236 results about "Fat emulsions" patented technology

The invention relates to an intralipid injection which contains soya oil, middle chain triglyceride, olive oil, and fish oil, wherein it comprises 48-72g.L soya oil, 48-72g/L middle chain triglyceride, 40-60g/L olive oil, and 24-36g/L fish oil, 108-162 mg/L dl-alpha-tocofecol, 9.6-14.4g/L lipovitellin, 22.5-27.5g/L pure glycerin, 240-360mg/L sodium oleate, 18-22mg/L caustic soda, and 1L injection water. The ratio between w-6 and w-3 aliphatic acid is 3.0-2.2:1. The invention optimizes and balances the aliphatic acid mode.

The invention relates to the technical field of medicine, which is a preparation of a taxane drug for intravenous drug delivery, consisting of two parts of drug solution and an emulsion. The drug solution is composed of paclitaxel or docetaxel, a pH regulator and a solvent for injection, wherein, the solvent for injection is an organic solvent; the emulsion comprises a fat emulsion and is composed of oil for injection, an emulsifier, an antioxidant, an isotonic regulator, a stabilizer, a pH regulator and water for injection. When in use, the drug solution can be added and evenly mixed in the emulsion for direct intravenous drip according to the clinical drug dosage and can also be firstly added in the emulsion with the volume that is not less than 5 times of the volume of the drug solution according to the clinical drug dosage and then added with a certain amount of physiological saline or glucose injection for intravenous drip. The preparation of the invention does not contain solubilizer and has the advantages of little toxicity, safety, effectivity, stability and economy. The fat emulsion can also be taken as a nutrition replenisher for a patient, thus achieving better treatment effects. The physiological saline or the glucose injection can also replace a certain amount of the emulsion, so the storage and the transportation are convenient, and the preparation is more economical.

The invention discloses a formula and preparation method of a novel propofol fat emulsion preparation which causes no pain or can be used for obviously lowering injection stimulation and pain. The novel preparation comprises the main constituents of propofol, an emulsifier, refined soybean oil or other refined oil as an oil-soluble diluent, oleic acid or oleate with the effect of assisting emulsification, vitamin E or derivatives thereof with an antioxidation effect, an ionic complexing agent, and glycerol or micro molecular sugar as an isoosmotic adjusting agent.

The invention aims to develop medicinal composition fat emulsion injection containing eucalyptol, limonene and alpha-pinene and a preparation method. The preparation comprises the following components in percentage by weight: 0.0128 to 0.0320 percent of eucalyptol, 0.0084 to 0.0210 percent of limonene, 0.0028 to 0.0070 percent of alpha-pinene, 10 to 30 percent of soybean oil for injection, 1.0 to 1.5 percent of yolk lecithin for injection or 0.8 to 1.5 percent of soybean phospholipids for injection, 2.0 to 2.5 percent of glycerol for injection, and water for injection added to 100 milliliters. The preparation method has the characteristics of strong controllability of production quality, and definite treatment effect of a product. The invention fills up the blank of the medicinal composition fat emulsion injection preparation containing the eucalyptol, the limonene and the alpha-pinene.

The invention relates to a fat emulsion of Paricalcitol. The fat emulsion comprises oil for injection, an emulsifier, a stabilizer, an isoosmotic adjusting agent, and a pH adjusting agent. Emulsion droplets have an average diameter of 50nm-1000nm. The fat emulsion can be prepared into injection emulsions, freeze-dried emulsions or capsules. Specifically, organic solvents cannot be employed as injections so as to reduce stimulation on blood vessels during injection and avoid injection package material impurity leaching caused by organic solvents, thus ensuring product quality and safety, and reducing the difficulty of product quality control.

The invention provides high oxidation resistance long chain fat emulsion injection and a preparation method thereof. The fat injection consists of soybean oil for active component injection, emulsifier, isoosmotic adjusting agent, metal ion chelation agent and water for injection. The preparation method comprises the following steps: under inert gas environment, adding the emulsifier and coemulsifier into the heated soybean oil for injection, and uniformly stirring the mixture serving as oil phase at high speed; uniformly mixing the isoosmotic adjusting agent and the metal ion chelation agent with proper water for injection, and filtering the solution serving as water phase; in high speed stirring, combining the oil phase and the water phase, continuously stirring the mixture to foremilk at high speed, adjusting the pH of the foremilk to be between 9.0 and 10.0, adding the water for injection to the volume of 1,000ml; homogenizing the foremilk after the foremilk is uniformly mixed by a high pressure homogenizer until the milk particles are qualified; and preparing the fat emulsion injection through filling, nitrogen introducing, plugging, capping, sterilizing and cooling after filtration.

