C, and AKR1A1, an anti-body or fragment thereof for use in the prophylaxis and / or treatment of cancer, preferably melanoma, further preferably melanoma with leptomeningeal spread, highly preferably melanoma with meningeosis carcinomatosa, a pharmaceutical composition comprising said antibody or fragment thereof, a nucleic acid encoding said antibody or fragment thereof, a vector comprising said nucleic acid, a prokaryotic or eukaryotic host cell comprising said vector, and to a method for the prophylaxis and / or treatment of cancer, preferably melanoma, further preferably melanoma with leptomeningeal spread, highly preferably melanoma with meningeosis carcinomatosa, in a living being, comprising the admin- istration of a prophylactically and / or therapeutically effective amount of said antibody or fragment thereof or said pharmaceutical composition.

The utility model discloses a meninx raw material rough cleaning device which comprises a machine body, a transmission shaft and a rough cleaning mechanism, the surface of the machine body is provided with the transmission shaft connected with an internal power device, the machine body is movably connected with the rough cleaning mechanism through the transmission shaft, and the rough cleaning mechanism comprises a washing barrel, an inner ring wall, a through hole, a fixing disc, a screw rod, a clamping cover and a nut. An inner ring wall is welded to the position, close to the inner wall, of the inner periphery of the washing barrel, a through hole is formed in the surface of the inner ring wall, the machine body drives the washing barrel to continuously turn over through a transmission shaft, a clamping arm and a universal joint, internal washing liquid continuously makes contact with the surface of the bovine pericardium to wash the surface of the bovine pericardium, and a fixing disc is matched with a clamping cover in the washing process; the cow pericardium has a certain activity space, comprehensive cleaning is facilitated, meanwhile, damage to the cow pericardium caused by excessive movement is avoided, and compared with a manual cleaning mode, the cleaning efficiency and quality are greatly improved, and follow-up fine cleaning operation is facilitated.

The invention discloses an application of GW9662 in treatment of meningeal carcinoma. The application finds that GW9662 can effectively inhibit meningeal carcinoma cells for the first time, the discovery of the application is expected to overcome the existing treatment difficulty, opens up a new path for the treatment of meningeal carcinoma, remarkably improves the treatment effect, prolongs the life of a patient, and has a wide application prospect clinically.

Various embodiments of a spinal shield having a shield body including a plurality of lateral extensions configured to be positioned over an exposed spinal canal for establishing a protective barrier around the contents of the exposed spinal canal are disclosed.

The invention provides a subdural hematoma targeted drug delivery system, a preparation method thereof and a pharmaceutical preparation, and belongs to the technical field of targeted drugs. The targeted drug delivery system is a drug-loaded liposome, and the drug-loaded liposome comprises a drug active substance and a liposome carrier loaded with the drug active substance; the liposome carrier is prepared from the following components: cholesterol, lecithin, DSPE-PEG (Distearoyl Phosphate Polyethylene-Polyethylene Glycol) and DSPE-PEG-CLTX. The targeted drug delivery system provided by the invention is spherical, small and uniform in particle size, negatively charged on the surface and good in serum stability, can deliver the drug to the subdural hematoma part in a targeted manner, reduces systemic toxicity of the drug, inhibits pyroptosis, relieves inflammatory response, promotes hematoma absorption and meningeal lymphatic vessel drainage, and has a good application prospect. And the purpose of accurate treatment is achieved.

The present invention relates to a spinal needle that clearly identifies the presence of cerebrospinal fluid (CFS) to dispense a drug or anaesthetic in the correct direction and site of the meninges. The response of the sensor to the presence of CFS does not depend on environmental factors and is performed quickly to prevent excessive loss of CFS in the patient. The spinal needle comprises a hub having a proximal end and a distal end, said hub comprising a transparent tank arranged at the proximal end of the hub that is configured to receive CFS, an expandable CFS sensor arranged inside the transparent tank and a connection port arranged at the distal end of the hub configured to couple to a device for medical fluids, and a cannula comprising a tip fluidically connected to the proximal end of the hub.

The embodiment of the invention provides a color Doppler ultrasonic hemodynamic analysis method for an artery in a semi-open mouth meninx, which comprises the following steps of: taking a semi-open mouth of a patient, and maintaining an acoustic window through an occlusion object to enlarge a subtemporal fossa; a linear array or convex array probe is selected according to the body type of a subject, and ultrasonic equipment parameters are set; scanning in the subtemporal fossa to identify the trunk of the maxillary artery (MXA) and the branch of the middle meninx artery (MMA); measuring inner diameters and hemodynamic parameters of the MXA and the MMA, wherein the parameters comprise a systolic peak flow rate (PSV), an end-diastolic flow rate (EDV), a resistance index (RI) and a pulsation index (PI); compared with the prior art, the subtemporal fossa is expanded by 5-10 mm through the medical silica gel occlusion object with the occlusion thickness of 3-8 mm, the anterior-posterior diameter of the subtemporal fossa is expanded to 25-35 mm, the upper-lower diameter of the subtemporal fossa is expanded to 18-28 mm, and bone shielding of the condylar process on the initial section of the middle meninx artery (MMA) is thoroughly relieved.

