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1063 results about "Creaming" patented technology

Creaming, in the laboratory sense, is the migration of the dispersed phase of an emulsion, under the influence of buoyancy. The particles float upwards or sink, depending on how large they are and how much less dense or more dense they may be than the continuous phase, and also how viscous or how thixotropic the continuous phase might be. For as long as the particles remain separated, the process is called creaming.

Preparation method for stable fatty alcohol emulsion

A preparation method for a stable fatty alcohol emulsion. A silane coupling agent is used for carrying out surface modification on silicon dioxide to finally obtain modified silicon dioxide, and the modified silicon dioxide is adsorbed on the interface of defoaming active substances and water, so that the active substances are dispersed, the problem of product creaming caused by aggregation is avoided, and the defoaming performance of the product is improved; in addition, during emulsification, a non-ionic surfactant and an acrylate polymer act synergistically to emulsify the active substances, so that the stability of the emulsion is further improved.
Owner:JIANGSU SIXIN SCI-TECH APPL RES INST CO LTD

Stable organic silicon emulsion and preparation method thereof

PendingCN119775592APolymer scienceGlycerol
According to the stable organic silicon emulsion and the preparation method thereof provided by the invention, polyglycerol ricinoleate with different polymerization degrees, polydihydric alcohol oleate with different molecular weights and silicon polyether are introduced, so that the emulsifying capacity of the emulsion is improved, and the stability of the emulsion is improved; the polyglycerol ricinoleate serving as an emulsifier and a stabilizer can disperse water-soluble substances and oil-soluble substances, so that all the components are uniformly mixed, the emulsification is more sufficient, and the stability of the emulsion is improved; the emulsion enters the emulsification pump for emulsification under the condition of high rotating speed, so that the particle size of the emulsion is smaller, and the stability is better.
Owner:JIANGSU SIXIN SCI-TECH APPL RES INST CO LTD

High-stability endotoxin-free PHA nano-emulsion and preparation method thereof

The invention discloses a high-stability endotoxin-free PHA nano-emulsion and a preparation method thereof, and belongs to the technical field of biodegradable high polymer material compositions and processing thereof. The nano-emulsion is characterized in that the endotoxin content is not higher than 0.10 EU / g, the median particle size d50 is 100-200 nm, and the PDI is not higher than 0.15, and the nano-emulsion is stable in long-term storage. The preparation method is a continuous solvent-free process and comprises the steps of melt extrusion, high-pressure thermal emulsification and deep endotoxin removal. By adopting the specific pH-insensitive cationic polymer emulsifier and the crystallization inhibitor, the chemical contradiction that an efficient alkaline purification process is incompatible with a nano-emulsion stable system is solved, physical aging is inhibited, and an unexpected technical effect is obtained. The invention also discloses an O / W type cream containing the nano emulsion.
Owner:DU BAI CHENG NEW MATERIAL TECH (SHANGHAI) CO LTD +1

Method for determining critical safety diameter of emulsion drop of liquid energetic material synthesis reaction conveying pipeline

The invention discloses a method for determining the critical safety diameter of an emulsion drop of a liquid energetic material synthesis reaction conveying pipeline, which comprises the following steps of: curing and heating a sampled emulsion, determining pyrolysis kinetic parameters of the detected emulsion, constructing a heat production and heat transfer heat insulation system model of a mixed solution of an acid ester emulsion and the emulsion drop by utilizing Comsol, and determining the critical safety diameter of the emulsion drop of the liquid energetic material synthesis reaction conveying pipeline. Calculating a temperature rise change rule of the mixed liquid heat insulation system under different emulsion droplet sizes, determining a function relationship between the emulsion droplet particle size and the temperature rise of the mixed liquid heat insulation system, and deriving to obtain the critical safety diameter of the emulsion droplet; the method comprises the following steps: adsorbing emulsified liquid by using a porous particle material, testing whether the emulsified liquid explodes due to collision and friction of emulsified liquid with different pore diameters at different rates in an impact tank-piston device to obtain the relationship among the movement rate of emulsified liquid drops, the particle size of the emulsified liquid drops and the explosion risk, and determining the explosion risk of the emulsified liquid drops under a specific conveying speed condition according to the relationship. The liquid energetic material is used for synthesizing the optimal size of emulsified liquid drops in a reaction mixed solution.
Owner:NANJING UNIV OF SCI & TECH

