3 results about "Semiliquidambar cathayensis" patented technology

This invention belongs to the field of traditional Chinese medicine preparations, and relates to the preparation method and application of a compound preparation of Yao Yu effervescent tablets with anti-rheumatoid arthritis effect. The compound preparation comprises the following traditional Chinese medicine components: 4 parts by weight of Dioscorea cirrhosa, 3 parts by weight of Tinleaf Vine, 2 parts by weight of Camphor Tree, 2 parts by weight of Rhus chinensis, 3 parts by weight of Rhododendron molle, 1 part by weight of Ephedra sinica, 2 parts by weight of Semi-Acer palmatum, 2 parts by weight of Gynostemma pentaphyllum, and 1 part by weight of Cinnamomum cassia. The preparation steps include: placing Dioscorea cirrhosa, Tinleaf Vine, Camphor Tree, Rhus chinensis, Rhododendron molle, Gynostemma pentaphyllum, Semi-Acer palmatum, Gynostemma pentaphyllum, and Cinnamomum cassia in 6000 parts by weight of 70% ethanol. Extract for 2 hours, repeat three times, filter, and combine the filtrates; concentrate, freeze-dry, pulverize, and pass through an 80-mesh sieve for later use; mix 27.5% freeze-dried powder with 26.45% citric acid, 34.11% sodium bicarbonate, 5.61% PEG6000, and 6.33% lactose evenly, pass through an 80-mesh sieve, and prepare a soft mass using anhydrous ethanol as a wetting agent; pass the soft mass through a 20-mesh sieve and dry at 37℃ for 30 minutes to obtain compound preparation granules; granulate through a 20-mesh sieve for granulation, add lubricant PEG6000 and mix evenly; compress into tablets to obtain compound preparation effervescent tablets. This invention, through pharmacological experiments, confirms that the Yaoyu effervescent tablet compound preparation has a good anti-rheumatoid arthritis effect: it can reduce local inflammatory mediators and serum IL-1β, IL-6, TNF-α, and PEG2 levels, downregulate MDA and increase SOD to improve oxidative stress, inhibit the expression of MMP3, COX-2, and P38 proteins in the synovial membrane, and reduce pathological tissue damage. The medium and high dose groups showed the best effect, and it has a good therapeutic and protective effect on the ankle joint of AA rats, with good clinical application value.

This invention discloses a Yao bath composition for promoting blood circulation and dispelling wind, its preparation method, and its application, belonging to the field of Yao medicine technology. The Yao bath composition of this invention uses *Polygonum cuspidatum*, *Uncaria rhynchophylla*, and *Symplocos buergeriana* as the principal herbs, serving as the main anti-inflammatory and analgesic agents; *Clematis chinensis*, *Cinnamomum cassia*, *Angelica pubescens*, *Commiphora myrrha*, and *Artemisia argyi* as the assistant herbs, promoting blood circulation, dispelling cold, and relieving pain; *Polygonum multiflorum*, *Eucommia ulmoides*, and *Achyranthes bidentata* as adjuvant herbs, strengthening the body's resistance and guiding the medicine downwards; and *Glycyrrhiza uralensis* as the guiding herb, harmonizing the effects of all the herbs. It can be seen that the composition follows the traditional Chinese medicine theory of "promoting blood circulation, removing blood stasis, dispelling wind, clearing heat, and promoting diuresis." The combined effects of these herbs are anti-inflammatory, analgesic, and improve pelvic microcirculation, exerting therapeutic effects through multiple components, targets, and pathways. The pharmacological targets are clearly defined, effectively improving symptoms such as pain and inflammation caused by pelvic inflammatory disease, and showing significant therapeutic effects on pelvic inflammatory disease and other gynecological inflammations. Furthermore, through process optimization, the extraction of active ingredients can be promoted, thereby significantly improving the efficacy of the Yao bath composition.

This invention relates to the field of traditional Chinese medicine extracts and drug preparation technology, and discloses a *Hypericum perforatum* extract composition, its preparation method, and its application, including the application of an ethanol extract of *Hypericum perforatum* or components isolated from its ethanol extract in the preparation of drugs for the prevention and / or treatment of psoriasis. In vitro and in vivo experiments have demonstrated that *Hypericum perforatum* extract can significantly improve imiquimod (IMQ)-induced psoriasis-like skin lesions (erythema, scaling, and skin thickening) in mice and reduce PASI scores. Its mechanism of action differs from single-target biological agents; instead, it simultaneously regulates the IL-23 / IL-17 inflammatory axis, corrects Th17 / Treg immune imbalance, and inhibits abnormal activation of the NF-κB signaling pathway, demonstrating the advantages of multi-component, multi-target synergistic effects of natural drugs. Furthermore, *Hypericum perforatum* is a unique plant resource in my country with a wide distribution. Compared to expensive biological agents, this invention has a significant cost advantage and is expected to be developed into a more affordable and accessible anti-psoriasis drug.