255 results about "Drug Utilization" patented technology

A drug-eluting balloon apparatus comprises a balloon surface (10), a polymer layer (14) that comprises drugs or both drugs and additives, and one or multiple drug layers or drug-and-additive layers (16). When a balloon (8) expands at a target lesion, the polymer layer (14) and the drug layers or the drug-and-additive layers (16) fall off the balloon surface (10) and bond on a blood vessel wall. The polymer layer (14) of the drug-eluting balloon apparatus can prevent a great loss of drugs during a pushing process of the balloon (8), and can also protect the drugs bond on the blood vessel wall from being brushed by blood, thus improving a drug utilization rate.

The invention discloses a health-care eye patch composed of a back lining layer (1), heating bodies (2), a middle interlayer (3), a gel layer (4) and a lining membrane (5). The heating bodies (2) are located between the back lining layer (1) and the middle interlayer (3), the gel layer (4) is located between the middle interlayer (3) and the lining membrane (5) and attached and applied to the eyes, the heating bodies (2) continuously release heat to enable drugs or other active ingredients in the gel layer (4) to be released sufficiently and rapidly to act on the attached and applied portions, and significant effects on eliminating eye swellings, relieving eye fatigue, improving black eyes and crow's feet and the like are achieved. The health-care eye patch has the advantages of being high in drug utilization ratio, rapid in action, safe and comfortable to use and the like.

The invention relates to an injection slow-release micro ball of Finasteride and similar component, wherein said micro ball contains 5-80% Finasteride and biological degradable polymer at 95-20%. The production comprises emulsion disperse (oil/water or oil/oil method), liquid drying method, or atomization drying method. The inventive agent can prolong function time and improve drug utilization.

The invention relates to a method for transplanting big tea plant successfully. Wherein, it comprises that cutting root before transplanting and not cutting root, drug utilization, management, water keep, management in later transplanting, management at half year after the transplanting, and the management in 2-4 years. The invention can make the survival rate of tea tree higher than 90%.

The invention discloses a preparation method and use of a traditional Chinese medicine asiaticoside carrying core/shell structure nanometer fiber film. The traditional Chinese medicine asiaticoside carrying core/shell structure nanometer fiber film is prepared from a lactic acid/glycollic acid copolymer (PLGA) as a shell and polycaprolactone (PCL) as an inner core through a coaxial electrospinning method. The preparation method has the advantages of use of easily available raw materials, operation easiness, good controllability and large scale industrial production easiness. The traditional Chinese medicine asiaticoside carrying core/shell structure nanometer fiber film can be used for wound dressing and has the advantages of controllable drug loading amount, high drug utilization rate and excellent wound healing promoting effect.

The invention relates to a compound nano drug carrier system with tumor promotion target capability and a preparation method of the system. The preparation method comprises the steps of connecting a 2,4,6-trimethoxybenzene ring to the surface of a mesoporous silicon nanoparticle through an epoxy ester bond, adopting beta-cyclodextrin as a 'valve' material, capping the surface of the mesoporous silicon nanoparticle with the beta-cyclodextrin by a subject-object effect of the cyclodextrin and the benzene ring, and grafting benzaldehyde terminated PEG (polyethylene glycol) to the surface of the beta-cyclodextrin through a pH (potential of hydrogen) sensitive imine bond to construct the compound nano drug carrier system capable of performing targeted release of a drug in a tumor cell. The constructed PEG/beta-CD/MSN (polyethylene glycol/beta-cyclodextrin/mesoporous silicon nanoparticle) compound nano drug carrier system is high in drug loading capacity, has double pH sensitivity mechanismsand more efficient targeted administration capability in the cancer cell, and can effectively increase a utilization ratio of the drug, reduce toxic and side effects of the drug, and better achieve targeted controlled release treatment of a cancer.

The invention relates to a cyclosporine-containing composition and a preparation method thereof. The compound eye drops are prepared from cyclosporine, anti-inflammatory or antibiotic drugs, a surfactant, a stabilizer, a thickener, an isoosmotic adjusting agent, a pH adjusting agentr and water or oil, the preparation is a mixed suspension agent or an emulsion, and one or two of a high pressure homogenization method and a wet grinding technique is/are combined for use in the preparation method. The cyclosporine compound eye drops have the advantages that the ophthalmic tolerance is excellent, the drug utilization degree is high, the tear secretion of people suffering from xerophthalmia can be effectively improved, the tear film is stabilized, the anti-inflammation function of the anti-inflammatory or antibiotic drugs and the immunoregulation function of cyclosporine can be synergistically exerted, xerophthalmia can be effectively treated, and the compound eye drops have a better treatment effect compared with the separate application of cyclosporine.