Emulsification cooling device

To provide an emulsification cooling device capable of increasing the contact area between a cooling liquid and an emulsion, enhancing the cooling effect, reducing precipitation of the emulsion, and accelerating discharge to reduce clogging. [Solution] The present invention is an emulsification cooling device including a can body 1 with a cooling mechanism 2 attached inside and a mixing mechanism 3 attached to the bottom, wherein the cooling mechanism includes a spiral tube, the spiral tube is attached inside the can body, a flow groove is opened penetrating the inside of the inner wall of the can body, a spiral plate is attached inside the flow groove, an identical water supply pipe is welded to the top of the spiral tube and the flow groove, and an identical drain pipe is welded to the bottom of the spiral tube and the flow groove, the inside of the inner wall of the can body is hollow, the water supply pipe and the drain pipe are attached penetrating the top of the can body and a position near the bottom end of the outer periphery, and the spiral tube is located inside the can body and arranged in a spiral shape.
Owner:WEISHUO (SHANGHAI) DAILY NECESSITIES CO LTD

Preparation process and product of intragastric volume hydrogel

The invention relates to the field of hydrogel materials, in particular to a preparation process of intragastric volume hydrogel, a product and application. The preparation process comprises the following steps: S1, preparing a KGM filtrate: adding konjaku flour into an acid solution for swelling, performing high-temperature treatment after swelling, and then adding an alkali solution to terminate the reaction to obtain the KGM filtrate; s2, preparing an oil phase mixture; s3, preparing KGM particles: mixing the oil phase mixture and the KGM filtrate, stirring and emulsifying, and then adding a cross-linking agent for cross-linking reaction to obtain the KGM particles; s4, hydrogel preparation: washing the KGM particles, and freeze-drying to obtain KGM microspheres, namely a hydrogel product. According to the invention, the konjac flour is selected as a main raw material to prepare the intragastric volume hydrogel particles, and the obtained product has good hydrophilicity, different swelling characteristics and an adjustable degradation period, can prolong the emptying time of the hydrogel in the stomach, and has a wide application prospect.
Owner:SHANGHAI RUINING BIOTECH CO LTD

Emulsifier-free face cream and preparation method thereof

The invention belongs to the technical field of cosmetics, and particularly relates to an emulsifier-free face cream and a preparation method thereof. The face cream provided by the invention is mainly prepared from the following components in parts by weight: 50 to 67 parts of water, 10 to 40 parts of grease, 5 to 25 parts of a humectant, 0.2 to 0.7 part of a thickening agent, 0.5 part of a preservative and 0.1 to 0.4 part of a pH (Potential of Hydrogen) regulator. According to the face cream provided by the invention, the system stability can be kept without adding an emulsifier, the requirement on the compatibility of the used grease is low, the high stability of the system can be kept only by adjusting the melting point of the oil phase, and the grease proportion of the system can reach 40%. The system is extremely low in irritation, more friendly to sensitive skin, capable of rapidly dissolving water in use, free of sticky feeling after being smeared and capable of providing strong moistening feeling after being absorbed. Compared with a traditional emulsification system, the preparation process has a relatively wide requirement on a homogenizing temperature range, and the temperature is kept above the melting point of an oil phase during homogenizing dispersion.
Owner:FUJIAN PIENTZEHUANG COSMETICS CO LTD +1

Pregabalin sustained-release type dissolving microneedle patch based on PLGA microspheres as well as preparation method and application of pregabalin sustained-release type dissolving microneedle patch