The application discloses a kind of implanted nerve electrode devices of magnetic control telescopic contact and separation cerebral cortex, belong to brain signal research technical field.It includes: flexible substrate, magnetostrictive deformation substrate, magnetostrictive film, elastic component and electrode;The flexible substrate side is provided with several rectangular grooves arranged in order;Two pieces of the magnetostrictive film are pasted to the two sides of the magnetostrictive deformation substrate, and the magnetostrictive film on one side is used to fix the magnetostrictive deformation substrate in the rectangular groove of the flexible substrate;The electrode is fixed on the magnetostrictive deformation substrate, for collecting electroencephalogram;The elastic component is used to pull the deformed magnetostrictive deformation substrate to restore flat state.The device is fixed under dura mater, and can be bent under the drive of magnetic field, realizes the effective contact of nerve electrode and cerebral cortex, compared with traditional semi-invasive nerve electrode, improves the detection quality and stability of electroencephalogram.

The application discloses a marker for depression and application thereof in prevention and treatment of depression. Through the marker, whether an individual is suffering from depression can be detected and diagnosed, so that corresponding treatment strategies can be given in time, and hidden troubles brought by depression to the individual can be reduced. The application also discloses application of the marker in prevention and treatment of depression phenotype. Taking a marker with specific up-regulation as an example, through blocking the function of the marker, prevention and treatment of depression can be realized. Specifically, in addition to specific material markers, it is disclosed that abnormality of meningeal lymphatic vessels is closely related to depression phenotype, and detection of the meningeal lymphatic vessels is expected to be a new marker for early diagnosis and prediction of clinical depression treatment effectiveness. Improvement of the meningeal lymphatic vessels is expected to be applied to treatment of depression and other neurosychiatric diseases related to stress and play an effective treatment role.

The invention provides an epileptic seizure prediction method, device, equipment and program product, and the method comprises the steps: obtaining a normal electroencephalogram signal baseline of a dura mater of an epileptic in an epileptic non-seizure period, and a personalized feature library, the personalized feature library comprises features of the cerebral dura mater electroencephalogram signals of the epileptic within at least one time period before epileptic seizure; acquiring an electroencephalogram signal of the current dura mater of the epilepsy patient; according to the normal electroencephalogram signal base line, the personalized feature library and the current electroencephalogram signal of the dura mater, predicting whether the epilepsy is about to seizure epilepsy or not; under the condition that the epilepsy is about to seize, a first early warning signal is sent out, and the first early warning signal is used for reminding an epileptic that the epilepsy is about to According to the prediction method, the electroencephalogram characteristics of the patient can be reflected more accurately, the false alarm rate and the missing report rate caused by individual differences are reduced, the accuracy of epileptic seizure prediction is improved, and the robustness of the prediction method is enhanced.

The invention belongs to the technical field of medicine, discloses a skull rapid growth marker and application thereof, and provides a skull rapid growth marker based on a pressure / dura mater FAK-Twist1 pathway and an application method of the marker in child skull defect repair. By detecting the expression level of the marker, the growth and development state of the pediatric skull can be accurately judged, and a scientific basis is provided for clinical doctors to select proper skull repair opportunities, so that the success rate and safety of pediatric skull defect repair operations are improved, and postoperative complications are reduced. The rapid skull growth markers determined by the invention are closely related to the growth and development mechanism of the child skull based on a pressure / dura mater FAK-Twist1 pathway, and the growth state of the skull can be accurately reflected by detecting the expression level of the markers, so that a reliable diagnostic basis is provided for opportunity selection of a child skull defect repair operation.

The invention belongs to the field of biological medicines, and particularly relates to a medicine for treating meningeal metastasis of malignant tumors with NTRK and / or ROS1 mutations and a preparation method, and the medicine is a freeze-dried powder preparation or injection for subarachnoid space injection of NTRK / ROS1-TKIs. The invention also provides an application of the NTRK / ROS1-TKIs in preparation of a medicine for treating meningeal metastasis of malignant tumors with NTRK and / or ROS1 mutation. The prepared NTRK / ROS1-TKIs injection can be directly injected into the subarachnoid space of a patient, the drug concentration in cerebrospinal fluid of the patient is greatly improved, the cerebrospinal fluid / plasma concentration ratio can reach 20 times or more, the problem of insufficient dosage caused by the blood-brain barrier after the targeted drug is orally taken can be completely solved, and the drug has the advantages of fast effect taking, no toxic or side effect and no toxic or side effect. The treatment effect on meningeal metastasis of malignant tumors such as lung cancer can be obviously improved.

