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35 results about "Cataract surgery" patented technology

Cataract surgery, also called lens replacement surgery, is the removal of the natural lens of the eye (also called "crystalline lens") that has developed an opacification, which is referred to as a cataract, and its replacement with an intraocular lens. Metabolic changes of the crystalline lens fibers over time lead to the development of the cataract, causing impairment or loss of vision. Some infants are born with congenital cataracts, and certain environmental factors may also lead to cataract formation. Early symptoms may include strong glare from lights and small light sources at night, and reduced acuity at low light levels.

Dioptric dura-nucleus cataract dynamic intraocular pressure stable control ultrasonic emulsification system adaptive to dual-channel operation

PendingCN121845843AEye surgeryTonometersPressure curveIntraocular pressure
The invention discloses a dioptric scleroderma cataract dynamic intraocular pressure stable control ultrasonic emulsification system adaptive to a dual-channel operation, which comprises a host control unit, an ultrasonic emulsification handle, a perfusion and suction system, an intraocular pressure monitoring unit, a pressure balance module and a scleroderma fragmentation module, through cooperation of the intraocular pressure control module and the two-way operation type adaptive control module, a high-precision filling valve and a closed-loop suction pump are synchronously adjusted in real time according to anterior chamber built-in and external monitoring fusion data, and intraoperative intraocular pressure fluctuation is controlled within + / -2 mmHg; through pulse modulation and a self-adaptive negative pressure curve of the hardcore fragmentation enhancement module, the stability of the anterior chamber is ensured while the hardcore fragmentation efficiency is improved; fluid dynamics and energy parameters can be automatically optimized according to conventional incisions or micro incisions; according to the system, the anterior chamber stability problem in the high-difficulty cataract surgery is solved.
Owner:HEBEI XIONGAN SENSHI MEDICAL TECHNOLOGY CO LTD

Stm2457-plga nanodrug, intraocular lens and preparation method and application thereof

PendingCN122376597AMicrosphereFreeze-drying
The application discloses an STM2457-PLGA nano drug, an artificial lens and a preparation method and application thereof, and relates to the technical field of biological medicine. The preparation method of the STM2457-PLGA nano drug comprises the following steps: preparing nano microspheres by injecting an oil phase comprising STM2457 and PLGA and a water phase comprising PVA into a microfluidic chip, and obtaining the STM2457-PLGA nano drug after freeze-drying of the nano microspheres, wherein the particle size of the STM2457-PLGA nano drug is 50-300 nm. The long-acting release of STM2457 carried by the surface-modified artificial lens is realized through the controlled release effect of the PLGA nano microspheres, and the slow-release period can cover the high-incidence period of postoperative complications of cataract surgery through process optimization, far exceeding the traditional short-term release system, and can continuously meet the long-term prevention and treatment needs after surgery, and effectively reduce the risk of complications such as after-cataract.
Owner:BEIJING TONGREN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV

Capsularhexis assist device for cataract surgery

ActiveCN224441573UCataract surgeryReoperative surgery
The utility model discloses a kind of cataract surgery tear capsule auxiliary devices, including vertically arranged U-shaped seat, U-shaped seat is connected in one side of two movable seats by drive assembly, movable seat is fixedly connected in one end of long rod, the other end of long rod is screw-connected with the first screw rod perpendicular to long rod, the one end of first screw rod is equipped with first knob, the other end of first screw rod is equipped with annular groove, the both sides of U-shaped seat are equipped with corresponding connecting block, connecting block is fixed to patient face by corresponding bandage, this kind of cataract surgery tear capsule auxiliary device uses, first, by bandage, the whole is fixed to patient face, then by drive assembly, two movable seats drive corresponding first screw rod in opposite or opposite direction synchronous movement, to tear open by two first screw rods respectively to upper eyelid and lower eyelid, annular groove is equipped on first screw rod, support eyelid by annular groove, it is convenient to tear capsule to eyeball.
Owner:LIUZHOU WORKERS HOSPITAL

