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Fat emulsion injection of 'Xingnaojing' and its preparing process

A technology of injection and fat emulsion, applied in the field of medicine, can solve problems such as side effects and safety hazards of Xingnaojing injection, insufficient extraction of active ingredients, loss of geniposides, etc. Fast-acting, specific effects

Inactive Publication Date: 2005-06-22
JIANGSU QINGJIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Since the existing preparation process of Xingnaojing Injection is mainly extracted by simple steam distillation, only part of the volatile substances with low boiling points are collected, which leads to insufficient extraction of active ingredients, especially in the process that does not collect The water-soluble components lead to the complete loss of geniposides, which have good heat-clearing, purging fire, cooling blood and detoxification activities in the gardenia medicinal material, seriously affecting the curative effect; at the same time, in order to make the volatile lipid The soluble components are fully dissolved, and a large amount of Tween 80 is added to the prescription. As we all know, Tween 80 has a strong hemolytic property, so the original Xingnaojing injection has relatively large side effects and potential safety hazards during treatment.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Take 30g of turmeric, 7.5g of musk, and 30g of gardenia, crush them, and extract the volatile oil fraction (A) by supercritical extraction under the conditions of extraction pressure of 25MP, extraction temperature of 40℃, analysis pressure of 20MP, and analysis temperature of 35℃ ; The dregs are extracted with 8 times the amount of water for 2 times, 1.5 hours each time, the extract is passed through the HPD-400 macroporous adsorption resin column, after the water is fully eluted, it is eluted with 75% ethanol, the eluate is collected, and the ethanol is recovered , Dissolve in water to obtain 800ml of water-soluble component (B) with geniposide as the water phase; take 1g of borneol, add 150g of soybean oil for injection to dissolve, and add the above-mentioned volatile oil part (A) and egg yolk Phospholipid 20g, glycerol 5g, mixed thoroughly, as the oil phase; under the protection of nitrogen, add the oil phase to the water phase and make colostrum under high-speed stirr...

Embodiment 2

[0062] Take 300g of turmeric, 75g of musk, and 300g of gardenia, crush them, and extract the volatile oil fraction (A) by supercritical extraction under the conditions of extraction pressure of 15MP, extraction temperature of 30°C, desorption pressure of 10MP, and desorption temperature of 25°C; The drug residue was extracted with 6 times the amount of water for 3 times, each time for 1 hour. The extract was passed through the HPD-100 macroporous adsorption resin column. After the water was fully eluted, it was eluted with 70% ethanol. The eluate was collected and the ethanol was recovered. Dissolve in water to obtain 8000ml of water-soluble component (B) with geniposide as the water phase; weigh 250g soybean oil for injection and 250g medium-chain fatty acid triglyceride, mix well, add 10g borneol to dissolve, and add The above-mentioned volatile oil fraction (A), 50g of soybean lecithin, and 10g of glycerin were mixed thoroughly and used as the oil phase; under the protection of...

Embodiment 3

[0064] Take 30g of turmeric, 7.5g of musk, and 30g of gardenia, crush them, and extract the volatile oil fraction (A) by supercritical extraction under the conditions of extraction pressure of 35MP, extraction temperature of 60℃, analysis pressure of 30MP, and analysis temperature of 50℃ ; The medicine residue is extracted with 8 times the amount of water for 2 times, each 1 hour, the extract is passed through the HPD-400 macroporous adsorption resin column, after the water is fully eluted, it is eluted with 50% ethanol, the eluate is collected, and the ethanol is recovered , Add water to dissolve to obtain 750ml of water-soluble component (B) with geniposide as the water phase; take 1g of borneol, add 250g of soybean oil for injection to dissolve, and add the above-mentioned volatile oil part (A) and egg yolk 30g of mixture of phospholipid and soybean phospholipid (1:1, weight ratio), 10g of glycerol, mix thoroughly and use it as the oil phase; under the protection of nitrogen, a...

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Abstract

Disclosed is a fat emulsion injection of 'Xingnaojing' and its preparing process, which comprises using supercritical extraction technology and macroscopic adsorption resin technology for isolating and purifying the water soluble and fat soluble parts in the medicinal materials including musk, cape jasmine, and curcuma root, finally utilizing emulsion technology to obtain the end product.

Description

Technical field [0001] The invention relates to a Xingnaojing fat emulsion injection and a preparation method thereof. The invention belongs to the field of medicine. Background technique [0002] Cardiovascular and cerebrovascular diseases are the number one killer of human health. At present, about 110 million people in my country suffer from hypertension, arteriosclerosis and other cardiovascular and cerebrovascular diseases, 60 million suffer from coronary heart disease, and 70 million suffer from cerebral infarction or cerebral hemorrhage. About 57% of people over 40 years old suffer from cardiovascular and cerebrovascular diseases of varying degrees. Cardiovascular and cerebrovascular diseases (such as stroke, cerebral hemorrhage, myocardial infarction, and coronary heart disease) are characterized by high mortality, high recurrence rate, and high disability rate, which have brought huge suffering to countless families. As our country gradually enters an aging society, the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K35/55A61P9/10
Inventor 杨永安张来芳晏彩霞王衡奇张琼光张锡昌张喜全
Owner JIANGSU QINGJIANG PHARMA
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