34 results about "Polymeric microspheres" patented technology

The invention discloses a preparation method of surface-modified degradable polymer microspheres, which comprises the following steps: (1) preparing dry microsphere powder: putting an oil-phase solution and a water-phase solution into emulsifying equipment for mixing and emulsifying to obtain emulsion; carrying out temperature rise and pressure reduction curing on the emulsion to obtain biodegradable microsphere dry powder; (2) dissolving the modification material: dissolving the modification material containing the amino group to obtain a solution containing the modification material; (3) swelling: dispersing the biodegradable microsphere dry powder in a third solvent and stirring to swell the surface structure of the biodegradable microsphere; (4) activation: adding a carbodiimide compound and an N-hydroxyl activator into the swollen biodegradable microsphere solution for activation, so that an O-acyl isourea intermediate is formed on the surface of the microsphere, and a surface-activated microsphere precipitate is obtained; and (5) modification: mixing the microsphere precipitate with a solution containing a modification material, and stirring to obtain the surface-modified degradable polymer microsphere. Compared with the prior art, the hydrogel has good hydrophilicity and biocompatibility.

The present disclosure relates to biodegradable polymeric microspheres comprising a biodegradable polymer and an immunotherapeutic agent selected from the group consisting of a poly ADP ribose polymerase inhibitor (PARP inhibitor) and / or a Toll-like receptor (TLR) agonist, wherein (a) 50% of the total amount of the immunotherapeutic agent in the biodegradable polymer microspheres is released from the biodegradable polymer microspheres to a PBS solution containing 0.05% of Tween 20 at 37 DEG C at a certain time point between 3 days and 14 days; (b) releasing the immunotherapeutic agent with the dry weight of 1 mg / g to 100 mg / g from the biodegradable polymer microspheres to a PBS solution containing 0.05% of Tween 20 at 37 DEG C at a certain time point between 3 days and 14 days; or (c) satisfies both (a) and (b). Other aspects of the present disclosure relate to methods of using such microparticles and kits comprising such microparticles.

The invention describes an extended-release composition comprising PLGA or PLA polymeric microspheres comprising an isoxazoline, preferably sarolaner, and a macrocyclic lactone, preferably moxidectin, and wherein the composition further comprises at least one pharmaceutically acceptable excipient; and uses thereof.

Provided herein are pharmaceutical compositions comprising biodegradable polymeric microspheres comprising triptorelin or a pharmaceutically acceptable salt form thereof and a lactic acid polymer.

The invention provides a polymer microsphere-assisted copper / carbon nitrogen composite material as well as a preparation method and application thereof. The material is a composite material formed by loading copper nanoparticles on a carbon-nitrogen matrix, and the carbon-nitrogen matrix is of an amorphous structure and is loaded with monometallic copper or copper nanoparticles doped with cobalt, nickel, iron and zinc. A polymeric microsphere precursor containing copper nanoparticles obtained through hydrothermal synthesis is subjected to inert atmosphere high-temperature treatment, and the composition structure of the copper / carbon nitrogen composite material is regulated and controlled by adjusting high-temperature treatment conditions. The polymer microsphere-assisted copper / carbon nitrogen composite material is stable in structure, the synthesis method is safe and simple, and the polymer microsphere-assisted copper / carbon nitrogen composite material has excellent hydrogen production activity when being applied to photocatalytic water reaction and can be expanded in application in light and heat catalytic reaction.

The invention relates to the technical field of polymer synthesis, in particular to polymer microspheres and a preparation method and application thereof.The preparation method of the polymer microspheres comprises the following steps that pyridoxal, an anhydrous aprotic polar solvent, organic alkali and methacryloyl chloride are mixed to be subjected to an esterification reaction under the conditions of protective gas and light shielding, and the polymer microspheres are obtained. Pyridoxal methacrylate is prepared; dissolving inorganic salt and a dispersing agent in water to prepare a water phase; the preparation method comprises the following steps: mixing pyridoxal methacrylate, styrene, divinyl benzene and an initiator to prepare an oil phase; heating the water phase to 65-75 DEG C, and adding the oil phase into the water phase under a stirring condition to prepare a suspension dispersion system; under the protection of protective gas, the suspension dispersion system is subjected to a reaction for 8-12 h at the temperature of 65-75 DEG C, the polymer microspheres are prepared, and the polymer microspheres can keep efficient adsorption of uranyl ions within a wide pH range.

