46 results about "Suprachoroidal space" patented technology

Devices and methods for treating intraocular pressure are disclosed. The devices include shunts for draining aqueous humor from the anterior chamber to the uveoscleral outflow pathway, including the supraciliary space and the suprachoroidal space. The shunts are preferably implanted by ab interno procedures.

The present invention provides an implant configured to be deployed in an eye by a deployment tool to facilitate conduction of fluid from a posterior chamber of the eye to a suprachoroidal space, the implant comprising an elongate member, and an elongate member having a proximal section configured to be disposed in the posterior chamber of the eye and a distal section configured to be disposed in the suprachoroidal space of the eye, the elongate member is configured to maintain a curved configuration that substantially conforms to an anatomical curvature of the posterior chamber and the suprachoroidal space. The invention also provides a deployment tool for inserting the implant described herein into an eye to facilitate conduction of fluid from the posterior chamber of the eye to the suprachoroidal space, and provides a system for facilitating conduction of fluid from the posterior chamber of the eye to the suprachoroidal space.

The invention provides an ophthalmology department minimally invasive drainage implantation device and a delivery system thereof, the ophthalmology department minimally invasive drainage implantation device is a pipe fitting with an inner cavity, the ophthalmology department minimally invasive drainage implantation device is in a two-dimensional wave shape or a three-dimensional spiral shape, and the ophthalmology department minimally invasive drainage implantation device is provided with wave crests and wave troughs; the inner cavity is used for communicating the anterior chamber of the eye with the suprachoroidal space; the external diameter of the minimally invasive drainage implantation device for the ophthalmology department ranges from 0.3 mm to 0.6 mm, and the internal diameter of the minimally invasive drainage implantation device for the ophthalmology department ranges from 0.05 mm to 0.3 mm. The minimally invasive drainage implantation device for the ophthalmology department is prepared from the pipe fitting with the inner cavity, and the loading and implantation requirements can be met; after the drainage tube is released, the drainage tube recovers to be in the preset shape, the drainage effect is achieved, and meanwhile the preset shape of the specific structure can achieve the effects of preventing sliding and enhancing the intraocular fixing effect.

The invention discloses an eye implant which comprises an implant body, the implant body is in a strip shape, the outer contour of the upper surface of the implant body is in a protruding arch shape or a semi-arch shape and used for making contact with a sclera, and the lower surface of the implant body is in a plane shape and used for making contact with a choroid; a longitudinal drainage groove is formed in the upper surface of the implant body in the front-back direction of the implant body. The whole implant body is of a structure that the front end and the rear end are gradually thin and the middle is thick or the rear end is gradually thin and the middle is thick to the front end, the implant body can smoothly enter the suprachoroidal space, an originally narrow gap of the suprachoroidal space is expanded, the outflow amount of aqueous humor from the suprachoroidal space is increased through the longitudinal drainage grooves, the drainage effect is good, blocking is not prone to occurring, and the application range is wide. The effect of reducing the intraocular pressure is achieved. The lower surface of the implant body is planar, so that the attachment area of the implant body and the choroid is larger, the implant body can be stably attached to the choroid, the risk of displacement of the anterior chamber and the choroid is reduced, the implant body is prevented from being exposed to the anterior chamber to touch the cornea, and the risk of loss of corneal endothelial cells is reduced to the maximum extent.

The invention provides an ophthalmology minimally invasive drainage device with an expansion fixing function and a delivery system thereof, the ophthalmology minimally invasive drainage device comprises a drainage main body with a hollow cavity and an expansion fixing device, and the drainage main body comprises a near-end part and a far-end part far away from the near-end part; the expansion fixator is in a two-dimensional plane shape or a three-dimensional shape and is provided with a first end and a second end, the first end is connected with the near end part of the drainage main body, and the second end is connected with the far end part of the drainage main body; the near end part is one end close to the suprachoroidal space and has the length of 0.2-2.5 mm, and the far end part is one end close to the anterior chamber of the eye and has the length of 0.5-3.0 mm. According to the ophthalmology department minimally invasive drainage apparatus with the expansion and fixing functions, the drainage body with the hollow cavity is adopted, and the loading and implanting requirements can be met; after being released, the dilation fixer recovers to a preset shape, so that the dilation fixer can play a role in enhancing the intraocular fixing effect while playing a drainage role, ciliary body dissociation is formed, and then the effects of promoting aqueous humor absorption and inhibiting aqueous humor secretion are achieved.

Provided herein are pharmaceutical compositions for administration to a suprachoroidal space of an eye of a subject. The pharmaceutical compositions can include a recombinant adeno-associated virus (AAV) encoding a transgene. Also provided herein are methods for treating or preventing a disease in a subject by administering a therapeutically effective amount of the pharmaceutical compositions to the subject in need.

