19 results about "Drug nanoparticles" patented technology

The invention discloses a gelatinized and / or micronized nucleoside drug and a preparation method thereof, and belongs to the technical field of drugs. The preparation method comprises the following steps: mixing lipoic acid, a nucleoside drug and an esterification catalyst, carrying out a grafting reaction in a reaction solvent to obtain a lipoic acid grafted nucleoside drug, dispersing the lipoic acid grafted nucleoside drug in an organic solvent to obtain a dispersion liquid, dropwise adding the dispersion liquid into hot water, and carrying out ring opening polymerization to obtain the lipoic acid grafted nucleoside drug. The nucleoside drug nanogel, nanoparticle or nanofiber is obtained, and the structure and performance improvement based on the drug itself is realized. The gelated and / or micronized nucleoside medicine prepared by the invention has obviously improved scavenging rates of DPPH free radicals and ABTS free radicals, and the method can improve the oxidation resistance of the nucleoside medicine and has the characteristic of improving the stability and functionality of the medicine.

The invention relates to the technical field of burn and scald treatment, in particular to an intelligent hydrogel dressing for targeted regulation and control of Mongolian medicine release. The dressing comprises a core-shell microsphere drug loading system used for realizing physical segmentation of a functional area; the dual-release system is used for realizing surface adsorption of quick-release drug nanoparticles and internal wrapping of sustained-release microspheres; a hydrogel matrix for forming a nanofiber network; and the magnetic control regulator is magnetic nanoparticles dispersed in the hydrogel matrix, and regulates the aperture of the hydrogel network through the action of an external magnetic field. According to the intelligent hydrogel dressing for targeted regulation and control of Mongolian medicine release, the Mongolian medicine compound intelligent hydrogel dressing is developed on the basis of a TRIZ innovative method; through a core-shell microsphere drug loading system and a dual release design, high drug loading capacity and accurate drug release control are synchronously realized.

This invention discloses a polymer-loaded drug-eluting nanoparticle with high encapsulation efficiency and its application in coatings and surface film materials. The polymer-loaded drug-eluting nanoparticles are prepared via emulsion polymerization, simultaneously loading antibacterial drugs with different log P values. The preparation process is simple, and the resulting product has small particle size, high molecular weight, high uniformity, and high drug encapsulation efficiency, achieving the substitution of non-reactive surfactants with reactive surfactants. A coating can be prepared using the above-mentioned polymer-loaded drug-eluting nanoparticles. The coating can be further used to prepare sustained-release antibacterial surface film materials through cross-linking film formation, exhibiting good mechanical properties, excellent chemical resistance, and high safety. This invention can be widely applied to various environmental and material surfaces, including but not limited to surface modification of instruments and building materials in residential and medical environments, thereby achieving a long-lasting antibacterial effect.

The invention discloses a micro-channel reactor system for continuous preparation of a drug nano-preparation, and relates to the technical field of micro-reactors, the micro-channel reactor system comprises micro-reactor equipment and a control assembly, the micro-reactor equipment is provided with a reaction medium inlet, a reaction medium outlet, a heat exchange medium inlet and a heat exchange medium outlet; the control assembly comprises an industrial personal computer, an air compressor, a booster pump, a pressure reducing valve, a gas mass flow meter, a high-pressure constant-current infusion pump, a back pressure valve and a high-low temperature all-in-one machine, the air compressor, the booster pump, the pressure reducing valve and the gas mass flow meter are sequentially connected, and the gas mass flow meter and the high-pressure constant-current infusion pump are respectively connected with the reaction medium inlet; the back pressure valve is connected with the reaction medium outlet, and the high and low temperature all-in-one machine is connected with the heat exchange medium inlet and the heat exchange medium outlet. Accurate automatic control is carried out on operation of the microreactor equipment through the control assembly, continuous preparation of nano-drugs is achieved, the production yield and efficiency are remarkably improved, and meanwhile the automatic control level is improved.

The invention discloses preparation and application of algal polysaccharide-based co-drug-loading tumor targeting nanoparticles. The algal polysaccharide-based co-drug-loaded nano particle disclosed by the invention is a self-assembled targeting nano particle co-constructed by biotin modified algal polysaccharide sulfate and arginine modified chitosan. The algal polysaccharide-based co-drug-loaded nano particle disclosed by the invention is an algal polysaccharide-based co-drug-loaded nano particle. The algal polysaccharide-based nanoparticles encapsulate anti-tumor hydrophilic drugs and hydrophobic drugs to realize targeted co-delivery of the drugs in solid tumor tissues, self-assembly is generated through electrostatic interaction of polysaccharide molecules to drive the encapsulated drugs to enter inner cores of the nanoparticles, and meanwhile biotin molecules are mainly distributed in shell layers of the nanoparticles. According to the algal polysaccharide-based co-drug-loading nano particle, the targeting property to solid tumor tissues is enhanced, the defect that a conventional drug-loading system can only encapsulate a single hydrophilic or hydrophobic drug is innovatively overcome, efficient co-delivery of hydrophilic and hydrophobic drugs with different attributes is realized, and proliferation and migration of tumors can be remarkably inhibited.