The invention provides a pregabalin slow-release type dissolving microneedle patch based on PLGA microspheres as well as a preparation method and application thereof. The method comprises the following steps: dissolving pregabalin and hyaluronic acid in deionized water to form an inner water phase (W1); dissolving PLGA in dichloromethane to form an organic phase (O); performing ultrasonic emulsification on the internal water phase and the organic phase to form W / O primary emulsion; rapidly adding the primary emulsion into an external water phase (W2) containing PVA and NaCl to form a W1 / O / W2 type multiple emulsion, and then carrying out solvent evaporation curing, centrifugal washing and freeze drying to obtain PLGA (at) PG microspheres; and uniformly dispersing the PLGA (at) PG microspheres in a hyaluronic acid solution, adding into a microneedle mold, vacuumizing, centrifuging, drying, and demolding the microneedle to obtain the dissolution type microneedle patch. By optimizing microsphere preparation, drug sustained release and microneedle patch preparation technologies are realized, and an efficient, safe and continuous local delivery platform is provided.
Owner:ZHONGNAN HOSPITAL OF WUHAN UNIV

Method and system for evaluating emulsification stability of high pour-point oil

PendingCN119124943Ahigh freezing pointhigh wax contentTransmissivity measurementsThermodynamicsActive agent
The embodiment of the invention provides a method and system for evaluating the emulsification stability of high pour-point oil, and the method comprises the steps: carrying out the constant temperature of an initial emulsion according to a preset temperature, the initial emulsion containing the high pour-point oil and a target surfactant; when the constant temperature reaches a preset duration, controlling the initial emulsion to be mixed under a rotation condition to obtain a target emulsion; according to a preset time interval, obtaining an average particle size of a dispersed phase in the target emulsion and a stability index of the target emulsion to obtain a plurality of average particle sizes and a plurality of stability indexes; and evaluating the stability of the target emulsion according to the plurality of average particle sizes and the plurality of stability indexes. According to the technical scheme provided by the embodiment of the invention, the emulsification stability of the high pour-point oil can be accurately evaluated, so that the screening of the surfactant can be guided.
Owner:PETROCHINA CO LTD

Whitening and soothing composition, nano microemulsion containing same and preparation method of nano microemulsion

The invention relates to a whitening and soothing composition, a nano microemulsion containing the same and a preparation method of the nano microemulsion. The whitening and soothing composition comprises a litchi fruit extract, a quercus root extract, a malt extract and palmitoyl tripeptide-5. According to the functional composition, the litchi fruit extract, the oak root extract, the malt extract and the palmitoyl tripeptide-5 are creatively combined for use, so that the functional composition has excellent skin whitening and soothing effects, and the four components have an obvious synergistic interaction effect in the aspects of whitening and soothing the skin; the functional composition can be widely applied to cosmetics with related functions. The nano micro-emulsion prepared from the functional composition is subjected to shearing emulsification and then high-pressure micro-jet treatment, so that the prepared nano micro-emulsion is better in stability and better in appearance property, and the nano micro-emulsion can stably play a role in whitening and relieving for a long time.
Owner:GUANGZHOU SHANGYUE BIOTECHNOLOGY CO LTD

Chitosan nanocapsule as well as preparation method and application thereof

The invention relates to the technical field of functional materials, in particular to a chitosan nanocapsule as well as a preparation method and application thereof. The preparation method of the chitosan nanocapsule comprises the following steps: (a) mixing and emulsifying a chitosan solution, an oil-in-water emulsifier and essential oil to form an oil-in-water emulsion, adding an aqueous solution of sodium tripolyphosphate into the oil-in-water emulsion, and stirring to obtain a first mixture; (b) adding the first mixture into an oil phase solvent containing a water-in-oil emulsifier, and stirring to obtain a multiple emulsion; and (c) adding an aqueous solution of a dialdehyde cross-linking agent into the multiple emulsion, carrying out a cross-linking reaction, collecting a solid-phase substance, and drying. The physical / chemical double-crosslinking chitosan nanocapsule is obtained by utilizing physical crosslinking between the chitosan and the sodium tripolyphosphate and chemical crosslinking between the chitosan and the binary aldehyde crosslinking agent, so that the encapsulation efficiency and the encapsulation efficiency of the nanocapsule are remarkably improved; meanwhile, the nanocapsule also has pH responsiveness and has a slow release effect after pH response.
Owner:DONGHUA UNIV +1

