15 results about "Semiliquidambar cathayensis" patented technology

The application discloses application of Rhamnus hemisphaerica in preparation of anti-pancreatic cancer drugs, wherein the Rhamnus hemisphaerica is dry root of Semiliquidam bar cathayensis Chang of Rhamnaceae. Researches show that the Rhamnus hemisphaerica can inhibit proliferation, invasion and migration of pancreatic cancer cells Pan-1, promote apoptosis, has anti-pancreatic cancer activity, can significantly inhibit growth of tumor of a subcutaneous nude mouse xenograft model of pancreatic cancer cells Panc-1, significantly inhibit expression of a tumor proliferation related factor Ki67, and has no obvious toxic side effect on mice. The application firstly discloses that the Rhamnus hemisphaerica has obvious anti-pancreatic cancer activity, can be used for preparation of anti-pancreatic cancer drugs, provides a new efficient and safe drug source for treatment of pancreatic cancer, and provides a basis for further development and utilization of the Rhamnus hemisphaerica.

The invention discloses all-traditional Chinese medicine traumatic injury medicinal liquor and a preparation method thereof, and belongs to the field of traditional Chinese medicine. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25-35 parts of rubus suavissimus, 35-45 parts of ventilago leiocarpa benth, 25-35 parts of fructus schisandrae chinensis, 12-18 parts of asarum sieboldii, 35-45 parts of semiliquidambar cathayensis, 35-45 parts of entada phaseoloides, 17-23 parts of kadsura pepper stem, 25-35 parts of lindera glauca, 35-45 parts of lysimachia christinae hance, 25-35 parts of angelica sinensis, 25-35 parts of berchemia lineate, 35-45 parts of oxalis, 35-45 parts of radix achyranthis bidentatae, 17-23 parts of artabotrys hexapetalus, 25-35 parts of sappanwood The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 35 to 45 parts of radix notoginseng, 25 to 35 parts of bodhi, 25 to 35 parts of radix aristolochiae fordianae, 17 to 23 parts of crane knee, 30 to 40 parts of caulis sargentodoxae, 20 to 30 parts of cyathea spinulosa wall, 35 to 45 parts of tinospora sinensis merr, 25 to 35 parts of ardisia punctata, 35 to 45 parts of knottedflower knotweed root, 20 to 30 parts of flos carthami, 35 to 45 parts of cynanchum otophyllum, 25 to 35 parts of schizophragma serratum, 25 to 35 parts of radix cynanchi paniculati and 35 to 45 parts of champion bauhinia root. The traditional Chinese medicine is reasonable and unique in compatibility, remarkable in curative effect and comprehensive in efficacy and gives consideration to exterior and interior.

The invention relates to a traditional Chinese medicine composition for treating ankylosing spondylitis, a medicine and a preparation method, and relates to the technical field of traditional Chinese medicines. The invention provides a traditional Chinese medicine composition for treating ankylosing spondylitis. The traditional Chinese medicine composition is prepared from the following raw materials: garden balsam stem, herb of Chinese rabdosia, spina gleditsiae, pangolin scales, camellia oleifera, radix angelicae, sargentgloryvine stem, folium artemisiae argyi, herba asari, leech, ficus microcarpa, semiliquidambar cathayensis, radix gleditsiae, sarcandra glabra, fructus liquidambaris and senecio scandens. The traditional Chinese medicine composition has the effects of dredging tendons and activating blood circulation, can deeply permeate into the body of a patient, enables swollen and calcified muscles and bones to recover to be normal, enables the skin color of a diseased region to recover to be normal, has a very good treatment effect on ankylosing spondylitis, is a neutral medicine, can be accepted by wet, cold and damp-heat constitutions, and is free of toxic and side effects. And the method has wide acceptability.

