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Method for preparing polymeric microspheres

A polymer and microsphere technology, applied in the field of polymer synthesis and technical processing, can solve the problem of high production cost, achieve the effects of low energy consumption, suitable for large-scale preparation and simple process

Inactive Publication Date: 2009-11-25
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The prepared microspheres can meet the production and use requirements, but a large amount of solvents and surfactants are used in the preparation process, and it involves the separation of products, recycling of solvents and environmental pollution, and the production cost is relatively high.

Method used

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  • Method for preparing polymeric microspheres
  • Method for preparing polymeric microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1, preparation polymer microsphere

[0016] Use a 1.7MHz ultrasonic atomizing humidifier to atomize the secondary water into water droplets with a diameter of less than 5um, and use a catheter to guide the atomized airflow (flow rate of 1m / s) to the ethyl 2-cyanoacrylate spread on the glass surface On the surface of the liquid film, OH- in water initiates a polymerization reaction. After a few seconds, the liquid film appears white. After one minute, the reaction is complete. Remove the atomized water flow and dry at room temperature.

[0017] Observed under the electron microscope, there are polymer beads with a diameter of 1-10 microns, such as figure 1 shown.

Embodiment 2

[0018] Embodiment 2, preparation polymer microsphere

[0019] Use a 1.7MHz ultrasonic atomizing humidifier to atomize the secondary water into micro-water droplets with a diameter of less than 5um, and use a catheter to guide the atomized airflow (flow rate of 5m / s) to the 2-cyanoacrylic acid n-butylene spread on the glass surface On the surface of the ester liquid film, OH- in water initiates a polymerization reaction, and the liquid film appears white after a few seconds, and the reaction is complete after one minute, remove the atomized water flow, and dry at room temperature.

[0020] Observed under the electron microscope, there are polymer beads with a diameter of 1-10 microns, such as figure 2 shown.

Embodiment 3

[0021] Embodiment 3, preparation polymer microsphere

[0022] Use a 1.7MHz ultrasonic atomizing humidifier to atomize the secondary water into droplets with a diameter of less than 5um, and use a catheter to guide the atomized airflow (flow rate of 5m / s) to the isobutyl cyanoacrylate spread on the glass surface On the surface of the ester liquid film, OH- in water initiates a polymerization reaction, and the liquid film appears white after a few seconds, and the reaction is complete after one minute, remove the atomized water flow, and dry at room temperature.

[0023] Observed under an electron microscope, there are polymer balls with a diameter of 1-10 microns.

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Abstract

The invention discloses a method for preparing polymeric microspheres. In the method, fog drops are applied to a cyanoacrylate monomer or the surface of a dispersion containing more than 50 weight percent of the monomer for reaction. The fog drops can be water or ethanol and can contain any or a mixture in arbitrary radio of OH, I, CH3COOH, Br and amino acid. The cyanoacrylate monomer preferably is one or a mixture in arbitrary radio of cyanoacrylate, n-butyl cyanoacrylate, iso-butyl cyanoacrylate and tert-butyl cyanoacrylate. The reaction time is between 0.1 and 5 minutes. The flow rate of the fog drops is 0.1 to 10 m / s and the diameter of the fog drops is 0.1 to 100mum. The method is simple in process, stable and reliable and low in energy consumption and avoids using a large amount of solvent; after being dissolved in water, ethanol and other solvents, medicaments and other functional materials can be made into polymeric microspheres by the method to form polymeric microspheres having special functional properties such as medicinal properties directly; and the method can be used on special occasions to directly form microspheres on the surfaces of objects and is extremely suitable for large-scale preparation.

Description

technical field [0001] The invention relates to a method for preparing micron microspheres, which belongs to the field of polymer synthesis and technical processing. Background technique [0002] Polymer microspheres are a new type of functional material with excellent performance. They have the characteristics of surface effect, volume effect, magnetic effect, biocompatibility, and functional groups. They can be used in biomedical fields such as drug-controlled release carriers and analytical chemistry. Polycyanoacrylate is biocompatible and widely used in biomedical adhesives and drug controlled release carriers. Water, ethanol, and amino acids can all initiate anionic polymerization of cyanoacrylate monomers. [0003] Traditional methods for preparing polymer microspheres include suspension polymerization, emulsion polymerization, dispersion polymerization, and seed polymerization. The prepared microspheres can meet the production and use requirements, but a large amoun...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F20/42C08F2/00
Inventor 李晓锋戴鸿君张小莉徐坚
Owner INST OF CHEM CHINESE ACAD OF SCI
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