The invention belongs to the field of medical technology, relating to a new diketone piperazidine-like derivative and application thereof, specifically relating to a new diketone piperazidine-like derivative capable of treating tumor diseases. The structural formula of the compound is shown in the figure I and the figure II; n can be 0, 1, 2; the base group R can be amino-group, ethylamino group, tri-amino, abnormal tri-amino, fourth amino, abnormal fourth amino, tertiary butyl amino, circular tri-amino, circular fifth-amino, hexamethylene amino, dimethyl amino, diethylin, tetralin pyrrolyl, hexahydropyridine group, 4-methyl hexahydropyridine group, morpholinyl, piperazine group, and nitrogen methyl piperazine group. The compound has stable and definite structure, and the anti-tumor activity experiments show that the compound has very strong antitumor activity and has the advantages of strong active activity, small dosage, and the like. The diketone piperazidine-like derivative can be made into preparation for treating tumor diseases.