163 results about "Polymeric microspheres" patented technology

Methods and apparatus for forming a fluid for use within in a subterranean formation including crosslinking a polymer along the surface of microspheres in a water-in-water emulsion and introducing the microspheres into the subterranean formation. Methods and apparatus for forming a fluid for use within in a subterranean formation including crosslinking a polymer along the surface of microspheres in a water in water emulsion, isolating the microspheres from the emulsion, and introducing the microspheres into the subterranean formation. Methods and apparatus for forming a fluid to treat a subterranean formation including introducing a crosslinkable polymer, partitioning agent, and crosslinker into a solvent, crosslinking the crosslinkable polymer, isolating beads of the crosslinkable polymer from the partitioning agent, introducing the beads into a fluid for treating a subterranean formation.

The present invention relates to a method for preparing microsphere and microspheres produced thereby. The method comprises: mixing a water-insoluble organic solvent with a dispersion solvent; mixing a polymer compound, a drug and a water-insoluble organic solvent to prepare a dispersed phase; mixing the dispersed phase with the dispersion solvent mixed with the water-insoluble organic solvent to prepare an emulsion; and adding a base or an acid to the prepared emulsion. With the method, it is possible to prepare a drug-containing polymeric microsphere cost-effectively and conveniently.

The present invention provides compositions and methods for preventing the development of or reducing the growth of gastrointestinal tumors. The composition comprises polymeric microspheres encapsulating sulindac, IL-12 or both. These polymeric microspheres can be administered orally to individuals to reduce the growth of or prevent the development of gastrointestinal tumors.

The invention discloses a preparation method of molecularly imprinted polymeric microspheres for 2,4,6-trinitrophenol detection. The preparation method is characterized in that polynitrophenol derivatives-imprinted molecules generated through reaction between 2,4,6-trinitrophenol and N,N'-diisopropyl carbodiimide have luminous yellow fluorescent light, the fluorescent light of the imprinted molecules has open and close characteristics under an acid-base condition, the imprinted molecules located in an imprinting layer of the molecularly imprinted polymeric microspheres can be eluted, a hole structure which is complementary with the structure, the size and the functional groups of the imprinted molecules is formed in the imprinting layer, polymeric microspheres of which the imprinted molecules are eluted have specific recognition sites on target analyte molecules, target molecules enter the specific recognition sites, selective recognition on the target analyte molecules is realized, sensitivity detection of the target analyte molecules can be realized through opening and closing of the fluorescent light of the target molecules, the specific surface area of the molecularly imprintedmicrospheres is large, and space in which the recognition sites are formed is stable in structure, has more effective sites, and is capable of carrying out high-selective recognition and high-sensitive detection on the target molecules.

The invention relates to a novel carrier with good permeability for immobilizing enzymes. The carrier is a polymer microsphere not only with small and medium pores smaller than 90nm, but also with large pores of hundreds of nanometers. The carrier can be used for both single-enzyme immobilization and multiple-enzyme immobilization. The utilization rate of the microsphere surface can reach 70%-100%. The present invention also relates to the use of the carrier for immobilizing enzymes in immobilizing enzymes and the carrier immobilized with enzymes. Because the enzyme can be immobilized inside the carrier and can be well protected by the carrier, it has good stability, activity and reusability, and is especially suitable for column packing for continuous reactions.

The present invention relates to the removal of bilirubin from blood, and is especially cyclodextrin crossed polymer microsphere for adsorbing bilirubin and its preparation and application. The microsphere is prepared with diisocyanate as crosslinking agent and through condensation with cyclodextrin monomer. The polymer microsphere of the present invention has low cost and results in simplified experiment process, and the efficient removal of bilirubin with the polymer microsphere shows that the said material has excellent clinical application latent.

