25 results about "Membrane emulsification" patented technology

The present application relates to a kind of surface patterning microspheres of uniform size and its preparation method and purposes, the preparation method includes: preparing W1 / O initial milk or oil phase O'; adding stabilizer and initiator synthesis W1 / O / W2 complex emulsion emulsion or O' / W2 single emulsion emulsion;Different surface patterning microspheres are prepared by rapid membrane emulsification method.The preparation method of the present application is simple in operation, mild condition, good batch repeatability and easy to enlarge.

The present application relates to a kind of multiple membrane emulsification device and the method for being used as the preparation of narrow particle size distribution microspheres, device includes first emulsification kettle and second emulsification kettle;The first emulsification kettle and the second emulsification kettle bottom are respectively connected first check valve and second check valve, two the first check valve is connected to porous membrane tube jacket and the membrane tube outer cavity formed by porous membrane tube, and the direction of conduction direction points to membrane tube outer cavity, two second check valve is connected to the membrane tube inner cavity of porous membrane tube, and the direction of conduction direction points to emulsification kettle, the porous membrane tube is arranged in the porous membrane tube jacket;The first emulsification kettle and the second emulsification kettle top are communicated pressure conversion mechanism, and the pressure conversion mechanism is used to control first emulsification kettle and second emulsification kettle to carry out pressure conversion, to drive emulsion to realize multiple membrane emulsification. Utilize multiple passage conversion valve control emulsification kettle between pressure difference conversion, drive emulsion multiple membrane emulsification, obtain uniform particle size emulsion, preparation solidification polymer microsphere.

The invention provides a construction method and application of lactoferrin-phospholipid-based emulsion with a three-layer breast milk fat globule membrane imitating structure, and belongs to the technical field of dairy products, the construction method comprises the following steps: carrying out ultrasonic treatment on lactoferrin to obtain emulsion with a single-layer membrane structure; piling phospholipid and cholesterol through a microporous membrane to obtain a microporous membrane with a bimolecular membrane; and carrying out electrostatic self-assembly secondary covering on the emulsion with the single-layer membrane structure and a microporous membrane with a bimolecular membrane to obtain the lactoferrin-phospholipid-based emulsion with the three-layer breast milk fat globule membrane imitating structure. The lactoferrin-phospholipid-based emulsion with the three-layer breast milk fat globule membrane imitating structure is used for preparing infant formula emulsion. The invention establishes a novel breast milk fat globule structure imitating emulsion construction method, namely a microporous membrane stacking-electrostatic self-assembly secondary covering combined ultrasonic-premixed membrane emulsification technology, and the method is simple in equipment, simple and convenient to operate, green and pollution-free, energy-saving and consumption-reducing, free of temperature rise and shear force input, and suitable for heat-sensitive and mechanical force-sensitive materials.

The invention relates to the technical field of compounds, in particular to poly-L-lactic acid microspheres for injection and a preparation method of the poly-L-lactic acid microspheres. The microspheres prepared under the condition of high-speed shearing dispersion or mechanical stirring are uniform in particle size, narrow in particle size range and good in reproducibility. A polylactic acid raw material with proper molecular weight is screened, microspheres are manufactured through a membrane emulsification method, then the microspheres with the required particle size are screened through a screening mechanism, and the surfaces of the microspheres are smooth.

This invention discloses a uniform-size silk fibroin microsphere, its preparation method, and its application, comprising the following steps: taking a regenerated silk fibroin solution, digesting it with trypsin to obtain a modified silk fibroin precipitate, dissolving it in an aqueous solution of a β-sheet inhibitor to obtain a silk fibroin solution as the dispersed phase; emulsifying it using an external pressure membrane emulsifier to obtain an emulsion containing silk fibroin droplets; adding a cross-linking agent to the emulsion to carry out a cross-linking reaction, and then adding a crystallization inducing agent to induce crystallization to obtain primary silk fibroin microspheres; and freeze-drying under vacuum to obtain silk fibroin microspheres. This invention modifies silk fibroin by enzymatic digestion to retain silk fibroin fragments with high β-sheet content, exhibiting high structural stability; and uses membrane emulsification combined with a multiple crystallization induction method to improve the crystallinity of the microspheres, obtaining silk fibroin microspheres with uniform particle size and smooth surface.

