67 results about "Membrane emulsification" patented technology

The invention discloses uniform-particle-size silk fibroin microspheres and a preparation method and application thereof.The preparation method comprises the following steps that a regenerated silk fibroin solution is taken and subjected to trypsin digestion to obtain modified silk fibroin sediment, and the modified silk fibroin sediment is dissolved in an aqueous solution of a beta-folding inhibitor to obtain a silk fibroin solution serving as a dispersed phase; emulsifying through an external pressure type membrane emulsifier to obtain an emulsion containing the silk fibroin emulsion droplets; adding a cross-linking agent into the emulsion to carry out cross-linking reaction, and then adding a crystallization inducer to induce crystallization to obtain primary silk fibroin microspheres; and performing vacuum freeze drying to obtain the silk fibroin microspheres. Silk fibroin is subjected to enzyme digestion modification, silk fibroin fragments with high beta-folding content are reserved, and high structural stability is achieved; the crystallinity of the microspheres is improved by adopting a membrane emulsification mode and combining a multiple crystallization induction method, and the silk fibroin microspheres with uniform particle size and smooth surfaces are obtained.

The invention provides a polycaprolactone microsphere as well as an interfacial membrane emulsification preparation method and application thereof, and the interfacial membrane emulsification preparation method comprises the following steps: firstly, respectively preparing a dispersion phase containing polycaprolactone and a continuous phase containing a surfactant, and then centrifugally mixing the dispersion phase containing polycaprolactone and the continuous phase containing the surfactant in a planetary centrifugal emulsifying machine to form emulsion droplets; and finally, stirring the emulsion droplets to volatilize the organic solvent, washing with water, centrifuging and drying to obtain the polycaprolactone microspheres. The interfacial membrane emulsification preparation method is simple in process, convenient to operate and short in consumed time, and meanwhile, the prepared polycaprolactone microspheres are very uniform in particle size distribution, relatively narrow in particle size distribution, good in sphericity and good in application prospect, and the appearance of the polycaprolactone microspheres is of a spherical structure.

The invention discloses a filler composition as well as a preparation method and application thereof. The preparation method of the filler composition comprises the following steps: A, preparation of polycaprolactone microspheres: (a) preparation of a water phase: adding a surfactant into purified water; the viscosity of the aqueous phase solution is 2-10cP, (b) preparing an organic phase: adding polycaprolactone into an organic solvent, (c) emulsifying and granulating: uniformly mixing the organic phase and the aqueous phase, emulsifying by using a membrane emulsifier, and preparing microspheres, (d) stirring and volatilizing: stirring to completely volatilize the organic solvent, and (e) collecting the microspheres; and B, preparation of a filler composition: (1) weighing a buffer solution, (2) adding a suspension stabilizer and polynucleotide and / or polydeoxynucleotide after filtration, and (3) adding polycaprolactone microspheres into the solution. The filler composition prepared by the invention can stimulate the growth of collagen, and can effectively avoid the defects of aggregation, pinhole blockage, nodule formation and the like during injection.

Non-aqueous membrane emulsion methods for producing polymeric and polymer-coated microparticles are provided. Some embodiments provide methods for producing a sustained release or controlled release microparticle by combining micronized protein powder and a polymer into a hydrocarbon solvent to form a non-aqueous first solution, agitating the first non-aqueous solution to form a suspension, feeding the suspension into a dispersion pump, wherein the suspension is infused through a porous membrane into a continuous phase comprising a fluorocarbon liquid and a fluorosurfactant to form a hydrocarbon-in-fluorocarbon emulsion. The hydrocarbon solvent, the fluorocarbon liquid, and the fluorosurfactant are removed, and the microparticles are collected.

The invention provides a poly-L-lactic acid microsphere. The poly-L-lactic acid microsphere is obtained by performing membrane emulsification on a poly-L-lactic acid-polyethylene glycol copolymer synthesized by taking lactide and polyethylene glycol as raw materials. According to the L-polylactic acid microspheres disclosed by the invention, the uniformity, the stability and the biocompatibility of the microspheres are improved, and meanwhile, the synthesis of skin collagen is promoted.

