Antineoplastic agent containing hydrophobic chemotherapeutic drug nano-particles and fibrin glue
A technology of fibrin glue and anti-tumor agent, which is applied in the field of pharmaceutical preparations, can solve the problems of inability to give chemotherapy drugs immediately, low drug concentration in tumor lesions, and missing the best treatment period, so as to avoid systemic adverse reactions and inhibit tumors. The effect of recurrence and inhibition of tumor cell growth
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Embodiment 1
[0042] Example 1 A preparation and application method of an antitumor agent containing hydrophobic chemotherapeutic drug nanoparticles and fibrin glue
[0043] 1. Use 2.5ml of physiological saline containing 3.414mg of paclitaxel nanoparticles (the particle size distribution is shown in figure 1 ) dissolving 100 mg of porcine-derived fibrinogen to form a uniformly dispersed porcine-derived fibrinogen solution containing paclitaxel nanoparticles.
[0044] 2. Dissolve the thrombin with 2.5ml calcium chloride solution, stir and oscillate slightly until it is completely dissolved, and obtain the thrombin solution.
[0045] 3. After the tumor resection is completed for the patient who needs to be treated, the above two solutions are sprayed around the wound of the patient's tumor resection site separately or at the same time.
[0046] Complete the preparation and application of anti-tumor agents containing hydrophobic chemotherapeutic drug nanoparticles and fibrin glue
Embodiment 2
[0047]Example 2 A preparation and application method of an antitumor agent containing hydrophobic chemotherapeutic drug nanoparticles and fibrin glue
[0048] 1. Dissolve 100 mg of porcine-derived fibrinogen with 2.5 ml of physiological saline containing 3.414 mg of docetaxel nanoparticles to form a uniformly dispersed porcine-derived fibrinogen solution containing docetaxel nanoparticles.
[0049] 2. Dissolve the thrombin with 2.5ml calcium chloride solution, stir and oscillate slightly until it is completely dissolved, and obtain the thrombin solution.
[0050] 3. After the tumor resection is completed for the patient who needs to be treated, the above two solutions are sprayed around the wound of the patient's tumor resection site separately or at the same time.
[0051] Complete the preparation and application of anti-tumor agents containing hydrophobic chemotherapeutic drug nanoparticles and fibrin glue
Embodiment 3
[0052] Example 3 A preparation and application method of an antitumor agent containing hydrophobic chemotherapeutic drug nanoparticles and fibrin glue
[0053] 1. Dissolve 100 mg of porcine fibrinogen with 2.5 ml of physiological saline containing 3.414 mg of paclitaxel nanoparticles to form a homogeneously dispersed porcine fibrinogen solution containing paclitaxel.
[0054] 2. Dissolve the thrombin with 2.5ml calcium chloride solution, stir and oscillate slightly until it is completely dissolved, and obtain the thrombin solution.
[0055] 3. Mix the two solutions obtained above to obtain an antitumor agent containing paclitaxel nanoparticles and fibrin glue, and then place it on the patient's tumor resection site.
[0056] Complete the preparation and application of anti-tumor agents containing hydrophobic chemotherapeutic drug nanoparticles and fibrin glue
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