52 results about "Fat emulsions" patented technology

The invention discloses a novel method and equipment for filling and filling nitrogen to protect liquid medicine, and relates to the technical field of filling equipment in pharmaceutical machinery, and the filling and nitrogen filling process is as follows: A, feeding bottles and plugs; b, inflating and plugging; c, station transfer; d, taking the plug and filling; e, pressing the plug again; f, bottle discharging; the novel nitrogen filling and filling device comprises a rack 15, a bottle feeding mechanism 1, a nitrogen filling station 7, a transfer station 9, a filling station 12 and a finished bottle discharging mechanism 16, wherein the bottle feeding mechanism 1, the nitrogen filling station 7, the transfer station 9, the filling station 12 and the finished bottle discharging mechanism 16 are sequentially arranged at the upper part of the rack 15 from right to left. The nitrogen filling machine has the characteristics of simple process, simple equipment structure, low use cost, relatively small occupied area of equipment, capability of greatly improving the quality of filled medicines and the like, and can be used for nitrogen filling of high-added-value products such as glucose, antibiotics, amino acid, fat emulsion, oral liquid, nutrient solution, biological agents and the like.

The present disclosures provides methods for decreasing injuries associated with intraoperative hypotension by intravenously administering to a subject a therapeutically effective amount of a fat emulsion, following a period of intraoperative hypotension and after the subject's mean arterial blood pressure has recovered. The disclosure also provides methods for preventing injuries associated with intraoperative hypotension, particularly for surgical candidates that have an increased risk for intraoperative hypotension. Non-limiting examples of injuries contemplated herein include myocardial injury, myocardial infarction, and acute kidney injury.

The invention discloses an alfacalcidol emulsion and a preparation method thereof, the pH value of the alfacalcidol emulsion is 6.5-8.0, and each 1000 ml of the alfacalcidol emulsion comprises 1-30 g of alfacalcidol, 100-300 g of oil for injection, 6-20 g of a phospholipid emulsifier, 0-20 g of poloxamer 188, 20-30 g of an osmotic pressure regulator and a proper amount of water. The preparation method of the drug-loaded fat emulsion injection comprises the following steps: preparing an oil phase; preparing a water phase; preparing a primary emulsion; performing high-pressure homogenization; adjusting the pH value; and sterilizing and storing. The alfacalcidol serves as an oil-soluble substance, can be dissolved in small oil drops (emulsion particles) of the emulsion or on an interfacial film, and can keep stable physicochemical properties and enhance the slow release performance in the storage process under certain conditions, so that the drug effect time is prolonged.

The utility model discloses a rotary filling, nitrogen charging and plugging device, which relates to the technical field of filling equipment in pharmaceutical machinery, and comprises a rack 9, a bottle conveying mechanism 2, a bottle separating mechanism 3, a nitrogen charging and plugging mechanism 4, a plug arranging mechanism 1 and a plug taking, nitrogen charging, filling and pressing mechanism 8, the bottle feeding mechanism 2 is arranged on the front side of the upper portion of the rack 9, and the bottle separating mechanism 3 is arranged on the front side of the right end of the bottle feeding mechanism 2. The nitrogen charging and plugging mechanism 4 is arranged on the rear side of the right part of the bottle conveying mechanism 2, and the plug arranging mechanism 1 is arranged on the right side of the nitrogen charging and plugging mechanism 4; the plug taking, nitrogen charging, filling and pressing mechanism 8 is arranged at the middle left part of the upper part of the rack 9, and the right part of the plug taking, nitrogen charging, filling and pressing mechanism 8 is respectively connected with the nitrogen charging and plugging mechanism 4 and the bottle conveying mechanism 2. The nitrogen filling machine has the characteristics of simple process, lower use cost, smaller occupied area of equipment, capability of greatly improving the quality of filled medicines and the like, and can be used for nitrogen filling of high-added-value products such as glucose, antibiotics, amino acid, fat emulsion, oral liquid, nutrient solution, biological agents and the like.