High-bioaccessibility calcium emulsifying and embedding system and preparation method thereof

The invention provides a preparation method of a calcium emulsifying and embedding system with high bioaccessibility, which comprises the following steps: S1) heating and mixing biomacromolecules and an emulsifier in water to obtain a water phase; the biomacromolecules are protein colloids and / or polysaccharide colloids; the method comprises the following steps: heating and mixing a calcium source substance and anhydrous cream to obtain an oil-solid phase; and S2) mixing the oil-solid phase with a water phase, and emulsifying to obtain the calcium emulsifying and embedding system. Compared with the prior art, the preparation method has the advantages that the natural macromolecular protein and / or polysaccharide with high nutritional value is used as a carrier, the calcium source substance is embedded through a water-oil-solid three-phase emulsification technology, and the preparation method is simple, easy to operate, low in cost and environmentally friendly; in addition, a water-oil-solid three-phase homogenized emulsion is created, the problem that the dispersion stability of milk mineral salt in a liquid food matrix is poor is effectively solved, release of free calcium ions in the small intestine environment can be promoted, and the calcium bioaccessibility is remarkably improved.
Owner:INNER MONGOLIA YILI IND GROUP CO LTD

Water-blocking microcapsule and fish oil composite hair beautifying ointment and preparation method thereof

The invention provides a water-blocking microcapsule, a fish oil composite hair beautifying ointment and a preparation method, and relates to the technical field of animal health products. The water-blocking microcapsule is a solid particle formed by a core material and a wall material coating the core material; the core material is fish oil emulsion subjected to bile salt emulsification treatment; the wall material sequentially comprises an inner-layer wall material and an outer-layer wall material from inside to outside; the inner-layer wall material is a wall material formed by solidifying alginate; and the outer-layer wall material is a water-blocking wall material which is arranged outside the inner-layer wall material and is made of nanocrystalline cellulose. The water-blocking microcapsule provided by the invention realizes multiple beneficial effects of efficient digestion and absorption of fish oil, improvement of palatability, enhancement of oxidation resistance and stability, fixed-point release of intestinal tracts and the like, provides an innovative technical scheme for development of animal health products, and has wide application prospects and market values.
Owner:SHENZHEN REDRAY BIOTECHNOLOGY CORP LTD

Application of particle stabilizer, oil-in-oil Pickering emulsion as well as preparation method and application of oil-in-oil Pickering emulsion

The invention discloses application of a particle stabilizer, an oil-in-oil Pickering emulsion as well as a preparation method and application of the oil-in-oil Pickering emulsion, and relates to the technical field of emulsion preparation. The particle stabilizer is used for preparing the oil-in-oil Pickering emulsion, and the particle stabilizer is solid insoluble nanoparticles and is selected from one or more of inorganic nanoparticles, organic nanoparticles, composite oleophobic nanoparticles and stimuli-responsive nanoparticles. The preparation method of the oil-in-oil Pickering emulsion comprises the following steps: mixing the first oil phase, the second oil phase and the particle stabilizer, and carrying out an emulsification technology to obtain the oil-in-oil Pickering emulsion. According to the emulsion system prepared by the invention, the oil phase components with different polarity differences are reasonably matched, and the oil phase type is flexibly selected according to specific requirements of target application, so that the environmental adaptability and the function application range of the emulsion can be remarkably improved, and the emulsion system has a good application prospect.
Owner:WUHAN XIRUISI NEW MATERIAL TECH CO LTD +1

