40 results about "Butyl cyanoacrylate" patented technology

A medical adhesive for adhering skin and hemostasis of viscera is prepared from at least two organic compounds chosen from alpha-ethyl cyanoacrylate, alpha-ethoxyethyl cyanoacrylate, alpha-butyl cyanoacrylate and alpha-octyl cyanoacrylate through proportional mixing.

Cyanoacrylate adhesive compositions comprise a mixture of two cyanoacrylate monomers, including 2-octyl cyanoacrylate and n-butyl cyanoacrylate. The monomers are stabilized and sterilized by irradiation, and do not substantially increase in viscosity after sterilization or after two years of shelf storage. These compositions have anti-microbial properties, and may be used to close wounds as well as secure catheters inserted into the body in place.

The invention discloses a method for preparing nano rose essence capsules, which comprises the following steps of: a, mixing 0.3 to 0.8 weight percent of rose essence and 2.0 to 3.2 weight percent of polyoxyethylene (20) sorbitan monolaurate, stirring the mixture at the rotation speed of 1,100rpm, adding deionized water into the mixture and stirring to form a uniform emulsion; and b, dripping 0.6 to 1.6 weight percent of N-butyl cyanoacrylate into the emulsion, reacting for 2 to 4 hours, adjusting the pH value of the system with 1mol / L solution of sodium hydroxide to 7.0, and continuously reacting for 0.5 hour until the reaction is completed. The nano rose essence capsules prepared by the emulsion polymerization method of the invention have an average particle size of 91nm and a peak width of 16.8nm, have uniform particle size distribution and can be applied to goods for everyday consumption, such as textiles, cosmetics and detergents and the like.

The invention belongs to the technical field of preparation of drugs, and specifically relates to quercetin-modified nano sulfur as well as a preparation method and application thereof to an anti-AD (Alzheimer's Disease) drug. According to the preparation method disclosed by the invention, quercetin is modified on nano sulfur by utilizing the microsize and a high surface energy effect of nano sulfur, not only a function of the quercetin for reducing endoplasmic reticulum stress in cells of the quercetin is utilized, but also the water solubility is improved, so that quercetin-modified nano sulfur integrating high biocompatibility and an AD treatment effect is obtained. The quercetin-modified nano sulfur is further embedded in a microbubble shell prepared from alpha-butyl cyanoacrylate by adopting a one-pot method, so that a drug preparation containing quercetin-modified nano sulfur is prepared; microbubbles of the drug preparation can be destroyed under ultrasonic action, sonoporationcan be generated, a blood brain barrier can be temporarily opened, and quercetin-modified nano sulfur can further enter the brain by penetrating through the blood brain barrier so as to take a treatment effect, so that high brain targeting performance is obtained. The preparation method of the drug preparation is simple, and products are convenient to preserve and use.

The invention belongs to the technical field of biomedical materials, particularly relates to a medical adhesive material capable of rapidly stopping bleeding, and further discloses a preparation method of the medical adhesive material. According to the medical adhesive material disclosed by the invention, alpha-n-butyl cyanoacrylate and alpha-n-octyl cyanoacrylate are used as a mixed medical adhesive matrix, and a hemostatic material namely carboxymethyl chitosan is swelled and modified in a manner that CO2 supercritical fluid carries selected ionic liquid, so that the bleeding stopping performance of the carboxymethyl chitosan is effectively improved, the bleeding stopping performance of the whole medical adhesive material is greatly improved, and rapid bleeding stopping is achieved.

