Polyethylene glycol-modified integrin blocking agent HM-3 and application thereof

An integrin blocker, HM-3 technology, applied in the field of medicine to achieve the effect of inhibiting tumor growth and metastasis, and inhibiting tumor angiogenesis
CN102417540AInactive Publication Date: 2012-04-18CHINA PHARM UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHINA PHARM UNIV
Publication Date
2012-04-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the field of medicaments, in particular to an integrin blocking agent HM-3 which has the function of inhibiting tumor angiogenesis, integrin affinity and a bonding capacity and application thereof. The blocking agent is a polypeptide modified with polyethylene glycol, and the modified integrin blocking agent polypeptide can be applied to treatment of solid tumors. During application of the integrin blocking agent to preparation of a tumor treatment medicament, the sequence and structure of the integrin blocking agent is mPEG-SC20k-Ile-Val-Arg-Arg-Ala-Asp-Arg-Ala-Ala-Val-Pro-Gly-Gly-Gly-Gly-Arg-Gly-Asp. The integrin blocking agent polypeptide designed in the invention is scientific, reasonable, practical and effective, can be used for preparing a treatment medicament for treating human solid tumors, and has remarkable social value and market value; and the treatment spectrum of the integrin blocking agent is expanded greatly, and novel thought and prospect are provided for future development of medicaments.
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Description

technical field

[0001] The present invention relates to the field of medicine, in particular to an integrin blocker capable of inhibiting tumor angiogenesis, and having integrin affinity and binding ability. The blocker is a polyethylene glycol modified polypeptide, and the integrin blocker The interrupting agent polyethylene glycol modified polypeptide can be used for the treatment of solid tumors. Background technique

[0002] Studies have shown that the growth of solid tumors depends on angiogenesis, and angiogenesis can not only provide the nutrients and oxygen needed by the tumor, excrete metabolites, but also serve as a way for distant metastasis. Therefore, blocking neovascularization may be a means to prevent tumor growth and metastasis, thereby motivating extensive research on pro-angiogenic and anti-angiogenic molecules.

[0003] Compared with traditional tumor treatment drugs, the biggest advantages of tumor angiogenesis inhibitors are: ①Selective action on vascu...

Claims

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