The utility model discloses a medium-long chain fat emulsion injection filling device adapted to different soft bags, which comprises a transmission rod, a bearing disc, a filling pipe and a bag body locking mechanism, one end of the transmission rod is connected with an injection filling device body, the bearing disc is coaxially fixed at the other end of the transmission rod, and the filling pipe is fixed at the axis of the bearing disc. The soft bag filling device has the advantages that medium-chain and long-chain fat emulsion injection is filled into a soft bag through the filling pipe, the linkage barrel abuts against the soft bag in the filling process, then the linkage barrel slides on the filling pipe, the clamping rods are driven by the driven rods to be in linkage while sliding, and therefore the soft bag is filled with the medium-chain and long-chain fat emulsion injection, and the soft bag is filled with the medium-chain and long-chain fat emulsion injection. The filling device can be suitable for different soft bags, the soft bags are locked, the stability of the soft bags is guaranteed, the filling device is simple and practical, frequent replacement of bag body clamping sleeves of different models is avoided, and the working efficiency is greatly improved.

The invention discloses a preparation method of a fat emulsion injection with a C6-24 structure. According to the method, residual oxygen and dissolved oxygen are strictly controlled in the preparation process, unsaturated fatty acid in the structural fat emulsion injection (C6-24) is prevented from being oxidized, impurities such as peroxides, aldehydes and ketones are reduced, and the medication safety is improved; by controlling the flow rate of oil-water mixing, the emulsifying effect is improved, the uniformity of emulsion particles is improved, and the long-term stability of the injection is effectively ensured, so that the product quality is good.

The utility model relates to the technical field of medical infusion bags, and discloses an integrated parenteral nutrition multi-cavity bag which comprises a multi-cavity bag body, a plurality of sealing strips are arranged in the multi-cavity bag body and divide the multi-cavity bag body into an upper cavity body, a middle cavity body and a lower cavity body, an upper medicine feeding opening is formed in the opposite cavity wall of the upper cavity body, and a lower medicine feeding opening is formed in the opposite cavity wall of the middle cavity body. A middle medicine feeding opening is formed in the opposite cavity wall of the middle cavity, and a lower medicine feeding opening is formed in the opposite cavity wall of the lower cavity. The upper cavity, the middle cavity and the lower cavity are separated through the sealing strips, key nutrients such as glucose, amino acid and fat emulsion can be stored respectively, it is guaranteed that all the nutrients are kept independent before mixing, and cross contamination in the mixing process is avoided. Meanwhile, due to the design of the upper dosing opening, the middle dosing opening and the lower dosing opening, the dosing process is simpler and more convenient, and necessary nutrients such as vitamins and trace elements can be added through the corresponding dosing openings according to the specific requirements of patients. By means of the design, the sequence and accuracy of medicine adding are guaranteed, the pollution risk in the medicine adding process is reduced, and therefore infectious complications are reduced.

The invention discloses posaconazole fatty acid ester, posaconazole fatty acid ester fat emulsion and a preparation method of the posaconazole fatty acid ester fat emulsion, and belongs to the technical field of pharmaceutical preparations. The solubility of the posaconazole fatty acid ester provided by the invention in the oil for injection is remarkably improved, and the posaconazole fatty acid ester can be effectively applied to subsequent preparation of the posaconazole fatty acid ester fat emulsion. Meanwhile, by selecting components in a proper mass percentage range for mutual cooperation, the obtained posaconazole fatty acid ester fat emulsion is small in average particle size, and the pH value and the osmotic pressure are close to those of human plasma, so that the posaconazole fatty acid ester fat emulsion has excellent intravenous injection safety and can be effectively applied to preparation of antifungal injection. In addition, the preparation methods of the posaconazole fatty acid ester and the posaconazole fatty acid ester fat emulsion provided by the invention are simple to operate and beneficial to actual large-scale production.

The invention belongs to the field of medicine, and provides an aprepitant micelle composition and a preparation method thereof, the aprepitant micelle composition is composed of an active component aprepitant and auxiliary materials such as phospholipid, cholic acid or a salt thereof, a nano-micelle stabilizer, a pH regulator and the like, the dosage form is a freeze-dried powder injection, and the solubility of the aprepitant is remarkably improved; the combination of the nano-micelle stabilizer can significantly improve the stability of the preparation, avoids the use of a large amount of soybean oil for solubilization, and reduces the risk of hyperlipidemia. Ethanol is not contained, so that ethanol anaphylaxis is avoided, and the safety of clinical medication can be remarkably improved. After the freeze-dried powder injection is redissolved, a hot-pressing sterilization mode can be adopted, so that the sterile guarantee level is remarkably improved, and the clinical medication risk is reduced. The aprepitant micelle composition is prepared by adopting a tert-butyl alcohol-water freeze-drying method, the process is simple and convenient, large-scale production is easy, a common freeze-dried powder injection production line can be adopted, special equipment such as a high-pressure homogenizer and a special fat emulsion production line are not needed, and the production cost can be remarkably reduced.