The invention discloses a new medical material. The new material is prepared from the following raw materials in parts by mass: 80-150 parts of butyl cyanoacrylate, 0.01-0.1 part of hydroquinone, 5-24 parts of aloe nano micro-powder, 20-55 parts of soybean protein powder, 10-44 parts of chitosan, 1-5 parts of acetic acid and 8-18 parts of polyvinyl alcohol. According to the new medical material disclosed by the invention, the impact resistance is enhanced by the aloe nano micro-powder, and the product degradability is improved by the natural plant extraction essence and ingredients; the bacterium inhibiting activity of the product is enhanced by the chitosan component; and the product has the advantages of moderate curing speed, high bonding strength, low heat release in bonding, good toughness of a bonding film and little skin irritation, and realizes a high-strength quick bonding effect on various wounds and operative incisions while avoiding scars after curing.

The present invention discloses an antibiotic medicine which contains amoxicillin nano-particles and clavulanate potassium and is made from 0.2 percent to 0.4 percent of amoxicillin, 0.02 percent to 0.25 percent of the clavulanate potassium, 0.5 percent to 2 percent of carrier, 0.5 percent to 2 percent of stabilizing agent, 0.5 percent to 2 percent of surfactant and 93 percent to 98.5 percent of distilled water according to the following method that: carrier monomers and the surfactant are dissolved in the distilled water completely; the amoxicillin is added; pH value is adjusted to be 2 to 3; butyl cyanoacrylate is added while being stirred by magnetic force and is stirred continuously for 5 to 12 hours, the pH value is adjusted to be 6 to 7, flaxen amoxicillin poly butyl cyanoacrylate nano-particle colloid solution is obtained; the clavulanate potassium is added by the proportion of the amoxicillin and the clavulanate potassium of 2 ®U 1 to 10 ®U 1 to obtain the antibiotic medicine which not only has simple preparation method but also has the advantages of wide spectrum, high efficiency, being targeted, slow-released, safe, etc.

A dressing and method for treating high-tension wounds. First and second layers of a 1-butyl cyanoacrylate 16 adhesive are applied to a short, high-tension wound, with the first and second layers covering the wound and extending to at least about 2.5 mm (0.0984 in.) from each side of the wound. The first layer is allowed to set and polymerize before the second layer of 1-butyl cyanoacrylate is applied. The second layer extends at least about 2.5 mm (0.0984 in.) beyond each edge of the first layer. In the case of a long, high-tension wound, a third layer is applied after the first and second layers are allowed to set and polymerize. The third layer is at least about 2.5 mm (0.0984 in.) wide and is substantially perpendicular to the first and second layers. The third layer may occur intermittently every 2.5 cm (0.984 in.) over the length of the wound, and preferably extends at least about 5 mm (0.197 in.) beyond the edge of the first layer.

An adhesive for the wound of the pearl-culturing clam is proportionally prepared from alpha-butyl cyanoacrylate, alpha-isobutyl cyanoacrylate, hydroxymethyl cellulose, phenyldiphenol, and toluenesulfonic acid. Its advantages are short setting time, high water-proofing nature, and low dead rate of clam.

A dressing and method for treating high-tension wounds. First and second layers of a 1-butyl cyanoacrylate 16 adhesive are applied to a short, high-tension wound, with the first and second layers covering the wound and extending to at least about 2.5 mm (0.0984 in.) from each side of the wound. The first layer is allowed to set and polymerize before the second layer of 1-butyl cyanoacrylate is applied. The second layer extends at least about 2.5 mm (0.0984 in.) beyond each edge of the first layer. In the case of a long, high-tension wound, a third layer is applied after the first and second layers are allowed to set and polymerize. The third layer is at least about 2.5 mm (0.0984 in.) wide and is substantially perpendicular to the first and second layers. The third layer may occur intermittently every 2.5 cm (0.984 in.) over the length of the wound, and preferably extends at least about 5 mm (0.197 in.) beyond the edge of the first layer.

