Functional nanometer particle composite non-crosslinking microspheres and preparation method and application thereof

A nanoparticle and functional technology, applied in the field of functional nanoparticle composite non-crosslinked microspheres and its preparation, can solve the problem that the performance of functional particles is easily affected by the polymerization reaction environment, and there is no functional nanoparticle composite noncrosslinked microsphere. Problems such as microspheres, microsphere structure phase separation, etc., to achieve accurate and reliable detection results, small coefficient of variation, and excellent performance

Inactive Publication Date: 2013-02-06
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this method still faces the following problems: the particle size distribution is wide when preparing micron-scale composite microspheres, the performance of functional particles is easily affected by the polymerization reaction environment, and there may be phase separation between the functional particles and the formed microsphere structure
[0014] However, there have been no reports on the successful preparation of functional nanoparticle composite non-crosslinked microspheres using membrane emulsification technology.

Method used

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  • Functional nanometer particle composite non-crosslinking microspheres and preparation method and application thereof
  • Functional nanometer particle composite non-crosslinking microspheres and preparation method and application thereof
  • Functional nanometer particle composite non-crosslinking microspheres and preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0066] Example 1 Preparation of composite non-crosslinked microsphere powder (1)

[0067] Polystyrene-acrylic acid copolymer and gold nanoparticles were dissolved in toluene, the concentration of polystyrene-acrylic acid copolymer was 1 g / mL, and the concentration of gold nanoparticles was 1 nM / L, which was used as the dispersed phase. The MPG porous membrane with a pore size of 0.5 μm is used, and the dispersed phase is squeezed through the membrane by nitrogen at a pressure of 30 KPa, and enters the water continuous phase containing an emulsifier SDS concentration of 1 wt.%, and the flow rate of the continuous phase is 0.35 m / s , to obtain an oil-in-water emulsion with uniform droplet size. Stir and volatilize at 25 °C and 350 rpm magnetic stirring. After the toluene in the solution was completely volatilized, the obtained gold nanoparticle composite microsphere suspension was collected by centrifugation. Afterwards, it was centrifuged and washed three times with deioniz...

Embodiment 2

[0068] Example 2 Preparation of composite non-crosslinked microsphere powder (2)

[0069] Polystyrene-maleic anhydride copolymer and CdSe / CdS quantum dots with an emission wavelength of 528 nm were dissolved in toluene with a polymer concentration of 1 g / mL and a quantum dot concentration of 1 nM / L as the dispersed phase . A SPG porous membrane with a pore size of 5 μm is used, and the dispersed phase is squeezed through the membrane by nitrogen at a pressure of 15 KPa, and then enters a water continuous phase containing an emulsifier SDS concentration of 1 wt.%, and the flow rate of the continuous phase is 0.35 m / s , to obtain an oil-in-water emulsion with uniform droplet size. Stir and volatilize at 25 °C and 350 rpm magnetic stirring. After the toluene in the solution is completely volatilized, the obtained suspension of quantum dot-labeled fluorescent microspheres is collected by centrifugation. After that, it was centrifuged and washed three times with deionized wate...

Embodiment 3

[0072] Example 3 Preparation of composite non-crosslinked microsphere powder (3)

[0073] Polystyrene and Fe 3 o 4 Magnetic nanoparticles were dissolved in chloroform with a polystyrene concentration of 0.5 g / mL, Fe 3 o 4 The concentration of magnetic nanoparticles was 1 nM / L, which was used as the dispersed phase. The SPG porous membrane with a pore size of 4 μm was used, and the dispersed phase was squeezed through the membrane by nitrogen at a pressure of 21 KPa, and entered into the water continuous phase containing 0.5 wt.% emulsifier SDS and 0.5 wt.% stabilizer PVA. The flow velocity was 0.40 m / s, and an oil-in-water emulsion with uniform droplet size was obtained. Stir and volatilize at 25 °C and 350 rpm magnetic stirring. After the chloroform in the solution was completely volatilized, the obtained microsphere suspension was separated and collected by magnetic force. and centrifuged with deionized water for 3 times, with absolute ethanol for 3 times, and freeze...

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Abstract

The invention relates to functional nanometer particle composite non-crosslinking microsphere powder, and a preparation method and application of the functional nanometer particle composite non-crosslinking microsphere powder. The functional nanometer particle composite non-crosslinking microsphere powder contains functional nanometer particle composite non-crosslinking microspheres; the functional nanometer particle composite non-crosslinking microspheres contain functional nanometer particles and polymers, average particle size is 0.1micron to 20micron, and particle size distribution variable coefficient is less than or equal to 9.1%. The preparation method is a combination of a membrane emulsification technique and a solvent volatilization method. The invention also relates to a biometric probe and application of the biometric probe based on the above composite non-crosslinking microsphere powder. The preparation method has the advantages that the functional nanometer composite non-crosslinking microsphere powder which is uniform in particle size can be prepared; the prepared functional nanometer composite non-crosslinking microspheres belong to micron order, the particle size variable coefficient is small, monodispersity is good, and performance is excellent; and the prepared functional nanometer composite non-crosslinking microspheres have broad application prospect in biometric and biomedical fields and the like.

Description

technical field [0001] The invention relates to the field of preparation and application of micro-nano materials, in particular, functional nanoparticle composite non-crosslinked microspheres and a preparation method and application thereof. Background technique [0002] Functional nanoparticle composite microsphere refers to a functional composite microsphere obtained by combining functional nanoparticles and microspheres by a certain method. At present, nanoparticles prepared by various methods have various special optical, electrical, magnetic and biological characteristics, so these characteristics are often endowed to the microsphere itself after being combined with the microsphere. Microspheres also provide support and effective protection for these nanoparticles. At the same time, the chemical and physical properties of the microspheres themselves, such as light sensitivity, pH responsiveness, temperature sensitivity, adsorption properties, and surface active functio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02G01N21/64A61K47/32A61K47/34A61K47/36A61K47/42
Inventor 孙康孙锟窦红静李万万沈立松王刚王露王解兵
Owner XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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