The invention provides donepezil sustained-release microspheres and a preparation method, a pharmaceutical preparation and application thereof. The preparation method comprises the following steps: forming a water phase (containing a surfactant, an osmotic pressure regulator and water, and regulating the pH value with a pH regulator); forming an oil phase (comprising donepezil, a carrier material and an organic solvent); and adding the oil phase into the water phase, dispersing to form a pre-emulsion, performing membrane emulsification on the pre-emulsion to form an emulsion, and finally curing, washing and freeze-drying the emulsion to obtain the donepezil sustained-release microspheres. The preparation process is stable and controllable, the batch-to-batch repeatability is good, the surface of the microsphere is smooth and complete, the particle size distribution is uniform, the size is controllable, the microsphere has high drug loading capacity, long-term stable release can be realized, the injectability is excellent, the administration frequency can be reduced, and the adverse reaction of gastrointestinal tracts can be reduced.

The invention relates to the technical field of compounds, in particular to poly-L-lactic acid microspheres for injection and a preparation method of the poly-L-lactic acid microspheres. The microspheres prepared under the condition of high-speed shearing dispersion or mechanical stirring are uniform in particle size, narrow in particle size range and good in reproducibility. A polylactic acid raw material with proper molecular weight is screened, microspheres are manufactured through a membrane emulsification method, then the microspheres with the required particle size are screened through a screening mechanism, and the surfaces of the microspheres are smooth.

The invention discloses an anisotropic Pickering emulsion, a preparation method of the anisotropic Pickering emulsion, polymer particles and a preparation method of the polymer particles, and relates to a method for preparing the anisotropic Pickering emulsion by utilizing a membrane emulsification technology and nano particle-polymer interface electrostatic co-assembly and further preparing the anisotropic polymer particles by taking the Pickering emulsion as a template. The method is simple, efficient, green and environmentally friendly, the shape and size of the prepared anisotropic particles are controllable, mass production can be achieved, and the method has wide application prospects in the fields of catalysis, separation, optics and the like.

The embodiment of the invention provides narrow-distribution PLA (polylactic acid) microspheres as well as a preparation method and application thereof. The preparation method comprises the following steps: dissolving a PLA material in an organic solvent to obtain a dispersed phase; based on the total volume of the dispersion phase, the concentration of the PLA material in the dispersion phase is 60-300 mg / mL; dissolving polyvinyl alcohol in hot water to obtain a continuous phase; the mass concentration of the polyvinyl alcohol in the continuous phase is 1.5-5% by taking the total weight of the hot water as 100%; enabling the dispersed phase and the continuous phase to form a stable primary emulsion by adopting a porous membrane tube through a membrane emulsification method; stirring the primary emulsion under an ice bath condition at the temperature of 10 + / -2 DEG C to obtain a cured emulsion; and sequentially centrifuging, screening, collecting and freeze-drying the cured emulsion to obtain the narrow-distribution PLA microspheres. The PLA microspheres prepared by the preparation method provided by the invention are smooth and regular in surface, free of cracks, not easy to adhere, narrow in particle size distribution and high in yield.

The present invention relates to a method and device for preparing biodegradable polymer microspheres, and an injection formulation preparation method using same and, more specifically, to a parallel-type continuous reaction membrane emulsification method and device which can not only adjust the size but also mass produce biodegradable polymer microspheres maintaining a uniform size while maintaining the spherical shape, and a method for preparing a microsphere injection same. According to the formulation composition comprising parallel-type continuous reaction membrane emulsification method and device for preparing biodegradable polymer microspheres according to one embodiment of the present invention, since the particle size of the biodegradable polymer microspheres can easily be adjusted, and also spherical particles of a uniform size can easily be prepared, the method and device are suitable for mass production. According to the injection formulation preparation method according to one embodiment of the present invention, the biodegradable polymer microspheres, which have a low injection pressure due to uniform particle size distribution and are optimized for drug encapsulation due to enhanced mechanical strength, may be utilized for an injection formulation for drugs or medical devices.

The invention provides a multicolor fluorescent microsphere, a tracer agent, a preparation method of the tracer agent and a detection method.The preparation method of the multicolor fluorescent microsphere comprises the steps that S1, a dispersion phase is provided, the dispersion phase comprises a hydrophilic polymer, a hydrophobic polymer, a hydrophilic fluorescent material, a hydrophobic fluorescent material and a non-polar solvent, and emission peaks of the fluorescent materials are different; providing a continuous phase, wherein the continuous phase comprises water and a surfactant; s2, respectively adding the dispersed phase and the continuous phase into an SPG film emulsifier, and extruding a film to form seed microspheres; removing the non-polar solvent to form a microsphere body; and S3, mixing the microsphere body solution, a monomer solution and an initiator, and carrying out polymerization reaction to form a shell layer coating the microsphere body, thereby obtaining the multicolor fluorescent microsphere.