The invention provides a washable, waterproof, breathable and moisture-permeable protective fabric. The protective fabric is mainly prepared through the following steps that (1) extraction is performed on peels of gooseberry fruits to obtain gooseberry peel extracts; (2) carbon nano tubes are added into the gooseberry peel extracts, heating is performed for ultrasonic agitation to obtain mixed liquid, solids are obtained after the mixed liquid is subjected to suction filtering, the solids are added into dichloropentafluoropropane, ultrasonic oscillation is performed to obtain a carbon nano tube solution; and (3) tridecafluorooctyl triethoxysilane, alpha-n-butyl cyanoacrylate and the carbon nano tube solution are added into dichloropentafluoropropane, a mixed solution is obtained after stirring to uniform mixing, a cotton fabric is dipped into the mixed solution, dried and taken out to obtain a mixed fabric, steam is led to the surface of the mixed fabric for fumigation, and then the washable, waterproof, breathable and moisture-permeable protective fabric is obtained. The washable, waterproof, breathable and moisture-permeable protective fabric provided in the invention has good washable, waterproof, breathable and moisture-permeable properties simultaneously.

The invention discloses a cyanoacrylate medical adhesive and a preparation method thereof, and belongs to the field of biomedical materials. The cyanoacrylate medical adhesive comprises the following components in percentage by mass of 100 parts of alpha-n-butyl cyanoacrylate, 2-8 parts of tributyl citrate, 1-7 parts of hydroxypropyl methacrylate,1-5 parts of sebacate, 0.05-3 parts of a stabilizer, 0.5-2.5 parts of tannic acid, 1-5 parts of a thickening agent, and 0.001-0.05 part of a coloring agent; and the preparation method comprises the following steps of weighing alpha-n-butyl cyanoacrylate, tributyl citrate, hydroxypropyl methacrylate, sebacate, the stabilizer, tannic acid, the thickening agent and the coloring agent according to a mass ratio to prepare the cyanoacrylate tissue adhesive. The cyanoacrylate medical tissue adhesive prepared by the invention takes the alpha-cyanoacrylate alkyl ester as a main component; and due to high reaction activity, the prepared cyanoacrylate medical adhesive has the advantages of strong bactericidal activity, strong adhesive force, high bonding speed and the like.

A dressing for a wound site and method of using same. The dressing includes a first layer comprising a butyl-cyanoacrylate adhesive applied directly to the wound site and extending a distance beyond the wound site to form a peripheral edge. The dressing also includes a second layer comprising a butyl-cyanoacrylate adhesive applied directly to the first layer and overlapping the peripheral edge of the first layer a distance. In a moderate-tension wound the second layer extends the entire area of the first layer, but also extends a distance beyond the peripheral edge.

The invention belongs to the technical field of biomedical materials, in particular to an anti-inflammatory medical glue material for rapid hemostasis, and further discloses a preparation method thereof. The medical adhesive material of the present invention uses α-n-butyl cyanoacrylate and α-n-octyl cyanoacrylate as a mixed medical adhesive matrix, and is mixed with CO 2 The supercritical fluid carries selected ionic liquids and anti-inflammatory active ingredients to swell and modify the hemostatic material carboxymethyl chitosan, which not only effectively improves the hemostatic performance of carboxymethyl chitosan, but also makes the whole medical adhesive material hemostatic The performance is greatly improved, and rapid hemostasis is realized, and the medical glue has better antibacterial performance, and can be applied to more clinical occasions.

The invention discloses a preparation method of a tension-resistant medical conduit material and application thereof. The preparation method comprises the following steps: performing wet-method ball milling on wollastonite powder and calcium hydroxide, and drying so as to obtain dried mixed powder; performing a high-temperature stirring reaction on methacrylate and ethylene glycol dimethacrylate in a vacuum reaction kettle, cooling, adding methyl phenyl silicon oil, leaving to stand, performing a heat-preservation reaction so as to obtain a high-temperature reactant, cooling, adding dimaleamicacid, di-tert-butyl peroxide and cyan-butyl cyanoacrylate, and performing a pressurization reaction in a nitrogen environment so as to obtain a secondary reactant; further mixing and stirring the dried mixed powder, the secondary reactant and an additive so as to obtain a thermal mixed material, further adding dimethyl sulfoxide, and implementing processes such as ultrasonic treatment, extrusionpelletization, injection molding, partitioning, packaging and sterilization, thereby obtaining a finished product, namely a medical conduit material. The medical conduit material prepared by using themethod is good in tension property, high in biological security and good in application prospect in medical materials.