The invention provides a lipid index quality control product as well as a preparation method and application thereof. The lipid index quality control product comprises serum, a fat emulsion injection and a preservative; the serum, the fat emulsion injection and the preservative are mixed according to different preset proportions to obtain quality control products with different lipid indexes; the preset proportion is that the volume ratio of the serum to the fat emulsion injection to the preservative is 100: (2-10): (0.05-0.1); the preservative is 0.05% of sodium azide. By applying the provided lipid index quality control product, the accuracy and stability of a detection system on a lipid blood sample can be evaluated, and the reliability of a detection result in the presence of lipid interference is ensured.

The utility model belongs to the technical field of fat emulsion injection production, particularly relates to quantitative filling equipment for medium-chain and long-chain fat emulsion injection production, and aims to solve the problem that an existing solution overflows after being filled, and adopts the following scheme that the quantitative filling equipment comprises a bottom frame, a liquid injection barrel and a liquid storage barrel, and a supporting table and a supporting frame are mounted at the upper end of the bottom frame; a liquid storage barrel and a liquid injection barrel are installed on the supporting frame, a sliding groove is formed in the upper end of a vertical plate of the supporting frame, a fixing plate is slidably connected into the sliding groove, a connecting rod is installed on one side of the lower end of the fixing plate, and a piston is installed at the lower end of the connecting rod and slidably connected to the inner side of the liquid injection barrel. The first motor is matched with the lead screw to drive the connecting plate to move up and down along the sliding groove, the first one-way valve and the second one-way valve are matched to achieve suction and liquid injection operation, the threaded rod drives the connecting rod to move up and down, and the two connecting pipes on the bottom side of the liquid injection barrel are connected to the liquid inlet pipe and the liquid outlet pipe through the first one-way valve and the second one-way valve respectively. And quantitative operation is realized by matching with scale marks.

A yolk phospholipid composition having a lysophosphatidyl ethanolamine content of 1% by mass or less and an amino acid content of 50 mg / 100 g or more and 500 mg / 100 g or less.

The invention belongs to the technical field of pharmaceutical preparations, and discloses a stable aprepitant injection and a preparation method thereof. The aprepitant injection comprises the following raw materials in percentage by mass: 0.5-1% of aprepitant, 8-12% of soybean oil, 8-12% of egg yolk lecithin, 0.05-2% of egg yolk phosphatidyl glycerol, 0.5-0.8% of sodium oleate, 5-8% of cane sugar, 2-4% of ethanol and the balance of water for injection, totaling 100%. The selected co-emulsifier egg yolk phosphatidyl glycerol has two hydroxyl groups at the hydrophilic end, so that the egg yolk phosphatidyl glycerol has extremely strong emulsifying performance, is well compatible with aprepitant, has a good emulsifying effect of the preparation, and can well encapsulate aprepitant, so that the dosage of egg yolk lecithin is reduced by about one third, and the stable drug-loaded fat emulsion is formed; the preparation method is suitable for industrial production, the preparation cost is low, and the accessibility of the medicine is improved.

This invention relates to a method for preparing and applying a fat emulsion injection, belonging to the field of pharmaceutical technology. The preparation steps include preparing an oil phase using egg yolk lecithin with a specific PC and PE mass ratio as an emulsifier, mixing it with an aqueous phase to obtain a colostrum, homogenizing the colostrum, and then adding sodium oleate to obtain the fat emulsion injection. The fat emulsion injection prepared by the method of this invention has the characteristics of a low SPAN value and a small number of large-diameter emulsion particles.

The present invention relates to the food and pharmaceutical industry, i.e. Food, functional nutritional products, dietary supplements, beverages, and represents methods for improving the digestibility of functional nutritional products using inert gases. A method for improving the digestibility of a product using an inert gas comprises mixing the inert gas with a functional nutritional product wherein the functional nutritional product used is a fat emulsion, an oil, a water-soluble ingredient for making the nutritional product, a dietary supplement, a beverage, and the active ingredient is at least one gas from the group comprising xenon, krypton, the nutritional product has a gas content of 5 ml / l to 2.8 l / l, or a mixture thereof in various proportions. The use of the invention makes it possible to enhance the digestion of functional nutritional products.