The invention provides an array structure fabric surface and a preparing method and application thereof. According to the preparing method for a conical array structure fabric surface, the surface of a semiconductor substrate is paved with a single polymeric microsphere thin film layer, a pillar array structure is etched on the surface of the semiconductor substrate with the polymeric microsphere as a protection layer, a foundation pillar in the semiconductor substrate is oxidized, and an oxidation layer is removed to obtain the fabric surface of a conical array structure. The specific surface area of the fabric surface of the conical array structure manufactured through the method is small, the surface recombination possibility of a photon-generated carrier is low, the preparing technology of the array structure fabric structure is simple, a template is not needed, cost is low, and the defects that in the prior art, large-scale generation cannot be achieved, the preparing steps are complex, and cost is high are overcome.

The invention provides a water injection well multi-slug profile control method. A multi-slug injection method is adopted, wherein a first slug adopts an organic jelly glue aqueous solution system including volume expansion grains; and a last slug comprises two stages, the first stage adopts an organic jelly glue aqueous solution system including volume expansion grains, and a profile control agent adopted by the second stage is a microsphere deep profile control modifying and flooding agent. In the water injection well multi-slug profile control method, a jelly glue type profile control agent selected and used by the first slug can form a powerful 'baffle' at the well bottom water injection front end, and the phenomena that a medicament is subsequently injected, and oily sludge directly dashes into an extraction oil well are avoided. In the last slug, the sizes of micro hole passageways are reduced through expansion performance of polymeric microspheres, depressurization and augmented injection are conducted through adsorbability of the polymeric microspheres, and well group oil production is increased through displacement performance of the polymeric microspheres. In the injection method adopting the three slugs, while consuming the oily sludge in a massive dose mode, the second slug enters large hole passageways and cracks to block a high-permeability layer band.

The invention relates to a method for preparing a half-strawberry type Janus particle. The method comprises the steps of: by taking a large-grain-size modified silicon dioxide microsphere as a core microsphere and taking a small-grain-size silicon dioxide or polymeric microsphere as a crown microsphere, using a Pickering emulsion method to modify the modified silicon dioxide microsphere into an initial Janus particle, and self-assembling with the crown microsphere by using the interaction between each function to obtain the half-strawberry type Janus particle. The preparation method has the characteristics of simple equipment and controllable operation, the product is pure, monodisperse and uniform in aperture. Compared with a common method, the method for preparing the half-strawberry type Janus particle has the advantages of controllable operation and simple method and is capable of preparing a complex Janus particle.

The present invention provides compositions and methods for reducing the severity of inflammatory bowel disease. The composition comprises polymeric microspheres encapsulating IL-10. These polymeric microspheres can be administered orally to individuals to treat inflammatory bowel disease.

The invention provides degradable polymer microspheres and a preparing method thereof. According to the characteristics of a micro flow method, a thin pipe is used in an emulsifying-curing method forpre-limiting the size of organic phases, and the organic phases are rapidly cut into microspheres of the preset size when being slowly injected into a large quantity of water phases. Organic solvent in the micron-level polymeric microspheres can be rapidly diffused into the water phases, and adhesion between the polymeric microspheres in the later period is avoided. According to the preparing method, the uniformity of the size of microspheres obtained with the traditional emulsifying-curing method is improved, the quality of the polymeric microspheres is improved, and the yield of the polymeric microspheres is increased. According to the preparing method for simply and rapidly preparing the degradable polymer microspheres with high uniformity, by deploying various technical parameters in the microsphere preparing process, the prepared microspheres are uniform in particle size distribution, the distribution coefficient of the diameter is 25% or below, and compared with particle size distribution of the microspheres prepared with a conventional multiple-emulsion method, the remarkable significance is achieved.

The invention provides an indepth fluid diverting agent of an oil reservoir and a preparation method and application of the indepth fluid diverting agent. The indepth fluid diverting agent comprises, by mass, 20-35wt% of acrylamide based monomers, 2-10wt% of vinyl-containing silane, 10-25wt% of arene-containing vinyl or olefine monomers, 0.03-0.1wt% of a cross-linking agent, 0.02-0.08wt% of an initiating agent, 0.5-2wt% of a dispersing agent, 2-12wt% of an anti-sticking agent, and the balance water. The invention further provides the preparation method of the indepth fluid diverting agent. The preparation method includes the steps that the acrylamide based monomers, the vinyl-containing silane, and the arene-containing vinyl or olefine monomers are mixed and then heated to 60-80 DEG C, the cross-linking agent, the initiating agent, and the dispersing agent are added, after 1-2 hours of reaction, the anti-sticking agent is added, after polymeric microsphere suspension is formed, precipitation separation is conducted, and the indepth fluid diverting agent of the oil reservoir is obtained. In addition, the invention provides the application of the indepth fluid diverting agent in profile control and oil displacement of a water injection well.