Skin bacteriostatic cream and preparation method thereof

The invention relates to the field of bacteriostatic cream, and particularly discloses skin bacteriostatic cream and a preparation method thereof. The skin antibacterial cream is prepared from the following raw materials in parts by weight: 4 to 6 parts of bran coat extract, 2 to 4 parts of chlorhexidine salt, 2 to 4 parts of rutin extract, 1 to 3 parts of carnosine, 0.5 to 0.8 part of sodium hyaluronate, 0.8 to 1.2 parts of film-forming agent and 5 to 8 parts of purified water. The preparation method comprises the following steps: mixing the film-forming agent and a part of water, and uniformly stirring to obtain a film-forming agent solution; the preparation method comprises the following steps: mixing sodium hyaluronate and water, heating, stirring until the sodium hyaluronate and the water are completely dissolved, adding the cavings extract, the rutin extract, the chlorhexidine salt and the carnosine, stirring until the mixture is uniformly dispersed, heating to 75-85 DEG C, emulsifying for 25-35 minutes, homogenizing, adding a film-forming agent solution into the homogenized emulsion, and stirring, concentrating, degassing and discharging the paste in vacuum to obtain the antibacterial paste. The composition can be used for diminishing inflammation and resisting bacteria of damaged skin, and has the advantages of being high in antibacterial rate and capable of avoiding skin pigmentation.
Owner:HANGZHOU YIPIN XINWUFENG PHARMA CO LTD

Emulsion type amino acid cleaning product and preparation method thereof

The invention discloses an emulsified amino acid cleaning product and a preparation method thereof, and belongs to the technical field of cosmetics. According to the emulsified amino acid cleaning product provided by the invention, the components with proper mass percent are selected, and the components have a good compounding effect, so that the obtained emulsified amino acid cleaning product has good foaming performance, is rich, fine and stable in foam, and is fine and smooth in paste and excellent in stability; after use, the percutaneous moisture loss of the skin can be effectively reduced, and the water-retaining property of the skin is improved.
Owner:GUANGZHOU BAFEORII CHEM

Pickering emulsion as well as preparation method and application thereof

The invention relates to Pickering emulsion, a preparation method and application thereof, and belongs to the technical field of emulsion preparation, and the preparation method comprises the following steps: S1, preparing a water phase: uniformly mixing and stirring gluten protein zymolyte obtained after gluten protein enzymolysis with polydextrose and a phosphoric acid buffer solution, heating in a water bath, and cooling to obtain the water phase; s2, preparation of an oil phase: dissolving fat-soluble active substances in edible oil to prepare the oil phase; s3, emulsion preparation: mixing the water phase and the oil phase, performing high-speed dispersion treatment, and homogenizing to obtain Pickering emulsion; the gluten protein zymolyte and the polydextrose conjugate are prepared by utilizing the Maillard reaction, and the emulsibility and the stability of the Pickering emulsion can be remarkably improved by taking the gluten protein zymolyte and the polydextrose conjugate as the emulsifier.
Owner:HENAN AGRICULTURAL UNIVERSITY

Cosmetic

To provide a powder-containing cosmetic with superior stability, dischargeability and usability.SOLUTION: A cosmetic has a container having a spout with a diameter of 1 to 9 mm, filled with an oil-in-water emulsion composition. The oil-in-water emulsion composition includes (A) a specific powder, (B) a higher alcohol, (C) a surfactant, (D) oil, and (E) water.SELECTED DRAWING: None
Owner:SHISEIDO CO LTD

Moisturizing anti-wrinkle cream and preparation method thereof

The invention provides moisturizing and anti-wrinkle cream and a preparation method thereof. The moisturizing and anti-wrinkle cream is prepared from the following raw materials in percentage by mass: 2%-10% of fibroin composite microsphere solution, 2%-5% of skin conditioner, 1%-2% of emollient, 8%-15% of humectant, 0.1%-1% of emulsifier, 1%-2% of emulsion stabilizer, 0.1%-0.2% of thickener and the balance of water. Wherein the fibroin composite microsphere is a spherical aggregate obtained by interpenetrating and entangling fibroin and poly-desoxyribonucleic acid in a cation environment and folding and compressing the fibroin and the poly-desoxyribonucleic acid; the composite microspheres can be percutaneously absorbed, and when the composite microspheres are applied to a formula of cream, the percutaneous permeation efficiency of the cream is greatly improved, and the moisturizing and anti-wrinkle effects of the cream are improved.
Owner:BEIJING AOSMEI BIOTECHNOLOGY CO LTD