The invention relates to lysosome-based nano drug-loaded particles and application thereof, and belongs to the technical field of biological medicines. According to the invention, the lysosome membrane is used as a biomimetic membrane source to coat the surface of the drug nanoparticle, so that the structure stability of the lysosome membrane is maintained, and the activity of hydrolase which naturally exists is retained to the greatest extent, so that the drug-loaded nanoparticle can perform in-situ degradation on an extracellular matrix of a tumor tissue in an in-vivo delivery process; therefore, the physical barrier of the tumor tissue is effectively weakened, the permeation, distribution and cellular uptake ability of the nano-drug in the tumor tissue are remarkably enhanced, the condition that immune cells enter the tumor tissue is improved on the basis, and finally the tumor treatment effect is improved.

The invention belongs to the technical field of nano materials and biological medicines, and relates to carrier-free self-assembled drug nanoparticles as well as a preparation method and application thereof. The carrier-free self-assembled drug nanoparticle provided by the invention is formed by self-assembling four components, namely a chemotherapeutic drug, a photosensitizer, a biomineralized shell and a cancer cell membrane; wherein the chemotherapeutic drug is doxorubicin hydrochloride, the photosensitizer is indocyanine green, the biomineralized shell is prepared from a potassium permanganate solution, and the cancer cell membrane is a 4T1 cancer cell membrane. The invention also provides a method for preparing the nanoparticles, a drug containing the nanoparticles and application of the nanoparticles in preparation of tumor treatment drugs. The nanoparticle provided by the invention has the characteristics of high drug loading rate, simple preparation and no carrier, and in-vitro cell experiments and animal experiments prove that the nanoparticle has a remarkable tumor treatment effect.

The present invention relates to methods for large tissue labeling, clearing and / or imaging using labeling agents such as antibodies, and uses and products related thereto. The present invention includes inter alia methods for preparing an animal tissue for fluorescence microscopy, an animal tissue obtainable by said methods, methods for analyzing said animal tissues, and methods for the detection of metastases, for analyzing the biodistribution of a biopharmaceutical drug, and for analyzing the biodistribution of nanoparticles. The methods for preparing an animal tissue according to the present invention encompass whole-body labeling, clearing and imaging methods. The methods of the invention are advantageous in that they, for instance, allow the visualization of single cells within mammalian tissues, including whole mouse bodies or other large tissues, tumor metastases at the single cell level and of the distribution of biopharmaceutical drugs (e.g. the distribution of cancer-targeting therapeutic antibodies in whole animals such as intact mice) at single cell level in whole mouse using labeling agents such as antibodies.

The invention discloses a preparation method of a photo-crosslinking hydrogel microneedle loaded with a finasteride drug, which comprises the following three steps: preparing drug nanoparticles, synthesizing a hydrogel precursor and preparing the photo-crosslinking hydrogel microneedle. The preparation method specifically comprises the steps of preparing finasteride (FIN)-loaded polyhydroxyalkanoate (PHA) nanoparticles (F-PHANPs), preparing F-PHANPs-loaded HAMA hydrogel (F-HAMA) and preparing a hydrogel microneedle, introduction of the F-PHANPs enhances the mechanical performance of the hydrogel, meanwhile, the hardness is remarkably enhanced, and the hydrogel has excellent drug release performance and biocompatibility and can be used for preparing the hydrogel microneedle. Potential application prospects are shown in the field of treating androgenetic alopecia through transdermal drug delivery.

The present application relates to a kind of lysosome-based nano drug-loaded particles and its application, belong to the field of biological medicine.The present application will be lysosome membrane as the source of biomimetic membrane to be coated on the surface of drug nano-particle, while keeping the stability of lysosome membrane structure Maximum degree retains its naturally occurring hydrolytic enzyme activity, so that the nano drug-loaded particle can be in situ degradation to tumor tissue extracellular matrix during in vivo delivery, thereby effectively weakening the physical barrier of tumor tissue, significantly enhance the permeability, distribution and cell uptake capacity of nano drug in tumor tissue, and on this basis, improve the conditions for immune cells to enter tumor tissue, ultimately improve the tumor treatment effect.

Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.

The invention discloses a nucleoside drug gelation method. The method comprises the following steps: providing a lipoic acid grafted nucleoside drug; the lipoic acid grafted nucleoside medicine is subjected to ring opening polymerization, nucleoside medicine gelation is completed, and a nucleoside medicine gelation product comprises nucleoside medicine nanogel, nucleoside medicine nanoparticles and / or nucleoside medicine nanofibers. The drug nanogel material is obtained by grafting lipoic acid on a nucleoside drug and then inducing ring opening polymerization, compared with drugs, the drug nanogel material has the advantages that the scavenging rate of DPPH free radicals and ABTS free radicals is increased by 3-5 times, and the oxidation resistance is obviously improved.

