48 results about "Ephedra sinica" patented technology

The invention discloses a preparation method and antipyretic and anti-inflammatory application of a novel carrier-free metal-organic small molecule supramolecular hydrogel derived from Maxing Shigan Decoction. The hydrogel drug raw materials of the invention include pseudoephedrine hydrochloride in Ephedra sinica in the prescription of Maxing Shigan Decoction, amygdalin in Armeniaca vulgaris, magnesium ions in Gypsum fibrosum, and glycyrrhizic acid in Glycyrrhiza uralensis Fisch. The preparation method of the quaternary magnesium hydrogel drug is simple, green, has good stability and high biocompatibility. In a rat fever model induced by lipopolysaccharide at different doses, the antipyretic effect of the hydrogel drug can last up to 12 hours, and the antipyretic effect is significantly better than that of other metal ions such as quaternary calcium hydrogel, quaternary zinc hydrogel, and quaternary copper hydrogel groups. At the same time, it has a more persistent antipyretic effect than the whole prescription of Maxing Shigan Decoction; the hydrogel drug does not require the addition of excipients, has no toxic and side effects, and has a high drug utilization rate.

The present invention relates to the technical field of traditional Chinese medicine, and provides a Chinese medicine composition for treating skin lesions and scars, and a preparation method and application thereof, which is mainly used to treat skin lesions and scars caused by carbuncle and ulcer. The Chinese medicine composition of the present invention comprises the following raw materials: Vaccaria segetalis, Astragalus membranaceus, Bletilla striata, Morus alba bark, Angelica dahurica, White Ampelopsis Root, Dictamni Cortex, Rhizoma Cyperi, Rhizoma Bletillae, Bletilla striata Rhizoma, Bletilla striata Rhizoma, Bletilla striata Rhizoma, Bletilla striata Rhizoma, Bark of Bombyx batryticatus, Magnolia officinalis, Pueraria root, Eucommia bark, Dipsacus asper, Smilax glabra, Honeysuckle vine, Chuanxiong, Angelica sinensis, Ephedra sinica, and Cinnamomum cassia. The Chinese medicine composition of the present invention has the effects of dispelling wind and relieving itching, relieving swelling and relieving pain, promoting pus and detoxifying, and reducing color and eliminating scars. It is mainly used to treat skin lesions and scars caused by carbuncle and ulcer, and is significantly effective for treating skin ulcers, swellings, and furuncles. It also treats pruritus caused by deep infected wounds and psoriasis lesions, and reduces the use of antibiotics.

A traditional Chinese medicine composition for treating acute and chronic inflammation of the ear, nose, and throat, and its preparation method, characterized in that, by weight, it is made from the following traditional Chinese medicinal materials: 10-30 parts of Lycium chinense root bark, 8-30 parts of Gardenia jasminoides, 10-30 parts of Sanguisorba officinalis root bark, 8-25 parts of Schizonepeta tenuifolia root bark, 6-16 parts of Angelica dahurica root bark, 10-35 parts of Asparagus cochinchinensis root bark, 11-35 parts of Platycodon grandiflorus root bark, 7-46 parts of Paeonia lactiflora root bark, 8-46 parts of Rehmannia glutinosa root bark, and 5-10 parts of Oroxylum indicum root bark. 14 parts of the following ingredients are used: Astragalus membranaceus 12-50 parts, Magnolia biondii 10-30 parts, Trichosanthes kirilowii 10-35 parts, Stellaria dichotoma 5-20 parts, Imperata cylindrica 7-30 parts, Fagopyrum dibotrys 10-35 parts, Coix lacryma-jobi 13-60 parts, Lepidium apetalum 5-15 parts, Gypsum fibrosum 14-50 parts, Sophora tonkinensis 3-20 parts, Lonicera japonica 12-50 parts, Xanthium sibiricum 6-35 parts, Ephedra sinica 6-30 parts, and Styrax benzoin 1-3 parts. After grinding into powder, the mixture is steamed with rice wine to obtain pills. The principle of treating all three (ear, nose, and throat) simultaneously, considering the anatomical structure and physiological function of the ear, nose, and throat, aims to reduce cross-infection, promote recovery, and achieve ideal medicinal properties.