The present disclosure relates to injectable pharmaceutical compositions comprising lumateperone or deuterolumateperone or tetradeuterolumateperone, in free, or pharmaceutically acceptable salt form, suspended, dissolved or encapsulated in polymeric microspheres, devices comprising such compositions, and methods of use thereof in the treatment or prophylaxis of disease.

The invention relates to the field of isopropyl alcohol preparation, and discloses a chelate resin and a preparation method thereof, and a method for preparing electronic grade isopropyl alcohol, the method comprises the following steps: styrene-divinylbenzene polymeric microspheres are contacted with N-hydroxymethyl phthalimide, and an imidization reaction, a hydrolysis reaction and a carboxylation reaction are sequentially carried out. By using the chelate resin and the method for preparing the electronic-grade isopropanol, the content of isopropanol in the product can be effectively increased, and the content of water, zwitterions and particles can be reduced.

To provide an immediately usable composition for subcutaneous or intradermal injection, and a method for performing restoration or cosmetic dermatology treatment.SOLUTION: Provided is an immediately usable injectable composition containing polymeric microspheres or fine particles originated from non-animal, hydrogel containing water and cellulose derivative gelatinizer, and polysorbate 80. Further provided is a method for using an immediately usable injectable composition for restoration or formation surgery, cosmetic dermatology, contour formation of a face, contour formation of a body, and gum augmentation.SELECTED DRAWING: None

The invention discloses a preparation device for dissolving polymeric microsphere composite unblocking acid, which comprises a reaction kettle, a limiting groove is arranged in the reaction kettle, a sealing cover is slidably connected in the limiting groove, a feeding pipe is fixedly communicated in the sealing cover, a stirring mechanism is arranged in the sealing cover, and a lifting mechanism is arranged on the outer side of the reaction kettle. A first bearing plate is fixedly connected to the outer surface of the reaction kettle, a second bearing plate is fixedly connected to the outer surface of the reaction kettle, a cleaning mechanism is arranged above the first bearing plate, a discharging pipe is fixedly communicated with the interior of the reaction kettle, and two groups of supporting legs are fixedly connected to the bottom surface of the reaction kettle. According to the preparation device for dissolving the polymer microsphere composite blocking removal acid, reactant residues adhered to the stirring mechanism can be cleaned in time, the influence on the normal proportion of reactants for preparing the blocking removal acid next time is avoided, and the normal use effect of the blocking removal acid is guaranteed.

This invention discloses a method for preparing a multi-template molecularly imprinted polymer that selectively adsorbs multiple pigments and its application in solid-phase extraction packing. The method includes the following steps: mixing 50-80 mg of carboxyl-modified polymeric microspheres, 80-120 mL of template molecule-functional monomer complex, 80-110 μL of EGDMA, 50-80 μL of tetraethyl orthosilicate, 30-50 mg of AIBN, and 0.1-0.3 mL of ammonia water; degassing and deoxygenating the mixture; sealing the reaction chamber; Soxhlet extraction and elution to remove unreacted templates, crosslinking agents, and functional monomers; rinsing with an eluent; and purification and elution with a purification solution. After purification, centrifugation is performed to collect the precipitate, and the precipitate is dried to obtain the multi-template molecularly imprinted polymer that selectively adsorbs multiple pigments. This polymer is then mixed with PSA packing at a mass ratio of 2-6:5 to obtain the solid-phase extraction packing. The advantage of this method is that it effectively removes pigment matrix interference while ensuring analyte recovery.

The present invention relates to a method for preparing a multiplicity of containers of paints or pre-paints from separate vessels containing an aqueous solution of a rheology modifier, optionally an aqueous dispersion of an opacifying pigment, an aqueous dispersion of polymer particles, and an aqueous dispersion of organic polymeric microspheres. The process of the present invention provides a simple and cost-effective way of preparing a wide variety of a large quantity of contained and finished paints at point-of-sale.