The utility model relates to a device for low-carbon green manufacturing of glass by taking biological heavy oil as fuel power. Comprising a membrane emulsification system for producing a biological heavy oil W / O emulsion; the kiln system is used for realizing glass production by utilizing the biological heavy oil W / O emulsion; the medium-concentration product membrane separation system is used for capturing CO2 in flue gas produced in the glass production process at a time, part of produced medium-concentration CO2 product gas flows into the biological carbon sequestration system, and the other part of the produced medium-concentration CO2 product gas flows into the compensation type-high-concentration product membrane separation system after being pressurized; the biological carbon sequestration system is used for immobilizing and utilizing CO2 obtained by the medium-concentration product membrane separation system; and the compensation type-high-concentration product membrane separation system is used for carrying out secondary trapping and concentration on the medium-concentration CO2 product gas, and the produced high-concentration CO2 product gas is recycled to the membrane emulsification system.

The invention relates to a temperature change microcapsule preparation method, a temperature change microcapsule and an LED display module, the temperature change microcapsule preparation method comprises the following steps: preparing a core material dispersion liquid based on a core material component, preparing a shell material premix liquid based on a shell material component, combining the core material dispersion liquid and the shell material premix liquid to carry out film passing emulsification treatment to obtain emulsion particles, and carrying out staged UV curing treatment on the emulsion particles to obtain the temperature change microcapsule. The core-loaded microcapsule is obtained. And finally, depositing and curing a functional layer on the surface of the core-loaded microcapsule to obtain the temperature change microcapsule sequentially comprising the core material, the shell material and the functional layer from inside to outside. According to the scheme, the preparation process accuracy and application compatibility of the temperature change microcapsule can be effectively improved, and the problem that the temperature change microcapsule is poor in performance suitability and process compatibility in the application of an LED display screen is solved.

The invention relates to the technical field of daily chemicals, in particular to a bacteriostatic and acarus-killing laundry detergent and a preparation method thereof. According to the laundry detergent, a multi-stage microcapsule technology is adopted, and intelligent controlled release of sterilization components is achieved through a gradient silicon shell structure and a chitosan quaternary ammonium salt nano-micelle system; the preparation method comprises the following steps: preparing an enzyme preparation and a protective agent into an internal phase solution, and performing membrane emulsification on the internal phase solution and a sodium alginate shell phase solution to form microcapsules; a single silicon shell structure is constructed through modification of a silane coupling agent; then reacting with a composite nano-micelle dispersion liquid and water glass to form a composite microcapsule; and finally, compounding with a surfactant to obtain a finished product. The invention solves the technical problem that the bio-enzyme and the bactericide in the traditional laundry detergent are difficult to coexist, and the product has the characteristics of high-efficiency bacteriostasis and acarus killing, long-acting enzyme activity maintenance and low skin irritation, and can meet the diversified requirements from daily cleaning to professional sterilization.

The application discloses a TiO2@MXene ceramic membrane, a preparation method and application in milk preparation or demulsification, wherein the preparation method comprises the following steps: at least one layer of MXene nanosheet is prepared by using a wet chemical etching method; and a TiO2@MXene ceramic membrane with a 0D-2D structure is prepared on a ceramic support by using a high-temperature in-situ oxidation method or a self-assembly method; the TiO2@MXene ceramic membrane has a unique 0D-2D sandwich structure, the transmission path of a dispersed phase is enlarged, and the transmission resistance of a separated phase between layers is reduced, which is of great significance for a hydrophilic membrane to be used in membrane emulsification for preparing monodisperse W / O emulsion with controllable particle size; meanwhile, the TiO2@MXene ceramic membrane exhibits excellent oil stain resistance and a low flux decay rate in an oil-water separation process, and is also of great significance for realizing a high-stable oil-water separation process.

The invention provides a polylysine-containing composite embedded particle and a continuous membrane emulsification preparation method thereof, and the method comprises the following steps: dissolving epsilon-polylysine and galactose araban in water to obtain an internal water phase, mixing mixed MCT oil, phospholipid, polyglycerol fatty acid ester and hinokiol to obtain an external membrane oil phase, and carrying out continuous membrane emulsification on the external membrane oil phase to obtain the polylysine-containing composite embedded particle. Mixing the inner water phase and the outer membrane oil phase in a membrane emulsification mode to obtain W / O type primary emulsion; mixing polyglycerol fatty acid ester, cetostearyl alcohol, glycerol and water to obtain an out-of-membrane water phase, and mixing the W / O primary emulsion and the out-of-membrane water phase in a secondary membrane emulsification manner to obtain W / O / W multiple emulsion; the W / O / W multiple emulsion and maltodextrin are uniformly mixed in water and then spray-dried to obtain composite embedded particles containing polylysine, and stable encapsulation of epsilon-polylysine is realized by adopting an efficient and mild encapsulation technology.