The invention relates to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine composition which comprises the following raw materials: radix angelicae, radix scutellariae, herba ephedrae, flos magnoliae, scalded semen armeniacae amarae, rhizoma belamcandae, herba pogostemonis and radix platycodonis. The invention further provides a traditional Chinese medicine mixture prepared from the traditional Chinese medicine composition and a preparation method of the traditional Chinese medicine mixture. The invention also provides application of the traditional Chinese medicine composition, the traditional Chinese medicine mixture or the preparation method in preparation of medicines for preventing and / or treating acute respiratory system infection. According to the traditional Chinese medicine composition, the traditional Chinese medicine mixture and the preparation method of the traditional Chinese medicine composition and the traditional Chinese medicine mixture, the curative effect on acute respiratory system infection is obvious, and no side effect exists.

This invention relates to the field of traditional Chinese medicine technology, and more particularly to the application of a traditional Chinese medicine composition in the preparation of drugs for the prevention and treatment of lung injury. The traditional Chinese medicine composition includes Astragalus membranaceus, Eupolyphaga sinensis, Morus alba root bark, Fritillaria cirrhosa, Perilla frutescens seed, Lepidium apetalum seed, Prunus armeniaca seed, Pheretima aspergillum, Ephedra sinica, and Clematis chinensis. Experiments show that this traditional Chinese medicine composition can significantly reduce the level of the inflammatory factor TNF-α, decrease the lung index, and alleviate pathological damage to lung tissue, and can be used for the prevention and treatment of lung injury.

This invention belongs to the technical field of skin disease treatment products, specifically relating to a topical hot compress for treating scleroderma and its preparation method. The topical hot compress for treating scleroderma is made from the following raw materials in parts by weight: 20-40 parts of Artemisia argyi, 20-40 parts of Cinnamomum cassia, 10-20 parts of Sparganium stoloniferum, 10-20 parts of Curcuma zedoaria, 10-20 parts of Loranthus parasiticus, 15-30 parts of Gynostemma pentaphyllum, 10-20 parts of Spirodela polyrhiza, 15-30 parts of Spirodela polyrhiza, 15-30 parts of Ephedra sinica, 20-40 parts of Clematis chinensis, 5-15 parts of Eupolyphaga sinensis, 15-25 parts of Eriocaulon buergerianum, 5-15 parts of Carthamus tinctorius, 3-6 parts of Dracaena cochinchinensis, 3-6 parts of processed Strychnos nux-vomica, 20-40 parts of Vaccaria segetalis, 20-40 parts of Astragalus membranaceus, 10-20 parts of Magnolia officinalis, 10-20 parts of Aconitum carmichaelii, and 22-40 parts of rice wine. This invention is a topical medication that eliminates the need for oral administration, treating the disease externally and guiding the pathogenic factors to a cure. It avoids the inconvenience of bitter medications and effectively relieves symptoms and promotes the cure of localized scleroderma.

The invention discloses a screening method of macroporous resin for purifying tannin in the root of ephedra sinica stapf, which comprises the following steps: loading the macroporous resin to be screened into a chromatographic column, and enabling an extracting solution of the root of ephedra sinica stapf to pass through the pretreated chromatographic column; washing the chromatographic column with deionized water until the absorbance value of effluent is stable, desorbing with an ethanol solution, and collecting a desorption solution; measuring the wet stacking density of the adsorbed resin; inputting the ephedra tannin adsorption quantity in unit time in an adsorption stage, the ephedra tannin recovery rate in a desorption stage and the wet stacking density rho into a first sub-model based on a linear regression algorithm, a second sub-model based on a support vector regression algorithm and a third sub-model based on a random forest algorithm; and adding the scores of the sub-models according to the dynamic weight to calculate a comprehensive score, and selecting the macroporous resin with the highest comprehensive score. According to the macroporous resin screening device, accurate screening of macroporous resin can be achieved.

The invention belongs to the field of traditional Chinese medicine, and provides a mind-stabilizing composition, a preparation method, a preparation and a quality control and content determination method thereof, the mind-stabilizing composition is prepared from the following raw materials in parts by weight: 5-10 parts of gastrodia elata, 5-10 parts of stiff silkworm, 3-6 parts of uncaria, 2-4 parts of ephedra, 5-10 parts of fried spina date seed, 2-4 parts of tabasheer, 10-20 parts of poria cocos and 3-6 parts of rhizoma acori graminei. The tranquilizing composition is prepared from eight traditional Chinese medicines, namely gastrodia elata, stiff silkworm, uncaria, ephedra, fried spina date seed, tabasheer, poria cocos and rhizoma acori graminei, and has the effects of calming liver wind, tonifying spleen, clearing heat, reducing phlegm, soothing nerves and stopping movement. The traditional Chinese medicine is used for treating infantile touretic disorder (touretic disorder), liver-wind internal movement of hyperactivity and phlegm-heat disturbing spirit.