The invention discloses application of semiliquidambar cathayensis in preparation of a medicine for preventing and treating heart diseases, and belongs to the technical field of traditional Chinese medicines. The application refers to application of the semiliquidambar cathayensis, the extract thereof or the pharmaceutical composition thereof in preparation of drugs for preventing and treating myocardial fibrosis, drugs for preventing and treating heart diseases by improving myocardial fibrosis and drugs for preventing and treating heart diseases. Tests prove that the semiliquidambar cathayensis disclosed by the invention has a protection effect on the heart, and can be used for reducing fiber tissue hyperplasia and relieving cardiac fibrosis, so that a basis is provided for clinical medication conversion of the semiliquidambar cathayensis.

The invention discloses application of semiliquidambar cathayensis in preparation of a medicine for preventing and treating kidney diseases, and belongs to the technical field of traditional Chinese medicines. The application refers to application of the semiliquidambar cathayensis, the extract thereof or the pharmaceutical composition thereof in preparation of drugs for preventing and treating kidney fibrosis, drugs for preventing and treating kidney diseases by improving kidney fibrosis and drugs for preventing and treating kidney diseases. Experiments show that the semiliquidambar cathayensis can reduce fiber tissue hyperplasia and relieve renal fibrosis, a new way is provided for treatment of kidney diseases, and meanwhile, the application field of the semiliquidambar cathayensis is expanded.

The application provides semi total flavonoids of Liquidambar, which is obtained by using stems of Liquidambar cathayensis Hung T.Chang as raw materials and adopting ultrasonic-assisted low eutectic solvent extraction, wherein the yield of the total flavonoids is 71.95%±6.49%. The application also provides a preparation method and application of the semi total flavonoids of Liquidambar. The semi total flavonoids of Liquidambar have significant antioxidant activity, can be used for nerve protection, can be used for treating cerebral ischemia or anti-ischemic stroke, can improve cerebral ischemic nerve function injury, can reduce cerebral infarction volume, can reduce neuron damage degree, can reduce activation of astrocytes, can reduce expression level of apoptotic proteins, can protect neurons and synapses, and can protect vascular endothelial cells. The drug efficacy is clear and controllable, is equivalent to that of positive drug nimodipine, can reach significant drug efficacy at a low dose, is safer in clinical use, and provides a new selection for clinic.

The invention discloses application of semiliquidambar cathayensis in preparation of a medicine for preventing and treating lung diseases, and belongs to the technical field of traditional Chinese medicines. The application refers to application of the semiliquidambar cathayensis, the extract thereof or the pharmaceutical composition thereof in preparation of drugs for preventing and treating pulmonary fibrosis, drugs for preventing and treating lung diseases by improving pulmonary fibrosis and drugs for preventing and treating lung diseases. Tests prove that the semiliquidambar cathayensis can improve the pathological process of pulmonary fibrosis, a new way is provided for treatment of lung diseases, and meanwhile, the application field of the semiliquidambar cathayensis is expanded.

This invention belongs to the field of traditional Chinese medicine preparations, and relates to the preparation method and application of a compound preparation of Yao Yu effervescent tablets with anti-rheumatoid arthritis effect. The compound preparation comprises the following traditional Chinese medicine components: 4 parts by weight of Dioscorea cirrhosa, 3 parts by weight of Tinleaf Vine, 2 parts by weight of Camphor Tree, 2 parts by weight of Rhus chinensis, 3 parts by weight of Rhododendron molle, 1 part by weight of Ephedra sinica, 2 parts by weight of Semi-Acer palmatum, 2 parts by weight of Gynostemma pentaphyllum, and 1 part by weight of Cinnamomum cassia. The preparation steps include: placing Dioscorea cirrhosa, Tinleaf Vine, Camphor Tree, Rhus chinensis, Rhododendron molle, Gynostemma pentaphyllum, Semi-Acer palmatum, Gynostemma pentaphyllum, and Cinnamomum cassia in 6000 parts by weight of 70% ethanol. Extract for 2 hours, repeat three times, filter, and combine the filtrates; concentrate, freeze-dry, pulverize, and pass through an 80-mesh sieve for later use; mix 27.5% freeze-dried powder with 26.45% citric acid, 34.11% sodium bicarbonate, 5.61% PEG6000, and 6.33% lactose evenly, pass through an 80-mesh sieve, and prepare a soft mass using anhydrous ethanol as a wetting agent; pass the soft mass through a 20-mesh sieve and dry at 37℃ for 30 minutes to obtain compound preparation granules; granulate through a 20-mesh sieve for granulation, add lubricant PEG6000 and mix evenly; compress into tablets to obtain compound preparation effervescent tablets. This invention, through pharmacological experiments, confirms that the Yaoyu effervescent tablet compound preparation has a good anti-rheumatoid arthritis effect: it can reduce local inflammatory mediators and serum IL-1β, IL-6, TNF-α, and PEG2 levels, downregulate MDA and increase SOD to improve oxidative stress, inhibit the expression of MMP3, COX-2, and P38 proteins in the synovial membrane, and reduce pathological tissue damage. The medium and high dose groups showed the best effect, and it has a good therapeutic and protective effect on the ankle joint of AA rats, with good clinical application value.

