7 results about "Osteopathy" patented technology

To provide improved gene therapy vectors comprising a polynucleotide sequence encoding a TCIRG1 polypeptide or a functional variant thereof, methods of use thereof, pharmaceutical compositions, and more, and in particular, to provide lentiviral vectors for treatment of infantile malignant osteopetrosis (IMO).SOLUTION: Provided is a transfer plasmid, comprising an expression cassette comprising a coding polynucleotide encoding a T cell immune regulator 1 (TCIRG1) polypeptide and a promoter, wherein the polynucleotide is operatively linked to the promoter, and wherein the transfer plasmid comprises an RNA-OUT repressor and a CMV IE promoter, and also comprises a polynucleotide sharing at least 95% identity to a specific sequence.SELECTED DRAWING: Figure 1

This invention belongs to the field of biomedical inorganic nanomaterials technology, and discloses a copper-doped bioglass and its application in the treatment of chronic liver injury and hepatic osteodystrophy. The bioglass is prepared by a sol-gel method, with copper as a dopant (Cu). 2+ It is doped in a form with a doping amount of 0.1-5 wt%, has a mesoporous structure, a particle size of approximately 163 nm, and can slowly release Cu in environments with pH 7.4 or 5.5. 2+ The treatment duration is 48-96 hours. This invention is the first to use the aforementioned material for the simultaneous treatment of chronic liver injury (such as metabolic-associated steatohepatitis) and its secondary hepatic osteopathy, achieving liver-targeted therapy via intravenous injection. Its mechanism of action includes: regulating glucose and lipid metabolism in the liver, enhancing mitochondrial function, and inhibiting inflammation and fibrosis; simultaneously upregulating the liver-derived factor LCAT, promoting osteogenic differentiation via the liver-bone axis, thereby synergistically improving liver injury and bone loss. This invention overcomes the limitations of separate liver and bone treatment, providing a safe and effective integrated treatment strategy.

The invention belongs to the technical field of intelligent medical treatment, and particularly relates to a renal bone disease diagnosis and treatment scheme generation method and system, acupoint stimulation equipment and a medium, and the method comprises the steps: collecting clinical data, related to renal bone diseases, of a target object; on the basis of a pre-constructed clinical data and acupuncture point data relation library, acupuncture point data corresponding to the clinical data are obtained through matching, and the acupuncture point data comprise target acupuncture point identification and acupuncture point stimulation data corresponding to the target acupuncture point identification; acquiring a human body image of the target object, and acquiring acupuncture point position data of the target acupuncture point identification on the human body image; and generating an acupoint stimulation scheme of the acupoint stimulation device in multiple stimulation modes based on the acupoint position data and the acupoint stimulation data. According to the renal bone disease diagnosis and treatment scheme generation method, different stimulation modes and stimulation parameters can be flexibly selected and adjusted, a personalized acupoint stimulation scheme is formulated, and the accuracy and adaptability of acupoint stimulation are improved.

The invention discloses a fracture reduction external fixing device based on traditional osteopathy and a fracture reduction method of the fracture reduction external fixing device, and relates to the technical field of medical instruments, and the key points of the technical scheme are that the fracture reduction external fixing device comprises a fracture part fixing structure and a displacement preventing structure, and the fracture part fixing structure is detachably connected with the displacement preventing structure; the fracture part fixing structure comprises a clamping plate and a connecting band, a through groove is formed in the clamping plate, the connecting band penetrates through the through groove to be connected with the clamping plate, a locking device is arranged at the head of the connecting band, the connecting band comprises a soft part and a hard end, the displacement preventing structure comprises connectors and fixing rotary knobs used in cooperation with the connectors, and the top of each connector is fixedly connected with a clamping piece. A fixing band is connected between the two clamping pieces, an adjusting band is arranged on the side, away from the fixing band, of one clamping piece, an adjusting switch is arranged on the side, away from the fixing band, of the other clamping piece, and the connector is rotationally connected with an angle adjuster. The device can well fix a fracture part and effectively prevent the fracture part from falling off and shifting.