A pre-cataract surgery visual function expectation assessment method

The application discloses a pre-cataract surgery visual function expectation evaluation method, collects preoperative basic examination data, subjective expectation expression data and a preset visual task scene library, and screens a candidate visual task scene set; a scene acceptance result set is obtained through patient acceptance interaction discrimination; subjective expectation expression data are combined and analyzed to generate a visual function requirement parameter set; a visual task tolerance threshold is further quantified and structured and coded into an expectation feature vector, and a preoperative visual function expectation evaluation result is output, which is used for preoperative lens matching, preoperative communication prompting or postoperative satisfaction risk prediction.
Owner:NINGXIA HUI AUTONOMOUS REGION PEOPLES HOSPITAL

Cataract capsulorhexis guide ring structure

ActiveCN224126161UAchieve suctionEasy to follow upEye surgeryCataract surgerySilica gel
The utility model discloses a cataract capsulorhexis guide ring structure, and relates to the technical field of cataract surgery, the cataract capsulorhexis guide ring structure comprises a guide ring body, the guide ring body is provided with a connecting part, the connecting part is fixedly provided with a positioning support, the guide ring body is provided with a girdling assembly, the middle position of the guide ring body is provided with an adsorption mechanism, and the adsorption mechanism is provided with an adsorption mechanism. The adsorption mechanism comprises an adsorption head mounted in the middle of the guide ring body, an adsorption opening is formed in the bottom of the adsorption head, a silica gel ring is arranged at the adsorption opening, a positioning ring seat is fixedly mounted in the adsorption head, a mounting notch is formed in the positioning ring seat, a locking mechanism is fixedly mounted in the mounting notch, and the silica gel ring is arranged on the silica gel ring. A butt joint opening is formed in the side wall of the adsorption head, and an adsorption pipeline is connected to the butt joint opening. According to the cataract capsulorhexis guide ring structure, through cooperative use of the adsorption mechanism and the locking mechanism, the annularly-cut capsular membrane can be rapidly taken out, the number of operation steps is reduced, and the operation time is shortened.
Owner:CHANGZHOU QINYU INFORMATION TECH CO LTD

Cataract surgery cooperation method and system based on wearable intelligent surgical glove

The invention discloses a cataract surgery cooperation method and system based on a wearable intelligent surgical glove, and belongs to the technical field of man-machine interaction.The method comprises the steps that through the intelligent surgical glove worn on the hand of a user, operation actions of all parts of the hand are tracked in real time, and hand action parameters of the user are obtained; performing anomaly detection on the hand action parameters based on a preset optimal operation path and an intraoperative OCT image stream; wherein the optimal operation path is obtained based on historical trajectory data and a corneal topographic map of the patient; according to the operation risk early warning corresponding to the abnormal detection result, the hand action of the user is adjusted through the intelligent operation glove. Therefore, by implementing the method and the device, the operation path indication can be provided for the operator during the cataract operation, and the operator can be reminded in time when the abnormal operation may cause the operation risk.
Owner:广州爱尔眼科医院有限公司

Method of treating operative complications of cataract surgery

PendingPH12025552551A1Cataract surgeryReoperative surgery
Owner:FORMOSA PHARM INC

Reversible expandable pupil expander

PendingUS20260191520A1Cataract surgeryReoperative surgery
A pupil expansion device for ophthalmic surgery includes a closed-loop ring body defining a central aperture and a plurality of flanges arranged circumferentially around the ring body. The flanges comprise non-folded flanges defining a plane of the device and folded flanges positioned alternately between the non-folded flanges. The folded flanges are connected to the ring body by notch regions and are movable between a resting configuration and an expanded configuration to enlarge the pupil. In one embodiment, the non-folded flanges, folded flanges, and notch regions are coplanar in the resting configuration. In another embodiment, the folded flanges are tilted posteriorly relative to the plane defined by the non-folded flanges by an angle between approximately 1 degree and 30 degrees. The device may be formed as a single-piece structure and is configured for use during ophthalmic surgical procedures, including manual small incision cataract surgery.