The invention relates to a potting paste composition for honeycomb reinforcement having improved fire retardancy characteristics. The potting paste composition comprises (a) a curable polymer; (b) a curing agent for the curable polymer; (c) a fire retardant comprising an ammonium polyphosphate in combination with an ingredient selected from the group consisting of metal hydroxides, expandable graphites, liquid phosphate esters, phosphorous organic compounds or salts thereof, and zeolites; and (d) a filler selected from the group consisting of polymeric microspheres, hollow glass microspheres, and thixotropic fillers; wherein the potting paste has an uncured density determined by the method according to EN ISO 1183 of not more than 0.7100 g / cm3, preferably of at most 0.680 g / cm3, more preferably of at most 0.673 g / cm3, still more preferably of at most 0.660 g / cm3, even more preferably of at most 0.658 g / cm3, yet more preferably of at most 0.653 g / cm3 and in particular of at most 0.620 g / cm3; and wherein the total content of the fire retardant is at least 5.0 wt.-%, preferably at least 10 wt.-%, more preferably at least 15 wt.-%, relative to the total weight of the potting paste composition.

A polishing pad for chemical mechanical polishing comprises a polishing layer that comprises a polymer matrix that is the reaction product of an isocyanate terminated prepolymer with a curative, wherein the polymer matrix has hard segments and soft segments wherein multi-lobed polymeric elements formed from pre-expanded polymeric microspheres are present in the polymer matrix. The polishing pad can be made by preparing a pre-blend of the isocyanate terminated prepolymer and the pre-expanded fluid filled polymeric microspheres in a stirred tank; pumping a portion of the pre-blend from a bottom of the stirred tank through a conduit and recycling to a top region of the stirred tank, mixing a portion of the pre-blend with the curative to form a mixture, casting the mixture in a mold, curing the mixture in the mold.

A preparation method of the adsorbent resin comprises the following steps: S1, dispersing an oil-phase monomer, a pore-foaming agent and an initiator in a water-phase solution, and heating and stirring for reaction; s2, adding the polymeric microspheres into dichloroethane, heating, stirring and swelling, then adding chloromethyl ether and zinc chloride, and heating for reaction; s3, adding the chloromethylated microspheres into a solvent, stirring and swelling, dropwise adding ethanolamine, and heating and stirring for reaction; s4, introducing nitrogen, adding dichloroethane into the intermediate product, stirring for swelling, adding a catalyst, and heating and stirring for reaction; s5, performing Soxhlet extraction and vacuum drying on the post-crosslinked resin to obtain the hypercrosslinked adsorption resin. The adsorbent resin provided by the invention has an ultrahigh specific surface area.

The invention discloses a foil strain gauge preparation process, which comprises the following steps: uniformly spin-coating a transparent first glass substrate with a water-soluble adhesive mixed with first polymer microspheres, curing the water-soluble adhesive, and pasting a first metal foil on the water-soluble adhesive; preparing a polyimide coating on the first metal foil to obtain a first strain gauge crude body; the hydrosol layer is heated, so that the first liquid in the first polymeric microspheres is vaporized and expanded to damage the hydrosol layer, and the interface attaching tension is reduced; putting the first strain gauge crude body into a first stripping container filled with water, so that the water enters the hydrosol layer to thoroughly dissolve the hydrosol layer, stripping between the first glass substrate and the first metal foil is realized, and a second strain gauge crude body is obtained; and drying and etching the second strain gauge crude body to obtain the foil type strain gauge. The stripping efficiency and stripping quality of the metal foil in the preparation process are improved, damage to the metal foil is reduced, and the quality of foil type strain gauge products is improved.

The invention discloses a preparation method of oil-soluble monodisperse black polymeric microspheres, and relates to the technical field of polymeric microspheres. The preparation method comprises the steps of water-phase mother liquor preparation, water-in-oil emulsification, high-temperature sealing polymerization and water-phase removal and purification. The black polymeric microspheres prepared by the method have the advantages of excellent color rendering property, good dispersity, uniform particle size, low preparation cost and excellent oil solubility, and can be matched with a solid-phase carrier for a POCT reagent of an oil-phase detection system.

Described are ready-to-use injectable compositions comprising polymeric microspheres or microparticles of non-animal origin, a hydrogel comprising water and a cellulose-derivative gelling agent, and polysorbate 80. Further described are methods of using the ready-to-use injectable compositions for reparative or plastic surgery, esthetic dermatology, facial contouring, body contouring, and gingival augmentation.