Membrane emulsification can be performed using a membrane (16) having a microstructured surface. In some examples, a first side (50) of the membrane is contacted with a phase to be dispersed and the second side (52) of the membrane is contacted with a second liquid that is immiscible with the phase to be dispersed. The membrane includes microstructures formed on at least the second side of the membrane, e.g., to control the wettability of the membrane. The phase to be dispersed can be dispersed through a plurality of through holes (46) extending through the membrane to form droplets (48) and polymer beads formed from the droplets.

The invention discloses a self-repairing hydrophobic discontinuous air diffusion electrode, a preparation method and an application in electro-catalysis. The preparation method comprises the following steps: preparing a silicone oil-in-water emulsion by using a membrane emulsification method; preparing SiO2 silicone oil microspheres with a core-shell structure on the surface of the silicone oil emulsion by using a Stober method; preparing a self-repairing hydrophobic discontinuous air diffusion electrode by using a spraying method; the SiO2-coated silicone oil microsphere has a unique mesoporous structure, silicone oil can be periodically released from mesopores, the electrowetting resistance of an air diffusion electrode is improved, and the hydrophobic SiO2-coated silicone oil microsphere is of great significance in electrocatalytic efficient preparation of H2O2; and meanwhile, the method also has important significance for preparing an anti-electrowetting air diffusion electrode.

The invention discloses a device and method for large-scale preparation of liquid drops with uniform particle size, and belongs to the technical field of multi-channel membrane emulsification, and the device comprises a micro-channel emulsification membrane, a first chamber and a second chamber. The micro-channel structure is composed of an outlet, an inlet and a channel connecting the outlet and the inlet, wherein the outlet comprises a rectangular first groove and second grooves located in the two sides of the short edge of the outlet and communicated with the first groove. And etching a plurality of micro-channel structures on the thin film in an array manner to form the micro-channel emulsion film for preparing liquid drops with uniform particle sizes. And uniformly dispersing the curable dispersion phase in the continuous phase under the action of surface tension by using the emulsified film to form liquid drops with uniform particle size, then curing the liquid drops to form microspheres, and cleaning to obtain the microspheres with uniform particle size. The device provided by the invention can generate liquid drops and microspheres with more uniform particle sizes at a higher speed, the amplification process is easy, and the device is suitable for large-scale preparation of liquid drops and microspheres with uniform particle sizes.

The invention belongs to the technical field of medicine preparation, and particularly relates to a perampanel sustained release microsphere, a pharmaceutical preparation and a preparation method based on membrane emulsification. The invention firstly provides a preparation method which comprises the following steps: (1) dissolving perampanel and a polylactic acid-glycolic acid copolymer in an organic solvent to prepare an oil phase; (2) preparing a water phase; (3) adding the oil phase into the water phase to prepare a pre-emulsion; (4) adding the pre-emulsion into a membrane emulsifier, and dispersing to obtain an emulsion; and (5) curing to obtain the drug microspheres. By strictly controlling the membrane emulsification process, the drug microspheres with uniform size and stable quality are obtained.

The present disclosure provides a process for preparing biopolymer particles, the process comprising emulsifying a dispersed phase film into a continuous phase, wherein the dispersed phase comprises a biopolymer in a solvent, and wherein the dispersed phase forms an emulsion of the biopolymer in the continuous phase through the film; and phase inversion with an antisolvent to form particles of the biopolymer; wherein prior to (b), the emulsion is cooled to a temperature T1. Also provided are biopolymer particles obtained from the process.

The invention relates to the technical field of microsphere preparation, and discloses a system for preparing liposome polymer microspheres by using a through-hole tubular filter membrane and a control method. The system for preparing the liposome polymer microspheres by using the through-hole tubular filter membrane comprises a membrane emulsification device, the membrane emulsification device comprises a plurality of tubular filter membranes; the plurality of tubular filter membranes are arranged in parallel; an outer flow channel is formed between every two adjacent tubular filter membranes; an inner flow channel is formed in the tubular filter membrane in the axial direction of the tubular filter membrane, a plurality of micropores are formed in a tube arm of the tubular filter membrane, and the outer flow channel is communicated with the inner flow channel through the micropores. By arranging a plurality of tubular filter membranes in parallel, a large amount of raw materials can be synchronously treated, the microsphere yield in unit time is remarkably improved, the bottleneck of low efficiency of a traditional single filter membrane is overcome, the device is suitable for industrial enlarged production, and the problems that in the prior art, the yield of a membrane emulsification device is limited, and the production efficiency is low in a large-scale emulsification scene are solved. A plurality of film emulsifying devices need to be arranged to participate in the emulsifying process at the same time, so that the cost of the emulsifying process is relatively high.