Chimeric antigen receptor (CAR)-expressing neutrophils loaded with nanoparticles comprising a drug; and a method of treating cancer or other disorders in a subject comprising administering to the subject a therapeutically effective amount of the CAR-expressing neutrophils.

The application provides albumin-paclitaxel twin drug nanoparticles based on a peptide linker and an application thereof, wherein the linker between the paclitaxel and the drug molecule is a dipeptide linker, the linker has higher stability, and the speed of the linker breaking in a tumor microenvironment response is faster. The application compares and analyzes twin drug nanoparticles synthesized by different linkers between paclitaxel and drug molecules, screens a dipeptide linker capable of effectively improving the antitumor effect of albumin-paclitaxel twin drug nanoparticles, realizes efficient co-loading of multiple drugs, increases drug accumulation, reduces indiscriminate killing of normal cells by drugs, is successfully targeted to a tumor region, achieves the purpose of treating and regressing tumors, and is expected to break through the current efficacy bottleneck of malignant tumors.

The application discloses a kind of albumin-paclitaxel twin drug nanoparticles and application, belong to the field of pharmaceutical chemistry and biopharmaceutical technology, specifically related to albumin is mixed with water, and albumin solution is prepared;Paclitaxel or paclitaxel twin drug compound is mixed with organic solvent, and drug solution is obtained;Albumin solution and drug solution are mixed, and after ultrasonic dispersion, spinning, ultrafiltration are carried out to prepare albumin binding type paclitaxel or albumin-paclitaxel twin drug nanoparticles.The albumin-paclitaxel twin drug prepared in the application can utilize the special GP60-cellar protein-SPARC transport mechanism of albumin, increase the accumulation of drug in tumor, and in vivo and in vitro experiments prove that the albumin-paclitaxel twin drug nanoparticles described in the application have good antitumor effect.

The invention belongs to the technical field of medicine, and discloses a collaborative treatment method of high-permeability drug-loaded albumin nanoparticles for bladder tumor, the fluorinated albumin nanoparticles EN (at) F-HSA successfully constructed by the invention can be used for enhancing the permeability of bladder mucosal barrier and remolding fiber barrier to cooperate with immunotherapy, so that the bladder tumor can be effectively treated, and the bladder tumor can be effectively treated by the fluorinated albumin nanoparticles EN (at) F-HSA. The chemical immunotherapy curative effect of the bladder tumor is obviously improved. The strategy overcomes the delivery limitation of traditional chemotherapy, and provides a new thought for local treatment of mucous membrane related tumors. The delivery efficiency is enhanced through fluorination modification, specifically, the HSA is subjected to fluorination modification through PFHA for the first time, the bladder epithelium barrier is broken through through the hydrophobic and lipophobic characteristics, the mucous membrane permeability is remarkably improved, the Papp is improved by 15.6 times, and the core problem that traditional HSA is low in delivery efficiency is solved.

The invention discloses a targeted traditional Chinese medicine nano tablet for treating cancerous hemorrhage and a preparation method of the targeted traditional Chinese medicine nano tablet. The preparation is prepared from colla corii asini beads, carbonized hair, lily, radix stemonae, radix ophiopogonis, radix polygonati officinalis, lalang grass rhizome, dandelion, hairyvein agrimony, cacumen biotae, charred gardenia, bletilla striata, adenophora stricta, pseudo-ginseng, sculellaria barbata and oldenlandia diffusa according to a specific weight part ratio. The anti-tumor effect of treating the root causes is enhanced. According to the dosage form, the modified silicon dioxide nano-carrier is adopted for loading the medicine, and the cellulose-chitosan compound with biological responsiveness is supplemented, so that an intelligent targeted delivery system is constructed. The preparation method integrates modern processes such as ethanol reflux extraction, carbon medicine nanocrystallization, nano medicine loading and dry tabletting. The tablet disclosed by the invention has the advantages of multi-target comprehensive treatment, rapid hemostasis effect, intelligent drug release at a focus part, high bioavailability, good patient compliance and the like, and is suitable for cancerous hemorrhage caused by various malignant tumors such as gastric cancer, cervical cancer, breast cancer and the like.

This application discloses a drug nanoparticle targeting PD-L1, its preparation method, and its application, belonging to the field of oncology drug technology. The drug nanoparticle includes a drug and a carrier loading the drug. The drug is atorvaquinone. The carrier is prepared by coupling a second intermediate product with a first intermediate product. The first intermediate product is obtained by reacting bovine serum albumin with a heterobifunctional cross-linking agent. The second intermediate product is generated by reducing a thiol-modified nucleic acid aptamer, where the nucleic acid aptamer is a PD-L1 aptamer, and the heterobifunctional cross-linking agent is Sulfo-SMCC. This application uses a PD-L1-targeting nucleic acid aptamer coupled with bovine serum albumin to encapsulate atorvaquinone, preparing a novel atorvaquinone nanoparticle-targeted drug. This improves the precise targeting effect of atorvaquinone, overcomes the drawbacks of poor water solubility and high dosage of atorvaquinone, and reduces its systemic toxicity.