The present invention relates to methods, devices, and compositions for treating macular edema associated with non-infectious uveitis. For example, the methods include treatment of certain populations of subjects having macular edema associated with non-infectious uveitis by administering to the subjects a triamcinolone composition via non-surgical administration to the suprachoroidal space (SCS) of the eye.

The invention relates to an injector adapter, an injection assembly and a using method. The injector adapter comprises a connecting piece, and a cavity is formed in the connecting piece; the guide pipe penetrates through the connecting piece and penetrates through the cavity, and the pipe wall, located in the cavity, of the guide pipe is provided with a penetrating channel; the elastic sheath is located in the cavity, the elastic sheath is arranged outside the catheter in a sleeving mode, a potential gap cavity is formed between the elastic sheath and the catheter, and the potential gap cavity is in fluid communication with the catheter through the penetrating channel. The injector adapter can be used in cooperation with an existing injector, so that an operator can more visually judge whether a needle head penetrates through the sclera to reach the suprachoroidal space or not so as to guide the operator to conduct medicine injection, and the injection convenience of the operator is remarkably improved.

The present disclosure provides methods for administering formulations to the suprachoroidal space of the eye to achieve targeted drug delivery to a desired site of action within the eye. The methods include using a pushing formulation that includes a material such as a gel that expands due to physiochemical cues; or using an electric field to affect the movement of a formulation within the suprachoroidal space; or a combination of a pushing formulation with an electric field.

An intraocular implant, kit, and method are disclosed. In one configuration, the implant is a frame that is installable in the suprachoroidal space of the eye and has an arcuate elongated shape that promotes the drainage of aqueous humor through the suprachoroidal space when installed in the suprachoroidal space and is configured to take on an elastically recoverable shape. The frame has a first axial end and a second axial end with respect to the longitudinal axis of the elongated shape, and the arcuate elongated shape defines a channel. The channel has a first axial opening at the first axial end of the frame, a second axial opening at the second axial end of the frame, and a longitudinal opening that extends continuously from the first axial end to the second axial end of the frame.

The invention discloses a device and method for medicine injection of a suprachoroidal space, and relates to the technical field of medical instruments.The device for medicine injection of the suprachoroidal space comprises an injector shell; the injection cylinder is arranged in the injector shell in a penetrating mode, a needle head is fixedly arranged at the end, located in the injector shell, of the injection cylinder, and an injection piston is arranged at the other end of the injection cylinder in a penetrating mode. The tail end of the needle head can penetrate through the end, away from the injection piston, of the injector shell, and a pressure measuring device is arranged on the needle head. The linkage device can be switched to fix the injector shell and the injection cylinder or fix the injection cylinder and the injection piston; and the signal conversion module is in signal connection with the pressure measuring device and the linkage device, and can control the switching action of the linkage device according to the pressure signal at the needle head measured by the pressure measuring device. According to the device and the method for suprachoroidal cavity medicine injection, the suprachoroidal cavity part can be accurately positioned.

Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.

An ocular access instrument (20) includes an attachment assembly (32) configured to engage a sclera of an eye, and an actuator assembly (34) configured to bear against the sclera. When the attachment assembly engages the sclera, movement of the actuator assembly inwardly against the eye displaces the choroid from the sclera, thereby creating an enlarged suprachoroidal space. The ocular access instrument may also include a needle guide (40) configured to receive the needle and guide the needle into the enlarged suprachoroidal space.

Described herein are devices and methods for treating eye conditions. Described is an ocular implant including an elongate member having an internal lumen forming a flow pathway, at least one inflow port communicating with the flow pathway, and at least one outflow port communicating with the flow pathway. The elongate member is adapted to be positioned in the eye such that at least one inflow port communicates with the anterior chamber, at least one outflow port communicates with the suprachoroidal space to provide a fluid pathway between the anterior chamber and the suprachoroidal space when the elongate member is implanted in the eye. The elongate member has a wall material imparting a stiffness to the elongate member. The stiffness is selected such that after implantation the elongate member deforms eye tissue surrounding the suprachoroidal space forming a tented volume.

