5 results about "Alfacalcidol" patented technology

The utility model provides a kind of for the illumination reaction device of alfacalcidol, including the liquid storage tank to be lighted, circulating pump and illumination reaction tank formed by pipeline connection circulation passway, wherein: illumination reaction tank center is provided with the LED light of cylindrical shape, and there are a plurality of upper and lower interval arrangement partition plates in periphery, and the serpentine reaction channel of upper and lower bending is formed between a plurality of partition plates.The utility model illumination reaction device can realize uniform stable illumination reaction by the design of illumination reaction tank and serpentine reaction channel, reduce the optical path of reaction liquid, improve alfacalcidol illumination reaction efficiency and product quality consistency, effectively overcome the technical defects of traditional equipment.

The application belongs to the technical field of pharmaceutical preparations, and discloses a soft capsule preparation containing alfacalcidol and a preparation method thereof. The soft capsule preparation comprises a soft capsule shell and content filled in the soft capsule shell, and the content is composed of a drug-containing oil phase and alfacalcidol sustained-release pellets dispersed in the oil phase. The drug-containing oil phase comprises immediate-release alfacalcidol dissolved in an oily base. The sustained-release pellets comprise a blank pellet core, a drug-loaded layer and a separation layer, and the separation layer comprises a combined coating material of Eudragit RS30D and Eudragit RL30D. After oral administration, the alfacalcidol in the oil phase is rapidly released to achieve immediate effect, and the alfacalcidol in the sustained-release pellets is slowly released to maintain the steady state of blood drug concentration. The soft capsule preparation of the application realizes the dual-phase drug release behavior of immediate release and sustained release in the same soft capsule, so that the blood drug concentration is smooth and controllable within 24 hours, the steady state of blood drug concentration is maintained, the frequency of drug administration is reduced, and the risk of side effects such as hypercalcemia is reduced.

The present application relates to the field of new drug preparations, and specifically discloses a kind of alfacalcidol soft capsule composition and preparation method thereof, the alfacalcidol soft capsule composition is prepared from alfacalcidol content drug liquid and soft capsule shell, wherein the soft capsule content drug liquid includes alfacalcidol co-crystal, oily base, the soft capsule shell is made of gelatin, plasticizer, purified water and light shielding agent;The alfacalcidol soft capsule composition prepared by the present application has high stability, and improves the problems of low solubility of raw material, easy oxidation and poor water solubility, the preparation method of the alfacalcidol soft capsule composition is simple and easy to operate, low in cost, and easy to mass production.

The invention belongs to the technical field of chemical synthesis of medicines, and discloses a novel process for producing an alfacalcidol raw material medicine, which comprises the following steps of: introducing a Lewis acid catalyst in a key addition reaction, obviously shortening the reaction time and inhibiting side reaction; a quenching mode of dilution dropwise adding and real-time pH and temperature monitoring is adopted to replace one-time adding of a quenching agent, so that product decomposition or polymerization caused by too high local concentration is avoided; an acetone-ethanol cosolvent system is combined with a programmed gradient cooling crystallization process, so that the freezing point of the solvent is reduced, and crystals with uniform particle size and good fluidity are obtained; and a microwave-vacuum combined drying technology is adopted, so that the drying efficiency is greatly improved, and the moisture absorption stability of the product is improved. The method has the advantages of high overall efficiency, stable product quality, significantly improved product purity and yield, and suitableness for industrial production.

The invention discloses alfacalcidol gel which is prepared from the following components in percentage by mass: 0.01 to 0.05 percent of alfacalcidol, 1 to 3 percent of nanocrystalline stabilizer, 3 to 8 percent of oil phase, 6 to 12 percent of emulsifier, 3 to 6 percent of co-emulsifier, 4 to 8 percent of gel matrix and the balance of purified water. The invention aims to solve the technical problems of low oral absorption rate and low curative effect stability of medicines.