The invention relates to the technical field of traditional Chinese medicine compositions, and particularly discloses a Yao bath lotion for diminishing inflammation and relieving itching and a preparation method thereof.The Yao bath lotion is composed of a traditional Chinese medicine raw material extracting solution, auxiliary materials and water, and the traditional Chinese medicine raw material extracting solution is prepared from traditional Chinese medicine raw materials; the traditional Chinese medicine raw materials comprise ovateleaf holly bark, pogostemon cablin, lemongrass, cinnamomum camphora, semiliquidambar cathayensis, folium artemisiae argyi, vitex negundo, rhizoma acori graminei, alpinia pumila, poria peel, tuber fleeceflower stem, caulis spatholobi, uncaria rhynchophylla, liquidambar formosana hance, cortex albiziae, rock bean vine and cardamom. The preparation method comprises the following steps: S1, carrying out water extraction on part of the traditional Chinese medicine raw materials, and filtering and concentrating to obtain a water extraction concentrated solution; s2, carrying out ethanol reflux extraction on the residual traditional Chinese medicine raw materials, filtering to recover ethanol, and concentrating to obtain an ethanol extraction concentrated solution; s3, the two concentrated solutions are mixed, auxiliary materials are added for dissolution, the water amount is adjusted, then homogenization and filtration are conducted, and the Yao bath lotion is obtained.The Yao bath lotion has the advantages that active ingredients are enriched through water extraction and alcohol extraction, volatile oil and fat-soluble and water-soluble ingredients are in synergistic effect, itching and inflammation are quickly relieved, and skin inflammation and pruritus symptoms are effectively relieved.

The invention discloses a construction method and application of a semiliquidambar cathayensis fingerprint spectrum, and belongs to the technical field of traditional Chinese medicine analysis. The construction method of the semiliquidambar cathayensis fingerprint spectrum comprises the following steps: (1) extracting total triterpenoid saponins in roots or leaves of semiliquidambar cathayensis; and (2) detecting the total triterpenoid saponins of the semiliquidambar cathayensis prepared in the step (1) by adopting high performance liquid chromatography to obtain a chromatogram of the semiliquidambar cathayensis, and the chromatogram of the semiliquidambar cathayensis is the fingerprint spectrum of the semiliquidambar cathayensis. The invention provides the construction method of the semiliquidambar cathayensis fingerprint spectrum, the fingerprint spectrum can be used for evaluating the batch quality stability of the semiliquidambar cathayensis, and reliable technical support is provided for standardized application of the semiliquidambar cathayensis.

The invention discloses application of semiliquidambar cathayensis in preparation of a medicine for preventing and treating liver diseases, and belongs to the technical field of traditional Chinese medicines. The application refers to application of the semiliquidambar cathayensis, the extract thereof or the pharmaceutical composition thereof in preparation of drugs for preventing and treating hepatic fibrosis, drugs for preventing and treating hepatic diseases by improving hepatic fibrosis and drugs for preventing and treating hepatic diseases. Experiments prove that the semiliquidambar cathayensis has a good treatment effect on liver fibrosis, and a basis is provided for clinical medication conversion of the semiliquidambar cathayensis.