The invention relates to an analysis method of medium-long chain structure triglyceride. Specifically, the invention relates to a method for detecting the medium-long chain structure triglyceride component in medium-long chain structure oil and structure fat emulsion injection (C6-24), and the method specifically comprises the following steps: carrying out separation and quantification by adopting a high performance liquid chromatography-electrospray detector (LC-CAD), and carrying out qualitative analysis by adopting a high performance liquid chromatography-high resolution mass spectrometry (LC-HRMS) combined method. The method can be used for directly analyzing medium-long chain structure triglyceride with complex components, and has the advantages of simplicity in operation, high sensitivity, accurate determination result and the like.

The invention belongs to the technical field of food processing, and particularly relates to fat emulsion gel as well as a preparation method and application thereof. The invention provides a preparation method of fat emulsion gel. The preparation method comprises the following steps: mixing tilapia mossambica protein isolate freeze-dried powder with water, hydrating, re-mixing, and carrying out ultrasonic treatment to obtain protein dispersion liquid; mixing the flaxseed gum powder with water, cooling and hydrating to obtain a flaxseed gum aqueous solution; the protein dispersion liquid and the flaxseed gum aqueous solution are mixed, the pH value is adjusted, then mixing is conducted, and a tilapia mossambica protein isolate-flaxseed gum complex is obtained; mixing the tilapia mossambica protein isolate-flaxseed gum complex with edible vegetable oil, and emulsifying to obtain fat emulsion gel. The fat emulsion gel easy to swallow is prepared by taking the tilapia isolated protein as a construction base material, can improve dietary nutrition of people with dysphagia, and can also provide technical reference for green and high-value utilization of the tilapia isolated protein.

The utility model discloses a novel filling and nitrogen charging device, which relates to the technical field of filling equipment in pharmaceutical machinery and comprises a rack 16, a bottle feeding mechanism 1, a nitrogen charging station 10, a filling station 14 and a finished bottle discharging mechanism 17, and the bottle feeding mechanism 1, the nitrogen charging station 10, the filling station 14 and the finished bottle discharging mechanism 17 are sequentially arranged on the upper portion of the rack 16 from right to left. And the bottle feeding mechanism 1 and the finished bottle discharging mechanism 17 are respectively suspended at the right end and the left end of the upper part of the rack 16. The nitrogen filling machine has the characteristics of simple process, simple equipment structure, low use cost, relatively small occupied area of equipment, capability of greatly improving the quality of filled medicines and the like, and can be used for nitrogen filling of high-added-value products such as glucose, antibiotics, amino acid, fat emulsion, oral liquid, nutrient solution, biological agents and the like.

The invention relates to an enzymatic determination method of beta-hydroxybutyric acid, a kit thereof and a use method of the kit, the determination method comprises the following steps: generating NADH by using D-3-hydroxybutyric acid dehydrogenase in the presence of NAD < + >, reducing Fe < 3 + > into Fe < 2 + > by using the NADH in the presence of 1-methoxy-5-methylphenazinium methyl sulfate (1-Methyl PES), then reacting Fe < 2 + > with Nitoso-PSAP to generate a colored substance, and determining the beta-hydroxybutyric acid by using the colored substance. The colored substance has a maximum absorption peak at 756nm, and the content of beta-hydroxybutyric acid is determined by detecting the absorbance of the colored substance. The kit comprises a reagent R1 and a reagent R2, the reagent R1 is prepared from D-3-hydroxybutyrate dehydrogenase, FeCl3 and a buffer solution; and the reagent R2 is prepared from NAD (Nicotinamide Adenine Dinucleotide) < + >, 1-Methoxy PES (Polyether Sulfonate), Nitroso-PSAP (Phosphatidylcholine) and a buffer solution. The linear correlation coefficient of the kit is greater than 0.999; the linear range is not less than 4mmol / L, and the polypeptide can resist the interference of vitamin C, bilirubin, fat emulsion, hemoglobin and uric acid, and is still stable in 7 days in an environment at 37 DEG C.