The present application relates to a kind of surface patterning microspheres of uniform size and its preparation method and purposes, the preparation method includes: preparing W1 / O initial milk or oil phase O'; adding stabilizer and initiator synthesis W1 / O / W2 complex emulsion emulsion or O' / W2 single emulsion emulsion;Different surface patterning microspheres are prepared by rapid membrane emulsification method.The preparation method of the present application is simple in operation, mild condition, good batch repeatability and easy to enlarge.

The SPG membrane emulsifier comprises a shell, the upper end and the lower end of the shell are each provided with two counter bores, two membrane tubes are arranged in the shell, and the two ends of each membrane tube are located in the upper counter bores and the lower counter bores respectively; the upper end and the lower end of the shell are each connected with an interface piece. Two bosses are arranged at one end of the connector piece, stepped holes are formed in the bosses, the bosses are in butt joint in the counter bores, and the stepped holes wrap the ends of the membrane tube; and a sealing ring is arranged between the outer wall of the membrane tube and the inner wall of the counter bore. The shell is connected with a first flange, the interface piece is connected with a second flange, and the first flange and the second flange are connected through a knob bolt. And the sealing ring is tightly pressed by the boss. The outer wall of the shell is connected with an inlet pipe and an outlet pipe. The SPG membrane emulsifier with the limiting function aims to overcome the existing defects, and displacement of the membrane tube after installation is avoided.

The utility model relates to the field of heavy oil emulsification, in particular to a biological heavy oil emulsification combustion device which comprises a heavy oil storage tank, a combustion chamber and a combustion chamber. The combustion improver storage tank is used for storing a combustion improver; the water storage tank is used for storing water or an aqueous solution; the heavy oil storage tank and the combustion improver storage tank are connected to the mixer through pipelines, and then are connected to the first side of the dispersion medium in the membrane emulsifier through the mixer; the water storage tank is connected to the second side of the dispersion medium of the membrane emulsifier through a pipeline; moreover, a first flow control device is arranged on a pipeline for connecting the combustion improver storage tank and the mixer; the device further comprises a combustor connected to the first side of the dispersion medium and used for combusting the obtained emulsified oil as fuel, resource utilization of the biological heavy oil is achieved through the device, traditional fossil fuel can be partially replaced, and the contradiction between petroleum resource shortage and demand in China is solved.

The application discloses a high-drug-loading sustained-release microsphere and a preparation method and application thereof, and the raw materials of the microsphere comprise an active drug, a carrier material, a foaming pore-forming agent and a surfactant. In the microsphere preparation process, the SPG membrane emulsification method is adopted and the foaming pore-forming agent is added, so that the drug loading and the encapsulation efficiency of the microsphere can be effectively improved, the active drug can be released immediately and continuously and slowly, the injection amount and the injection volume of the microsphere are reduced, the release lag period of the drug-loaded microsphere is eliminated, and no oral supplement preparation needs to be combined in the early injection period, so that the patient compliance is improved.

The invention discloses a titanium dioxide slurry, a modified dispersant and a preparation method and application thereof, and the preparation method of the modified dispersant comprises the following steps: adding an organic dispersant into an ethanol aqueous solution, and uniformly mixing to obtain a mixed solution; enabling the mixed solution to penetrate through a membrane emulsifier to obtain a first mixture; mixing the first mixture with deionized water to obtain a second mixture; and adding an inorganic dispersant into the second mixture, and uniformly mixing to obtain the modified dispersant. The titanium dioxide dispersion agent is used for dispersing a titanium dioxide primary product, and in obtained titanium dioxide slurry, the concentration of titanium dioxide is 500-550 g / L; when the temperature is 25 DEG C, the viscosity of the slurry is 4.52-10.77 in 5 minutes; the viscosity of the slurry in 30 minutes is 5.17 to 10.76; the viscosity of the slurry in 60 minutes is 5.16 to 9.77. The dispersing agent is creatively made to penetrate through the membrane emulsifier, the physical property state of the dispersing agent is improved, the uniform and stable small-diameter dispersing agent liquid drop mixed liquid is prepared, the wetting and dispersing performance of the dispersing agent is greatly improved, rapid wetting and dispersing are achieved in the titanium dioxide dispersing process, and the dispersing and stabilizing time is shortened.