The invention discloses a hydroxycamptothecin slow-release microsphere and a preparation method thereof, relates to an anti-tumor pharmaceutical preparation and provides a hydroxycamptothecin slow-release microsphere and a preparation method thereof with long time of continuous drug release, stable drug release and high drug utilization; a carrier is polylactic acid, anti-cancer drug of hydroxycamptothecin is packed in the carrier and a modifying layer of water soluble derivative of chitosan is arranged on the surface of the carrier; the hydroxycamptothecin and the polylactic acid are dissolved in an organic solvent so as to obtain solution A; polyvinyl alcohol solution with the concentration of 0.5 percent to 5 percent is prepared and sodium dodecyl sulfate is added to prepare mixed solution B with the concentration of 0.5 percent to 1 percent; the solution A is transferred into a disperse phase container of a film emulsifier, the mixed solution B is added into a continuous phase container, a water suction pump is started to lead the continuous phase to be cycled, a mobile phase is collected, a certain pressure is maintained and a pressure indicating value which is operated to the film emulsifier is reduced to 0kPa. The collected mobile phase is centrifugated, precipitation is collected and freeze-dried to obtain the unmodified drug-carrying microsphere and then the surface modifying of the microsphere is carried out.

The invention relates to a traditional Chinese medicine composition for treating vital myocarditis and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following crude drugs in parts by weight of 10-15 parts of astragalus mongholicus, 6-15 parts of codonopsis pilosula, 6-10 parts of schisandra chinensis, 8 parts of radix ophiopogonis, 10-15 parts of fingered citron, 10-15 parts of radix bupleuri, 6-15 parts of radix polygonati officinalis, 5-13 parts of hawthorn, 2-5 parts of coptis chinensis, 6-10 parts of honeysuckle, 8-12 parts of root of common peony, 8-12 parts of radix paeoniae alba, 4-8 parts of cassia twig, 10-15 parts of root of red-rooted salvia, 10-20 parts of honey-fried licorice root, 10-20 parts of folium isatidis, 10-15 parts of glossy privet fruit, and 6-12 parts of radix curcumae. The traditional Chinese medicine composition has the advantages of being good in curative effect, rapid to become effective, free of side effect, advanced in preparation process, good in preparation stability, and high in drug utilization degree; and the effective rate of the traditional Chinese medicine composition for treating vital myocarditis is 94% by clinical verification.

The invention discloses a beta-poly malic acid/chitosan nano drug sustained-release microcapsule and a preparation method thereof. The beta-poly malic acid/chitosan nano drug sustained-release microcapsule comprises a core material and a wall material, wherein the core material is a medicine, and the raw material of the wall material consists of beta-poly malic acid and chitosan; and the mass ratio of beta-poly malic acid to chitosan to the medicine in the beta-poly malic acid/chitosan nano drug sustained-release microcapsule is 10:2.5:(3-5). The preparation method comprises the step of preparing the beta-poly malic acid/chitosan nano drug sustained-release microcapsule from beta-poly malic acid, chitosan and the medicine by utilizing a polyelectrolyte self-assembly principle. The beta-poly malic acid/chitosan nano drug sustained-release microcapsule prepared by the preparation method disclosed by the invention has the advantages of homogeneous granularity, good stability, good sustained release effect and no damage to a human body; and the preparation method disclosed by the invention is simple, mild in conditions and suitable for industrial production.

The invention provides a drug balloon catheter, a drug balloon catheter system and a control method of the drug balloon catheter system. The drug balloon catheter comprises a balloon with the outer surface coated with a drug coating, a catheter body penetrating through the balloon and a shock wave component connected to the catheter body, wherein the shock wave component is used for emitting shock waves to the drug coating after the catheter body is conveyed to a preset position, so that the drug coating falls off from the outer surface of the balloon; the drug coating comprises a protective layer and a drug carrying layer, and the drug carrying layer is located between the outer surface of the balloon and the protective layer; or the drug coating comprises an active drug and a polymer carrier; or the drug coating comprises an active drug and a liposome for wrapping the active drug; and the drug balloon catheter system comprises a control assembly and the drug balloon catheter, and the shock wave component is connected to the control assembly through a wire. The drug balloon catheter, the drug balloon catheter system and the control method of the drug balloon catheter system have the advantages of being high in medicine utilization rate, simple in structure and convenient to operate.

The invention relates to a composite propolis soft capsule, which comprise a skin packing the mixture of propolis, lucid ganoderma spore oil and purple perilla oil. The purple perilla oil can express the functions as blood sugar reduction and the solvent or the like, to dissolve the solid propolis and lucid ganoderma spore oil, without deposit in the mixture, to improve the adsorption by human body and improve the cooperation of said three drugs. The invention has high drug utilization, non side effect and better effect, to be used to reduce blood grease and blood sugar, or the like.