A method for preparing a bulk emulsion gel phantom that mimics animal fat

The application belongs to the technical field of plant raw material processing, and particularly relates to a preparation method of a blocky emulsion gel product simulating animal fat, which is formed based on a soybean protein and sodium alginate composite base and comprises the following steps: (1) mixing pure water, soybean protein and sodium alginate, then shearing at high speed, and dispersing and emulsifying in perilla oil; (2) adding gluconolactone, stirring and mixing, then immediately adding calcium carbonate while stirring, to form a first gel network; (3) after stirring, pouring into a mold for shaping, placing in a 4 DEG C refrigerator for gelation, forming a second protein network, and obtaining a simulated fat product with strong stability. The application forms a simulated fat with a complex double-network structure under the action of two kinds of inducing agents by constructing a protein-polysaccharide composite gel system, improves the stability and oiliness of the gel, and expands the cooking adaptability of the simulated fat.
Owner:BEIJING TECH & BUSINESS UNIV

Liquid crystal emulsion compound for promoting toner permeation as well as preparation method and application of liquid crystal emulsion compound

The invention provides a liquid crystal emulsion compound for promoting toner permeation as well as a preparation method and application thereof, and belongs to the technical field of personal care products. According to the invention, oleyl alcohol polyether and P2O5 are subjected to an esterification reaction, the product is hydrolyzed and then is mixed and stirred with oleyl alcohol polyether sodium sulfate, stearyl alcohol sodium sulfate and oleic acid MEA salt / ammonium salt to prepare the liquid crystal emulsified compound, and the liquid crystal emulsified compound is used for preparing emulsion and cream, can form a stable and uniform liquid crystal phase, and can be used for preparing the liquid crystal. The hair dye can be used as an additive to be applied to daily chemicals (especially permanent hair dyeing products), so that the stability of the products, the saturation degree of the hair dyeing products on hair and the color persistence after dyeing are remarkably enhanced; and the permanent hair dyeing paste with strong pearlescent appearance and moderate paste viscosity can be easily prepared.
Owner:GUANGZHOU DIAOLING FINE CHEM CO LTD

Donepezil sustained-release microspheres, and preparation method, pharmaceutical preparation and application thereof

The invention provides donepezil sustained-release microspheres and a preparation method, a pharmaceutical preparation and application thereof. The preparation method comprises the following steps: forming a water phase (containing a surfactant, an osmotic pressure regulator and water, and regulating the pH value with a pH regulator); forming an oil phase (comprising donepezil, a carrier material and an organic solvent); and adding the oil phase into the water phase, dispersing to form a pre-emulsion, performing membrane emulsification on the pre-emulsion to form an emulsion, and finally curing, washing and freeze-drying the emulsion to obtain the donepezil sustained-release microspheres. The preparation process is stable and controllable, the batch-to-batch repeatability is good, the surface of the microsphere is smooth and complete, the particle size distribution is uniform, the size is controllable, the microsphere has high drug loading capacity, long-term stable release can be realized, the injectability is excellent, the administration frequency can be reduced, and the adverse reaction of gastrointestinal tracts can be reduced.
Owner:HUILLY PHARMA CO LTD

High-absorption side-leakage-preventing 3D liquid sanitary towel and preparation method thereof

The invention belongs to the technical field of daily necessities, and particularly relates to a high-absorption side-leakage-preventing 3D liquid sanitary towel and a preparation method thereof. A high-absorption side-leakage-prevention 3D liquid sanitary towel sequentially comprises a surface layer, an absorption layer and a leakage-prevention layer from top to bottom. The preparation method of the absorption layer comprises the following steps: (1) introducing a first oil phase, a water phase A and a water phase B into a first continuous emulsification device to obtain a first emulsion; (2) introducing the second oil phase, the water phase C and the water phase D into a second continuous emulsification device to obtain a second emulsion; and (3) coating the upper surface of a non-woven fabric with the first emulsion, coating the lower surface of the non-woven fabric with the second emulsion, performing illumination and steam treatment, and then performing dehydration and drying to obtain the absorption layer. The absorption layer of the liquid sanitary towel is high in flow conductivity and liquid absorption capacity, and the absorption capacity and the side leakage prevention capacity of the liquid sanitary towel are improved.
Owner:LITTLE NURSE (TIANJIN) TECH CO LTD