The invention discloses a superpara magnetism polymeric microsphere magnetic resonance imaging (MRI) contrast agent and a preparation method of the superpara magnetism polymeric microsphere MRI contrast agent, and relates to the MRI contrast agent used for diagnosis and treatment and the preparation method of the MRI contrast agent used for the diagnosis and the treatment. Polymeric microspheres are formed by polymerizable amphiphilic macromolecules, styrene monomers and Fe3O4 nano particles in a one-time batch feeding polymerization mode. Each microsphere comprises a core-shell structure, an inner core envelopes the superpara magnetism Fe3O4 particles, and a shell layer surface contains abundant functional groups. The microspheres are enabled to have targeting functions through coupling targeting molecules, and suitable for targeting MRI for certain diseases. The superpara magnetism polymeric microspheres are simple in synthetic process, low in preparation cost, controllable in microsphere particle diameter, stable in form, good in biocompatibility (BC) and MRI effect, and good in popularization and application values.

The invention belongs to the field of material sciences and engineering and environmental sciences and particularly relates to a thermosensitive bisphenol A (BPA) imprinted polymeric microsphere and application of the thermosensitive BPA imprinted polymeric microsphere. According to the thermosensitive BPA imprinted polymeric microsphere, polystyrene is used as a carrier, BPA is used as template molecules in combination with thermosensitive material monomers, and the temperature-responsive BPA imprinted polymeric microsphere is obtained through polymerization. The thermosensitive BPA imprinted polymeric microsphere is used for detection of the BPA. The thermosensitive BPA imprinted polymeric microsphere is clear in principle, novel in design, low in cost and easy and convenient to operate; the imprinted polymeric microsphere obtained through dispersion polymerization, swelling polymerization, precipitation polymerization and other methods is regular in morphology, stable in nature, capable of adsorbing the BPA quickly, high in bonding capacity, good in specificity and reproductibility, capable of achieving the standard recovery rate of more than 90% when applied to detection of sea water or yoghourt samples containing the BPA, and good in reuse performance; besides, the obtained intelligent imprinted polymers are sensitive in response to external temperatures, and different temperatures of solutions have a great influence on the adsorption capacity of the thermosensitive BPA imprinted polymeric microsphere.

The invention features core-shell microsphere compositions, hollow polymeric microspheres, and methods for making the microspheres. The microspheres are characterized as having a polymeric shell with consistent shell thickness.

The invention discloses a preparation method of surface-functionalized elution micro-spheres capable of carrying drugs, relating to the field of bio-medical materials. The preparation method comprises the following steps: (1) by taking carboxymethyl chitosan as a raw material and polyethylene glycol diglycidyl ether as a cross-linking agent, preparing cross-linking carboxymethyl chitosan micro-spheres of which the particle sizes are mainly distributed in 300-400mu m by a reverse micro-suspension cross-linking method; and (2) putting the prepared dry cross-linking carboxymethyl chitosan micro-spheres into an aqueous solution of 2-acrylamide-2-methylpropanesulfonic acid for soaking, and carrying out graft polymerization on the 2-acrylamide-2-methylpropanesulfonic acid on the surfaces of the micro-spheres by taking ammonium ceric nitrate as an initiator, so as to modify the micro-spheres. As the surfaces of the micro-spheres, modified by graft polymerization, have a large number of sulfonic acid groups, drugs with positive charges, such as doxorubicin hydrochloride, can be effectively carried, so that the elution micro-spheres can be hopefully prepared.