Antineoplastic agent containing hydrophobic chemotherapeutic drug nano-particles and fibrin glue

A technology of fibrin glue and anti-tumor agent, which is applied in the field of pharmaceutical preparations, can solve the problems of inability to give chemotherapy drugs immediately, low drug concentration in tumor lesions, and missing the best treatment period, so as to avoid systemic adverse reactions and inhibit tumors. The effect of recurrence and inhibition of tumor cell growth

Inactive Publication Date: 2017-07-25
BEIJING DELI FURUI MEDICAL SCI & TECH
View PDF5 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, cancer chemotherapy mainly adopts systemic administration, but there are some problems in this administration method: first, the drug is distributed to various organs and tissues of the whole body with the blood, which will bring systemic toxic and side effects; second, the drug that can be distribu

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Antineoplastic agent containing hydrophobic chemotherapeutic drug nano-particles and fibrin glue
  • Antineoplastic agent containing hydrophobic chemotherapeutic drug nano-particles and fibrin glue
  • Antineoplastic agent containing hydrophobic chemotherapeutic drug nano-particles and fibrin glue

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1 A preparation and application method of an antitumor agent containing hydrophobic chemotherapeutic drug nanoparticles and fibrin glue

[0043] 1. Use 2.5ml of physiological saline containing 3.414mg of paclitaxel nanoparticles (the particle size distribution is shown in figure 1 ) dissolving 100 mg of porcine-derived fibrinogen to form a uniformly dispersed porcine-derived fibrinogen solution containing paclitaxel nanoparticles.

[0044] 2. Dissolve the thrombin with 2.5ml calcium chloride solution, stir and oscillate slightly until it is completely dissolved, and obtain the thrombin solution.

[0045] 3. After the tumor resection is completed for the patient who needs to be treated, the above two solutions are sprayed around the wound of the patient's tumor resection site separately or at the same time.

[0046] Complete the preparation and application of anti-tumor agents containing hydrophobic chemotherapeutic drug nanoparticles and fibrin glue

Embodiment 2

[0047]Example 2 A preparation and application method of an antitumor agent containing hydrophobic chemotherapeutic drug nanoparticles and fibrin glue

[0048] 1. Dissolve 100 mg of porcine-derived fibrinogen with 2.5 ml of physiological saline containing 3.414 mg of docetaxel nanoparticles to form a uniformly dispersed porcine-derived fibrinogen solution containing docetaxel nanoparticles.

[0049] 2. Dissolve the thrombin with 2.5ml calcium chloride solution, stir and oscillate slightly until it is completely dissolved, and obtain the thrombin solution.

[0050] 3. After the tumor resection is completed for the patient who needs to be treated, the above two solutions are sprayed around the wound of the patient's tumor resection site separately or at the same time.

[0051] Complete the preparation and application of anti-tumor agents containing hydrophobic chemotherapeutic drug nanoparticles and fibrin glue

Embodiment 3

[0052] Example 3 A preparation and application method of an antitumor agent containing hydrophobic chemotherapeutic drug nanoparticles and fibrin glue

[0053] 1. Dissolve 100 mg of porcine fibrinogen with 2.5 ml of physiological saline containing 3.414 mg of paclitaxel nanoparticles to form a homogeneously dispersed porcine fibrinogen solution containing paclitaxel.

[0054] 2. Dissolve the thrombin with 2.5ml calcium chloride solution, stir and oscillate slightly until it is completely dissolved, and obtain the thrombin solution.

[0055] 3. Mix the two solutions obtained above to obtain an antitumor agent containing paclitaxel nanoparticles and fibrin glue, and then place it on the patient's tumor resection site.

[0056] Complete the preparation and application of anti-tumor agents containing hydrophobic chemotherapeutic drug nanoparticles and fibrin glue

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Average particle sizeaaaaaaaaaa
The average particle sizeaaaaaaaaaa
Login to view more

Abstract

The invention belongs to the field of pharmaceutic preparations, and relates to an antineoplastic agent containing hydrophobic chemotherapeutic drug nano-particles and fibrin glue. The antineoplastic agent can be a pharmaceutic preparation composed of hydrophobic chemotherapeutic drug nano-particles and fibrin glue, and can also be an oncotherapy agent prepared from a hydrophobic chemotherapeutic drug nano-particle preparation and a fibrin glue preparation right before use. The antineoplastic agent can be used for local drug delivery after tumor excision, and can make local drug concentration stay at a high level for a long time.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations and relates to an antitumor agent containing hydrophobic chemotherapeutic drug nanoparticles and fibrin glue. [0002] Background of the invention [0003] At present, cancer chemotherapy mainly adopts systemic administration, but there are some problems in this administration method: first, the drug is distributed to various organs and tissues of the whole body with the blood, which will bring systemic toxic and side effects; second, the drug that can be distributed to the tumor site Compared with the dosage, the amount is very small, resulting in low local drug concentration and short duration of tumor lesions; third, patients cannot be given chemotherapy drugs immediately after tumor resection due to their physical condition, resulting in missing the best treatment period. Local administration of chemotherapeutic drugs can well solve the above problems. Local administration of chemoth...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/51A61K9/10A61K45/06A61K31/337A61K47/42A61P35/00
CPCA61K9/5169A61K9/0019A61K9/0041A61K9/007A61K9/0085A61K9/10A61K31/337A61K45/06A61K47/42A61K2300/00
Inventor 吴翠栓张强代文兵黄昌盛马凤中
Owner BEIJING DELI FURUI MEDICAL SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap