63 results about "Drug Utilization" patented technology

The invention discloses a targeted anti-aging microneedle drug delivery system for chronic wound repair as well as a preparation method and application of the targeted anti-aging microneedle drug delivery system. The system is composed of functionalized nanoparticles and a microneedle platform: a nano drug-loading unit which takes a polydopamine nanosphere as a carrier, entraps an anti-aging drug Bem, and modifies the surface of the nano drug-loading unit with a targeting peptide E7; according to the micro-needle delivery unit, hyaluronic acid-nitrogen carboxymethyl chitosan hydrogel is used as a matrix, a nano drug-loading unit and silver ions (Ag) are loaded, a micro-needle array is formed, and minimally invasive transdermal drug delivery is achieved. According to the invention, multiple mechanisms of anti-aging (APCs aging inhibition), antioxidation (ROS removal), antibiosis (Agaction) and immunoregulation (macrophage M2 type polarization promotion) are synergistically exerted, and the bottleneck problems of single intervention target, low drug availability and difficulty in regulating and controlling pathological microenvironment of chronic wounds (such as diabetic foot ulcer) in the traditional therapy are effectively solved.

The invention relates to the technical field of atomizers, in particular to an intelligent atomization control system for medicine dosage homogenization, which comprises a temperature feedback control module, a laser granularity measurement module, an airflow fluctuation compensation module, a flow regulation module and a data analysis module. By intelligently controlling the flow, granularity, airflow and temperature of liquid medicine, accurate adjustment of the atomization process can be achieved, it is ensured that medicine is evenly and stably released in the whole treatment process, waste of the liquid medicine is remarkably reduced, the medicine utilization rate is increased, and by monitoring the temperature change in real time, the atomization effect is improved. The flow is adjusted to cope with the influence of temperature fluctuation on the liquid medicine flow characteristic and the atomization effect, medicine conveying stability in different environments is guaranteed, meanwhile, based on particle size control, airflow and flow can be adjusted in time to guarantee consistency of atomized particles, uneven medicine dosage caused by particle size fluctuation is avoided, and through airflow fluctuation compensation, the atomization effect is improved. It can be ensured that the influence on medicine flow is minimized when airflow is unstable, and dosage instability is avoided.

The invention belongs to the technical field of medical apparatus and instrument control, particularly relates to an atomization control system for respiratory nursing, and aims to solve the problems of low medicine deposition efficiency, serious waste and incapability of precise medicine administration caused by the lack of the capability of sensing and responding to the real-time respiratory state of a patient in a traditional atomization device. The system comprises a breathing state real-time monitoring module, an aerosol generation and regulation module, an intelligent control center, a man-machine interaction interface and a cloud data collaboration platform. Breathing parameters are collected through a high-sensitivity sensor, the particle size and the output opportunity of fog drops are dynamically adjusted in combination with a dual-mode ultrasonic atomization technology, and accurate inspiration phase dosing is achieved; a self-adaptive learning engine is arranged in the intelligent control center, the breathing cycle can be predicted, atomization can be started in advance, and the response speed is increased; local closed-loop control and remote personalized management are supported, and the medicine utilization rate and treatment compliance are remarkably improved.

The invention discloses a non-small cell lung cancer intrathoracic precise drug delivery device matched with a pH-responsive metal organic framework drug delivery system, and belongs to the technical field of intrathoracic drug delivery. The device comprises an injector, the injector is fixedly installed on a micro-injection pump, a drug delivery connector is inserted into a connection connector, and the drug delivery connector is connected with a pH-responsive metal organic framework drug delivery system. A needle head is fixedly connected to the end, away from the dosing connector, of the liquid inlet pipe, a protection mechanism is arranged outside the connecting connector and the dosing connector, a butt-joint limiting mechanism is arranged on the side wall of the protection mechanism, and the connecting connector and the dosing connector are fixed to the butt-joint limiting mechanism. Stable power and accurate control are provided for the injector through the micro-injection pump, the dosing requirements of local high concentration and accurate dosage in non-small cell lung cancer treatment are met, curative effect fluctuation caused by manual operation errors is reduced, the connecting joint and the dosing joint are protected and fixed by arranging the protective sleeve and the butt-joint limiting mechanism, and the non-small cell lung cancer dosing device is convenient to use. Liquid medicine leakage caused by loosening of the connector in the dosing process is effectively prevented, and the medicine utilization rate is guaranteed.

This invention provides a chemotherapy catheter for spinal tuberculosis, comprising a catheter with a drug channel, a flexible tube at the front end of the catheter with multiple through holes communicating with the drug channel, and a built-in one-way structure. The one-way structure includes an elastic rubber sheet at one end fixed to the inner wall of the drug channel; multiple elastic rubber sheets are stacked together in a conical shape; and a connector is connected to the rear end of the catheter, with a drug injection end for injecting medication. This invention, by inserting the catheter into the patient's body, injects medication through the drug injection end, which then passes through the drug channel and the one-way structure to prevent backflow, and finally flows out through the multiple through holes, thereby widely dispersing the medication and improving drug utilization.

The present application relates to the technical field of medicine and provides a lanosterol derivative, a preparation method therefor and a use thereof. The structural formula of the lanosterol derivative provided by the present application is as shown in formula I or II. The lanosterol derivative provided by the present application has both lipid solubility and water solubility, and can effectively penetrate into the pathological site in the body, thereby improving the drug utilization rate. The results of embodiments show that the lanosterol derivative provided by the present application has a significantly higher solubility in water than lanosterol or 25-hydroxylanosterol and shows a significant therapeutic effect on a cataract in animal in vivo experiments. Therefore, the derivative has wide prospects in the preparation of drugs for treating eye diseases or conditions.

The utility model relates to the technical field of unmanned aerial vehicles, in particular to a centrifugal sprayer for an unmanned aerial vehicle, which comprises a barrel, a water inlet channel is arranged in the barrel, a hose is arranged in the water inlet channel, one end of the hose is used for extending out of the water inlet channel to be connected with a water pipe, and a nozzle for spraying liquid medicine is arranged at the other end of the hose. The hose is used for introducing liquid medicine into the nozzle, the nozzle is rotationally connected with the barrel, a motor is further arranged in the barrel and fixedly connected with the barrel, a rotating shaft of the motor is fixedly connected with the nozzle, and a plurality of atomizers used for atomizing the sprayed liquid medicine are arranged on the nozzle. The nozzle is rotationally connected with the barrel, the motor drives the nozzle to rotate, and the motor can rotate the nozzle, so that the liquid medicine is centrifugally thrown out, the liquid medicine can be sprayed uniformly, and the coverage range is wider. The atomizer further improves the atomization effect of the liquid medicine, so that the liquid medicine is finer and easy to diffuse, and the medicine utilization rate and the treatment efficiency are improved.

The present application relates to the technical field of medicine, and provides a lanosterol derivative, a preparation method and application thereof.The structural formula of the lanosterol derivative provided by the present application is shown as formula I or formula II.The lanosterol derivative provided by the present application has both fat solubility and water solubility, can effectively penetrate into the pathological site in the body, and improves the drug utilization degree;the results of examples show that the solubility of the lanosterol derivative provided by the present application in water is obviously higher than that of lanosterol or 25-hydroxy lanosterol, and the lanosterol derivative shows obvious cataract treatment effect in animal body experiments, and has a broad prospect in the preparation of drugs for treating eye diseases or conditions.

The application discloses a drug design method and device based on topological data analysis, equipment and medium, relates to the technical field of computer-aided drug design, and the method comprises the steps of obtaining a plurality of three-dimensional structure conformations of a target protein, determining the binding pocket region of each three-dimensional structure conformation, and constructing a conformation set; calculating a topological descriptor representing the topological relationship between atoms based on the atomic coordinates of the binding pocket region of each three-dimensional structure conformation, and converting the topological descriptor into a corresponding conformation feature vector; performing a pooling operation on the conformation feature vector corresponding to each three-dimensional structure conformation to generate a unified topological feature representation representing the common topological feature mode of the target protein binding pocket under a plurality of three-dimensional structure conformations; and screening or generating candidate drugs based on the unified topological feature representation. The common topological invariant information of a plurality of conformations is used to represent the flexible protein binding pocket, the screening omission caused by single conformation representation is reduced, and the representation accuracy and the calculation efficiency are considered.

The invention belongs to the technical field of medical instruments, and discloses an automatic hot compress device for traditional Chinese medicine, which comprises a box body, a top cover and a bottom frame, a partition plate is arranged in the box body and used for vertically dividing an inner cavity of the box body into a storage cavity and a medicine steam cavity, the storage cavity is used for storing medicine bags, and a plurality of air holes are formed in the partition plate. The top cover is hermetically arranged at the top of the box body, a heating assembly is arranged on the bottom surface of the top cover, a pressure adjusting assembly is arranged on the top surface of the top cover, and the pressure adjusting assembly is communicated with the medicine steam cavity and used for adjusting the pressure in the box body; the bottom frame is hermetically arranged at the bottom of the box body, a flexible breathable film is arranged in the bottom frame, the flow resistance of the flexible breathable film is smaller than that of the partition plate, and a flexible rubber ring is arranged on the bottom surface of the bottom frame and used for fitting the skin of a patient; the flexible breathable film and the flexible rubber ring make contact with the skin of a patient to form sealing, the heating assembly heats the medicine bag to generate medicine steam with medicine components, the pressure in the box body is adjusted through reciprocating action of the pressure adjusting assembly, the medicine steam is directionally conveyed, and the medicine utilization rate and the treatment effect are improved.

The invention belongs to the field of biological material preparation, and particularly relates to degradable drug-loading hydrogel and a preparation method thereof.Acrylate groups are introduced into 6s-PLA, 6s-PLA-HA is synthesized, a hydrogel material is synthesized through a photopolymerization method, then cefprozil serves as a model drug, and drug loading is conducted on the hydrogel through the supercritical impregnation technology. The composite material is self-prepared six-arm star-shaped polylactic acid (6s-PLA), the 6s-PLA is terminated by using acryloyl chloride to synthesize 6s-PLA-HA, PLA-PEG hydrogel is prepared by using a photopolymerization method, and a hydrogel material loaded with cefprozil is prepared by using a supercritical carbon dioxide impregnation technology. The material has the advantages of being excellent in mechanical property, non-toxic, good in biological safety, non-irritant, easy to process and form, degradable, anti-inflammatory and the like, and is expected to be widely applied to the field of biomedical materials.

This invention belongs to the field of DNA hydrogel technology, specifically relating to a VEGF-responsive, on-demand release smart DNA hydrogel of glycyrrhizin, its preparation method, and its applications. This invention constructs a VEGF-responsive smart DNA hydrogel, efficiently encapsulating glycyrrhizin within a three-dimensional gel network, utilizing the high expression of VEGF in the tumor microenvironment to trigger on-demand drug release. This invention achieves precise on-demand release of glycyrrhizin, significantly improving drug utilization efficiency and reducing systemic toxicity. Simultaneously, the VEGF aptamer introduced into the system can specifically bind to and neutralize free VEGF, blocking angiogenesis, cutting off tumor nutrient supply, and further inhibiting tumor proliferation and progression, achieving a synergistic effect of intelligent drug delivery and anti-angiogenesis.

The invention relates to the field of drug utilization value analysis, and particularly discloses a data stream-based drug utilization value analysis system, which comprises a data layer, an application layer and a user layer, according to the method, the multi-source drug data stream is constructed and stored in the multi-source drug database, and based on systematic management of drug information, drug use errors caused by drug name confusion, dosage errors and dosage form confusion can be reduced, the drug use safety is improved, and the method is beneficial to quickly and accurately retrieving and querying specific types of drug information; by integrating the elderly physiological features and the drug feature information, the drug utilization value analysis model is constructed, the elderly physiological features and the drug features are comprehensively considered, the utilization value of the drug on the elderly can be comprehensively evaluated, and the influence of the drug on the elderly patient can be predicted more accurately.

The invention discloses a pharmaceutical composition for treating rheumatoid arthritis as well as a preparation method, a traditional Chinese medicine preparation and application thereof, and belongs to the technical field of pharmaceutical compositions. The technical problem to be solved is to provide a preparation method of a pharmaceutical composition with higher drug utilization rate aiming at the current situation that a heat-clearing and blood-activating formula in the prior art is high in active ingredient loss and low in drug utilization rate. The key point of the technical scheme is that the preparation method of the pharmaceutical composition comprises the following steps: (1) mixing rhizoma smilacis glabrae, rhizoma atractylodis stir-fried with bran, rhizoma dioscoreae septemlobae and caulis sinomenii, adding water, soaking, performing enzyme extraction, performing solid-liquid separation, and concentrating enzymatic hydrolysate to obtain enzymatic hydrolysate; (2) mixing honeysuckle, cortex phellodendri and radix paeoniae rubra, performing alcohol extraction, performing solid-liquid separation, combining filtrate, and concentrating an alcohol extract to obtain an alcohol extract; (3) mixing the vinegar-processed curcuma zedoary, salvia miltiorrhiza and astragalus membranaceus with water, performing water extraction, performing solid-liquid separation, combining filtrate, and concentrating a water extracting solution to obtain a water extract; and (4) mixing the enzymolysis paste, the alcohol extraction extract and the water extraction extract, and drying.