Compositions, delivery assemblies, and methods for use or of medical imaging of a composition of a plurality of particles and fluid within a subject include delivering the composition of the plurality of particles and fluid into a target area of a body of the subject, the plurality of particles comprising a plurality of non-radioactive polymeric microspheres comprising a biocompatible material; imaging the plurality of particles of the composition disposed within the body of the subject using a medical imaging source disposed external to the body of the subject; and estimating a lung shunt activity, tumor to normal (T:N) ratio, or both based off the imaging of the plurality of particles of the composition at the target area using the medical imaging source.

The invention relates to a method for recovering 2, 5-hexanedione from p-xylene bio-based reaction liquid, which comprises the following steps: uniformly mixing a skeleton monomer, a cross-linking agent, a functional monomer, a pore-foaming agent, an initiator and a dispersing agent, and then carrying out suspension polymerization reaction; collecting the polymeric microspheres, removing the pore-foaming agent, and drying to obtain the polar macroporous adsorption resin for specific separation. A chromatographic column is filled with adsorption resin for column packing, and an adsorption resin separation system is formed; the method comprises the following steps: introducing a p-xylene bio-based reaction liquid containing 2, 5-hexanedione into an adsorption resin separation system, and further adsorbing and separating 2, 5-hexanedione in the p-xylene bio-based reaction liquid; and regenerating the resin by using an eluent, and collecting the 2, 5-hexanedione. Compared with the prior art, the method provided by the invention successfully realizes efficient recovery of p-2, 5-hexanedione from the p-xylene bio-based reaction liquid.

The invention describes an extended-release composition comprising PLGA or PLA polymeric microspheres comprising an isoxazoline, preferably sarolaner, and a macrocyclic lactone, preferably moxidectin, and wherein the composition further comprises at least one pharmaceutically acceptable excipient; and uses thereof.

The invention relates to the technical field of medicine packaging materials, and particularly discloses a double-layer injection molding gasket and a preparation method and application thereof. The double-layer injection molding gasket comprises a structural layer and a functional layer, the structural layer is a thermoplastic elastomer composition, and the functional layer is a coating composition; the thermoplastic elastomer composition is prepared from the following components in parts by weight: 40 to 80 parts of medical grade styrene thermoplastic elastomer, 25 to 40 parts of medical white oil, 5 to 10 parts of polyolefin resin, 0.2 to 1 part of high molecular weight hindered phenol antioxidant, 1 to 5 parts of functional adsorbent and 0.5 to 3 parts of interface compatilizer. The coating composition comprises the following components in parts by weight: 80-99 parts of a high-inertia polymer and 1-20 parts of a polymer microsphere supported stabilizer. Through multiple synergistic effects of physical screening and chemical targeting adsorption synergy, intelligent response release and interface chemical bridging, the contradiction between drug compatibility and interlayer binding force is solved from the source of a formula system.

A polishing pad for chemical mechanical polishing comprises a polishing layer which comprises a polymer matrix which is the reaction product of an isocyanate terminated oligomer or polymer, with a curative blend comprising two or more polyamine curatives wherein pores are present in the polymer matrix, such pores being formed by expansion of pre-expanded fluid filled polymeric microspheres such expansion occurring during reaction of the isocyanate terminated oligomer or polymer with the two or more curatives, wherein the polishing layer is characterized by one or more of a ratio of shear loss modulus (G″) at 104° C. to shear loss modulus (G″) at 150° C. of at least 5:1; and a specific gravity of the polishing layer is less than or equal to 95% of a calculated specific gravity for the isocyanate terminated oligomer or polymer, the curative blend and the pre-expanded fluid filled polymeric microspheres.

The invention relates to the technical field of lubricating grease, and particularly discloses an ultrahigh-rotation-speed lubricating grease composition and a preparation method thereof. The ultrahigh-rotating-speed lubricating grease composition is prepared from the following raw materials: 64 to 84.8 parts of base oil, 15 to 30 parts of a thickening agent, 1 to 5 parts of polymeric microspheres, 0.1 to 1 part of an antioxidant and 0.1 to 1 part of a corrosion inhibitor, and the polymeric microspheres are prepared from the following raw materials: alpha, omega-aminopropyl disiloxane, isocyanate and an amine chain extender. The ultrahigh-rotation-speed lubricating grease composition has excellent structure stability and anti-oxidation stability under the ultrahigh-rotation-speed working condition, can effectively lubricate under the extreme working condition, prolongs the service life of equipment, and can be suitable for the condition that the DN value reaches 2 million.