The invention relates to an alpha-butyl cyanoacrylate derivative and a preparation method thereof. The structure of the alpha-butyl cyanoacrylate derivative has the following general formula. The preparation method comprises: with n-butyl cyanoacetate and formaldehyde as raw materials, the alpha-butyl cyanoacrylate derivative is prepared from a condensation reaction in the presence of a catalyst by virtue of vacuum distillation. The reaction is simple to operate, high in total yield and is suitable for industrial production. The prepared alpha-butyl cyanoacrylate derivative is free of shear strength, low in viscosity, good in fluidity, and can be used as a regulator of alpha-butyl cyanoacrylate medical adhesives. The formula is shown in the specification, wherein n is equal to 1-6.

The invention discloses a process for detecting the performance of plastic particles in an injection molding machine. The main formula of the plastic particles is as follows: 25-33 parts of low-density polyethylene; 5-8 parts of silane crosslinked polyethylene, 15-18 parts of chloroprene rubber, 5-8 parts of polyphthalamide, 4-6 parts of poly-p-hydroxybenzoate, 2-5 parts of alpha-n-butyl cyanoacrylate, 4-6 parts of dibutyltin dilaurate, 3-5 parts of tributyl borate and 1-4 parts of dioctyl phthalate. According to the invention, different methods for detecting the plastic particles are used foranalyzing the performance of the plastic particles in different environments; therefore, the performance of the plastic particles can be analyzed more accurately, data can be better recorded for theperformance of the plastic particles in different environments, and the plastic particles with different characteristics can be produced and used differently.

The invention discloses a preparation method of a polybutylcyanoacrylate nanowire. The preparation method comprises the following steps of: preparing an oil-phase mixture, namely dispersing alpha-n butyl cyanoacrylate with the volume ratio of 0.2-0.3% and ethyl acetate with the volume ratio of 3-6% in acetone; preparing emulsified-phase mixture, namely dispersing a 5-8 g / L emulsifying agent and a 8-10 g / L stabilizer, wherein the emulsifying agent is sodium lauryl sulphate, and the stabilizer is dextran-70; carrying out interface emulsification polymerization reaction; and at room temperature, gradually dropwise adding the prepared oil-phase mixture into the prepared emulsified-phase mixture for carrying out interface emulsification polymerization. The preparation method disclosed by the invention has the characteristics of stable performance and no toxicity and no harm to a human body, animals and microorganisms.

The invention discloses a medical novel biomaterial prepared from, by mass, 80-200 parts of butyl cyanoacrylate, 0.01-0.1 parts of hydroquinone, 5-24 parts of aloe nano-powder, 20-55 parts of soy protein powder, 10-44 parts of chitosan, and 1-5 parts of acetic acid. A preparation method includes: preparing a chitosan solution, concentration being 20-40%, with deionized water, adding the deionizedwater by 2-4 times by volume as the chitosan solution, heating the liquid to 40-60 DEG C and adding other components, uniformly mixing and stirring the liquid and regulating solid content to production demand. By adding the aloe nano-powder, anti-impact capacity of the material is improved; the material is easy to degrade due to natural plant extracts and components. The chitosan can improve antibacterial activity of the product. The material has a proper curing speed, is high in adhesion speed, is low in heat release during adhesion, has good flexibility of adhesion film, is low in skin irritation, has high-strength quick adhesion effect on various injuries and surgical incisions, and is free of scars after curing.