The invention relates to the technical field of image processing, in particular to a brain tumor focus area segmentation method based on CT image analysis. The method comprises the following steps: segmenting a meninx CT image to obtain an initial segmentation region, and preprocessing the initial segmentation region to obtain an enhanced image; obtaining a gray gradient direction vector of each pixel point in the enhanced image; skeleton lines in each foreground area and tangent lines of all end points of all the skeleton lines are obtained, and then suspected cut-off end points of all the end points are obtained; according to the gray gradient direction vector of each pixel point of the foreground area where each suspected truncation end point of one end point is located, screening the pixel points of the area where each suspected truncation end point is located to obtain disordered pixel points of the end point, and further obtaining each tumor part area of the end point; and taking the central point of each tumor partial region of each end point as a seed point of region growth, and respectively carrying out region growth in each tumor partial region to obtain a tumor region. According to the invention, the brain tumor region can be effectively segmented.

The invention discloses a kit for rapidly and efficiently diagnosing lung cancer meningeal metastasis, and relates to the technical field of medical equipment, and the key points of the technical scheme are as follows: the kit is a disposable plastic shell, and four independent chromatography channels are arranged in parallel in the kit, namely a Compleent C7 channel, a Frizzled-9 channel, an Interleukin-1 receptor protein channel and an Alpha-1-anticmotrypsin channel. Four markers can be detected at the same time, when the kit is used for diagnosing lung cancer meningeal metastasis, the dosage of cerebrospinal fluid can be reduced, the diagnosis sensitivity is improved, the detection time is shortened, the sampling frequency is reduced, and by setting an objective interpretation threshold value and an automatic analysis module, subjective judgment errors are reduced, and diagnosis consistency and repeatability are improved.

A method of inducing lymphangiogenesis in the brain or central nervous system of a subject is provided in which an effective amount of a lymphangiogenesis inducer is administered. A method of inducing lymphangiogenesis in a tumor in the brain or central nervous system of a subject is provided in which an effective amount of a lymphangiogenesis inducer is administered. A method of treating a cancer of the brain or central nervous system is also provided in which an effective amount of a lymphangiogenesis inducer is administered. An example of a lymphangiogenesis inducer is VEGFC. The lymphangiogenesis inducer can be in the form of a protein or a polynucleotide encoding the protein, such as an mRNA or AAV. The lymphangiogenesis inducer can be administered to the cistema magna or directly into the lymphatic system. An immunotherapeutic agent, such as a checkpoint inhibitor, may also be administered.

The utility model discloses a scalp scar incision knife for the edge of a bone window, which is divided into an L type and a T type, and each type is divided into two edging directions, namely a clockwise edging direction and an anticlockwise edging direction; the T-shaped scalpel comprises a scalpel handle, a first blade or a second blade, the scalp of a surgical part of a patient is transversely and longitudinally cut open at the same time through the additional arrangement of the first blade or the second blade, and the convenience of medical staff in surgical use is improved; a downward edged blade and an upward edged blade are arranged on the blade side, the skull side blade is edged downwards, periosteum and skull of a patient are separated, the downward blade can prevent the scalp from being too thin, and it is guaranteed that the blade is tightly attached to the surface of the skull to be pushed. The blade in the bone window is edged upwards, so that damage to meninx and brain tissue of a patient caused by the blade can be avoided, the use safety is improved, the situation that medical staff frequently replace tools in the operation process is avoided, and the use difficulty of the medical staff is reduced.

The invention belongs to the field of biological medicine, and particularly relates to a medicine for treating EGFR mutation non-small cell lung cancer meningeal metastasis, application, a medicine box and a preparation method of the medicine, the medicine is a freeze-dried powder preparation or injection of EGFR-TKIs for subarachnoid space injection, the amount of EGFR-TKIs per person in the medicine is 0.01-5 mg, and the amount of EGFR-TKIs in the medicine is 0.01-5 mg. The injection method comprises any one of lumbar puncture, bridge forebay indwelling catheter injection and Ommaya capsule injection. The prepared EGFR-TKIs injection can be directly injected into the subarachnoid space, the drug concentration in cerebrospinal fluid of a patient is greatly improved, the cerebrospinal fluid / plasma concentration ratio of the EGFR-TKIs injection is increased from far less than 1 to more than 2 times and even can reach more than 10 times, and the EGFR-TKIs injection can completely solve the problem of insufficient dosage caused by a blood-brain barrier after oral administration of a targeted drug and has a good application prospect. The medicine takes effect quickly, and the treatment effect on lung cancer meningeal metastasis can be remarkably improved.