Adjustable anterior chamber depth phacoemulsification cannula

This invention provides an adjustable anterior chamber depth cataract surgery irrigation cannula, belonging to the field of irrigation cannula technology. It includes an irrigation mechanism comprising a housing with an ultrasonic emulsification needle disposed inside, a tube body at one end of the housing, the tube body being fitted over the ultrasonic emulsification needle, a rubber ring on the inner wall of the tube body, a circular ring on the outer wall of the housing, a driving part on the circular ring, a follower part on the driving part, and a pulling part on the tube body for expanding the tube body diameter; an auxiliary mechanism including a groove on the tube body, a clamping part on the pulling part for preventing the tube body from sliding on the housing, and a cutting part on the pulling part for facilitating separation of the tube body from the housing; and an anti-fall mechanism including a threaded ring on the housing with a locking part, and a snap-fit ​​part on the driving part. This invention, through the inclusion of the irrigation mechanism, auxiliary mechanism, and anti-fall mechanism, makes the installation of the tube body faster.
Owner:TIANJIN EYE HOSPITAL

Crystal nucleus delivery device for ophthalmic cataract surgery

PendingCN121845839AEye surgeryCataract surgeryReoperative surgery
The crystal nucleus delivery device structurally comprises a connecting ring, a grip, a supporting tube, a recycling tube and an adjusting rod, the connecting ring is connected between the supporting tube and the recycling tube, the adjusting rod is arranged in the recycling tube in a sliding fit mode, and the end of the adjusting rod is connected with the grip; the transition ball is arranged on the delivery pipe, and the transition ball is matched with the rubber plate, so that when a crystal nucleus rolls on the rubber plate, the crystal nucleus gradually rotates to be close to the delivery pipe and can collide and abut against the transition ball, the transition ball rotates at the pipe opening of the delivery pipe in the same direction, and the crystal nucleus is meshed for multiple times and divided into broken nucleuses; and then the crystal nucleus enters the instrument to be ground and crushed into smaller volume, and is scattered into the delivery pipe, so that the delivery of the crystal nucleus is better assisted, and the delivery capability of the instrument on the crystal nucleus for the ophthalmic cataract surgery is ensured.
Owner:CHONGQING ZHONGXIAN PEOPLES HOSPITAL

Operating bed for femtosecond laser assisted cataract surgery

ActiveCN224235702UOperating tablesOphthalmology departmentCataract surgery
The utility model discloses an operating bed for a femtosecond laser-assisted cataract surgery, and aims to solve the problem that a patient can not conveniently lie on an existing ophthalmic operating bed in the cataract surgery. The operating bed comprises a bed body and a base, a lifting mechanism is arranged between the bed body and the base, an upper connecting piece is arranged at the bottom of the bed body, and a lower connecting piece matched with the upper connecting piece is arranged at the top of the lifting mechanism. The lower connecting piece comprises a guide stud and a positioning hole, the upper connecting piece comprises a connecting plate and a sleeve, and the sleeve is provided with a first guide hole matched with the guide stud and a drawing pin matched with the positioning hole. Through the arrangement of the upper connecting piece and the lower connecting piece, the bed body can be rotated by a certain angle when a patient lies on the bed body, the patient can lie down normally conveniently, then the bed body can be rotated back to an operation position, meanwhile, the height of the bed body can be adjusted through the lifting mechanism, different operation requirements are met, and the use convenience and practicability of the operation bed are improved.
Owner:TAIAN GUANGMING AIER EYE HOSPITAL CO LTD

Intraocular lenses that improve peripheral vision

Lenses and methods are provided for improving peripheral and / or central vision for patients who suffer from certain retinal conditions that reduce central vision or patients who have undergone cataract surgery. The lens is configured to improve vision by having an optic configured to focus light incident along a direction parallel to an optical axis at the fovea in order to produce a functional foveal image. The optic is configured to focus light incident on the patient's eye at an oblique angle with respect to the optical axis at a peripheral retinal location disposed at a distance from the fovea, the peripheral retinal location having an eccentricity between −30 degrees and 30 degrees. The image quality at the peripheral retinal location is improved by reducing at least one optical aberration at the peripheral retinal location. The method for improving vision utilizes ocular measurements to iteratively adjust the shape factor of the lens to reduce peripheral refractive errors.
Owner:AMO GRONINGEN

Cataract surgical instrument

PendingUS20260130796A1Laser surgeryCataract surgeryCatheter
A cataract surgical instrument includes a guide tube, a deformation member, and a net bag. An end portion of the guide tube is provided with an opening in communication with an inner cavity of the guide tube. The deformation member includes a deformation part and a connecting part that is connected to the deformation part. The connecting part is arranged through the inner cavity and can move in the axial direction of the guide tube. The net bag is connected to the deformation part. The connecting part drives the deformation part and the net bag to move in the axial direction of the guide tube, such that the deformation part and the net bag retract into the inner cavity or expand out of the inner cavity.
Owner:RUGAO WEN NUO MEDICAL TECHNOLOGY CO LTD