This invention discloses an implantable stent for aqueous humor drainage in glaucoma, belonging to the field of ophthalmic implantable medical devices. The stent comprises a flexible tubular body, a passive pressure regulating valve, a pressure response module, an anchoring structure, a variable-diameter main drainage channel, a porous diffuse diversion structure at the tail, and a surface functionalized layer. The inflow end is placed in the anterior chamber or anterior chamber angle, and the outflow end is placed in the suprachoroidal space. When the pressure difference between the inflow and outflow ends reaches a preset threshold, the pressure valve opens, allowing aqueous humor to be uniformly introduced into the suprachoroidal space through the main channel and the porous diversion structure; when the pressure difference is below the threshold, the valve closes, limiting excessive drainage. The anchoring structure fixes the stent's position and prevents displacement. This invention achieves effective aqueous humor drainage while reducing the risk of excessive drainage, and improves the stent's implantation stability, drainage uniformity, and long-term follow-up evaluation capabilities.

Disclosed is electrical stimulation apparatus and an associated method for delivering therapy to an eye of a patient is disclosed, the apparatus comprising: an implantable device comprising one or more electrodes for delivering therapeutic electrical stimulation to the eye, the implantable device being configured for implanting in a suprachoroidal space between the sclera and choroid layers of the eye. Also disclosed is electroretinography (ERG) apparatus for monitoring an eye of a patient, the apparatus comprising: an implantable device comprising one or more electrodes for monitoring properties of the eye, the implantable device being configured for implanting in a suprachoroidal space between the sclera and choroid layers of the eye. Also disclosed are implantable devices, apparatuses and methods for the eye.

A triamcinolone acetonide pharmaceutical composition and a preparation method therefor. The pharmaceutical composition contains the following ingredients: (i) a triamcinolone acetonide active ingredient, (ii) hyaluronic acid or a salt thereof. (iii) a buffering agent; and (iv) a tonicity adjustment agent. The pharmaceutical composition has a suitable viscosity, osmotic pressure and particle size range and is easily injected, especially administrated by means of a suprachoroidal space injection.

Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.

To provide methods and devices for the treatment of eye disorders in a human subject.SOLUTION: The present invention provides a method and device for non-surgically administering a drug formulation targeted to the suprachoroidal space (SCS) of the eye of a human subject in order to treat posterior ocular disorders or choroidal diseases. In one embodiment, the method comprises inserting hollow microneedle into the eye of an insertion site and injecting a drug formulation into suprachoroidal space through the inserted microneedle, wherein the injected drug formulation flows out of an insertion site and flows into suprachoroidal space during injection. In one embodiment, a fluid drug formulation comprises drug nanoparticles or drug microparticles.SELECTED DRAWING: None

Disclosed is electrical stimulation apparatus and an associated method for delivering therapy to an eye of a patient is disclosed, the apparatus comprising: an implantable device comprising one or more electrodes for delivering therapeutic electrical stimulation to the eye, the implantable device being configured for implanting in a suprachoroidal space between the sclera and choroid layers of the eye. Also disclosed is electroretinography (ERG) apparatus for monitoring an eye of a patient, the apparatus comprising: an implantable device comprising one or more electrodes for monitoring properties of the eye, the implantable device being configured for implanting in a suprachoroidal space between the sclera and choroid layers of the eye. Also disclosed are implantable devices, apparatuses and methods for the eye.

The invention provides a suprachoroidal implant system which comprises a suprachoroidal implant and a conveyor, the suprachoroidal implant is of a porous structure and is used for being implanted into a suprachoroidal cavity, and aqueous humor is discharged from a gap between the suprachoroidal cavity and the sclera to reduce intraocular pressure; the conveyor is used for implanting a suprachoroidal cavity implant into a suprachoroidal cavity, the conveyor comprises a shell, a sheath tube assembly, an ejection piece and a pushing assembly, and the shell forms a handle part of the conveyor; the sheathing canal assembly is detachably arranged at the head end of the handle part and can store a suprachoroidal space implant; the ejection piece is fixed in the handle part along the longitudinal direction of the handle part; the ejection piece is at least partially arranged in the guide sheath tube in a penetrating manner and can act on the suprachoroidal implant; the pushing assembly is at least partially exposed out of the handle part and can act on the sheathing canal assembly to guide the guiding sheathing canal to move in the longitudinal direction of the handle part, so that the ejection piece can push the suprachoroidal cavity implant out of the guiding sheathing canal and implant the suprachoroidal cavity implant into the suprachoroidal cavity.

Methods and devices are adapted for implanting into the eye. An incision is formed in the cornea of the eye and a shunt is inserted through the incision into the anterior chamber of the eye. The shunt includes a fluid passageway. The shunt is passed along a pathway from the anterior chamber through the scleral spur of the eye into the suprachoroidal space and positioned in a first position such that a first portion of the fluid passageway communicates with the anterior chamber and a second portion of the fluid passageway communicates with the suprachoroidal space to provide a fluid passageway between the suprachoroidal space and the anterior chamber.

Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.