The invention relates to the technical field of traditional Chinese medicine formulas, in particular to a traditional Chinese medicine formula for dispelling wind. 2-10 g of scorpion; 5-60 g of dendrobium nobile; 5-60 g of gastrodia elata; 5-60 g of angelica sinensis; 5-60 g of honey-fried licorice root; 5-60 g of ligusticum wallichii; 5-60g of notopterygium root; 5-60 g of herba schizonepetae; 5-60 g of divaricate saposhnikovia root; 5-60g of ephedra herb; 5-60 g of asarum sieboldii miq; 5-60 g of monkshood; 5-60 g of radix aconiti agrestis; 5-60 g of realgar; and 5-60g of fleece-flower root. The wind-dispelling traditional Chinese medicine formula has the beneficial effects that through reasonable compatibility of various medicinal materials with the effects of dispelling wind, eliminating dampness, relieving pain and the like, wind evil inside and outside a human body can be effectively removed, and the wind-dispelling traditional Chinese medicine formula has a remarkable treatment effect on various diseases caused by wind evil, such as rheumatic arthralgia, headache, numbness of limbs and the like. Meanwhile, most of the medicinal materials in the formula are natural traditional Chinese medicines, so that the safety is relatively high, and side effects on a human body are reduced.

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine composition for treating chronic obstructive pneumonia and a pharmaceutical preparation. The traditional Chinese medicine composition comprises blackberry lily, honey-fried ephedra, dried ginger, asarum, honey-fried aster, honey-fried tussilago farfara, exocarpium citri rubrum, schisandra chinensis, fried semen raphani, perillaseed, semen brassicae and liquorice. The traditional Chinese medicine composition and the pharmaceutical preparation provided by the invention are used for patients with chronic obstructive pneumonia, can recover the pulmonary ventilation function, effectively inhibit inflammatory response in the body and promote lung tissue injury repair, and have a relatively good treatment effect on chronic obstructive pneumonia.

The application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine extract with cold dispelling effect, a preparation method thereof and application of the traditional Chinese medicine extract in preparation of a rheumatoid arthritis medicine. The preparation method comprises the following steps: heating and refluxing guizhi and ginger with water, filtering, obtaining volatile oil, a filtrate and dregs 1; heating and refluxing the filtrate, peony, licorice, ephedra and an ethanol aqueous solution, obtaining extract 2 and dregs 2, and concentrating the extract 2 to obtain extractum 1; heating and refluxing baizhu, zhimu, fangfeng, fried aconite root, the dregs 1, the dregs 2 and solvent 1, obtaining extract 2 and dregs 3, and concentrating the extract 2 to obtain extractum 2; ultrasonic extracting the dregs 3, mixed enzymes and solvent 2, obtaining extract 3, and concentrating the extract 3 to obtain extractum 3; uniformly mixing the volatile oil, the extractum 1, the extractum 2 and the extractum 3 to obtain the traditional Chinese medicine extract; compared with other extraction methods, the traditional Chinese medicine extract prepared by the method has a remarkable cold dispelling effect and rheumatoid arthritis treatment effect.

This invention relates to the field of traditional Chinese medicine preparation technology, and particularly to a traditional Chinese medicine composition for treating cancer pain and numbness, as well as its preparation and application. This invention designs a traditional Chinese medicine composition for cancer pain and numbness, comprising: *Houttuynia cordata*, *Aconitum carmichaelii*, processed *Aconitum carmichaelii*, centipede, *Astragalus membranaceus*, *Ephedra sinica*, clove, frankincense, ephedra, menthol, and azone. The scientifically formulated combination of principal, assistant, and adjuvant herbs allows for multi-target action on both "cancer pain" (inflammation, compression, nerve infiltration) and "CIPN" (nerve damage), resulting in a superior analgesic effect, while also possessing anti-inflammatory, anti-swelling, potential tumor-suppressing, and nerve-repairing effects. The traditional Chinese medicine composition is prepared into a traditional Chinese medicine ointment, which is administered transdermally, allowing a high concentration of the drug to act directly on the lesion, avoiding the systemic side effects (addiction, constipation, etc.) associated with oral opioids. This is especially suitable for patients who cannot take oral opioids or cannot tolerate them.