The invention relates to the field of heavy oil emulsification, in particular to a device and a method for emulsifying and combusting biological heavy oil, which are characterized in that biological heavy oil is used as a raw material, water or urea water or other aqueous solution containing low-concentration ammonia is used as an emulsifying medium, and enters a shell pass of membrane emulsifying equipment under a certain temperature condition; heavy oil emulsion is generated under a certain pressure condition with biological heavy oil doped with a certain proportion of combustion-supporting liquid in a tube pass and enters a combustor to be combusted, so that the aims of sufficiently combusting the biological heavy oil and reducing the emission of NOx in tail gas are fulfilled. Biomass fuel such as biodiesel and biological methanol can be adopted as combustion-supporting liquid in the process. Along with the emulsion combustion process, the system dynamically adjusts the proportion of the combustion-supporting liquid in time. A set of biological heavy oil emulsion combustion process scheme is designed aiming at the contents, so that resource utilization of the biological heavy oil is realized, part of traditional fossil fuel is favorably replaced, and the contradiction between petroleum resource shortage and demand in China is solved.

The invention discloses a preparation method of embolism microspheres, and belongs to the technical field of medical instruments. The preparation method of the embolism microspheres comprises the following steps: taking a water phase as a dispersion phase and an oil phase as a continuous phase, and preparing the embolism microspheres through a membrane emulsification method. Wherein the water phase comprises a water-soluble high-molecular polymer, a water-soluble monomer, a water-soluble cross-linking agent and an initiator. The oil phase comprises an oily solvent and an oil-soluble dispersant. The preparation method comprises the following steps: by taking a water phase containing a water-soluble high-molecular polymer as a dispersed phase, slowly pressing the dispersed phase into a flowing continuous phase through a membrane hole of a membrane emulsifier under nitrogen pressure by virtue of a membrane emulsification method, so as to form water-in-oil liquid drops with relatively uniform particle size distribution in the continuous phase; the water-soluble high-molecular polymer and the water-soluble monomer in the liquid drops can be cross-linked to form embolism microspheres under the action of an initiator, a cross-linking agent, a catalyst and the like. The embolism microsphere provided by the invention has good particle size distribution uniformity.

The present disclosure relates to a travoprost sustained release biodegradable intracameral Implant comprising a biodegradable hydrogel and travoprost particles. The present disclosure also relates to travoprost particles optionally obtained by or obtainable by a process comprising a membrane emulsification step. The present disclosure also relates to a method of manufacturing travoprost particles, optionally wherein the method comprises a membrane emulsification step. The present disclosure also relates to a method of manufacturing a travoprost sustained release biodegradable intracameral implant. The present disclosure also relates to a method of treating an ocular disease, such as glaucoma or ocular hypertension, comprising administering the travoprost particles or inserting the intracameral implant of the present disclosure into an eye of a subject in need of treatment.

The invention discloses a preparation method and application of PAM-Fe (CO) 5 microspheres for magnetocaloric ablation treatment, a novel magnetocaloric microsphere is prepared through an SPG membrane emulsification method, and magnetocaloric microsphere mediated noninvasive magnetocaloric ablation treatment of HCC is carried out. A research result shows that the PAM-Fe (CO) 5MSs can effectively heat and kill tumor cells under the action of AMF, and meanwhile, the T cell immune response of an organism is activated, so that the anti-tumor effect is remarkably improved. Especially, when the compound is combined with an immune checkpoint inhibitor PD-1mAb for use, the effector function of immune cells is enhanced and the growth of distant metastatic tumors is inhibited through the displayed synergistic effect.

The present application relates to a kind of multiple membrane emulsification device and the method for being used as the preparation of narrow particle size distribution microspheres, device includes first emulsification kettle and second emulsification kettle;The first emulsification kettle and the second emulsification kettle bottom are respectively connected first check valve and second check valve, two the first check valve is connected to porous membrane tube jacket and the membrane tube outer cavity formed by porous membrane tube, and the direction of conduction direction points to membrane tube outer cavity, two second check valve is connected to the membrane tube inner cavity of porous membrane tube, and the direction of conduction direction points to emulsification kettle, the porous membrane tube is arranged in the porous membrane tube jacket;The first emulsification kettle and the second emulsification kettle top are communicated pressure conversion mechanism, and the pressure conversion mechanism is used to control first emulsification kettle and second emulsification kettle to carry out pressure conversion, to drive emulsion to realize multiple membrane emulsification. Utilize multiple passage conversion valve control emulsification kettle between pressure difference conversion, drive emulsion multiple membrane emulsification, obtain uniform particle size emulsion, preparation solidification polymer microsphere.