The embodiment of the invention discloses a fat emulsion preparation method, which comprises: (1) oil phase preparation: taking grease, and heating to obtain an oil phase; (2) preparing a water phase, namely heating water for injection, glycerol and a part of sodium hydroxide in the prescription to obtain the water phase; (3) preparing primary emulsion: mixing and shearing the oil phase and the water phase in proportion to obtain an oil-water mixed phase, circularly shearing uniformly, and filtering to obtain relatively stable primary emulsion; (4) front low-pressure homogenization: homogenizing the primary emulsion to obtain stable primary emulsion; (5) high-pressure homogenization: homogenizing the stable primary emulsion to obtain stable finished emulsion; (6) post-low-pressure homogenization: homogenizing the finished milk to obtain final milk; and (7) adding the residual sodium hydroxide in the prescription: adding the residual sodium hydroxide in the prescription into the final emulsion, and uniformly stirring to obtain the full-prescription fat emulsion.

The patent application relates to a paper-based packaging material with a carrier paper and a first coating arranged indirectly on at least one side of the carrier paper, wherein the first coating is a barrier layer and has an increased diffusion resistance to at least one substance selected from a group comprising fluid, gas, air, oxygen, carbon dioxide, nitrogen, inert gas, odorant, aromatic substance, water vapor, liquid, water, water-fat emulsion, fat, oil, mineral oil, and edible oil, odorant, flavorant, water vapor, liquid, water, water-fat emulsion, grease, oil, mineral oil, and edible oil individually or in combination, wherein the first coating is disposed between the carrier paper and a visually perceptible surface coating and directly contacts the surface coating. Furthermore, the invention relates to a package made of such a paper-based packaging material and a method of manufacturing the same.

The present application relates to a method for determining the content of impurity aluminum element in fat emulsion injection by high performance liquid chromatography. 9 mL of test sample and 1 mL of acid reagent are precisely added, heated at 80 DEG C for 30 min in a graphite digestion instrument, then heated at 100 DEG C for 1 h, the obtained product is concentrated at 120 DEG C, cooled, transferred with purified water and diluted to 10 mL, 3 mL of n-heptane is added for extraction, the solution is separated into two layers by standing, the water phase is filtered, and the filtrate is obtained as a test sample solution. 0.1 mL of aluminum element series control solution, blank control solution, test sample solution and blank test sample solution are precisely taken respectively, 0.9 mL of derivative reagent is precisely added, mixed, then injected into a liquid chromatograph respectively, and the chromatogram is recorded. The method of the present application selects a suitable demulsification acid solvent to destroy the structure of fat emulsion oil-in-water, release the wrapped impurity aluminum element, and obtain a clear solution at the same time, which meets the requirements of high performance liquid chromatography injection.

The invention provides bighead carp low-fat emulsion gel surimi printing ink as well as a preparation method and application of the bighead carp low-fat emulsion gel surimi printing ink. The method comprises the following steps: preparing a 1-4% (w / v) BCM particle suspension or BCS particle suspension by using a 200-1000mmol / L KCl solution, magnetically stirring, adjusting the pH value of the suspension to be neutral, hydrating for 24 hours, adding soybean oil, and homogenizing to obtain BCMPEs gel or BCSPEs gel; the preparation method comprises the following steps: carrying out unfreezing and blending pretreatment on minced bighead carp, adding 10-30% (w / w) of BCMPEs gel or BCSPEs gel, and uniformly mixing to obtain the minced bighead carp low-fat emulsion gel surimi ink. By optimizing a formula and a preparation process, the 3D printing material has good 3D printing adaptability, and a high-precision and high-stability product can be printed; the characteristics of minced fillet gel are improved, low fat is realized, and the nutritional and edible requirements of special crowds are met.

The application belongs to the technical field of medicine extraction and medicine detection, and discloses a detection method of related substances in palonosetron-containing fat emulsion injection. Methanol is used as a main demulsifier, and a sodium dihydrogen phosphate buffer salt solution with a suitable ionic strength is used for assistance, so that full demulsification is realized under the premise of not introducing a third organic phase; a water bath evaporation and redissolution method is used to enrich target components in the solution after demulsification, so that good chromatographic behavior and complete recovery of the target components are ensured, and the detection sensitivity is effectively improved. The palonosetron and related impurities have good separation degree, the method is simple to operate, accurate to measure, and strong in specificity, and is suitable for the determination of palonosetron related substances in rolapitant palonosetron fat emulsion.