Fluticasone propionate cream and preparation method thereof

PendingCN120284856AOrganic active ingredientsAerosol deliveryFluticasone propionatePropanoic acid
The invention discloses fluticasone propionate emulsifiable paste and a preparation method thereof. The preparation method of the fluticasone propionate emulsifiable paste comprises the following steps: S1, mixing liquid paraffin, isopropyl myristate and other auxiliaries, and heating to obtain an oil phase; s2, purified water, propylene glycol, disodium hydrogen phosphate dodecahydrate and other auxiliaries are mixed to obtain a water phase; and S3, adding the oil phase into the water phase, adding fluticasone propionate and the like after complete emulsification, uniformly stirring, and standing to obtain the cream. Compared with the prior art, the fluticasone propionate emulsifiable paste prepared by the invention is not easy to layer at high and low temperatures, and the obtained emulsifiable paste has better stability and is very beneficial to transportation, storage and the like of the product.
Owner:JIANGSU SEMPOLL PHARMA

Phase change cream composite material and preparation method thereof

The invention discloses a phase-change cream composite material and a preparation method thereof. The phase-change cream composite material comprises the following raw materials in percentage by weight: 10-60% of a phase-change material, 1.5-7% of an emulsifier, 0-2% of a thickening agent, 4-10% of an emulsion stabilizer, 0.5-4% of phase-change gel, 0.05-0.2% of a preservative and the balance of water, the cream composite material is an oil-in-water system; the phase change material exists in a cream system in the form of dispersed gel droplets, and forms a continuous cream composite material with a water phase. The phase-change cream composite material prepared by the invention is high in stability, good in dispersity, good in softness and small in flowability, and different product forms can be designed according to cold compress and hot compress parts of a human body.
Owner:SHANGHAI CHUANGSHI MEDICAL TECH (GRP) CO LTD

Preparation method of fusidic acid cream

The invention provides a preparation method of fusidic acid emulsifiable paste, and relates to the field of pharmaceutical preparations, and the preparation method comprises the following steps: step 1, preparation of fusidic acid nanoparticles, step 2, preparation of an oil phase of the emulsifiable paste, step 3, preparation of a water phase of the emulsifiable paste, step 4, emulsification, and step 5, mixing. According to the fusidic acid nanoparticles, firstly, a composite carrier is prepared, then fusidic acid, PLGA, the composite carrier and absolute ethyl alcohol are mixed, a nanoparticle oil phase is obtained, then PVA, PVP, sodium dodecyl glucoside sulfonate and dipotassium ethylenediaminetetraacetate are mixed with deionized water, a nanoparticle water phase is obtained, and finally a nanoparticle suspension is obtained through mixing. The fusidic acid emulsifiable paste prepared by the method can effectively solve the problems that the traditional emulsifiable paste bulk drugs are easy to agglomerate, the drug molecule particle size is large and the like, and the transdermal absorption rate and bioavailability of fusidic acid are improved, so that the antibacterial effect is enhanced.
Owner:CHONGQING CONQUER PHARML