The invention relates to the technical field of plant transaminase gene identification and gene engineering, in particular to an ephedra sinica stapf transaminase gene sequence and application thereof, and the ephedra sinica stapf transaminase gene sequence provided by the invention can be used for catalyzing 1-phenyl-1, 2-propanedione to generate cathinone. The ephedra sinica transaminase gene provided by the invention is obtained by cloning from an ephedra sinica transaminase (EsGluTA) family for the first time, and a theoretical basis is provided for the synthesis of ephedra sinica alkaloid. According to the invention, a pET32a-EsGluTA prokaryotic expression vector is constructed for the first time, and expression is carried out through Escherichia coli Rosetta. The invention researches the capability of the active protein of the ephedra transaminase gene EsGluTA for catalyzing 1-phenyl-1, 2-propanedione to generate cathinone. The ephedra sinica stapf transaminase gene EsGluTA provided by the invention can be used for directly catalyzing 1-phenyl-1, 2-propanedione to generate cathinone.

The invention discloses application of a traditional Chinese medicine composition in preparation of a medicine for treating infectious bronchitis, and belongs to the technical field of medicine. The traditional Chinese medicine composition is prepared from the following components: 6-35 parts of herba ephedrae, 10-30 parts of radix platycodonis, 15-40 parts of rhizoma phragmitis, 5-30 parts of semen armeniacae amarae, 6-60 parts of liquorice root, 12-25 parts of herba plantaginis, 5-30 parts of fructus aurantii, 75-200 parts of gypsum, 1-18 parts of radix stemonae and 2-30 parts of herba menthae. Experiments prove that the traditional Chinese medicine composition disclosed by the invention has an excellent treatment effect on avian infectious bronchitis, the cure rate of diseased chickens is remarkably improved, and the replication of viruses in chicken bodies is effectively restrained, so that the virus load is greatly reduced. Particularly, it is worth mentioning that the medicine can remarkably improve the egg laying performance of diseased laying hens, and the egg yield and the egg quality are remarkably improved.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating ankylosing spondylitis and a preparation method thereof. The traditional Chinese medicine is prepared from the following raw materials: 6-18 g of fructus psoraleae, 6-20 g of herba epimedii, 3-15 g of radix aconiti lateralis preparata, 6-20 g of rhizoma drynariae, 9-18 g of radix achyranthis bidentatae, 12-24 g of dipsacus root, 6-12 g of radix clematidis, 10-30 g of garden balsam stem, 10-30 g of lycopodium clavatum, 9-15 g of radix paeoniae rubra, 6-12 g of native copper, 3-9 g of Chinese polyphaga, 6-12 g of roasted rhubarb, 6-15 g of notopterygium root, 6-15 g of radix angelicae pubescentis, 6-12 g of radix saposhnikoviae, 3-9 g of ephedra, 9-15 g of radix paeoniae alba, 6- The traditional Chinese medicine composition is prepared by adding and reducing cassia twig, Chinese herbaceous peony and rhizoma anemarrhenae decoction which are Jingui to be a little, the inflammatory response, bone destruction and pain symptoms of ankylosing spondylitis are accurately improved through the synergistic effect of multiple target points, and meanwhile, the preparation process is standardized to ensure the stable medicine effect.

The invention discloses Yao-strengthening ointment for improving immune disorder of an HIV infected person. The Yao-strengthening ointment is mainly prepared from the following raw materials: astragalus membranaceus, poria cocos, rhizoma cimicifugae, radix achyranthis bidentatae, roasted ephedra, prepared radix aconiti carmichaeli, asarum, roasted liquorice, philippine flemingia root, giantleaf ardisia rhizome, caulis sinomenii, tripterygium wilfordii and gynostemma pentaphylla. The preparation method of the Zhuang Yao ointment comprises the steps of medicinal material treatment, medicinal material extraction and ointment preparation. The whole formula is mainly used for strengthening the body resistance (tonifying qi and warming yang) and eliminating evil (dehumidifying, activating blood and detoxifying), through the compatibility of monarch, minister, assistant and guide, the traditional Chinese medicine aims at core qi deficiency and yang deficiency of immune disorder of HIV infected people and also eliminates pathological products such as dampness, stasis and heat toxin, meanwhile, honey-fried licorice root is used for regulating the medicine property, CD4 cells of the HIV infected people can be improved, immune disorder can be improved to a certain extent, and immune reconstitution is promoted.