The invention relates to application of C18 ceramide in promoting adipose-derived stem cell osteogenic differentiation and a method for promoting adipose-derived stem cell osteogenic differentiation. The method comprises the following steps: S1, aseptically acquiring adipose tissues of a human body; s2, cutting the adipose tissue into small blocks, mixing the small blocks with collagenase, and incubating at 37 DEG C; s3, after enzymolysis is completed, performing centrifugal treatment and washing, and transferring the cells into a culture bottle containing a culture medium for further culture; s4, when the fusion degree of the cells is 80%, transferring the cells into a culture medium containing C18 ceramide for culture to obtain cultured adipose-derived stem cells; and S5, detecting and cryopreserving. According to the application, C18 ceramide is used for regulating a cell signal channel and membrane fluidity, the osteogenic differentiation capacity of the adipose-derived stem cells is remarkably promoted, the efficiency of differentiation from the adipose-derived stem cells to osteoblasts is remarkably improved through specific bioactive lipid molecule intervention, and a new way is opened up for application of drugs for bone injury and degenerative bone diseases.

The invention relates to the field of medicines, and particularly discloses a rheumatism bone disease plaster with effects of dispelling wind and eliminating dampness. The rheumatism bone disease plaster comprises medicinal materials with effects of dispelling wind and eliminating dampness, a drug effect stabilizer, a microcapsule encapsulating agent, bionic polymerized gel and the like, the wind-dispelling and dampness-eliminating medicinal materials comprise lysimachia foenum-graecum hance, streptocaulon griffithii, gaultheria yunnanensis, radix clematidis, radix aristolochiae, radix zanthoxyli, capparis acutifolia, berchemia lineate, dodecaichrysum lanceolatum, radix cynanchi paniculati, ardisia crenata, semiliquidambar cathayensis, lindera glauca, giantleaf ardisia rhizome, cynanchum chinense, ajuga decumbens, eucheuma nepalensis, caulis spatholobi, ligusticum wallichii, kadsura coccinea, sterculia lychnophora, ovate knotweed rhizome, kadsura coccinea, radix cudramiae A three-dimensional medicinal material system capable of dispelling cold, removing dampness, assisting in dredging collaterals, activating blood circulation, improving efficiency and resisting inflammation is constructed, the cold-dampness source of the rheumatism bone disease is precisely targeted, the plaster has the effects of being remarkable in wind dispelling and dampness removing effect, lasting in analgesic effect, low in skin irritation, environmentally friendly and degradable, and meanwhile the problems that an existing plaster has multiple emphases on single analgesia, treats the symptoms but not the root causes, and the pain cannot be relieved are solved. The symptoms are repeated if the cold-dampness inducement is not eliminated.

The invention provides traditional Chinese medicine liquor for treating cervical vertebra and lumbar vertebra bone diseases, and relates to the technical field of traditional Chinese medicine. Comprising the following raw materials: eucommia ulmoides, ligusticum wallichii, semen cuscutae, astragalus membranaceus, beautiful millettia root, philippine flemingia root, pseudo-ginseng, morinda officinalis, radix angelicae pubescentis, fructus psoraleae, radix achyranthis bidentatae, radix paeoniae alba, herba epimedii, cynomorium songaricum, radix rehmanniae preparata, rhizoma polygonati, cistanche deserticola, radix clematidis, rhizoma corydalis, radix angelicae, raspberry, antler tablets, angelica sinensis, codonopsis pilosula, lucid ganoderma, red dates, medlar, caulis spatholobi, cassia twig, kadsura pepper stem, fructus rosae laevigatae and safflower carthamus. By tonifying the kidney, nutrition supply of bones can be enhanced from the source, the toughness and repairing capacity of the bones are improved, and symptoms such as soreness and weakness of waist and knees, pain and the like caused by kidney deficiency are improved; meanwhile, the traditional Chinese medicine composition has the effects of promoting blood circulation and removing blood stasis, can promote local blood circulation, eliminate pain and swelling caused by qi and blood stasis, improve blood supply of cervical vertebra and lumbar vertebra parts, provide sufficient nutrients for damaged tissues and accelerate damage repair.