The invention relates to the technical field of dynamic membrane production equipment, and discloses a dynamic membrane emulsifying and homogenizing device which comprises a supporting sleeve and a limiting disc, the top end of the supporting sleeve is fixedly connected with a driving motor, the output end of the driving motor is fixedly connected with a rotating shaft, and a mixing and defoaming mechanism is arranged on the outer side of the limiting disc. The mixing and bubble eliminating mechanism is used for rapidly mixing the raw materials and eliminating large bubbles generated during mixing, and a supporting, clamping and fixing mechanism is arranged on the outer wall of the supporting sleeve. The driving motor drives the rotating shaft to rotate, the limiting disc drives the inclined guide pipe to generate centrifugal suction force, upper-layer liquid is sucked in and guided to the bottom, meanwhile, the shaftless auger pushes bottom-layer liquid upwards, two layers of liquid collide and are mixed in the middle, and the I-shaped beating plate beats and scatters the liquid and pushes the liquid outwards; bubbles are extruded and broken, so that emulsification, homogenization and defoaming are realized.

This disclosure provides a method for preparing biopolymer particles. The method comprises: membrane emulsification of a dispersed phase in a continuous phase, where the dispersed phase comprises the biopolymer in a solvent, and where passage of the dispersed phase through the membrane forms an emulsion of the biopolymer in the continuous phase; and phase inversion with an antisolvent to form biopolymer particles; wherein, prior to step (b), the emulsion is cooled to temperature T1. Biopolymer particles obtained from the method are also provided.

An apparatus for manufacturing polymer particles via membrane emulsification includes a tank (2) and a plurality of tubes (3), each tube including a membrane segment (26) mounted within a first tank chamber (14a) of the tank (2), the first tank chamber (14a) being configured to be connected to a source of a dispersed phase liquid, each tube including an inlet (22) configured to be connected to a source of a continuous phase, each membrane segment (26) including a plurality of pores (28) extending through a wall (16) of the membrane segment (26). Each tube (3) includes an outer tube segment (27) extending through a shell (11) of the tank surrounding the first tank chamber, wherein the plurality of pores or perforations are confined to the membrane segment (26) mounted within the first tank chamber (14a) of the tank (2), and wherein the outer tube segment (27) of each tube (3) is configured to be connected to an emulsion processing unit (30). Membrane tubes and a method for preparing biopolymer particles via membrane emulsification are also disclosed.

The invention provides a construction method of an emulsion with a three-layer breast milk-imitating fat globule membrane structure and application of the emulsion in preparation of a high-end infant formula emulsion, and belongs to the technical field of dairy products, the construction method comprises the following steps: carrying out membrane emulsification on lactoferrin and sphingosine to obtain an emulsion with a single-layer membrane structure; stacking the milk fat globule membrane phospholipid and cholesterol through a microporous membrane to obtain a microporous membrane with a bimolecular membrane; and carrying out electrostatic self-assembly secondary covering on the emulsion with the single-layer membrane structure and a microporous membrane with a bimolecular membrane to obtain the emulsion with the three-layer breast milk imitating fat globule membrane structure. The emulsion with the three-layer breast milk-imitating fat globule membrane structure is used for preparing high-end infant formula emulsion. The invention establishes a novel breast milk fat globule structure imitating emulsion construction method, which combines microporous membrane piling-electrostatic self-assembly secondary covering with direct membrane emulsification-premixed membrane emulsification technology, has the advantages of simple equipment, simplicity and convenience in operation, greenness, no pollution, energy conservation, consumption reduction, no temperature rise and high shear force input, and is suitable for heat-sensitive and mechanical force-sensitive materials.

The present invention provides a method of high-density cell culture comprising at least the following steps: S1: obtain hydrogel microcapsules through membrane emulsification; S2: encapsulate a selected number of cells per each obtained hydrogel microcapsule, and S3: culture the encapsulated cells in a cell culture medium. The invention further refers to Human Pluripotent Stem Cells (hPSCs) obtained through the above-described method, in particular for use in medicine, more in particular for use in a method of in vitro generation of mature megakaryocytes.