The invention discloses a soil particle fumigant taking one or two of activated carbon particles and activated aluminum oxide particles as a particle carrier which is absorbed with the fumigant, wherein the fumigant is one or two of acquinite and 1,3-dichloropropylene. The soil particle fumigant is characterized in that the particle carrier absorbed with the fumigant is externally coated with a coating made from at least one material of urea, polyvinyl alcohol and gelatin. The soil particle fumigant has good effects for killing nematodes and pathogenic bacteria, high drug utilization rate and long residual life, is safe, economic and convenient in use, and is the most dominant substitute for bromomethane (CH3Br) in the worldwide scope at present.

The invention discloses application of vitamin E TPGS (d-alpha tocopheryl polyethylene glycol 1000 succinate) in preparing porous drug carrier particles, a method for preparing porous drug carrier particles, and the porous drug carrier particles. The method comprises the following steps: dissolving vitamin E TPGS, medicines and organic macromolecular polymer, such as PLGA (poly(lactic-co-glycolic acid)), in an organic solvent; emulsifying, removing the organic solvent in a volatizing manner to obtain the drug-loaded porous drug carrier particles with a porous structure on the surface. The porous drug carrier particles have the characteristics of small toxicity, high target, high encapsulation rate, porosity and drug in-vitro release acceleration, can be used for inhibiting P-gp induced drug transportation due to TPGS, so that the multi-drug resistance effect of an administrated object can be inhibited; furthermore, the porous drug carrier particles are utilized in administration, and the drug utilization is high, so that the dosage can be effectively reduced, and side effects can be further reduced.

The invention relates to a method for preparing relieving mental stress tablet, which comprises 9-11g panaxoside, 995-1005g albizia flower, 495-505g schisandra fruit, and 495-505g lucid ganoderma; breaks the schisandra fruit into rough powder, adding 75% alcohol to be immerged for 30min, refluxing and extracting for two times while the first time costs 2.5h and the second time costs 2h, combining the extractive and recycling alcohol, concentrating into dense paste; adding water into albizia flower and lucid ganoderma to be boiled for two times, while the first costs 2h and the second costs 1.5h; filtering, combining the fluid liquors, concentrating into dense paste, combining the dense pastes, drying and breaking into fine powder, adding panaxoside, and 80-100g amidon, or adding 15-20g calcium sulfate, 10-15g pre-gelatinized amidon, and 55-65g amidon; using 35-55% alcohol or 8-15% syrup to prepare particles, drying, and adding 0.5-1% dolomol and 1% French chalk, mixing uniformly, pressing into 1000 tablets or 600 tablets, coating sugar package or film. The invention has high drug utilization without side effect.

The invention provides a preparation method of drug balloons as well as the drug balloons prepared by the preparation method and application thereof. The preparation method is characterized by comprising the following steps: curing chitosan to surfaces of balloons to obtain balloons with surfaces modified by the chitosan; spraying a drug solution on the obtained balloons with the surfaces modified by the chitosan to obtain the balloons with surfaces provided with drug coatings; carrying out surface solvation treatment on the balloons and carrying out segmented folding and packing to obtain the drug balloons. According to the drug balloons prepared by the preparation method provided by the invention, the drug coatings can be uniformly and firmly combined on the surfaces of the balloons and not easily fall off; drugs are prevented from being washed off in an in-vivo conveying process; the loss of drugs is reduced and the utilization rate of the drugs is improved; the preparation method provided by the invention is accurate, stable and efficient, is suitable for industrial large-scale production and has a wide application prospect.

The invention provides an electrostatic spinning-based pressure-sensitive adhesive patch, and a preparation method thereof, and belongs to the technical field of patch for external use. According to the preparation method, electrostatic spinning is adopted so as to obtain two kinds of nano fibers containing a lipophilic drug and a hydrophilic drug respectively, and release channels to the skin of different drugs are provided; wherein the nano fiber composed of a styrene series pressure-sensitive adhesive matrix possesses pressure-sensitive bonding capacity, local adhesion is observed, and an interpenetrating network structure is formed together with fiber composed of a hydrophilic drug release matrix, so that adhesion of a system onto skin surface is realized effectively. The advantages are that: firstly, electrostatic spinning is adopted to prepare the amphiphilic drug-containing nano fiber matrix, so that two phase incompatibility is avoided; secondly, the lipophilic drug and the hydrophilic drug can be independently stored in the corresponding nano fiber matrixes, and released, so that drug utilization ratio is high; and in addition, the amphiphilic drug-containing nano fiber matrix prepared via electrostatic spinning is high in porosity and permeability.

