Degradable polymer microspheres and preparing method thereof

A technology for degrading polymers and polymers, applied in the field of degradable polymer microspheres and their preparation, can solve the problems of polymer microspheres adhesion, agglomeration, and poor controllability of the size of the microspheres, etc., to prevent adhesion , The effect of uniform particle size distribution, simple and rapid preparation

Pending Publication Date: 2018-05-18
深圳市博立生物材料有限公司
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  • Abstract
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Problems solved by technology

These methods have poor control over the size of the microspheres, and are prone to the problem of polymer microspheres sticking or even agglomerating.

Method used

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  • Degradable polymer microspheres and preparing method thereof
  • Degradable polymer microspheres and preparing method thereof
  • Degradable polymer microspheres and preparing method thereof

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preparation example Construction

[0045] see Figure 1 to Figure 3, in some embodiments of the present invention, a method for preparing degradable polymer microspheres, comprising the following steps:

[0046] S1: dissolving the polymer in a volatile organic solvent to obtain a polymer solution;

[0047] S2: Under stirring conditions, inject the polymer solution obtained in S1 into the emulsifier aqueous solution through a thin tube using a flow pump;

[0048] S3: After the mixing is completed, continue stirring to remove the organic solvent to obtain a suspension;

[0049] S4: leave the suspension obtained in S3 to allow the polymer microspheres to fully settle, and discard the supernatant;

[0050] S5: The polymer microspheres are collected by filtration, washed and dried to obtain degradable polymer microspheres.

[0051] As mentioned above, the present invention combines the characteristics of the microfluidic method, and uses a thin pipeline in the emulsification-solidification method to limit the siz...

Embodiment 1

[0069] Accurately weigh 15g of L-polylactic acid (intrinsic viscosity 1.18dL / g, solvent chloroform) and dissolve it in 250mL of analytically pure dichloromethane as the organic phase; at the same time prepare 2500mL of PVA-210 aqueous solution as the water phase; (600rpm), using a peristaltic pump to slowly inject the above organic phase under the PVA aqueous solution at an injection rate of 4mL / min through a 12G needle. After the injection was completed, the mixture was stirred at 360 rpm for 12 hours to remove the solvent. Then let it stand for 1 hour, discard the supernatant, filter the precipitate, wash with deionized water three times, and freeze-dry to obtain polylactic acid microspheres.

Embodiment 2

[0070] Embodiment 2 (instilled in control group)

[0071] The preparation method of the organic phase and the aqueous phase is the same as in Example 1; the preparation method of the microspheres is the same as in Example 1 except for the following differences:

[0072] During the addition of the organic phase, the needle is positioned above the liquid surface of the water phase, and the organic phase is added to the water phase in the form of droplets.

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Abstract

The invention provides degradable polymer microspheres and a preparing method thereof. According to the characteristics of a micro flow method, a thin pipe is used in an emulsifying-curing method forpre-limiting the size of organic phases, and the organic phases are rapidly cut into microspheres of the preset size when being slowly injected into a large quantity of water phases. Organic solvent in the micron-level polymeric microspheres can be rapidly diffused into the water phases, and adhesion between the polymeric microspheres in the later period is avoided. According to the preparing method, the uniformity of the size of microspheres obtained with the traditional emulsifying-curing method is improved, the quality of the polymeric microspheres is improved, and the yield of the polymeric microspheres is increased. According to the preparing method for simply and rapidly preparing the degradable polymer microspheres with high uniformity, by deploying various technical parameters in the microsphere preparing process, the prepared microspheres are uniform in particle size distribution, the distribution coefficient of the diameter is 25% or below, and compared with particle size distribution of the microspheres prepared with a conventional multiple-emulsion method, the remarkable significance is achieved.

Description

technical field [0001] The invention relates to the field of preparation of degradable microspheres, in particular to a degradable polymer microsphere and a preparation method thereof. Background technique [0002] Degradable polymers represented by polylactic acid are widely used in the medical, pharmaceutical and beauty industries because they can be completely degraded into small molecules that are non-toxic to the human body in the human body. In particular, polymer microspheres and microcapsules have been intensively studied and used because of their high added value. At present, the methods for preparing microspheres from polymers mainly include emulsification solidification method, spray drying method, precipitation method, liquid surface expansion method and membrane emulsification technology. Among them, the emulsification and solidification method is widely used because of its simple equipment, convenient operation, and easy scale-up production. The following tec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/16C08L67/04
CPCC08J3/16C08J2367/04
Inventor 王建其吴姗姗崔涛周花香杜元皆张平
Owner 深圳市博立生物材料有限公司
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