This invention discloses an injectable bone repair material and its preparation method, belonging to the field of biomaterials technology. The material is composed of grafted chitosan obtained by reacting N-formylglycine, allyl lactate, and S-allyl cysteine ​​with chitosan. The grafted chitosan, methacrylamide gelatin, and icariin-naringenin liposomes are then photocured to form a stable three-dimensional interpenetrating network hydrogel. The preparation method includes: first synthesizing grafted chitosan, then preparing icariin-naringenin liposomes, and finally mixing the grafted chitosan solution, methacrylamide gelatin solution, and liposomes, adding a photoinitiator, and then ultrasonically degassing and ultraviolet curing to obtain the finished product. This material utilizes thioether bonds to achieve intelligent drug release in response to reactive oxygen species, and liposome encapsulation improves drug utilization. The dual-network structure endows it with excellent injectability, mechanical strength, and biocompatibility, effectively adapting to irregular bone defects and promoting bone regeneration.

The invention provides a traditional Chinese medicine hydrogel and a preparation method thereof, the traditional Chinese medicine hydrogel comprises the following raw materials by weight: 20-30 parts of polyvinyl alcohol, 3-8 parts of epoxy modified polyvinyl alcohol, 20-30 parts of hyaluronic acid, 5-10 parts of a traditional Chinese medicine composition extract, 1-5 parts of star hyperbranched polylysine, and 200-300 parts of water. The traditional Chinese medicine hydrogel provided by the invention has the properties of antibacterial property, low sensitization, high drug utilization rate and high curative effect, star-shaped hyperbranched polylysine is introduced as a functional modifier, the star-shaped hyperbranched polylysine and the traditional Chinese medicine composition generate an antibacterial synergistic effect, and a hydrophobic drug is loaded through a hyperbranched three-dimensional structure of the star-shaped hyperbranched polylysine; the antibacterial property, the drug loading capacity and the slow release performance of the hydrogel are remarkably improved, so that the purposes of high curative effect and low sensitization are achieved. Epoxy modified polyvinyl alcohol is also added, so that the stability of the hydrogel is further improved, the drug release performance is regulated and controlled, and the drug utilization rate is improved.

This invention discloses a cinnamic acid-black phosphorus nanocomposite targeting Aβ, its preparation method, and its application. The composition uses 4-(dimethylamino)cinnamic acid as the Aβ-targeting group and consists of a drug-loaded host (BP, black phosphorus nanosheets), a modifying material C18-PEG-NH2 (amino polyethylene glycol stearic acid), a targeting material Tar (4-(dimethylamino)cinnamic acid), and a therapeutic material Cur (curcumin). The preparation method includes the following steps: (1) preparation of PEG-Tar, (2) preparation of PEG-Tar@Cur, and (3) preparation of the BP-PEG-Tar@Cur composition. This invention utilizes black phosphorus nanosheets to load Curcumin, whose excellent specific surface area significantly increases the drug loading capacity. Furthermore, by using 4-(dimethylamino)cinnamic acid as a group targeting Aβ, diffuse distribution of the drug in the brain is avoided, greatly improving the drug utilization rate of Curcumin. The synthesis process of this invention is simple, highly reproducible, and easy to scale up for industrial application, and it has a positive effect in the treatment of Alzheimer's disease.

The invention provides an atomizer system based on inspiration airflow sensing adjustment and an adjustment method, and relates to the technical field of medical instruments, and the atomizer system comprises an atomizer body, an airflow sensing module, a control module, an atomization output adjustment module and a voice broadcast module. The airflow sensing module is used for sensing inspiration airflow and converting the inspiration airflow into electric signals. The control module and the airflow sensing module are used for receiving the electric signals and sending control instructions. When the inspiration airflow intensity corresponding to the electric signal is lower than a preset threshold value, a reminding instruction is sent, the atomization output adjusting module is used for adjusting the atomization output quantity of the atomizer body according to a control instruction, and the voice broadcast module is used for receiving the reminding instruction and outputting electronic voice prompt information. Atomization output is matched with the inspiration state in real time, medicine loss is effectively reduced, and the medicine utilization rate is increased; by establishing mathematical models for different nebulizer types and combining breathing parameter correction, individualized accurate adjustment is achieved, and the treatment effect is improved.