The invention provides a construction method and application of lactoferrin-phospholipid-based emulsion with a three-layer breast milk fat globule membrane imitating structure, and belongs to the technical field of dairy products, the construction method comprises the following steps: carrying out ultrasonic treatment on lactoferrin to obtain emulsion with a single-layer membrane structure; piling phospholipid and cholesterol through a microporous membrane to obtain a microporous membrane with a bimolecular membrane; and carrying out electrostatic self-assembly secondary covering on the emulsion with the single-layer membrane structure and a microporous membrane with a bimolecular membrane to obtain the lactoferrin-phospholipid-based emulsion with the three-layer breast milk fat globule membrane imitating structure. The lactoferrin-phospholipid-based emulsion with the three-layer breast milk fat globule membrane imitating structure is used for preparing infant formula emulsion. The invention establishes a novel breast milk fat globule structure imitating emulsion construction method, namely a microporous membrane stacking-electrostatic self-assembly secondary covering combined ultrasonic-premixed membrane emulsification technology, and the method is simple in equipment, simple and convenient to operate, green and pollution-free, energy-saving and consumption-reducing, free of temperature rise and shear force input, and suitable for heat-sensitive and mechanical force-sensitive materials.

The invention relates to the technical field of compounds, in particular to poly-L-lactic acid microspheres for injection and a preparation method of the poly-L-lactic acid microspheres. The microspheres prepared under the condition of high-speed shearing dispersion or mechanical stirring are uniform in particle size, narrow in particle size range and good in reproducibility. A polylactic acid raw material with proper molecular weight is screened, microspheres are manufactured through a membrane emulsification method, then the microspheres with the required particle size are screened through a screening mechanism, and the surfaces of the microspheres are smooth.

An apparatus for polymer particle production by membrane emulsification comprising a tank (2) and a plurality of tubes (3), each tube comprising a membrane section (26) mounted within a first tank chamber (14a) of the tank (2), the first tank chamber (14a) configured to be connected to a source of a dispersed phase liquid, each tube comprising an inlet (22) configured to be connected to a source of a continuous phase, each membrane section (26) comprising a plurality of pores (28) extending through a wall (16) of the membrane section (26). Each tube (3) comprises an external tube section (27) extending through a casing (11) of the tank surrounding the first tank chamber, wherein the plurality of pores or perforations are confined to the membrane section (26) mounted within the first tank chamber (14a) of the tank (2), and wherein the external tube section (27) of each tube (3) is configured for connection to an emulsion processing unit (30). Also disclosed is a membrane tube, and a method for preparing biopolymer particles by membrane emulsification.

This invention discloses a uniform-size silk fibroin microsphere, its preparation method, and its application, comprising the following steps: taking a regenerated silk fibroin solution, digesting it with trypsin to obtain a modified silk fibroin precipitate, dissolving it in an aqueous solution of a β-sheet inhibitor to obtain a silk fibroin solution as the dispersed phase; emulsifying it using an external pressure membrane emulsifier to obtain an emulsion containing silk fibroin droplets; adding a cross-linking agent to the emulsion to carry out a cross-linking reaction, and then adding a crystallization inducing agent to induce crystallization to obtain primary silk fibroin microspheres; and freeze-drying under vacuum to obtain silk fibroin microspheres. This invention modifies silk fibroin by enzymatic digestion to retain silk fibroin fragments with high β-sheet content, exhibiting high structural stability; and uses membrane emulsification combined with a multiple crystallization induction method to improve the crystallinity of the microspheres, obtaining silk fibroin microspheres with uniform particle size and smooth surface.

The utility model relates to a device for low-carbon green manufacturing of glass by taking biological heavy oil as fuel power. Comprising a membrane emulsification system for producing a biological heavy oil W / O emulsion; the kiln system is used for realizing glass production by utilizing the biological heavy oil W / O emulsion; the medium-concentration product membrane separation system is used for capturing CO2 in flue gas produced in the glass production process at a time, part of produced medium-concentration CO2 product gas flows into the biological carbon sequestration system, and the other part of the produced medium-concentration CO2 product gas flows into the compensation type-high-concentration product membrane separation system after being pressurized; the biological carbon sequestration system is used for immobilizing and utilizing CO2 obtained by the medium-concentration product membrane separation system; and the compensation type-high-concentration product membrane separation system is used for carrying out secondary trapping and concentration on the medium-concentration CO2 product gas, and the produced high-concentration CO2 product gas is recycled to the membrane emulsification system.

