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Micro-capsule ultrasonic contrast agent and preparation method thereof

A technology of ultrasound contrast agent and microcapsule, which is applied in the direction of echo/ultrasound imaging agent, microcapsule, capsule delivery, etc. It can solve the problem that the size of the microcapsule is not concentrated, it is difficult to control and adjust the particle size and particle size of the microcapsule Distribution and other issues

Active Publication Date: 2013-12-11
厦门富源堂投资管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the size of the microcapsules prepared by the above method is not concentrated, and it is difficult to control and adjust the particle size and particle size distribution of the microcapsules. Therefore, it is urgent to invent a preparation method that can control the particle size and optimize the particle size distribution.

Method used

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  • Micro-capsule ultrasonic contrast agent and preparation method thereof
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  • Micro-capsule ultrasonic contrast agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1, preparation of microcapsule type ultrasound contrast agent

[0043] PLA with a number average molecular weight of 5,000 was dissolved in dichloromethane to prepare a 1 mg / mL solution. After the solution was mixed with water at a volume ratio of 40:1, it was ultrasonicated for 240 seconds at a power of 500 watts to obtain a water-in-oil primary emulsion. At a stirring speed of 2000 rpm, the primary emulsion obtained above was dropped into 50 times the volume of the primary emulsion in an aqueous solution of polyvinyl alcohol (5%, mass concentration), and stirred for 1 minute. The resulting mixed system was poured into a storage tank of a rapid membrane emulsification device (with a membrane pore size of 7 microns), and passed through the membrane 10 times under a nitrogen pressure of 180 kPa. The obtained water-in-oil-in-water multiple emulsion was stirred at room temperature for 24 hours at a speed of 60 rpm / membrane minute. The product was collected by ...

Embodiment 2

[0046] Embodiment 2, preparation of microcapsule type ultrasound contrast agent

[0047] PLGA having a number average molecular weight of 20,000 was dissolved in dichloromethane to prepare a 2 mg / mL solution. After the solution was mixed with water at a volume ratio of 35:1, it was ultrasonicated for 70 seconds at a power of 350 watts to obtain a water-in-oil primary emulsion. At a stirring speed of 1000 rpm, the primary emulsion was dropped into an aqueous solution of polyvinyl alcohol (5%, mass concentration) 40 times the volume of the primary emulsion, and stirred for 25 minutes. The resulting mixed system was poured into a storage tank of a rapid membrane emulsification device (with a membrane pore size of 7 microns), and passed through the membrane once under a nitrogen pressure of 50 kPa. The obtained water-in-oil-in-water multiple emulsion was stirred at room temperature at a speed of 150 rpm for 9 hours. The product was collected by centrifugation. The resulting pro...

Embodiment 3

[0050] Embodiment 3, preparation of microcapsule type ultrasound contrast agent

[0051] PLC with a number average molecular weight of 50,000 was dissolved in chloroform to prepare a 4 mg / mL solution. After the solution was mixed with water at a volume ratio of 30:1, it was ultrasonicated for 90 seconds at a power of 450 watts to obtain a water-in-oil primary emulsion. At a stirring speed of 120 rpm, the primary emulsion was dropped into an aqueous solution of polyvinyl alcohol (4.5%, mass concentration) 35 times the volume of the primary emulsion, and stirred for 30 minutes. The resulting mixed system was poured into a storage tank of a rapid membrane emulsification device (with a membrane pore size of 8 microns), and passed through the membrane 7 times under a nitrogen pressure of 140 kPa. The obtained water-in-oil-in-water multiple emulsion was stirred at room temperature at a speed of 80 rpm for 18 hours. The product was collected by centrifugation. The resulting produc...

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Abstract

The invention discloses a micro-capsule ultrasonic contrast agent and a preparation method thereof. The preparation method comprises the following steps of (1) dissolving biodegradable high polymer materials into an organic solvent to obtain a solution marked as a solution A, and dissolving a stabilizer into water to obtain a solution marked as a solution B; (2) mixing the solution A with water, and carrying out ultrasonic treatment to obtain a water-in-oil primary emulsion; (3) adding the primary emulsion into the solution B, and stirring to obtain an oil-in-water-in-water pre-composite emulsion; (4) adding the pre-composite emulsion into a membrane emulsification device for passing through the membrane to obtain an oil-in-water-in-water composite emulsion; (5) stirring and centrifuging the oil-in-water-in-water composite emulsion, and collecting the precipitate to obtain the micro-capsule ultrasonic contrast agent. The ultrasonic contrast agent is sent into the part of the human body to be detected through injection and intravenous perfusion, vibrates under the action of the ultrasonic so as to change the ultrasound characters of the tissue, and increases the contrast ratio between the lesion tissue and the normal tissue as well as between the motion part and the static part, thereby playing an ultrasonic developing effect.

Description

technical field [0001] The invention relates to a microcapsule ultrasonic contrast agent and a preparation method thereof. Background technique [0002] At present, the commonly used medical imaging diagnostic techniques in clinical practice include nuclear magnetic resonance, X-ray and ultrasound. Due to the advantages of safety, wide applicability, intuitiveness, high sensitivity, low cost, non-invasiveness, and portability, ultrasonic diagnosis has become the most commonly used method in current medical imaging diagnosis. Ultrasonic diagnostic technology is a technology that uses the difference in strength of reflected and scattered signals of ultrasonic waves at the interface of human tissue to display the normal and abnormal information of the structure and function of internal tissues and organs of the organism, so as to achieve the purpose of disease diagnosis. Although the ultrasonic imaging method has a good diagnosis and localization effect for the tissue structur...

Claims

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Application Information

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IPC IPC(8): A61K49/22A61K9/50
Inventor 吴德成刘宝霞杨飞
Owner 厦门富源堂投资管理有限公司
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