The present application relates to the technical field of medicine and provides a lanosterol derivative, a preparation method therefor and a use thereof. The structural formula of the lanosterol derivative provided by the present application is as shown in formula I or II. The lanosterol derivative provided by the present application has both lipid solubility and water solubility, and can effectively penetrate into the pathological site in the body, thereby improving the drug utilization rate. The results of embodiments show that the lanosterol derivative provided by the present application has a significantly higher solubility in water than lanosterol or 25-hydroxylanosterol and shows a significant therapeutic effect on a cataract in animal in vivo experiments. Therefore, the derivative has wide prospects in the preparation of drugs for treating eye diseases or conditions.

The application provides a tear duct indwelling drug delivery wearable device and a use method, and solves the problems of low drug utilization rate, easy tear duct adhesion and poor controllability of drug delivery pressure of existing tear duct indwelling medical devices in the field of ophthalmology; wherein the tear duct indwelling drug delivery wearable device comprises: a circulating flow pipeline, the circulating flow pipeline comprises a three-way pipe, an indwelling pipeline and a backflow pipeline, the three-way pipe comprises a first communication pipe, a second communication pipe and a third communication pipe which are in communication with each other at one end, the backflow pipeline is connected with the first communication pipe and the second communication pipe at two ends, the indwelling pipeline comprises a drug slow-release pipe and a circulating pipe which are in communication with each other at one end, the other end of the drug slow-release pipe is connected with the third communication pipe; the third communication pipe is arranged in the lacrimal canaliculus of a patient, the drug slow-release pipe is arranged in the lacrimal sac, the other end of the circulating pipe is connected with the backflow pipeline outside the body from the nasal cavity of the patient, and a drug flow loop is formed; a head-mounted support and a drug delivery assembly arranged on the head-mounted support.

The invention discloses a probiotic-nano-drug composite microneedle patch as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The probiotic-nano-drug composite microneedle patch is used as a delivery system, so that the probiotics and the drug can be efficiently delivered, the whole body is prevented from being exposed, and the safety is improved; in addition, the PLGA nanoparticles can control slow release of the medicine, so that the utilization rate and the treatment effect of the medicine are remarkably improved; in addition, after the microneedle substrate layer is encapsulated, the activity of probiotics can be maintained, and the local long-acting effect is achieved; when the probiotic-nano-drug composite microneedle patch is used for treating androgenetic alopecia, the androgenetic alopecia is efficiently treated by promoting hair growth, increasing the density and diameter of hair follicles, improving microcirculation and cell proliferation and reducing the expression level of inflammatory factors; therefore, the method has a good application prospect.

The present application belongs to the technical field of ultrasonic molecular imaging and biomedical engineering, and particularly relates to a nano-ultrasound contrast agent for enhancing immunotherapy and a preparation method and application thereof. The nano-ultrasound contrast agent for enhancing immunotherapy provided by the present application is a novel ultrasonic nano-vesicle formed by loading a protein drug for blocking an immune checkpoint into a nano-carrier with a special composition. The nano-ultrasound contrast agent has high biological safety, small and uniform particle size, can be long-circulated in vivo, has good imaging effect on the extravascular field of a tumor, has good penetration, is highly targeted, has high drug utilization rate, can improve the delivery efficiency of a tumor immunotherapy drug and the immunotherapy effect, can realize tumor diagnosis and immunotherapy integration under ultrasonic guidance, and effectively solves the current problems of difficult tumor ultrasonic diagnosis, low tumor responsiveness of an immunotherapy drug, weak targeting, and inability to be regulated in vitro.

The invention discloses a nasal delivery double-chain RNA / Mn < 2 + > nano-drug as well as a preparation method and application thereof in immunotherapy. And adding the polymer into a solution containing double-stranded RNA and manganese salt, and self-assembling to form the nasal delivery double-stranded RNA / Mn < 2 + > nano-drug. The invention provides a new technical scheme for the barrier of the BBB. The nano delivery system has the advantages in the aspects of overcoming the BBB and improving the in-vivo biological distribution of the drug, and the surface of the nano carrier is modified with a ligand targeted to an endothelial cell overexpression receptor, such as ApoE peptide and the like, so that the drug can be delivered to penetrate through the BBB; a non-invasive nasal-brain delivery strategy becomes a new scheme for improving drug availability and reducing toxic and side effects, the drug can bypass BBB and rapidly enter brain parenchyma through olfactory bulb and trigeminal nerve conduction pathways, and an immune drug delivered by the nasal cavity can rapidly enter nasopharynx-related lymphatic tissue (NALT) and is transferred to CLN through a lymphatic network around the nasal cavity, so that the immune drug can be rapidly delivered to the nasopharynx-related lymphatic tissue (NALT). Further, a potent local immune response aiming at the in-situ GBM is induced.