This invention discloses a library of traditional Chinese medicine (TCM) compositions based on general and local anesthesia mechanisms, along with various dosage forms and preparation methods. The invention constructs a systematic library of TCM anesthetic compositions: the general anesthetic composition consists of extracts from herbs such as Datura stramonium, Datura stramonium, processed Aconitum carmichaelii, processed Aconitum kusnezoffii, Saussurea involucrata, Jasminum sambac root, Rhododendron molle, and Sanqie Sanqie; the local anesthetic composition consists of extracts from herbs such as Asarum heterotropoides, Murraya paniculata, Ephedra sinica, Toad venom, and Corydalis yanhusuo. This invention further develops the above compositions into various modern dosage forms, including injections, tablets, capsules, and sprays. In particular, this invention innovatively introduces a clove-cinnamon natural preservative and flavoring system to replace chemical preservatives. In terms of preparation technology, advanced technologies such as supercritical CO2 extraction, microwave-assisted extraction, nano-embedding, and nanoemulsions are integrated, and a self-extraction scheme is adopted to achieve controllable quality and cost. Simultaneously, a quality detection method based on HPLC fingerprinting is established. This invention achieves full-scenario coverage of anesthesia and analgesia, from general to local, from emergency to routine care, with outstanding advantages of safety, effectiveness, and controllable quality.

A traditional Chinese medicine composition for treating Hashimoto's thyroiditis comprises the following raw materials in the indicated weight ratios: 50-200 parts Rehmannia glutinosa (processed), 10-60 parts Cinnamomum cassia, 30-100 parts Ephedra sinica, 10-60 parts Cervi cornu slices, 10-60 parts Zingiber officinale (dried), 30-80 parts Glycyrrhiza uralensis (processed), 50-200 parts Paeonia lactiflora (white), 50-200 parts Paeonia veitchii (red), 30-100 parts Paeonia suffruticosa (moutan bark), 50-200 parts Codonopsis pilosula, 50-200 parts Angelica sinensis, 50-200 parts Prunus persica, and 30-100 parts Carthamus tinctorius. The preparation method is as follows: Place Rehmannia glutinosa, Cinnamomum cassia, Ephedra sinica, deer antler slices, dried ginger, prepared licorice root, white peony root, red peony root, peony bark, Codonopsis pilosula, Angelica sinensis, peach kernel, and safflower in a container, add 8 times the total weight of the herbs in cold water, soak for 30 minutes to fully moisten the herbs, bring to a boil over high heat, then simmer over low heat for another 30 minutes; for the second decoction, filter out the liquid from the first decoction, add the remaining herbs and 6 times the total weight of the herbs in warm water, just enough to cover the herbs; soak for 30 minutes, bring to a boil over high heat, then simmer over low heat for another 20 minutes; after the decoction is completed, combine the two decoctions, filter out the dregs, and obtain the traditional Chinese medicine decoction.

This invention belongs to the field of traditional Chinese medicine preparations, and relates to the preparation method and application of a compound preparation of Yao Yu effervescent tablets with anti-rheumatoid arthritis effect. The compound preparation comprises the following traditional Chinese medicine components: 4 parts by weight of Dioscorea cirrhosa, 3 parts by weight of Tinleaf Vine, 2 parts by weight of Camphor Tree, 2 parts by weight of Rhus chinensis, 3 parts by weight of Rhododendron molle, 1 part by weight of Ephedra sinica, 2 parts by weight of Semi-Acer palmatum, 2 parts by weight of Gynostemma pentaphyllum, and 1 part by weight of Cinnamomum cassia. The preparation steps include: placing Dioscorea cirrhosa, Tinleaf Vine, Camphor Tree, Rhus chinensis, Rhododendron molle, Gynostemma pentaphyllum, Semi-Acer palmatum, Gynostemma pentaphyllum, and Cinnamomum cassia in 6000 parts by weight of 70% ethanol. Extract for 2 hours, repeat three times, filter, and combine the filtrates; concentrate, freeze-dry, pulverize, and pass through an 80-mesh sieve for later use; mix 27.5% freeze-dried powder with 26.45% citric acid, 34.11% sodium bicarbonate, 5.61% PEG6000, and 6.33% lactose evenly, pass through an 80-mesh sieve, and prepare a soft mass using anhydrous ethanol as a wetting agent; pass the soft mass through a 20-mesh sieve and dry at 37℃ for 30 minutes to obtain compound preparation granules; granulate through a 20-mesh sieve for granulation, add lubricant PEG6000 and mix evenly; compress into tablets to obtain compound preparation effervescent tablets. This invention, through pharmacological experiments, confirms that the Yaoyu effervescent tablet compound preparation has a good anti-rheumatoid arthritis effect: it can reduce local inflammatory mediators and serum IL-1β, IL-6, TNF-α, and PEG2 levels, downregulate MDA and increase SOD to improve oxidative stress, inhibit the expression of MMP3, COX-2, and P38 proteins in the synovial membrane, and reduce pathological tissue damage. The medium and high dose groups showed the best effect, and it has a good therapeutic and protective effect on the ankle joint of AA rats, with good clinical application value.