This application provides a hierarchical porous aerogel thin film and an in situ confined liquid membrane, as well as methods for producing and using the same. The hierarchical porous aerogel thin film has micron-sized pores distributed on its surface, micron-sized channels, submicron-sized channels, and nano-sized three-dimensional network mesopores distributed within the hierarchical porous aerogel thin film, and pores corresponding to the micron-sized channels, submicron-sized channels, and nano-sized three-dimensional network mesopores are simultaneously distributed across the cross section of the hierarchical porous aerogel thin film. The hierarchical porous aerogel thin film can form an aerogel-based confined liquid membrane in situ during membrane emulsification and emulsion separation. The aerogel-based confined liquid membrane has excellent drag reduction and combines membrane emulsification and emulsion separation functions. When used in membrane emulsification, it can produce emulsions with a uniform size distribution, and when used in emulsion separation, it can achieve an oil-water separation efficiency of over 99%.

The invention relates to a continuous hydrogenation-assisted metal sodium deep desulfurization system and method, which are used for solving the problems of limited reaction interface, low sodium utilization rate, dependence on high-pressure hydrogen compensation and the like of metal sodium in the field of deep desulfurization in fuel oil. A cross-flow membrane emulsification (CF-ME) technology is introduced into a metal sodium desulfurization system, and an ultrafine sodium emulsion is prepared by regulating and controlling emulsification parameters, so that a reaction interface is greatly improved. A normal-pressure hydrogen compensation mechanism is adopted, a circular flow simulation plug flow system is designed, and an interface Na2S deposition layer is continuously stripped by utilizing fluid disturbance. 0 # diesel oil is used as a complex system for verification and shows that the desulfurization efficiency and the sodium utilization rate are synergistically improved by optimizing reaction parameters, and the desulfurization rate meets the deep desulfurization standard. According to the invention, normal-pressure continuous operation of metal sodium desulfurization is realized for the first time, and key technical support is provided for industrial amplification.

This invention discloses an integrated digital nucleic acid detection chip based on vertically perforated membrane emulsification and its application. The chip's main structure consists of three layers: upper, middle, and lower. The upper layer is the main part, including a nucleic acid extraction and purification zone, a vertically perforated membrane emulsification droplet generation zone, and a digital isothermal amplification and detection zone. The chip uses a vertically perforated membrane to prepare uniformly sized microdroplets, reducing the requirements for chip manufacturing processes and improving the uniformity of microdroplet size. This reduces the complexity of subsequent image recognition and artificial intelligence algorithm development, improving the scientific rigor and accuracy of the detection results. In this chip, nucleic acid quantification uses absolute quantification, eliminating the need for plotting working curves and avoiding errors caused by standards. Furthermore, by integrating nucleic acid extraction, purification, amplification, and digital detection onto a single chip, it achieves integrated nucleic acid detection with a "sample in - result out" process.

The invention discloses an MXene / ZIF-8 composite membrane for preparing a monodisperse water-in-diesel nano-emulsion and a preparation method of the MXene / ZIF-8 composite membrane, and belongs to the technical field of membrane emulsification. Aiming at the problems of uncontrollable emulsion droplet size, poor stability, easy instability during combustion and the like caused by strong hydrophilicity and wide pore size distribution of a traditional ceramic membrane, a ceramic tube is used as a support body, and a composite membrane with a regular two-dimensional heterogeneous channel is constructed by alternately loading TiCTxMXene nanosheets and ZIF-8 nanosheets. The ZIF-8 nanosheet is used as a nano spacer to be inserted between MXene layers, so that self-stacking is effectively inhibited, the interlayer distance is regulated and controlled, meanwhile, the surface of the membrane is endowed with the under-oil super-hydrophobic characteristic, and a unique'slippage-rolling 'droplet separation mechanism is formed. The composite film can be used for directly preparing the monodisperse water-in-diesel nano-emulsion with the average particle size of less than 100nm and the PDI of less than 0.13 at room temperature. Combustion performance contrast experiments show that the obtained nano-emulsion can still maintain stable combustion under the high water content of 20%, the flame stability is remarkably superior to that of a traditional submicron emulsion, NOx and CO emission is greatly reduced, and a new technical path is provided for clean and efficient utilization of high-water-content emulsion fuel.