This invention discloses a Yao bath composition for promoting blood circulation and dispelling wind, its preparation method, and its application, belonging to the field of Yao medicine technology. The Yao bath composition of this invention uses *Polygonum cuspidatum*, *Uncaria rhynchophylla*, and *Symplocos buergeriana* as the principal herbs, serving as the main anti-inflammatory and analgesic agents; *Clematis chinensis*, *Cinnamomum cassia*, *Angelica pubescens*, *Commiphora myrrha*, and *Artemisia argyi* as the assistant herbs, promoting blood circulation, dispelling cold, and relieving pain; *Polygonum multiflorum*, *Eucommia ulmoides*, and *Achyranthes bidentata* as adjuvant herbs, strengthening the body's resistance and guiding the medicine downwards; and *Glycyrrhiza uralensis* as the guiding herb, harmonizing the effects of all the herbs. It can be seen that the composition follows the traditional Chinese medicine theory of "promoting blood circulation, removing blood stasis, dispelling wind, clearing heat, and promoting diuresis." The combined effects of these herbs are anti-inflammatory, analgesic, and improve pelvic microcirculation, exerting therapeutic effects through multiple components, targets, and pathways. The pharmacological targets are clearly defined, effectively improving symptoms such as pain and inflammation caused by pelvic inflammatory disease, and showing significant therapeutic effects on pelvic inflammatory disease and other gynecological inflammations. Furthermore, through process optimization, the extraction of active ingredients can be promoted, thereby significantly improving the efficacy of the Yao bath composition.

This invention relates to the field of traditional Chinese medicine extracts and drug preparation technology, and discloses a *Hypericum perforatum* extract composition, its preparation method, and its application, including the application of an ethanol extract of *Hypericum perforatum* or components isolated from its ethanol extract in the preparation of drugs for the prevention and / or treatment of psoriasis. In vitro and in vivo experiments have demonstrated that *Hypericum perforatum* extract can significantly improve imiquimod (IMQ)-induced psoriasis-like skin lesions (erythema, scaling, and skin thickening) in mice and reduce PASI scores. Its mechanism of action differs from single-target biological agents; instead, it simultaneously regulates the IL-23 / IL-17 inflammatory axis, corrects Th17 / Treg immune imbalance, and inhibits abnormal activation of the NF-κB signaling pathway, demonstrating the advantages of multi-component, multi-target synergistic effects of natural drugs. Furthermore, *Hypericum perforatum* is a unique plant resource in my country with a wide distribution. Compared to expensive biological agents, this invention has a significant cost advantage and is expected to be developed into a more affordable and accessible anti-psoriasis drug.

Use of Semiliquidambar cathayensis H. T. Chang., an extract thereof, or a pharmaceutical composition thereof in preparing a drug for preventing and / or treating liver injury. Tests prove that Semiliquidambar cathayensis H. T. Chang. can relieve substantial damage such as liver cell inflammatory reaction and fat degeneration, effectively reduce AST and AST levels in serum, and have a good effect on preventing and / or treating liver injury.

The invention relates to a Congjiang Yao bath lotion for gynecological health care and a preparation method and application thereof, and belongs to the technical field of ethnic medicine modernization. The Congjiang Yao bath lotion for gynecological health care is prepared from the following medicinal raw materials by mass: 50 to 70 g of semiliquidambar cathayensis, 50 to 70 g of uncaria rhynchophylla, 50 to 70 g of sarcandra glabra, 30 to 40 g of basil, 80 to 100 g of motherwort, 20 to 30 g of dandelion, 30 to 50 g of golden cypress, 20 to 30 g of wintercreeper and 30 to 50 g of radix sophorae flavescentis. The motherwort herb is fed in two batches. According to the traditional Chinese medicine composition, the Yao medicine ternary theory, the traditional Chinese medicine monarch, minister, assistant and guide theory and the modern pharmacology theory are combined, the wind medicine, the spraying medicine, the drilling medicine, the wind dispelling and dampness eliminating medicine, the blood circulation promoting and blood stasis removing medicine and the anti-inflammation and antibacterial medicine are combined, the mutual complementing and compounding synergistic effect is achieved, and the traditional Chinese medicine composition has the remarkable gynecological health care effect.