The invention relates to a method for extracting ephedrine E from herba ephedrae, which can effectively extract ephedrine E from herba ephedrae and realize application in preparation of medicines for treating pulmonary arterial hypertension. The preparation method comprises the following steps: taking dried roots and rhizomes of ephedra sinica stapf, extracting by adopting a water decoction method, concentrating under reduced pressure to obtain total extract, dispersing with water, eluting, dissolving with methanol, stirring with silica gel, carrying out gradient elution, identifying, merging the same fractions, loading a target component on column chromatography, eluting, purifying, collecting the fractions within retention time, and drying to obtain ephedrine E; the preparation method is simple, the ephedrine E is easy to industrially prepare, the medicinal value of ephedra is expanded, the application in preparation of the medicine for treating the pulmonary arterial hypertension is realized, and the ephedrine E is a great innovation in preparation of the medicine for treating the pulmonary arterial hypertension and has practical popularization and application value.

This invention relates to the application of a traditional Chinese medicine composition in a drug for ulcerative colitis, characterized in that the traditional Chinese medicine composition comprises: 1-100 parts of Magnolia officinalis, 1-100 parts of Areca catechu (roasted), 1-100 parts of Amomum villosum (roasted), 1-100 parts of Ephedra sinica, 1-100 parts of Prunus armeniaca (bitter), 1-100 parts of Notopterygium incisum, 1-100 parts of Zingiber officinale (fresh), 1-100 parts of Pogostemon cablin, 1-100 parts of Eupatorium fortunei, 1-100 parts of Atractylodes lancea, 1-160 parts of Poria cocos, 1-120 parts of Atractylodes macrocephala, 1-100 parts of Gypsum fibrosum, 1-100 parts of Crataegus pinnatifida (roasted), 1-100 parts of Massa fermentata (roasted), 1-100 parts of Hordeum vulgare (roasted), 1-100 parts of Pheretima aspergillum, 1-100 parts of Cynanchum paniculatum, 1-100 parts of Dryopteris crassirhizoma, and 1-100 parts of Lepidium apetalum.

The application discloses a traditional Chinese medicine composition for treating vaginitis and a preparation method thereof. The traditional Chinese medicine composition mainly comprises 12 Chinese herbal medicines, i.e. Sophora flavescens, Phellodendron chinense, Dictamnus dasycarpus, Herba Artemisiae Scopariae, Herba Taraxaci, Chrysanthemum indicum, Herba Portulacae, Cnidium monnieri, Angelica polymorpha, Herba Verbena, Herba Menthae and Saposhnikovia divaricata, and further comprises Salix viminalis, Eucalyptus, Ephedra sinica, anthocyanin quaternary ammonium salt, Ocimum basilicum, Houttuynia cordata, polysialic acid, polydopamine, antibacterial polypeptide modified chitosan hydrochloride and artemether. The traditional Chinese medicine composition is prepared by mixing traditional Chinese medicines and bactericidal and bacteriostatic biocompatible materials to prepare various medicaments. The traditional Chinese medicine composition is used for treating pruritus and leukorrhagia caused by endogenous insect poison and burning of yin fluid, and is used for treating bacterial vaginitis, mycotic vaginitis, trichomonal vaginitis and vulvitis. In clinical tests, the traditional Chinese medicine composition has remarkable treatment effect, and the cure rate is more than 95%.