The invention discloses a preparation method of medical glue with functions of promoting healing and repairing, which is characterized in that it comprises the following components in parts by weight: 20-25 parts of n-butyl cyanoacrylate, isocyanoacrylate 25‑35 parts of octyl esters, 2‑6 parts of styrene thermoplastic elastomer microspheres, 25‑37 parts of highly effective healing and repair components, 2‑4 parts of sodium alginate, 3‑6 parts of sodium hyaluronate, 8‑10 parts of allantoin, 1 part of hydrolyzed wheat protein, 1 part of stabilizer, 150‑220 parts of compound fruit oil, 200 parts of sterile water. The medical adhesive of the present invention specially selects a variety of biological extracts with regenerative functions and adds three major healing-promoting and repairing components to promote healing and improve repairing effects, and has high bonding strength and good biocompatibility. It meets the clinical application requirements for medical adhesives.

An adhesive for the wound of the pearl-culturing clam is proportionally prepared from alpha-butyl cyanoacrylate, alpha-isobutyl cyanoacrylate, hydroxymethyl cellulose, phenyldiphenol, and toluenesulfonic acid. Its advantages are short setting time, high water-proofing nature, and low dead rate of clam.

The invention discloses a novel medical material. The novel medical material is prepared from the following raw materials in parts by mass: 80 to 150 parts of butyl cyanoacrylate, 0.01 to 0.1 part ofhydroquinone, 5 to 24 parts of aloe nano-micro powder, 20 to 55 parts of soybean protein powder, 10 to 44 parts of chitosan, 1 to 5 parts of acetic acid, 8 to 18 parts of polyvinyl alcohol, 2 to 4 parts of styrene butadiene latex, 2 to 5 parts of ethoxyethanol, 2 to 5 parts of dimethyl ether, 2 to 5 parts of miconazole nitrate, 2 to 5 parts of thiourea, 0.1 to 0.3 part of tungsten powder, 1 to 5 parts of polyamide, 2 to 7 parts of phenol and 0.5 to 1.0 part of methylimidazole. The product provided by the invention has the advantages of moderate curing speed, high bonding strength, low heat releasing in an adhesion process, good toughness of an adhered thin film and small irritation on skin; the product has high strength and rapid bonding effects on various wounds and surgical incisions andno scars are left after the product is cured.

The invention belongs to the technical field of biomedical materials, particularly relates to an anti-inflammatory rapid hemostatic medical adhesive material, and further discloses a preparation method thereof. According to the medical adhesive material disclosed by the invention, alpha-n-butyl cyanoacrylate and alpha-n-octyl cyanoacrylate are used as a mixed medical adhesive matrix, and a hemostatic material carboxymethyl chitosan is swelled and modified in a manner that a CO2 supercritical fluid carries selected ionic liquid and anti-inflammatory active ingredients, so that the hemostatic performance of the carboxymethyl chitosan is effectively improved, the hemostatic performance of the whole medical adhesive material is greatly improved, rapid hemostasis is achieved, and a medical adhesive has relatively good antibacterial performance and can be suitable for more clinical occasions.

The invention discloses a method for preparing polymeric microspheres. In the method, fog drops are applied to a cyanoacrylate monomer or the surface of a dispersion containing more than 50 weight percent of the monomer for reaction. The fog drops can be water or ethanol and can contain any or a mixture in arbitrary radio of OH, I, CH3COOH, Br and amino acid. The cyanoacrylate monomer preferably is one or a mixture in arbitrary radio of cyanoacrylate, n-butyl cyanoacrylate, iso-butyl cyanoacrylate and tert-butyl cyanoacrylate. The reaction time is between 0.1 and 5 minutes. The flow rate of the fog drops is 0.1 to 10 m / s and the diameter of the fog drops is 0.1 to 100mum. The method is simple in process, stable and reliable and low in energy consumption and avoids using a large amount of solvent; after being dissolved in water, ethanol and other solvents, medicaments and other functional materials can be made into polymeric microspheres by the method to form polymeric microspheres having special functional properties such as medicinal properties directly; and the method can be used on special occasions to directly form microspheres on the surfaces of objects and is extremely suitable for large-scale preparation.