The invention relates to a constructing method of a fetal-original bipolar disorder animal model and application thereof. The fetal-original bipolar disorder animal model is characterized in that a rodent animal is injected with 0.1 to 2.0mg/kg of dexamethasone in a subcutaneous way 9 to 20 days after getting pregnant; the rodent animal is conventionally and normally fed to 10 weeks after birth, the chronic stimulation by ice water swimming is performed for two weeks, and then the typical feature similar to human bipolar disorder appears. The fetal-original bipolar disorder animal model is novel, reliable, simple and convenient, and has important meaning on the instruction of clinical reasonable drug utilization in pregnant period, study of fetal-original bipolar disorder action mechanismand molecular targets, screening of intrauterine environment interference matters and medicines, and the like.

The invention discloses application of an emodin succinyl ester compound in preparation of a medicine for resisting myocardial ischemia and belongs to the technical field of medicines. The emodin succinyl ester compound has a structure shown as a formula I (R is C1 to C5 alkyl). Pharmacological experiments on rats and mice for experimenting myocardial infarction prove that the emodin succinyl ester compound has the advantages of remarkable myocardial ischemia resisting effect, good safety, simplicity and convenience for drug utilization, low raw material price and easiness for obtaining, and convenience for transportation and preservation. The emodin succinyl ester compound disclosed by the invention is used as a myocardial ischemia resisting drug and has a wide application prospect. The formula I is shown in the description.

The invention discloses a dual-valve multi-stimulation-responsive drug carrier constructed on the basis of mesoporous silicon/cyclodextrin/zinc oxide quantum dots and a preparation method thereof. With mesoporous silicon nanoparticles as a carrier, after drug loading, blocking is performed by using aminated zinc oxide quantum dots to obtain a drug carrier blocked by the zinc oxide quantum dots; then, after the drug carrier blocked by the zinc oxide quantum dots is connected with ferrocenecarboxylic acid through chemical bonds, the drug carrier further reacts with anhydrided cyclodextrin for secondary blocking to obtain a composite nanometer drug carrier system. The composite nanometer drug carrier system has the properties of dual pH sensitivity, H2O2 oxidation sensitivity and fluorescenceimaging, has more efficient targeting drug administering ability in cancer cells, and can effectively increase the drug utilization rate.

The invention discloses a medical atomizer. The medical atomizer comprises a drug storage device, a fog collecting tank and an atomization generating assembly; an accommodating cavity is formed between the lower portion of the drug storage device and the fog collecting tank and used for accommodating the atomization generating assembly; the atomization generating assembly comprises a sealing sleeve and an atomizing sheet; the fog collecting tank is shaped like a spindle. The medical atomizer is convenient to produce and assemble and high in drug utilization rate.

The invention discloses a hydrogen peroxide responding type targeted fluorescent medicine-carrying nanomaterial and a preparation method and belongs to the technical field of nanomaterials. A structural formula is shown in the description, and the preparation method of the nanomaterial includes the steps of synthesis of PHEMA, synthesis of FPEG, synthesis of PHEMA-Sim/Prv/Com/Lo, synthesis of PHEMA-Sim/Prv/Com/Lo-FPEG-ISO-1 and the like. The nanoparticles prepared by the preparation method have the functions of high drug utilization rate, fluorescence calibration and targeting of atherosclerotic plaques.

The invention relates to the technical field of medical equipment, and provides a shock wave assisted drug perfusion balloon catheter and medical equipment. The shock wave assisted drug perfusion balloon catheter comprises: an outer tube; a balloon which is connected with one end of the outer tube, wherein a liquid outlet hole is formed in the side wall of the balloon; an inner tube which is sequentially inserted into the outer tube and the balloon, wherein the inner tube penetrates through the balloon, and a gap between the inner tube and the outer tube forms a medicine conveying channel; and a shock wave generator which is located in the balloon and arranged on the outer wall of the inner tube. According to the shock wave assisted medicine perfusion balloon catheter, the liquid outlet holes are formed in the surface of the balloon, and the medicine conveying channel is formed through the gap between the inner tube and the outer tube, so that external medicine can reach the balloon through the medicine conveying channel and then enter a blood vessel through the infusion hole in the surface of the balloon. The medicine loss in the conveying and withdrawing process is avoided, the medicine utilization rate is improved, and the medicine dosage and the toxicity risk can be reduced.

The invention designs a liposome vector, a surface modified polypeptide and a functional nucleic acid aptamer for loading of the drug paclitaxel so as to realize drug loading. Based on the advantage that the polypeptide can mediate crossing of a blood cerebral barrier, a functional nucleic acid molecule specifically recognizing glioma cells is targeted to glioma cells and then a liposome is fusedwith target cells, so targeted drug delivery is realized; and thus, the drug utilization rate is increased, and drug toxicity is reduced.