The application discloses a kind of lipopeptide class for preventing and treating walnut rot disease and preparation method thereof, it is related to plant disease control technical field, including the nanocarrier core of lipopeptide class loading;And the responsive material shell of the carrier core outside is covered;Wherein, the responsive material shell can be degraded under the microenvironment of walnut tree disease site, the microenvironment characteristics include pH value is lower than 6.0 and there is pectinase activity.The present application realizes the precise and efficient prevention and treatment of walnut rot disease by constructing the intelligent nanometer drug delivery system of "nuclear shell structure", realizes the targeting and on-demand release of lipopeptide in lesion site using the shell with double response to disease microenvironment, greatly improves drug utilization and prolongs the effective period;Nanocarrier core effectively protects lipopeptide activity, and its 50-200 nanometer optimized particle size and surface modification promote drug delivery and enrichment in tree body.

The invention belongs to the technical field of medical treatment, and particularly relates to a pulse and ultrasonic energy time sequence synergistic drug delivery method and system. The pulse and ultrasonic energy time sequence synergistic administration method is characterized by comprising the following steps: (1) suspending medicament injection, and only washing with cooling liquid for 2-4 seconds; (2) the conveying of the cooling liquid is suspended, the medicament is sprayed for 0.5-1.5 seconds, and meanwhile, the ultrasound continuously works; (3) suspending injection of the medicament, re-inputting the cooling liquid, and continuing for 2-4 seconds; and (4) repeating the steps (1), (2) and (3) until completion. The system has the advantages that through pulse type drug delivery and time sequence cooperative control, periodic targeted release of high-concentration drugs is achieved, the drug utilization rate and the thrombolysis effect are remarkably improved, drug permeation is enhanced through the ultrasonic cavitation effect, and meanwhile the heat dissipation requirement of the system is met.

This invention belongs to the pharmaceutical field, and provides a chlorophyll derivative microneedle formulation, its preparation method, and its uses. The chlorophyll derivative microneedle formulation comprises the following raw materials by weight: 0.5-5 parts chlorophyll derivative, 5-20 parts excipient, 0.5-5 parts polysaccharide, and 70-94 parts solvent. The preparation method is as follows: the pH of the chlorophyll derivative dissolved in the solvent is adjusted to 6-8, and then the co-solvent, polysaccharide, and excipient are added to obtain a mixed solution; the mixed solution is loaded into a microneedle mold, vacuum-suctioned, and dried to obtain an integrated chlorophyll derivative needle. This microneedle can improve the targeted and transdermal drug delivery effect and drug utilization rate of the chlorophyll derivative, and the preparation method can improve the stability of the chlorophyll derivative and increase the local drug concentration at the affected area.

The invention provides a connexon, a polypeptide drug conjugate containing the connexon as well as a preparation method and application of the polypeptide drug conjugate. The polypeptide drug conjugate comprises a skeleton and zinc ions coordinated with nitrogen atoms of an imidazole ring on the skeleton, the skeleton has a structure as shown in a formula I or a formula II. The connexon and the polypeptide drug conjugate containing the connexon provided by the invention can stably target tumor cells, release a connection drug, realize high-concentration drug enrichment at a tumor tissue part without influencing a normal tissue microenvironment and increase the drug availability, and have a time-dependent killing effect on the tumor cells.

The present application belongs to the technical field of medicine crystal form, and particularly relates to a crystal form of lasmiditan-mellitic acid and a preparation method thereof. The crystal structure of the crystal form of lasmiditan-mellitic acid provided by the present application has a molar ratio of 1:1:2 of lasmiditan, mellitic acid and water, and an X-ray diffraction spectrum expressed in 2θ using Cu-Kα radiation has characteristic peaks at 6.59±0.2°, 10.73±0.2°, 16.14±0.2°, 23.62±0.2° and 24.10±0.2°. The crystal form is stable, has high solubility, is beneficial to the storage of the bulk drug, is beneficial to the improvement of the drug utilization, makes the drug better play a therapeutic role, has better tensile strength, improves the compression formability, and is convenient for the application of the preparation.