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Chitosan microsphere and preparation method thereof

A technology of chitosan microspheres and chitosan, which is applied in the preparation of microspheres and microcapsule preparations, can solve the problems of difficulty in regulating the particle size and distribution of microspheres, harsh conditions, and uneven particle sizes, and achieve The effect of mild conditions, simple process and broad application prospects

Active Publication Date: 2021-11-12
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The chitosan microspheres prepared by the above methods generally have the disadvantages of uneven particle size, harsh conditions, and difficulty in controlling the particle size and distribution of the microspheres.

Method used

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  • Chitosan microsphere and preparation method thereof
  • Chitosan microsphere and preparation method thereof
  • Chitosan microsphere and preparation method thereof

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preparation example Construction

[0029] The invention provides a kind of preparation method of chitosan microsphere, comprises the following steps:

[0030] a) dissolving the modified chitosan in an organic solvent, then adding a crosslinking agent to obtain a modified chitosan oil solution; then adding the modified chitosan oil solution to an emulsifier aqueous solution for pre-emulsification, Obtain an oil-in-water pre-emulsion;

[0031] b) The oil-in-water pre-emulsion obtained in step a) is subjected to rapid membrane emulsification, and the obtained emulsion is centrifuged to collect the precipitate after stirring; finally, the obtained precipitate is successively washed with water and freeze-dried to obtain chitosan microspheres; The membrane used in the rapid membrane emulsification is an SPG membrane with a pore size of 1 μm to 9 μm.

[0032] In the invention, firstly, the modified chitosan is dissolved in an organic solvent, and then a crosslinking agent is added to obtain the modified chitosan oil ...

Embodiment 1

[0063] Preparation of modified chitosan microspheres:

[0064] (1) carboxymethyl chitosan is dissolved in methylene chloride, is made into the solution of 50mg / ml, wherein adds the sodium trimetaphosphate of carboxymethyl chitosan quality 25%; Under the stirring speed of 1800r / min , adding the above-mentioned solution to 50 times the volume of a 2% polyvinyl alcohol aqueous solution and stirring for 1 minute to obtain a pre-emulsion.

[0065] (2) Pour the pre-emulsion obtained in step (1) into a rapid membrane emulsification device, and pass through the membrane 5 times under 0.2MPa inert gas pressure; the obtained emulsion is stirred at room temperature for 10h at a speed of 360r / min; the product is collected by centrifugation, After the product was washed several times with water, it was freeze-dried to obtain microspheres with an average particle diameter of 500 nm.

[0066] The scanning electron micrograph of the chitosan microsphere that the preparation method that the e...

Embodiment 2

[0068] Preparation of modified chitosan microspheres:

[0069] (1) hydroxypropyl chitosan is dissolved in ethyl acetate, is made into the solution of 100mg / ml, wherein adds the sodium trimetaphosphate of carboxymethyl chitosan quality 25%; Under the stirring speed of 800r / min , adding the above solution to 10 times the volume of 5% polyvinyl alcohol aqueous solution and stirring for 1 minute to obtain a pre-emulsion.

[0070] (2) Pour the pre-emulsion obtained in step (1) into a fast membrane emulsification device, and pass through the membrane 5 times under 0.2MPa inert gas pressure; the obtained emulsion is stirred at room temperature for 10h at a speed of 400r / min; the product is collected by centrifugation, After the product was washed several times with water, it was freeze-dried to obtain microspheres with an average particle size of 1 μm.

[0071] The scanning electron micrograph of the chitosan microsphere that the preparation method that the embodiment of the present...

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Abstract

The invention provides a chitosan microsphere and a preparation method thereof. The preparation method comprises the following steps: a) dissolving modified chitosan in an organic solvent, and then adding a cross-linking agent to obtain a modified chitosan oil solution; adding the modified chitosan oil solution into an emulsifier aqueous solution for pre-emulsification to obtain an oil-in-water pre-emulsion; b) carrying out rapid membrane emulsification on the oil-in-water pre-emulsion obtained in the step a), stirring the obtained emulsion, centrifuging, and collecting the precipitate; and finally, sequentially washing and freeze-drying the obtained precipitate to obtain the chitosan microsphere. The membrane adopted in the rapid membrane emulsification is an SPG membrane, and the aperture of the membrane is 1-9 microns. Compared with the prior art, the preparation method adopts a rapid membrane emulsification method, and the chitosan microspheres with uniform particle size distribution can be finally obtained by adjusting membrane emulsification process parameters, controlling the size of the microspheres and optimizing the particle size distribution of the microspheres.

Description

technical field [0001] The invention relates to the technical field of microsphere preparation, and more specifically relates to a chitosan microsphere and a preparation method thereof. Background technique [0002] Chitosan, also known as deacetylated chitin, soluble chitin, is a natural polysaccharide chitin deacetylated product, is a kind of renewable and easily degradable environment with good biocompatibility and cell affinity Friendly polymer material. Chitin is widely distributed in nature, its reserves are second only to cellulose, it is the second largest natural polymer, and it is inexhaustible. Chitosan has been more and more used in the fields of chemical engineering and biomedicine. However, natural chitosan has poor solubility, low mechanical strength, poor chemical stability, and difficult processing and molding, which greatly limits its application. The properties of the chemically modified chitosan derivatives can be greatly improved, laying the foundatio...

Claims

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Application Information

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IPC IPC(8): C08J3/16C08L5/08B01J13/02
CPCC08J3/16B01J13/02C08J2305/08
Inventor 王明哲黄宇彬齐延新潘勇郝登远何喜东李晓媛
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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