An ocular implant system is described herein in which an implant (200) is deployed in the posterior space of an eye - e.g., the suprachoroidal space or the subconjunctival space or the intrascleral space - through an access in the anterior chamber (160) for reducing intraocular pressure in the eye. The shunt device (200) is implanted using an implantation device that includes a hollow shaft (330) mounted on a fixed shaft (320). The shunt device (200) is located in the distal end of the hollow shaft (330) and adjacent to the distal end of the fixed shaft (320) at a location behind the distal end of the hollow shaft. Once the distal end of the hollow shaft (330) and the shunt device (200) are at the desired depth within the posterior space, the hollow shaft is withdrawn over the fixed shaft through the access in the anterior chamber (160) towards the proximal end of the fixed shaft, leaving the shunt device in the posterior space.

A pre-filled syringe for injecting a pharmaceutical composition into an eye, comprising: a syringe barrel (1) having a proximal end and a distal end; a floating seal member (3) located within the syringe barrel (1); a needle hub located at the proximal end of the floating seal member (3), the floating seal member (3) and the needle hub being elastically engaged with each other; the pharmaceutical composition contained in a chamber (7) formed by the needle hub, the floating seal member (3) and the distal end of the syringe barrel (1); and a needle (6) for intraocular puncture, the needle (6) a needle (6) including (i) a needle proximal end engaged with a needle hub, (ii) a needle distal end, (iii) a needle distal end opening (6a), (iv) a needle body opening (6b) located between the needle proximal end and the needle distal end, the needle body opening (6b) being located at a proximal end of the needle distal end opening (6a), and (v) a needle body passage connecting the needle distal end opening (6a) and the needle body opening (6b), wherein the needle hub is configured to advance the needle distally toward and / or through the floating seal member.

A stent implant for treating glaucoma by intraocular fluid drainage from the anterior chamber, for example into the suprachoroidal space. The stent implant is designed to change in shape after being inserted into the eye, during which change the width and / or thickness or the flow cross-section is increased by for example 20%, in another example more than 200%, and in a further example by more than 400%, at least one point of the stent implant. In the case of intraocular fluid drainage from the anterior chamber into the suprachoroidal space, a cyclodialysis cleft which may open can be largely or completely closed. With appropriate adjustments, the stent implant can also be applied in trabecular, uveoscleral, uveolymphatic and subconjunctival applications for intraocular fluid drainage from the anterior chamber. The implant can even be used for direct intraocular fluid discharge from the anterior chamber onto the surface of the eye.

The present invention provides devices to access the suprachoroidal space or sub-retinal space in an eye via a minimally invasive transconjunctival approach. The devices may also be used after a partial dissection, for example after dissection of the outer scleral layer of the eye, and using the device within the dissection to access the suprachoroidal space or the sub-retinal space.

There is provided an implant configured to be deployed in an eye by a deployer tool to facilitate conduction of fluid from a posterior chamber to a suprachoroidal space of the eye, the implant comprising, an elongate member having a proximal segment configured to be disposed in the posterior chamber of the eye and a distal segment configured to be disposed in the suprachoroidal space of the eye, wherein the elongate member is configured to maintain a bent configuration that substantially complies with anatomical curvatures of the posterior chamber and the suprachoroidal space, when deployed in the eye. There is also provided a deployer tool for inserting an implant as disclosed herein into an eye to facilitate conduction of fluid from a posterior chamber to a suprachoroidal space of the eye, and a system for facilitating the conduction of fluid from a posterior chamber to a suprachoroidal space of an eye.

The present invention provides an ophthalmic minimally invasive drainage device with an expansion and fixation function and a delivery system thereof, wherein the ophthalmic minimally invasive drainage device comprises a drainage body with a hollow cavity and an expansion fixator, wherein the drainage body comprises a proximal portion and a distal portion away from the proximal portion; the expansion fixator is in a two-dimensional plane or a three-dimensional solid shape and has a first end and a second end, the first end being connected to the proximal portion of the drainage body, and the second end being connected to the distal portion of the drainage body; the proximal portion is an end close to the suprachoroidal space, and its length is 0.2-2.5 mm, and the distal portion is an end close to the anterior chamber of the eye, and its length is 0.5-3.0 mm. The ophthalmic minimally invasive drainage device with an expansion and fixation function of the present invention adopts a drainage body with a hollow cavity, which can meet the requirements of loading and implantation; after being released, it returns to a preset shape. While playing a drainage role, the expansion fixator can enhance the fixation effect in the eye, form ciliary body dissociation, and thereby promote aqueous humor absorption and inhibit aqueous humor secretion.

1. The name of this design product: Suprachoroidal space syringe. 2. Application of this product design: for precise injection into the eye. 3. The key design point of this design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the key points of the design: main view.