Laser methods and systems for addressing conditions of the lens

ActiveUS12589033B2Laser surgeryMedical simulationBiologic AssaysCataract surgery
Systems and methods for performing laser cataract surgery, for using a biometric system to determine a material property of a structure of the eye, laser pulses in a laser shot pattern having different powers. A therapeutic laser, and laser delivery system having the capability to vary the power of the laser beam.
Owner:LENSAR INC

Ophthalmology visual effect dynamic simulation method and system based on multi-modal parameter fusion

The invention discloses a multi-modal parameter fusion ophthalmology visual effect dynamic simulation method and system, and relates to the technical field of biomedicine, and the method comprises the steps: obtaining eye condition information and a visual parameter set of a target user; determining a plurality of selectable models of the implantable intraocular lens; performing simulation state evaluation on the plurality of selectable intraocular lens models, and determining a plurality of prediction simulation complexity; and generating optimal operation parameters according to the visual parameter set, and controlling virtual reality (VR) equipment to carry out cataract postoperative vision recovery state evolution simulation. The technical problems that in the prior art, post-operation visual effect differences of implantation of different types of intraocular lenses in cataract surgery cannot be visually displayed to the patient, subjective experience bases are lacked when the patient selects the intraocular lenses, and the selected intraocular lenses are not matched with actual requirements of the patient are solved.
Owner:TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH

Multifunctional cataract surgery device and surgical hook thereof

ActiveCN224540435UOphthalmology departmentSurgical Hooks
The utility model relates to the field of ophthalmic medical instruments, disclose a multifunctional cataract surgery device and its operation hook, including handle, the handle is used for receiving whole, extension rod, one end fixedly connected with the hook head of extension rod, extension rod is used for adjusting the interval between hook head and handle, threaded sleeve, threaded sleeve is used for connecting adjustment sleeve, clamping block, one end annular array arrangement fixedly connected in threaded sleeve one end of clamping block, clamping block is used for fixed extension rod, fastening sleeve, fastening sleeve is connected in the outer wall of threaded sleeve, fastening sleeve is used for through clamping block to fixed extension rod. In the utility model, adjust the position of extension rod in handle to be in place, rotate fastening sleeve and make inner taper groove inner wall adhere to clamping block outer wall, make clamping block to extension rod carry out clamping fixed, reached the effect that the length of hook head is convenient to adjust, solved the interval of traditional operation hook to be unable to adjust handle to the diseased place according to actual situation, improved the convenience of operation hook.
Owner:FIRST PEOPLES HOSPITAL OF QUJING

Heterodimeric compositions and methods for treating ocular disorders

PendingCN122344226AOcular inflammationGlaucoma present
Described herein are processable compositions comprising at least one moiety that is processable in its free form. Also described herein are compositions and methods for treating ocular diseases or conditions, including glaucoma, blepharitis, ocular inflammation, diabetic macular edema, posterior inflammation, anterior inflammation, macular degeneration (e.g., wet macular degeneration (AMD) or dry AMD), post-cataract surgery, and retinal vein occlusion. The compositions and methods comprise steroids and prostaglandins that exhibit anti-inflammatory activity, reduce intraocular pressure (IOP), and / or other desirable activities. Injection of the compositions in the eye provides therapeutic benefits to patients suffering from ocular conditions.
Owner:RIPPLE THERAPEUTICS CORP

Adaptable intraocular lens for implantation under various capsular bag conditions

PCT designated stageWO2026093805A1Intraocular lensImplanted artificial lensCataract surgery
Intraocular lens (10) for implantation in patients undergoing cataract surgery, adaptable to various conditions of the capsular bag (17d), comprising a central optical portion (11) and two lateral haptics (12a, 12b), said lateral haptics (12a, 12b) being integral with said central optical portion (11) and having a polygonal shape with five sides and rounded vertices, the first end of the first side and the final end of the fifth side of each of said haptics (12a, 12b) being integral with said central optical portion (11).
Owner:BABINO ANTONIO