The application discloses a water-in-oil low-fat emulsion with multiple stabilities and a preparation method and application thereof. The water-in-oil emulsion prepared by the application has the advantages of simple process, low fat (water phase content is 60% to 90%) and the like, and has similar viscosity and friction coefficient to commercially available products. The emulsion of the application can maintain high water holding capacity and oil holding capacity after multiple freeze-thaw cycles in a wide temperature range (-20 to 70 DEG C), and can resist acidic environment and high ionic strength (<600 mM) environment, realize multiple environmental stability of the emulsion, and overcome the problem of poor stability of the water-in-oil emulsion when the water phase content is greater than 50%. The water-in-oil emulsion can be applied to bread, spread, food sandwich, ice cream, plant meat and the like as food ingredients, or directly added to food as a fat substitute.

Provided are an alphaxalone fat emulsion injection and a method for preparing same. The alphaxalone fat emulsion injection comprises alphaxalone and a pharmaceutically acceptable salt thereof, an oil phase, an emulsifier, a co-emulsifier, an osmotic pressure regulator, a stabilizer, a pH value regulator, and water for injection.

A yolk phospholipid composition having a lysophosphatidyl ethanolamine content of 1% by mass or less and an amino acid content of 50 mg / 100 g or more and 500 mg / 100 g or less.

The invention discloses a high performance liquid chromatography detection method for naphthalene in medium / long-chain fat emulsion injection (C8-24Ve). According to the method, the naphthalene in the medium / long-chain fat emulsion injection (C8-24Ve) can be detected in a short time by utilizing a high performance liquid chromatograph. The method is simple, convenient to operate, efficient and rapid, the most common chromatographic column and detector are adopted, naphthalene detection in the medium / long-chain fat emulsion injection (C8-24Ve) is achieved within 35 min, the selected mobile phase cannot damage an instrument, the detection time is short, and the method is an efficient and reasonable analysis method. The sample stability is good, the product quality is ensured, the production and daily detection of enterprises are facilitated, the efficiency is improved, and the detection cost is greatly reduced.

The invention discloses a preparation method of a medium-chain and long-chain fat emulsion injection, which comprises the following specific steps: S1, dissolving glycerol and part of sodium oleate in water for injection under the protection of nitrogen, heating, stirring and dispersing to obtain a water phase; s2, under the protection of nitrogen, dissolving egg yolk lecithin in the mixed oil, heating, shearing and stirring to dissolve the egg yolk lecithin, so as to obtain an oil phase; s3, under the protection of nitrogen, continuously feeding the oil phase and the water phase into a shearing machine according to a weight ratio, and shearing to obtain primary emulsion; s4, performing high-pressure homogenization on the primary emulsion for 2-3 times, supplementing the residual sodium oleate, and performing low-pressure homogenization once to obtain final emulsion; and S5, filling the final emulsion under a low-oxygen condition, filling nitrogen, plugging, capping, and sterilizing to obtain the medium-chain and long-chain fat emulsion injection product. The particle size distribution of the product can be effectively improved, the medium-chain and long-chain fat emulsion injection with uniform and stable particle size is prepared, and the stability of three-cavity liquid medicine in the mixing or compatibility process is guaranteed.

This invention discloses a method for detecting the encapsulation efficiency of dexamethasone palmitate injection, belonging to the technical field of encapsulation efficiency detection. The method involves mixing dexamethasone palmitate injection with a solvent for extraction; the dexamethasone palmitate injection comprises a fat emulsion and free dexamethasone palmitate; after extraction, the fat emulsion and free dexamethasone palmitate are separated, and the encapsulation efficiency is calculated by quantitative analysis using HPLC; the polarity of the solvent is similar to that of the dexamethasone palmitate. This invention utilizes the principle of "like dissolves like" to develop a method for determining the encapsulation efficiency of dexamethasone palmitate injection extracted with an organic solvent. This method effectively separates the fat emulsion from the free dexamethasone palmitate while ensuring that the structure of the fat emulsion is not damaged during the measurement process, thus avoiding falsely low encapsulation efficiency due to drug leakage.