A polishing pad for chemical mechanical polishing comprises a polishing layer which comprises a polymer matrix which is the reaction product of an isocyanate terminated oligomer or polymer, with a curative blend comprising two or more polyamine curatives wherein pores are present in the polymer matrix, such pores being formed by expansion of pre-expanded fluid filled polymeric microspheres such expansion occurring during reaction of the isocyanate terminated oligomer or polymer with the two or more curatives, wherein the polishing layer is characterized by one or more of a ratio of viscous modulus (G″) at 104° C. to shear loss modulus (G″) at 150° C. of at least 5:1; and a specific gravity of the polishing layer is less than or equal to 95% of a calculated specific gravity for the isocyanate terminated oligomer or polymer, the curative blend and the pre-expanded fluid filled polymeric microspheres.

The invention relates to a foamable polymer composition comprising a polyolefin polymer which polyolefin polymer does not bear silane moieties and comprises 20 to 99.99 wt. % linear low density polyethylene, and a blowing agent in an amount of 0.01 to 3 wt. % based on the total foamable polymer composition, wherein the blowing agent consists of citric acid and / or derivatives of citric acid or mixtures thereof. Further the invention relates to a foamable polymer composition comprising a polyolefin polymer, and a blowing agent in an amount of 0.01 to 3 wt. % based on the total foamable polymer composition, wherein the blowing agent consists of expandable polymeric microspheres, and the composition does not comprise fluororesin.Further the invention relates to a foamed polymer composition obtained by foaming this foamable polymer composition. Further the invention relates to the use of the foamable composition or the foamed polymer composition for a layer of a cable and a cable comprising at least one layer which comprises the foamable polymer composition or the foamed polymer composition.

The present invention provides an integrated multilayer article comprising alternating layers, the integrated multilayer article comprising: a) at least two inner layers of elastomeric foam, the at least two inner layers of elastomeric foam being inner layers of the integrated multilayer article, and the at least two inner layers of elastomeric foam comprising: i) a first elastomeric material, and the following distributed in the first elastomeric material: ii) expanded polymeric microspheres; wherein the elastomeric foam inner layers alternate with: b) at least two alternating layers directly bonded to adjacent elastomeric foam inner layers; and wherein at least one of the alternating layers is an inner layer of the integrated multilayer article. Also provided are adhesive films comprising the integrated multilayer articles of the present disclosure, the adhesive films additionally comprising at least one pressure sensitive adhesive attachment layer that is an outermost PSA layer bonded directly to the first face of the integrated multilayer article and that can be used to attach the adhesive film to an adherend.

A polishing pad for chemical mechanical polishing is disclosed comprising a polishing layer comprising a polymeric matrix that is a reaction product of an isocyanate-terminated oligomer or polymer and a curative blend comprising two or more polyamine curatives, wherein there are voids in the polymeric matrix, such voids are formed by the expansion of pre-expanded fluid-filled polymeric microspheres, such expansion occurring during the reaction of the isocyanate-terminated oligomer or polymer and the two or more curatives, wherein the polishing layer is characterized by one or more of: a ratio of shear loss modulus (G") at 104°C to shear loss modulus (G") at 150°C of at least 5:1; and a specific gravity of the polishing layer that is less than or equal to 95% of the calculated specific gravities of the isocyanate-terminated oligomer or polymer, the curative blend, and the pre-expanded fluid-filled polymeric microspheres.

The present disclosure provides a kind of cationic polymer microspheres and its preparation method. Among them, the preparation method of cationic polymer microspheres includes: chain transfer agent, aromatic monomer, initiator are mixed in water and organic solvent, obtain mixed solution, wherein the chain transfer agent is the cationic macromolecular chain transfer agent with molecular weight greater than 8000, and the aromatic monomer includes at least two benzene ring structures;The mixed solution is vacuum sealed and heated to initiate polymerization and self-assembly process, to form cationic polymer microspheres.