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Preparation and application of isobutylcyanoacrylate medical adhesive

A technology of isobutyl acetate and cyano group, used in the field of biomedical special functional adhesives and medical polymer materials, can solve the problems of low adhesive strength, hard cured product, insufficient hemostasis, etc.

Inactive Publication Date: 2009-07-01
孙丽华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The main glue of the current α-cyanoacrylate medical adhesive is α-butyl cyanoacrylate or n-octyl α-cyanoacrylate. Although the bonding time is very short, the adhesive layer is brittle and the cured product is relatively hard. , Insufficient hemostasis, low bonding strength, long shedding time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Formula: 50g of isobutyl α-cyanoacrylate, 13.5g of formaldehyde, 1.55g of hydroquinone, 0.7g of phosphoric acid, 13.5g of hexahydropyridine, and 19.3g of triphenylphosphate.

[0013] Performance Testing:

[0014] 1. Film formation time Add 50ml of 0.3g / L sodium bicarbonate solution (currently configured) to a plate with a diameter of 90mm, use a dropper to absorb medical glue, drop a drop at a distance of 5cm from the liquid surface, and record that the glue liquid surface begins to form a film time.

[0015] Test results: The film forming time is 8s.

[0016] 2. Adhesive strength Use pig, sheep or rabbit skin as the test leather, with a thickness of 1mm-1.5mm and a length of 50mm×10mm. Scrub the front surface of the leather test piece with phosphate buffer solution and dry it with a cotton swab. The front surface of Example 1 is connected to the front surface of the rubberized leather, so that the overlapping length is 5 mm, and pressed firmly for about 20 seconds, s...

Embodiment 2

[0023] Formula: 57.5g of isobutyl α-cyanoacrylate, 11.5g of formaldehyde, 1.15g of hydroquinone, 0.6g of phosphoric acid, 11.5g of hexahydropyridine, 17.3g of triphenyl phosphate, and 0.45g of others.

[0024] Performance Testing:

[0025] 1. Film formation time In a plate with a diameter of 90mm, add 50ml of 0.3g / L sodium bicarbonate solution (currently configured) for

[0026] The dropper sucks the medical glue, drops a drop 5cm away from the liquid surface, and records the time when the glue liquid surface starts to form a film.

[0027] Test results: The film forming time is 8s.

[0028] 2. Adhesive strength Use pig, sheep or rabbit skin as the test leather, with a thickness of 1mm-1.5mm and a length of 50mm×10mm. Scrub the front surface of the leather test piece with phosphate buffer solution and dry it with a cotton swab. The front surface of Example 1 is connected to the front surface of the rubberized leather, so that the overlapping length is 5 mm, and pressed firml...

Embodiment 3

[0035] Formula: α-isobutyl cyanoacetate 65g, formaldehyde 9.5g, hydroquinone 1.15g, phosphoric acid 0.5g, hexahydropyridine 9.5g, triphenyl phosphate 15.7g.

[0036] Performance Testing:

[0037] 1. Film formation time Add 50ml of 0.3g / L sodium bicarbonate solution (currently configured) to a plate with a diameter of 90mm, use a dropper to absorb medical glue, drop a drop at a distance of 5cm from the liquid surface, and record that the glue liquid surface begins to form a film time.

[0038] Test results: The film forming time is 8s.

[0039] 2. Adhesive strength Use pig, sheep or rabbit skin as the test leather, with a thickness of 1mm-1.5mm and a length of 50mm×10mm. Scrub the front surface of the leather test piece with phosphate buffer solution and dry it with a cotton swab. The front surface of Example 1 is connected to the front surface of the rubberized leather, so that the overlapping length is 5 mm, and pressed firmly for about 20 seconds, so that the bonding surfa...

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PUM

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Abstract

The present invention provides a medical adhesive which has the advantages of short adhesion time, good flexibility of adhesive layer, sufficient hemostasis, high adhesion strength and short break-off time. The invention is characterized in that the medical adhesive is manufactured by the following inventive formula and technique, wherein the inventive formula is as follows: 30-75 parts of alpha-isobutyl cyanoacetate by weight, 3.5-23.5 parts of formaldehyde by weight, 0.15-1.55 parts of polymerization inhibitor by weight, 0.1-15.5 parts of pH adjusting agent by weight, and 0.5-19.3 parts of stabilizing agent. The inventive technique comprises the following steps: executing polycondensation reaction with alpha-isobutyl cyanoacetate, formaldehyde and hexa-hydrogen pyridine as pH adjusting agent, executing suction-filtering to the product after water cleaning, and vacuum drying; adding the material which is executed with vacuum drying in a fractionating flask, then adding phosphoric acid as pH adjusting agent, tricresyl phosphate as stabilizing agent and hydrochinone as polymerization inhibitor, mixing to uniform, installing a capillary tube of SO2 protective gas, starting depolymerization, distilling, collecting the component with constant boiling point, and packaging or pouring-in. The medical adhesive can be applied to the aspects of medicine, health-care, beauty treatment, daily life, etc.

Description

Technical field: [0001] The invention is a biomedical special functional adhesive, which belongs to the category of medical polymer materials, and the medical adhesive can be applied in the fields of medicine, health care, beauty and daily life. Background technique: [0002] In the structure of α-alkyl cyanoacrylate monomers, electron-withdrawing groups (cyano groups, ester groups) are connected to the carbon atoms, making the monomers highly electrophilic, and when encountering substances with weak nucleophilicity (Water, amino, alcohol, weak base) can rapidly undergo anionic polymerization reaction, which reduces the electron cloud density of double bonds, and the liquid adhesive instantly becomes a solid bonding medium, bonding the two ends of the ruptured and damaged tissue. Alkyl α-cyanoacrylates are soft tissue adhesives, but their toxicity and tissue reaction increase with the increase of the number of alkyl carbon atoms. Some organizations have conducted toxicologi...

Claims

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Application Information

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IPC IPC(8): A61L15/58A61L24/06
Inventor 孙丽华李青山李永太郭晓峰李长生
Owner 孙丽华
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