Synthetic method of water soluble ultraviolet light absorber BP-9

By using a transition metal salt catalyst and sulfamic acid to perform methylation and sulfonation reactions in the synthesis process of BP-9, combined with the neutralization reaction, the problems of poor catalyst selectivity and waste acid pollution in the existing technology were solved, and achieved High-purity, low-cost BP-9 production meets the needs of the cosmetics industry for UV absorbers.

CN104262209AActive Publication Date: 2015-01-07HUANGGANG MEIFENG CHEM TECH +1
6 Cites 4 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HUANGGANG MEIFENG CHEM TECH
Filing Date
2014-09-02
Publication Date
2015-01-07

AI Technical Summary

Technical Problem

The existing synthesis process of BP-9 has problems such as poor catalyst selectivity, many by-products, low product purity, and serious waste acid pollution, making it difficult to meet the cosmetics industry's demand for high-purity, low-cost UV absorbers.

Method used

Use transition metal salt catalysts such as zinc chloride for methylation reaction, combine with sulfamic acid for sulfonation reaction, and improve product purity through neutralization reaction, reduce waste acid pollution, use cheap and easily available catalysts and stable sulfonation agents , control reaction conditions to improve conversion rate and product yield.

Benefits of technology

The production of high-purity, low-cost BP-9 products has been achieved, with a product yield of more than 96% and a chromatographic purity of more than 98.0%, which meets the standards of the cosmetics industry and is widely used in the field of skin care.

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Abstract

The invention discloses a synthetic method of a water soluble ultraviolet light absorber BP-9. The method mainly comprises the following process steps: (1) carrying out methylation on the main raw materials of 2, 2', 4, 4'-tetrahydroxyl benzophenone, a transition metal salt catalyst and a mixed solvent which is prepared from dichloroethane and anhydrous ethanol in equal parts by weight to obtain 2, 2'-dihydroxyl-4, 4'-dimethoxyl benzophenone; (2) carrying out sulfonation reaction on the main raw materials of methylate, sulfamic acid and C1-C3 halohydrocarbon to obtain 2, 2'-dihydroxyl-4, 4'-dimethoxyl benzophenone-5, 5'-disulfonic acid; and (3) carrying out neutral reaction on the main raw materials of sulfonated product, inorganic base and ethanol water to finally obtain the BP-9 product. The synthetic method disclosed by the invention is few in reaction step, low in cost, high in product purity and stable in quality, and raw materials are easily available.
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Citation Information

Patent Citations

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Cited By

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  • Preparation method of sunscreen agent 2-hydroxy-4-methoxy-5-sulfonic acid benzophenone

    CN112321461B

  • Water-soluble benzophenone ultraviolet light absorber and preparation method thereof

    CN118290311A