9 results about "Fat emulsions" patented technology

This invention relates to a method for preparing and applying a fat emulsion injection, belonging to the field of pharmaceutical technology. The preparation steps include preparing an oil phase using egg yolk lecithin with a specific PC and PE mass ratio as an emulsifier, mixing it with an aqueous phase to obtain a colostrum, homogenizing the colostrum, and then adding sodium oleate to obtain the fat emulsion injection. The fat emulsion injection prepared by the method of this invention has the characteristics of a low SPAN value and a small number of large-diameter emulsion particles.

This invention discloses a method for detecting the encapsulation efficiency of dexamethasone palmitate injection, belonging to the technical field of encapsulation efficiency detection. The method involves mixing dexamethasone palmitate injection with a solvent for extraction; the dexamethasone palmitate injection comprises a fat emulsion and free dexamethasone palmitate; after extraction, the fat emulsion and free dexamethasone palmitate are separated, and the encapsulation efficiency is calculated by quantitative analysis using HPLC; the polarity of the solvent is similar to that of the dexamethasone palmitate. This invention utilizes the principle of "like dissolves like" to develop a method for determining the encapsulation efficiency of dexamethasone palmitate injection extracted with an organic solvent. This method effectively separates the fat emulsion from the free dexamethasone palmitate while ensuring that the structure of the fat emulsion is not damaged during the measurement process, thus avoiding falsely low encapsulation efficiency due to drug leakage.

A method for determining the contents of linoleic acid and α-linolenic acid in a fat emulsion injection. The method comprises: demulsifying a fat emulsion, subjecting fatty acids to methyl esterification, separating methyl ester compounds of linoleic acid and α-linolenic acid by using gas chromatography, and performing quantitative calculation to obtain the contents of linoleic acid and α-linolenic acid. By means of demulsifying the fat emulsion and subjecting linoleic acid and α-linolenic acid to methyl esterification, followed by separation of the resulting methyl ester compounds, the contents of linoleic acid and α-linolenic acid in the fat emulsion can be accurately and rapidly determined. Moreover, the method involves a simple pretreatment process and high precision, realizing an efficient, rapid and accurate method for detecting the contents of linoleic acid and α-linolenic acid in a fat emulsion injection.

This utility model discloses an auxiliary squeezer for fat emulsion amino acid glucose injection, including a main roller shaft, and a first pressure roller and a second pressure roller parallel to the main roller shaft. The end of the first pressure roller is connected to the end of the main roller shaft via a first connecting rod, and the end of the second pressure roller is connected to the end of the main roller shaft via a second connecting rod. At least one end of the second connecting rod is pivotally connected to the second connecting rod or the main roller shaft. The main roller shaft is provided with a groove matching the thickness of the injection bag, and the groove extends axially to form an elongated structure. This utility model provides an auxiliary squeezer for fat emulsion amino acid glucose injection, which can simulate the action of existing manual squeezing, squeezing the bag from the edge of the injection bag, which is conducive to the rapid peeling of the seal between the chambers. At the same time, the fingers of the medical staff are not squeezed, thus protecting the fingers of the medical staff.

The application relates to the field of simulation devices and application methods of pharmacokinetics, in particular to a device for simulating an in-vivo two-compartment model and a method for accurately predicting the detoxification effect of fat emulsion, and independently designs a two-pool four-pump device, which comprises two pools for simulating a two-compartment system and four pump devices serving as a driving system for transporting liquid. The device has the characteristics of uniform stirring and constant system temperature, and adopts a dynamic environment of liquid continuous flow to simulate the distribution and elimination of drugs in the body. Based on the phenomenon that liposoluble drug molecules can be captured by fat emulsion and the capturing degree is positively correlated with the lipophilicity of the drugs, fat emulsion with adjustable flow rate is injected on the basis of the two-pool four-pump device, the change of the drug concentration is detected by using a high-performance liquid chromatograph, the dose-effect relationship between the fat emulsion infusion speed and the capturing effect of drugs with various properties is established, and the accuracy of the dose-effect relationship in in-vivo prediction is verified through animal experiments.

This invention discloses a bilayer hydrogel scaffold, its preparation method, and its applications, relating to the field of medical repair materials technology. The bilayer hydrogel scaffold comprises upper and lower hydrogel layers made of materials with different degradation rates and mechanical properties, both layers being loaded with nano-fat emulsions. The thickness of the upper hydrogel layer is greater than or equal to the thickness of the lower hydrogel layer. This invention utilizes the differences in degradation rates and mechanical properties of different materials to prepare a bilayer hydrogel scaffold, integrating functions such as promoting nerve repair, promoting vascular activity, and promoting bone activity. It achieves the effect of simultaneously adapting to two different pathological environments within the same implant, thereby avoiding secondary surgery for patients. This invention utilizes photocrosslinking technology to achieve integrated molding of the bilayer structure, ensuring a strong interface bond between the upper and lower layers and eliminating the risk of delamination. Simultaneously, the preparation process is controllable and highly customizable, allowing for flexible adjustment of the scaffold's size and pore structure according to the clinical defect morphology.

The present invention relates to the field of hemodialysis and peritoneal dialysis, in particular to a fat emulsion dialysate, and preparation method and the use thereof. Provided in the present invention is a fat emulsion dialysate, comprising a long-chain fat emulsion oil, a medium-chain triglyceride, an anti-oxidant, sodium oleate, glycerin, phospholipid, and a solvent. Compared with traditional dialysis, the fat emulsion dialysate provided by the present invention has a better advantage for protein-bound toxin removal. In addition, the fat emulsion dialysate not only has a simple preparation method and a low cost, but also has good stability and safety, and remains stable at room temperature for 14 days without obvious precipitation. Thus, the fat emulsion dialysate can become a hemodialysis dialysate or peritoneal dialysate with broad application prospects, and has good industrialization prospects.

METHOD FOR EXTRACTING OIL FROM MICROBIAL BIOMASS ABSTRACT The current invention relates to a method for extracting oil from a microbial biomass comprising the steps of: mechanically lysing a microbial biomass, thereby obtaining a fat-in-water emulsion; churning the fat-in-water emulsion, thereby obtaining a water-in-fat emulsion and an aqueous phase; and centrifuging the water-in-fat emulsion, thereby obtaining a microbial 0” containing fraction.

This invention discloses an alfasalol fat emulsion injection and its preparation method. The alfasalol fat emulsion injection comprises alfasalol and its pharmaceutically acceptable salts; an oil phase, an emulsifier, an osmotic pressure regulator, a stabilizer, a pH adjuster, and water for injection. The oil phase of this application is a 1:1 mixture of soybean oil and medium-chain oil, which can significantly reduce particle size and the occurrence of allergies, and has good stability.