An alprostadil lipid emulsion for injection and a preparation method therefor. The lipid emulsion contains alprostadil, phosphatidylcholine, phosphatidylglycerol, oil for injection and a lyophilized protective agent. Based on 1 part by weight of the alprostadil, the content of the phosphatidylcholine is 1200 to 4000 parts by weight, the content of the phosphatidylglycerol is 12 to 120 parts by weight, the content of the oil for injection is 2000 to 20000 parts by weight, and the content of the lyophilized protective agent is 16000 to 60000 parts by weight.

Disclosed are compounds based on ibuprofen, their preparation methods, uses and pharmaceutical preparation. The compounds have structures shown as formula (1), wherein, m, n are integers and fulfill the requirements of 0≦n≦6, 0≦m≦6, respectively. The preparation methods for the compounds based on ibuprofen are as follows: contacting and reacting 2-(4-isobutyl-phenyl) propionic acid to have contact reaction with a solution of an organic acid ester in the presence of a catalyst under substitution reaction conditions The present compounds can be used to prepare nonsteroidal anti-inflammatory drugs. The preparation can be preparation of fat emulsion, liposome, and dried emulsion and so on.

The present invention relates to the field of medical technology. More specifically, the present invention relates to a preparation of taxanes for intravenous administration, which consists of two parts: a drug solution and an emulsion. Said drug solution consists of paclitaxel or docetaxel, a pH regulator and a solvent for injection, wherein said solvent for injection is an organic solvent. Said emulsion includes a fat emulsion and is composed of oil for injection, an emulsifier, an antioxidant, an isotonic regulator, a stabilizer, a pH regulator and water for injection. When used, the drug solution at the clinical dosage can be added and mixed homogeneously in the emulsion to perform intravenous drip directly; or the drug solution at the clinical dosage can also be firstly added into the emulsion with no less than 5 times volume of the drug solution and then a predetermined amount of normal saline or glucose solution for injection is added to perform intravenous drip. The preparation of the present invention does not contain solubilizer and has advantages of little toxicity, safety, effectiveness, stability and economy. The fat emulsion is also used as a nutritional replenishment, thus achieving a better therapeutic effect. In addition, the normal saline or glucose solution for injection can be used to replace a considerable amount of the emulsion, which makes the preparation, therefore, not only cost-efficient, but also convenient for transportation and storage in practice.

The invention relates to a fat emulsion of triptolide and a preparation method thereof. The fat emulsion injection comprises an antitumor effective dose of triptolide and pharmaceutically-acceptable auxiliary materials, wherein an oil phase is a mixture prepared from long-chain fat acid triglyceride and middle-chain fat acid triglyceride in the mass ratio of 4:1-1:1. The preparation method comprises the following steps of: mixing triptolide, an emulsifier, fat oil, an isotonic regulator, an anti-oxidizing agent and a stabilizer, and heating to obtain an oil phase; weighing water for injection, adding the isotonic regulator, and heating to obtain a water phase; heating and mixing the oil phase and the water phase under the protection of nitrogen gas, and stirring to obtain a primary emulsion; homogenizing the primary emulsion under a high pressure to form a uniform emulsion; and adjusting the pH value to 6-7, sterilizing rotationally to obtain a product, i.e., the triptolide fat emulsion injection, and sterilizing. The average particle diameter of the fat emulsion is 250.9+/-60.0 nanometers, the polydispersion coefficient is 0.143, dispersion is uniform, a system is stable, the targeting property is high, and vessel irritation is low.