The invention discloses an external traditional Chinese medicine ointment for treating thyroid nodules as well as a preparation method and application thereof, and relates to the field of medicines. The external traditional Chinese medicine ointment comprises traditional Chinese medicine micro powder and a matrix, wherein the traditional Chinese medicine micro powder comprises nidus vespae, dung beetle, cowherb seed, garden balsam seed, ephedra, ground beetle, radix ranunculi ternati, prepared arisaema consanguineum schott, semen momordicae, leech, curcuma zedoary, borneol and selfheal. According to the traditional Chinese medicine micro powder, various insect medicines contain components such as chitinase or enzyme, fiber tissue or cyst can be degraded, targeted knot breaking can be achieved, various plant medicines contain volatile oil or alkaloid components, blood circulation can be improved, and nodule absorption can be promoted. Meanwhile, borneol and ephedra are used for enhancing transdermal absorption of drugs, a matrix promotes drug release, the ointment can directly act on a thyroid nodule focus area, the bioavailability is high, the treatment effect of removing stasis is improved, the burden of liver and kidney is reduced through external administration, skin irritation is small, safety is high, and operation is easy and convenient.

The present invention relates to the technical field of fertilizer preparation, and in particular to a traditional Chinese medicine composite microbial fertilizer for inhibiting angelica root rot. The composite microbial fertilizer for inhibiting angelica root rot provided by the present invention comprises 45-55 parts of composite fertilizer, 20-26 parts of plant ash, 6-10 parts of humic acid, 3-7 parts of diatomaceous earth, 4-8 parts of a composite microbial agent, and 8-12 parts of a traditional Chinese medicine extract. The composite microbial agent comprises Bacillus licheniformis, Bacillus cereus, Bacillus atrophaeus, Pseudomonas chlororaphis, Pseudomonas campestris, Trichoderma viride, and Trichoderma harzianum, with a mass ratio of 14-18:12-16:11-15:8-12:8-12:5-9:5-9, each containing 400-600 million bacteria per gram. The traditional Chinese medicine extract comprises Scutellaria baicalensis, Ephedra sinica, Tagetes erecta, Nerium oleander, Ginkgo biloba, and Sophora flavescens. This fertilizer not only prevents and treats angelica root rot but also significantly improves the yield and quality of angelica, achieving excellent results.

The application discloses a method for determining the content of aconite alkaloids in a traditional Chinese medicine composition containing Ramulus Cinnamomi, which comprises the following steps: detecting test sample solution and control sample solution of the traditional Chinese medicine composition, and obtaining the content information of the control sample of the traditional Chinese medicine composition according to the detection result; wherein the traditional Chinese medicine composition comprises Ramulus Cinnamomi, Radix Paeoniae Alba, Radix Glycyrrhizae, Ephedra, Rhizoma Zingiberis Recens, Rhizoma Atractylodis Macrocephalae, Rhizoma Anemarrhenae, Radix Saposhnikoviae and Heishunpian, and the control sample is benzoyl neoorientaline, benzoyl orientaline, benzoyl hypoorientaline, neoorientaline, hypoorientaline and aconitine. The application carries out the content monitoring research on the monoester type alkaloids of Heishunpian medicinal flavor in the reference sample of the traditional Chinese medicine composition containing Ramulus Cinnamomi, and carries out the limited control research on the diester type alkaloids, and the research on the reference sample of the traditional Chinese medicine composition containing Ramulus Cinnamomi is carried out from the multiple dimensions of safety and effectiveness, and has important quality control significance.

The application discloses a traditional Chinese medicine composition for treating chronic eczema and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: radix astragali 40-80, rhizoma et herba 10-50, raw ginger 5-40, radix glycyrrhizae 5-40, ephedra 5-40, ramulus cinnamomi 10-50, radix scrophulariae 10-40, radix sophorae 10-40, radix alpiniae oxyphyllae 10-50, rhizoma pinelliae 5-40, pericarpium citri reticulatae 5-40, rhizoma chuanxiong 5-40, radix ponicis cum cortex 10-40, fructus corni 5-40, radix gentianae 5-40, radix clematidis 10-40, radix rehmanniae 20-60, radix scrophulariae 10-50, radix paeoniae alba 10-50, cortex mali 5-40, radix et rhizoma 5-40, prepared scrophulariae 5-40, scolopendra 5-40 and rhabdophis 10-50. The traditional Chinese medicine composition can treat chronic eczema by oral administration, and has the advantages of remarkable effect and safety and reliability.