Artificial lens capsule

PCT designated stageWO2026024511A1Intraocular lensPosterior capsular ruptureCataract surgery
An artificial lens capsule is provided for use during cataract surgery or in cases of aphakia (absence of lens) or posterior capsule rupture (PCR). A common complication during cataract surgery is the rupture of the posterior capsule, preventing the placement of a monofocal intraocular lens in the lens capsule due to inadequate support. Typically, a 3-piece, long haptic intraocular lens can be placed in the ciliary sulcus or capsule if the monofocal intraocular lens is sufficient. However, for placing a toric (astigmatism correcting) or presbyopia-correcting intraocular lens (multifocal), there are currently no options for a 3-piece sulcus-fixated lens. The artificial capsule disclosed herein can be inserted and supported by the anterior capsular rim or sutured into the sclera if capsular support is inadequate. This provides a stable region for placing a single-piece toric or presbyopia-correcting intraocular lens, thereby enhancing the options for lens placement in cases of inadequate capsular support. The device can also be a reservoir for other future intraocular and / or drug-eluting devices.
Owner:THE RES FOUNDATION FOR THE STATE UNIV OF NEW YORK

AI-based video analysis of cataract surgery for dynamic anomaly recognition and correction

A computer-implemented method for recognizing deviations from plan parameters during an ophthalmological operation is described, the method including: providing video sequences of cataract operations, the video sequences having been recorded by means of an image recording apparatus, training a machine learning system using the video sequences provided and also, in each case, a planned refractive power of an intraocular lens to be inserted during a cataract operation and a target refraction value following the cataract operation as training input data and associated prediction results in the form of an actual refraction value following the cataract operation to form a machine learning model for predicting the actual refraction value following the cataract operation, and persistently storing parameter values of the trained machine learning system.
Owner:CARL ZEISS MEDITEC AG

A cataract surgery evaluation method and system based on deep learning and a medium

The application belongs to the technical field of deep learning, and provides a cataract surgery evaluation method and system based on deep learning and a medium, comprising the following steps: S1, classifying the surgery stage in which a video frame is located by using the surgery instrument features in the video frame in combination with the eye background features; S2, training a general network according to the initial feature labels of each link of the surgery to extract evaluation features in the video frames corresponding to each link for surgery evaluation; and S3, obtaining the quantitative information of each link of the surgery according to the preset labels of the extracted evaluation features, and inputting the quantitative information into the trained preset classification evaluation network to perform classification evaluation on each link of the surgery. The application has the advantage that the quantitative relationship between the descriptive evaluation indexes in the ICO-OSCAR standard and the learnable surgery features of the deep learning network is established, so that the full-process participation of expert doctors in surgery training is replaced by artificial intelligence technology, and the objectivity, reliability and response speed of the training effect are improved.
Owner:CIXI INST OF BIOMEDICAL ENG NINGBO INST OF IND TECH CHINESE ACAD OF SCI NINGBO +1

Crystal extraction device for cataract surgery

ActiveCN223787781UEye surgeryCataract surgeryLens extraction
The utility model relates to the technical field of eye treatment, and discloses a crystal taking-out device for cataract surgery, which comprises an operation plate and tweezers, an operation groove is arranged on the operation plate, a placing groove for placing a crystal is arranged in the operation groove, the placing groove is communicated with the operation groove, a through pipe is arranged in the placing groove, and the tweezers are movably inserted in the through pipe. Through the design of a control ring and a control rod, a surgeon can accurately control opening and closing of the tweezers by adjusting the control ring, it is ensured that the crystal is not damaged when clamped and taken out, through the arrangement of a control assembly, the stability and accuracy of the tweezers during crystal clamping are ensured, and crystal damage caused by overexertion is prevented; through the elastic plastic material of the clamping plate and the silica gel protective sleeve, when the crystal is clamped, good protection is provided for the crystal, damage caused by hard object contact is avoided, through the design of the protective cover, a protective layer of the crystal is further added, and the crystal is prevented from being damaged or displaced in a non-operation state.
Owner:NINGBO AIER GUANGMING EYE HOSPITAL CO LTD

Multimodal parameter fusion-based ophthalmic visual effect dynamic simulation method and system