Water-soluble soldering paste and preparation method thereof

The invention discloses water-soluble soldering paste and a preparation method thereof. A soldering flux A comprises a solvent A, a rosin-based material, a thixotropic agent A, an active agent A, a corrosion inhibitor and a surfactant; the rosin-based material comprises at least one of acrylic acid modified rosin, hydrogenated rosin or polyoxyethylene rosin; the soldering flux B comprises a solvent B, a rosin derivative, an active agent B and a thixotropic agent B; the solvent B is a hydrophobic solvent; the rosin derivative comprises at least one of polyoxyethylene rosin amine and polyoxyethylene polymerized rosin; and the soldering flux A and the soldering flux B are compounded into an emulsion structure. Refrigerating the soldering flux A, taking out the soldering flux B, returning to normal temperature, mixing, and emulsifying for 5-10 minutes at the stirring speed of more than 1000rpm to obtain the soldering flux C; and 85-92% of soldering powder is added into 8-15% of the soldering flux C, vacuum uniform mixing is carried out at the stirring speed of 20-40 rpm, and the water-soluble soldering paste is obtained.
Owner:SHENZHEN FITECH CO LTD

Organic-inorganic composite microsphere and preparation method thereof

InactiveCN119318735AUniform and concentrated particle size distributionadjustable sizeCapsule deliveryMicroballoon preparationMicrosphereFreeze-drying
The invention relates to an organic-inorganic composite microsphere and a preparation method thereof, and is characterized in that an amphiphilic polylactic acid organic material and inorganic particles are adopted, emulsification is carried out through a surfactant and supergravity equipment to form an S / O / W coated microsphere suspension emulsion, and then separation and freeze drying are carried out to obtain the organic-inorganic composite microsphere. The prepared organic-inorganic composite microsphere material is rich in various active components, can stimulate regeneration of tissue collagen in a more diversified manner as a component of a regenerative injection anti-aging filler, adopts a method for preparing microspheres through supergravity emulsification, and enhances a liquid-liquid heterogeneous micro-mixing process in a supergravity environment, so that the regeneration of the tissue collagen can be promoted, and the regeneration of the tissue collagen can be promoted. The prepared composite microsphere product is better in quality, the particle size distribution of the microspheres is more uniform and concentrated, the size of the microspheres is adjustable in a wide particle size range of 100nm-200mu m, and the method can realize continuous production, is good in stability and is easy to amplify.
Owner:NINGBO CIBEI MEDICAL TREATMENT APPLIANCE

Method for continuously producing microspheres

The invention relates to the field of microsphere production, in particular to a method for continuously producing microspheres, which is characterized by comprising the following steps: S1, injecting an external water phase into a multiple emulsion tank through an external water phase inlet, so that the internal volume of the multiple emulsion tank is substantially filled with the external water phase; s2, continuously injecting primary emulsion and an external water phase into the internal volume, and starting the homogenizer to emulsify and homogenize a mixed solution of the primary emulsion and the external water phase to generate homogenized multiple emulsion; and S3, collecting the homogenized multiple emulsion flowing out of the outlet into a volatilization tank, and blowing gas into the internal space of the volatilization tank. According to the method for continuously producing the microspheres, the embedding rate of the finally prepared microspheres is high (can reach about 95%), the residual amount of the organic solvent is extremely low (can be reduced to about 0.0015 ppm), the particle size is small (such as 11-13 microns), and the height is controllable.
Owner:GUANGZHOU BOFENG MICROSPHERE TECH CO LTD

Composite oil phase and composite emulsion matrix for site-mixed emulsion explosive and preparation methods therefor

A composite oil phase and composite emulsion matrix for site-mixed emulsion explosive and preparation methods therefor. The composite oil phase is divided into material A and material B, wherein in the material A, a high-viscosity polyisobutylene maleic anhydride amine esterification derivative is used as a primary emulsifier to increase the strength and thickness of an emulsification film of an emulsion matrix, thereby improving the stability of the emulsion matrix; in the material B, a low-viscosity polyisobutylene maleic anhydride amine esterification derivative and SP-80 are used as primary emulsifiers to regulate the ammonium nitrate dissolution rate of the emulsion matrix, thereby improving the sensitization characteristic of the emulsion matrix; and the emulsion matrix prepared from two composite oil phases can effectively improve the water resistance of the emulsion matrix while the problems of high-temperature over-sensitization and low-temperature insensitivity are solved, so that the explosion quality is guaranteed.
Owner:ANSTEEL GROUP MINING CO LTD +1