The invention provides an application of a traditional Chinese medicine composition in preventing influenza A virus replication at a cellular level. The traditional Chinese medicine composition is prepared from the following raw materials: cortex magnoliae officinalis, scorched betel nut, roasted amomum tsao-ko, herba ephedrae, semen armeniacae amarae, notopterygium root, ginger, pogostemon cablin, herba eupatorii, rhizoma atractylodis, bighead atractylodes rhizome, poria cocos, scorched hawthorn fruit, scorched medicated leaven, scorched malt, rhizoma dryopteris crassirhizomae, radix cynanchi paniculati, earthworm, gypsum and semen lepidii. It is confirmed for the first time that the traditional Chinese medicine composition can inhibit replication of influenza A viruses (such as influenza A H1N1 viruses) on the cellular level, has an obvious inhibiting effect on influenza A viruses, has the advantages of being clear in effective component, obvious in drug effect, small in taking dosage and the like, is good in application prospect, is suitable for industrial large-scale production, and has wide application prospects. The traditional Chinese medicine composition can be used for preparing medicines for preventing or treating influenza A virus infection, and has good economic benefits and social benefits.

The invention relates to the technical field of plant biology, and particularly discloses an agrobacterium rhizogenes-mediated tissue-culture-free euphorbia kansui transformation method, which is technically characterized by comprising the following steps: S1, constructing a pCAMBIA1300:: 35S-EkHMGR-GFP recombinant vector by using a specific primer; s2, establishing a euphorbia kansui regeneration system as an identification basis for obtaining a transgenic plant from an expanded root segment; s3, infecting wounds through agrobacterium rhizogenes K599 to induce hairy roots, and regenerating transgenic plants by utilizing expanded root segments. A set of rapid and stable euphorbia kansui genetic transformation system which is mediated by agrobacterium rhizogenes and does not need tissue culture is established, recombinant plasmids carrying a target gene EkHMGR are introduced into euphorbia kansui by the agrobacterium rhizogenes to obtain transgenic hairy roots, and positive plants obtained by culturing expanded root segments are transplanted. The transformation method constructed by the invention has potential application value on genetic transformation of euphorbia kansui and also has important reference value on genetic transformation of other plants, and research results provide theoretical guidance for promoting synthesis and accumulation of euphorbia kansui key medicinal component euphorbia dienol.

The invention provides a traditional Chinese medicine composition and application thereof in preparation of a medicine for treating reflux esophagitis, and relates to the technical field of traditional Chinese medicine pharmacy. According to the traditional Chinese medicine composition, thunberg fritillary bulb, fructus evodiae and fingered citron serve as monarch drugs, inula flower, buckeye, rhizoma nardostachyos, clove, amomum tsao-ko and membrane of hen egg serve as ministerial drugs, nacre mother of pearl, cortex fraxini, felwort, sweet-scented osmanthus and reed rhizome serve as adjuvant drugs, licorice serves as conductant drugs, and all the drugs are combined to achieve the effects of soothing the liver and harmonizing the stomach, calming the adverse-rising energy, relieving acid and regulating cold and heat. The traditional Chinese medicine composition can significantly improve the esophagitis index of RE rats, has an obvious inhibition effect on inflammatory injury, can significantly improve the pathological morphology of esophageal tissues of the RE rats, and achieves good anti-inflammatory and therapeutic effects on the RE rats. Meanwhile, the traditional Chinese medicine composition can remarkably improve and relieve clinical symptoms such as sour regurgitation, heartburn, abdominal distension and belching of reflux esophagitis patients, and the attack frequency of the clinical symptoms is reduced. The traditional Chinese medicine composition disclosed by the invention is expected to be further developed and popularized as a medicine for treating reflux esophagitis.

The present invention relates to a method for treating a coronavirus infectious disease and a complication thereof, including: administering a Chinese medicine composition to a subject in need thereof; wherein, the Chinese medicine composition is an extract of a first mixture including Ephedra sinica, Armeniacae Semen amarum, Glycyrrhizae radix et rhizoma, Gypsum fibrosum, Descurainiea semen, stephaniae Tetrandrae radix, Scutellariae radix, Poria, rhizoma alismatis, Polyporus umbellatus, Atractylodis rhizoma, Asteris radix et rhizoma, Tussilago farfara, Pinelliae rhizoma, and Rhei radix et rhizoma.