The present invention discloses an emulsification apparatus and process for kadsura coccinea extract production, and relates to the technical field of kadsura coccinea extract emulsification, the apparatus comprises an emulsification tank, and further comprises: a negative pressure filtration mechanism installed inside the emulsification tank; the continuous membrane emulsifying mechanism is mounted in the negative pressure filtering mechanism; according to the invention, the negative pressure filtering mechanism is mounted to filter the kadsura coccinea extract by utilizing negative pressure generated by extrusion discharging, the filtering speed of the kadsura coccinea extract is increased through the negative pressure, impurities entering the ceramic membrane filter cartridge are further reduced, the time for the impurities to block membrane holes is prolonged, the service life of the ceramic membrane filter cartridge is prolonged, and the service life of the ceramic membrane filter cartridge is prolonged. The emulsion quality of the kadsura coccinea extract is improved, the liquid pressure in the ceramic membrane barrel is kept consistent by installing a liquid drop uniformity control mechanism, and the situation that the particle size difference of liquid drops is large due to inconsistent discharging speeds caused by unbalanced pressure during material extrusion is avoided.

The invention relates to a temperature change microcapsule preparation method, a temperature change microcapsule and an LED display module, the temperature change microcapsule preparation method comprises the following steps: preparing a core material dispersion liquid based on a core material component, preparing a shell material premix liquid based on a shell material component, combining the core material dispersion liquid and the shell material premix liquid to carry out film passing emulsification treatment to obtain emulsion particles, and carrying out staged UV curing treatment on the emulsion particles to obtain the temperature change microcapsule. The core-loaded microcapsule is obtained. And finally, depositing and curing a functional layer on the surface of the core-loaded microcapsule to obtain the temperature change microcapsule sequentially comprising the core material, the shell material and the functional layer from inside to outside. According to the scheme, the preparation process accuracy and application compatibility of the temperature change microcapsule can be effectively improved, and the problem that the temperature change microcapsule is poor in performance suitability and process compatibility in the application of an LED display screen is solved.

The invention discloses a device and a method for realizing low-carbon green manufacturing of glass by taking biological heavy oil as fuel power, and belongs to the technical field of chemical engineering. The device comprises a membrane emulsification system for producing a biological heavy oil W / O emulsion; the kiln system is used for realizing low-carbon preparation of the glass by utilizing the biological heavy oil W / O emulsion; the medium-concentration product membrane separation system is used for capturing CO2 in the flue gas and producing medium-concentration CO2 product gas; the biological carbon sequestration system is used for producing high-added-value products by utilizing metabolism of aquatic organisms, and fixing and utilizing CO2 by combining a CO2 photocatalytic mediating material and cooperating with an aquatic organism compatibilization technology; and the compensation-type high-concentration product membrane separation system is used for carrying out secondary concentration on the medium-concentration CO2 product gas. The biological heavy oil emulsion is used for replacing or partially replacing fossil fuel, carbon emission in the founding stage is reduced, CO2 in flue tail gas is captured, and the multifunctional CO2 gradient utilization process is formed.

The invention relates to the technical field of daily chemicals, in particular to a bacteriostatic and acarus-killing laundry detergent and a preparation method thereof. According to the laundry detergent, a multi-stage microcapsule technology is adopted, and intelligent controlled release of sterilization components is achieved through a gradient silicon shell structure and a chitosan quaternary ammonium salt nano-micelle system; the preparation method comprises the following steps: preparing an enzyme preparation and a protective agent into an internal phase solution, and performing membrane emulsification on the internal phase solution and a sodium alginate shell phase solution to form microcapsules; a single silicon shell structure is constructed through modification of a silane coupling agent; then reacting with a composite nano-micelle dispersion liquid and water glass to form a composite microcapsule; and finally, compounding with a surfactant to obtain a finished product. The invention solves the technical problem that the bio-enzyme and the bactericide in the traditional laundry detergent are difficult to coexist, and the product has the characteristics of high-efficiency bacteriostasis and acarus killing, long-acting enzyme activity maintenance and low skin irritation, and can meet the diversified requirements from daily cleaning to professional sterilization.