The application discloses a multi-modal parameter fusion ophthalmic visual effect dynamic simulation method and system, and relates to the biomedical technology field. The method comprises the following steps: acquiring target user eye condition information and a visual parameter set; determining a plurality of optional models of implantable artificial lenses; performing simulation state evaluation on the plurality of optional artificial lens models to determine a plurality of predicted simulation complexities; generating optimal operation parameters according to the visual parameter set; and controlling a virtual reality (VR) device to perform post-cataract surgery visual acuity recovery state evolution simulation. The technical problem that the prior art cannot intuitively show the postoperative visual effect difference of implanting different models of artificial lenses in cataract surgery to patients, resulting in the lack of subjective experience basis for the patients when selecting, and causing the mismatch between the selected artificial lenses and the actual needs of the patients is solved.
Owner:TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH

Sleeve, use of an ultrashort pulse laser, method for processing a sleeve blank and method for manufacturing a sleeve

Sleeve (1), in particular a silicone sleeve, for aspirating fragments during the surgical treatment of cataracts, wherein the sleeve (1) comprises a surgical area (2) and a connection area (2) adjoining the surgical area (2), wherein the surgical area (2) is at least partially laser-processed with a laser beam of an ultrashort pulse laser, in particular a femtosecond laser, such that material has been removed from the surgical area (2) by the laser processing, wherein the laser beam during the laser processing has a spot size of 2 to 25 micrometers, preferably 5 to 22 micrometers, particularly preferably 8 to 20 micrometers and a pulse power of at least 25 watts, preferably at least 30 watts, particularly preferably at least 35 watts.
Owner:SILCOPLAST AG

Laser Methods and Systems for Addressing Conditions of the Lens

Systems and methods for performing laser cataract surgery, for using a biometric system to determine a material property of a structure of the eye, laser pulses in a laser shot pattern having different powers. A therapeutic laser, and laser delivery system having the capability to vary the power of the laser beam.
Owner:LENSAR INC

Ophthalmology detection equipment integrating biological measurement, wavefront refraction and corneal topography and measurement method

The invention belongs to the technical field of ophthalmology detection equipment, and relates to ophthalmology detection equipment integrating biological measurement, wavefront refraction and corneal topography and a measurement method. The device is based on a unified optical path structure and a system control platform. An ophthalmology biological measurement system used for obtaining longitudinal and transverse biological measurement parameters of human eyes, a Shack-Hartmann wavefront light spot array imaging system used for collecting refraction information of the human eyes and a Placido disc-based corneal topographic map imaging system used for analyzing morphological information of the cornea surface are integrated on the same detection platform. The corneal topographic map imaging system based on the Placido disc is optically connected with the polarization beam splitting cube through a plano-convex lens, a transmission light path of the polarization beam splitting cube is connected with the Shack-Hartmann wavefront imaging system, and a reflection light path of the polarization beam splitting cube is connected with the biological measurement system. Through optical path multiplexing and integrated calibration control of various ophthalmology detection modules, alignment errors and operation complexity caused by repeated switching among multiple devices are reduced, the detection efficiency and the consistency among different parameters are improved, and the system is suitable for clinical application such as refractive state evaluation, preoperative examination of refractive surgery and cataract surgery and the like.
Owner:BEIHANG UNIV

Intelligent Intraocular Lens Selection System for Cataract Surgery Based on Ocular Biometrics

PendingCN122368191AOcular biometricsSelection system
This application relates to the field of intelligent intraocular lens (IOL) selection, specifically disclosing an intelligent IOL selection system for cataract surgery based on ocular bioparameters. The system is not limited to the acquisition of traditional static geometric data such as axial length and corneal curvature, but further utilizes a deep convolutional neural network to extract texture features and perform dimensionality reduction mapping on anterior segment tomographic images, thereby resolving the capsular bag compliance feature vector characterizing the biomechanical properties of the ocular soft tissue. Based on this, the geometric parameters of the patient's eye, capsular bag compliance features, and the mechanical and physical properties of the IOL are combined. By introducing a physical constraint mechanism, the mechanical equilibrium state after lens implantation is simulated, thus accurately predicting the effective lens position. This effectively addresses the fitting challenges of non-standard eyeballs or special lens models, significantly improving the accuracy and stability of postoperative refractive prediction.
Owner:THE FIRST AFFILIATED HOSPITAL OF ANHUI MEDICAL UNIV