The present disclosure discusses a devices, systems and methods for transvascular, transvenous and / or transdural access, to the brain parenchyma, subarachnoid or subdural spaces. In some embodiments, the disclosed systems and methods may be used for local drug delivery, tissue biopsy, nanofluidic or microelectronic device / component delivery / insertion / implantation, in situ imaging, ablation of abnormal brain tissue and the like. Embodiments of the present disclosure include an access catheter system for extravascular procedures in the brain having an elongate, flexible tubular body, with at least one lumen extending axially there through between a proximal end, and a distal end. The access catheter system may include a side exit port and a distal end port. Further, the access catheter system may include a selective deflector positioned within the lumen configured to deflect a procedure catheter and permit a guide catheter.

Dural repair devices that are configured to effectively and reliably repair the damage of a dural tear due to incidental durotomies are provided, along with methods of use. The devices and methods enhance the ability of a surgeon to repair a patent's dura mater, or dura, during surgery of the central nervous system. The dural repair device has a multi-layer structure configured to exert a pressure or tamponade effect to compress a patient's dura to its state prior to the spinal surgery. Thus, the dural repair devices and methods of use may reduce the patient's risk morbidity, further surgery, spinal headaches, or other injuries and discomforts.

The invention relates to the field of medical apparatus and instruments, and discloses a knife-breaking-preventing mechanism which comprises a limiting sleeve and a top sleeve, the limiting sleeve is detachably connected with a skull milling cutter, and when the knife-breaking-preventing mechanism is connected with the skull milling cutter, the top sleeve is matched with a milling cutter hook to clamp the two sides of a skull; the end, abutting against the skull, of the ejector sleeve is perpendicular to the axis of the skull milling cutter, so that the axis of the skull milling cutter can be always kept to be approximately perpendicular to the skull, the cutter breaking phenomenon is prevented to the maximum extent, the problem that the dura mater is damaged is effectively avoided, and the safety coefficient of the skull milling cutter is improved. The top sleeve can slide relative to the limiting sleeve, so that it is ensured that the top sleeve can abut against the outer wall of the head, and the reliability of the knife breaking prevention mechanism is improved. The invention further provides a craniotomy milling cutter assembly which comprises the skull milling cutter, the milling cutter hook and the cutter breaking prevention mechanism, and the operation safety coefficient of the craniotomy milling cutter assembly can be effectively improved through the cutter breaking prevention mechanism.

The invention particularly relates to a flexible electrode implantation mechanism imitating a mosquito brain. The implanting mechanism comprises a base, an implanting driving device, an implanting cutting device, an implanting guiding device and an implanting stretching device; the implantation driving device is adjustably mounted on the base bottom plate; the implantation cutting device, the implantation guiding device and the implantation stretching device are sequentially and adjustably mounted on the base positioning table from top to bottom in the vertical direction; the implantation cutting device performs meninx cutting based on position adjustment in the vertical direction; the implantation stretching device is adjusted on the basis of the position in the vertical direction, and the cut meninx is stretched outwards; the implantation driving device performs flexible electrode implantation driving on the outwards stretched meninx based on reciprocating displacement in the vertical direction; and the implantation guide device is used for carrying out flexible electrode implantation path constraint on the outwards stretched meninx based on position adjustment in the vertical direction. According to the invention, when the flexible electrode is implanted, not only is the tissue damage probability reduced, but also the implantation effectiveness and success rate are improved.

The invention relates to a sprayable medical hydrogel and application thereof, the injectable medical hydrogel comprises a first component and a second component, the first component comprises chitosan or chitosan oligosaccharide with high deacetylation degree or a derivative thereof, and the second component comprises chitosan with high deacetylation degree or chitosan oligosaccharide with high deacetylation degree or chitosan oligosaccharide with high deacetylation degree or chitosan oligosaccharide with high deacetylation degree or chitosan oligosaccharide with high deacetylation degree; the second component is one of aldehyde group terminated multi-arm polyethylene glycol or succinimide terminated multi-arm polyethylene glycol; the medical hydrogel is absorbable medical hydrogel formed by in-situ crosslinking after a first component and a second component are subjected to bi-component injection physical mixing. The medical hydrogel can be used for sealing wounds of injured parts of dura mater or spinal cord; the temperature-sensitive hydrogel overcomes the defects of slow curing time and low gel strength of temperature-sensitive hydrogel, can be polymerized without open ultraviolet irradiation, and is suitable for in-vivo injection.