A catalyst for treating the photoresist sewage by catalytic wet oxidizing process is prepared from the active component chosen from Pt, Pd, Rh and Ru, the auxiliary component chosen from La, Ce, Pr and Nd, and TiO2-ZrO2 carrier through baking at 60-180 deg.c for 2-18 hrs and calcining at 300-800 deg.C for 2-18 hrs. It is applied under the conditions: 220-280 deg.c for reaction temp, 4-8 MPa for reaction pressure, 50-300 for air/sewage ratio and 0.5-6/hr for space speed. Its advantages are high reaction efficiency, high removal rate of COD up to 99%, and high BOD5/CODcr ratio increased from 0.02 to 0.6.