The invention discloses a method for measuring prostaglandin E1 and/or prostaglandin A1 in alprostadil fat emulsion injection, which comprises the following steps: (1) ultrasonically processing the alprostadil fat emulsion injection, obtaining an alprostadil solution of which the fat phase is removed; and (2) performing high performance liquid chromatography measurement to the alprostadil solution of which the fat phase is removed, obtaining the content of the prostaglandin E1 and/or prostaglandin A1, wherein the conditions of the high performance liquid chromatography measurement are as follows: stationary phase: octadecyl ether-bonded monolithic silica is filling agent, mobile phase: the ratio of phosphate buffer to acetonitrile is equal to 1-6:1, and the detection wavelength is 278 nm. The method can accurately measure the alprostadil and the degradation products thereof in the alprostadil fat emulsion injection.

The invention discloses a preparation method of low-fat regenerated cellulose emulsified liquid emulsion-type sausage. The preparation method comprises the following steps: preparing regenerated cellulose; preparing regenerated cellulose emulsified liquid; preparing emulsion-type sausage: acquiring hind leg pork and pork backfat, pickling the hind leg pork, chopping the hind leg pork, sequentially adding with pork backfat and regenerated cellulose emulsified liquid respectively, and chopping to acquire emulsified meat paste, wherein the temperature of each stage is controlled by addition of ice water in a chopping process, the chopping temperature is controlled to be within 12 DEG C; filling the chopped emulsified meat paste to prepare a semi-finished product of the emulsion-type sausage, boiling the semi-finished product of the emulsion-type sausage in hot water at 80 DEG C, taking out and cooling to acquire the finished low-fat emulsion-type sausage when the center temperature of the semi-finished product of the emulsion-type sausage reaches 72 DEG C, and refrigerating at 4 DEG C. The method has strong implementation, the content of fat in the produced emulsion-type sausage is reduced remarkably, the fatty acid type and the oxidation stability of the product are improved, the sensory quality of the emulsion-type sausage is not influenced and the nutritive value is high.

The present invention provides a pharmaceutical composition which can permit a sparingly water-soluble drug substance to be solubilized or dispersed in a pharmaceutically allowable liquid medium (e.g., fat emulsion, etc.), characterized in that said pharmaceutical composition contains (a) a base (e.g., polyethylene glycol, etc.), (b) a sparingly water-soluble drug substance and (c) a fatty acid or its pharmaceutically allowable salt. The pharmaceutical composition can be mixed with a pharmaceutically allowable liquid medium to produce a pharmaceutical preparation for administration, such as an injectable solution, etc., wherein mixing can be performed for a shortened period of time and the sparingly water-soluble drug substance can be uniformly solubilized or dispersed in a liquid medium.

The invention relates to a compound walnut and linseed oil fat emulsion oral solution, beverage and a preparation method. The oral solution comprises raw materials of walnut oil, linseed oil, lecithin, glycerin, sterile pure water, an antioxidant, a stabilizing agent, a pH regulating agent, a flavoring agent, essence, and the like. The preparation process comprises the following steps of: in the presence of the protection of nitrogen, heating, dissolving and mixing the walnut oil, the linseed oil and the lecithin into an oil phase; mixing the glycerin, the antioxidant, the stabilizing agent, the flavoring agent, the essence and the sterile pure water into a water phase; slowly adding the oil phase into the strongly stirred water phase and shearing into a primary emulsion at high speed; regulating the pH value of the primary emulsion to be 6.5-8.5 by using a few of pH regulating agent; emulsifying by using a high-pressure homogenizer; filtering by using a microporous membrane; and filling, sealing and sterilizing to obtain the oral solution with the oil content of 1-50 percent. The compound walnut and linseed oil fat emulsion oral solution is used in the field of healthy food, 5-50 percent of the fat emulsion oral solutions can be used as nutritional functional health-care beverages, and 1-20 percent of the fat emulsion oral solutions can be used as table beverages and popular beverages.

The invention relates to canning equipment, in particular to fat emulsion canning equipment for the neurosurgery department. The technical problem to be solved is how to provide the fat emulsion canning equipment for the neurosurgery department, which is high in canning speed, high in efficiency, low in cost and easy to operate. The fat emulsion canning equipment for the neurosurgery department comprises a bottom plate, placement racks arranged on the two sides of the bottom plate, a canning mechanism arranged between the bottom plate and the placement rack on one side, and a conveying mechanism arranged between the bottom plate and the canning mechanism. Through the effect of a correcting mechanism, the position of a material can be corrected, and then the material can be located under a collecting tank feeding guide pipe.