The invention discloses an effective and safe injection for treating spontaneous pneumothorax. The injection for treating spontaneous pneumothorax comprises alpha-n-butyl cyanoacrylate, nano silicon dioxide and a 50% glucose solution. The invention also provides an effective and safe injection for treating refractory pneumothorax. The injection for treating refractory pneumothorax comprises alpha-n-butyl cyanoacrylate, a human fibrin adhesive, 10g of talcum powder, a 50% glucose solution, normal saline and lidocaine hydrochloride. According to the invention, alpha-n-butyl cyanoacrylate is added, so that alpha-n-butyl cyanoacrylate can be used for quickly adhering body tissues at room temperature, and is strong in adhesion force and non-toxic; the reaction to tissues is small, thrombus is not formed, and simple sterilization can be realized; no trace is left after skin incision anastomosis, and the hemostatic function is achieved on a wound; the alpha-n-butyl cyanoacrylate can also be used for adhesion and hemostasis of visceral organs; and the adopted nano silicon dioxide has ultraviolet-resistant optical performance, so that the ageing resistance, strength and chemical resistanceof other materials can be improved.

The invention discloses a Chinese medicine for a medical polymer elastic bandage and a preparation method of the Chinese medicine composition. The Chinese medicine consists of the following components, in parts by weight: 6 parts of black soya bean, 12 parts of oncorhynchus mykiss bone, 16 parts of common curculigo rhizome, 12 parts of fructus kochiae, 7 parts of trogopterus dung, 10 parts of woodear, 3 parts of alpha-butyl cyanoacrylate, and 22 parts of water. Black soya bean, oncorhynchus mykiss bone, and wood ear are washed and dried, and then are grinded into powder. A 10-mesh sieve is used for screening, the screened mixture is added into water to dissolve, then the solution is subjected to ultrasonic vibration and drying again, and then a 20-mesh sieve is used for further screening.Common curculigo rhizome, fructus kochiae, and trogopterus dung are washed and dried, and then are grinded into powder, and a 20-mesh sieve is used for screening. The screened mixtures are both addedinto water, first stirring is conducted, and finally alpha-butyl cyanoacrylate is added, and then stirring is conducted for a second time. The stirred mixture is added to a ball mill to grind again for 22 minutes by adjusting the rotation speed, and then the composition is taken out. The Chinese medicine composition for the medical polymer elastic bandage of the invention has the advantages of low production cost, anti-inflammatory and analgesic effect, and effects of promoting blood circulation and removing blood stasis, improving repair enzyme activity and promoting calcium and phosphorus deposition at fracture ends.

The invention provides a quercetin nano sustained-release preparation capable of safely and effectively resisting silica-dust-caused pneumoconiosis fibrosis and a preparation method of the quercetin nano sustained-release preparation. The quercetin nano sustained-release preparation comprises poly (n-butyl cyanoacrylate) nanoparticles and quercetin loaded on the poly (n-butyl cyanoacrylate) nanoparticles. The invention provides the quercetin nano sustained-release preparation which is prepared by a spontaneous polymerization method by taking acetic acid as an initiator and is safe and effective in resisting silica-dust-caused pneumoconiosis fibrosis. According to the method, no toxic organic solvent is used for dissolving water-insoluble quercetin, instead, glacial acetic acid is used for dissolving the quercetin. The glacial acetic acid is weak acid, the acidity value changes slowly during pH adjustment, the pH value is easy to control, while strong acid hydrochloric acid cannot be used, acetic acid is easy to ionize acetate anions in water, the anions can be used as an initiator, and when a monomer is added into water, the monomer is automatically initiated to be polymerized into a polymer and nanoparticles can wrap quercetin, so that the solubility and bioavailability of the quercetin are improved. The method has the advantages of low cost, easiness in operation, low energy consumption, no pollution, high safety and the like.