135 results about "Drug Utilization" patented technology

The invention relates to a layered drug-loading microneedle patch as well as a preparation method and application thereof. The preparation method of the layered drug-loading microneedle patch comprises the following steps: S1, dissolving a drug and a soluble high-molecular polymer in a solvent according to a mass ratio of (2: 1)-(1: 12) to form a needle tip solution, then filling a needle tip cavity of a microneedle mold with the needle tip solution, drying, and removing redundant drug residues on the surface to form a drug-loading needle tip layer; and S2, filling a mold containing the drug-loading needle tip layer with a photocurable polymer, performing ultraviolet curing for 10-30 seconds under the wavelength of 365-405 nm, and then performing demolding to form a substrate layer, thereby obtaining the layered drug-loading microneedle patch. According to the method, one-time filling of the needle tip part is successfully achieved by combining needle tip auxiliary material proportion optimization, meanwhile, the curing process is rapid, the medicine utilization rate and the process stability are remarkably improved, the medicine stability is good, and the method is suitable for industrial production.

The invention aims to provide a preparation method and application of an inhalation drug-loading ultrasonic driving nano motor, and can effectively solve the problems of preparation of the inhalation drug-loading ultrasonic driving nano motor and application of the inhalation drug-loading ultrasonic driving nano motor in preparation of drugs for treating IPF. Comprising the following steps: firstly preparing PLGA-PFD nanoparticles, then preparing PDA-PLGA-PFD nanoparticles, and finally preparing BNN6 / PDA-PLGA-PFD, namely the asymmetric nano motor BPPP with the ultrasonic responsiveness. The product disclosed by the invention is scientific and advanced in preparation method, good in product performance, high in atomization administration and IPF lung pathological barrier penetrating capability, high in medicine utilization rate, good in curative effect, simple and convenient to operate, wide in application prospect and huge in economic and social benefits.

The invention discloses a drug eluting stent, which comprises a stent main body and a plurality of thorn-shaped components, the stent main body has a radially compressible contraction state and a radially self-expanding expansion state to support blood vessels, and the plurality of thorn-shaped components are arranged on the outer surface of the stent main body and coated with a drug coating for inhibiting vascular restenosis. The spine-shaped components are arranged on the stent body and are configured to protrude towards the outer side of the stent body from the outer surface of the stent body to penetrate into calcified lesions on the inner wall of a blood vessel when the stent body is switched from the contraction state to the expansion state, each spine-shaped component is provided with a part capable of generating elastic deformation, and the spine-shaped components are configured to be capable of generating deformation in a self-adaptive mode according to the thickness of the contacted calcified lesions. Therefore, the medicine can be uniformly distributed in a target lesion area, and the utilization rate of the medicine and the treatment effect are remarkably improved.

The invention discloses a preparation method and antipyretic and anti-inflammatory application of a novel carrier-free metal-organic small molecule supramolecular hydrogel derived from Maxing Shigan Decoction. The hydrogel drug raw materials of the invention include pseudoephedrine hydrochloride in Ephedra sinica in the prescription of Maxing Shigan Decoction, amygdalin in Armeniaca vulgaris, magnesium ions in Gypsum fibrosum, and glycyrrhizic acid in Glycyrrhiza uralensis Fisch. The preparation method of the quaternary magnesium hydrogel drug is simple, green, has good stability and high biocompatibility. In a rat fever model induced by lipopolysaccharide at different doses, the antipyretic effect of the hydrogel drug can last up to 12 hours, and the antipyretic effect is significantly better than that of other metal ions such as quaternary calcium hydrogel, quaternary zinc hydrogel, and quaternary copper hydrogel groups. At the same time, it has a more persistent antipyretic effect than the whole prescription of Maxing Shigan Decoction; the hydrogel drug does not require the addition of excipients, has no toxic and side effects, and has a high drug utilization rate.

The invention discloses composite hydrogel as well as a preparation method and application thereof. The composite hydrogel comprises a hydrogel matrix and a liposome loaded on the hydrogel matrix, the hydrogel matrix comprises a methacrylated natural protein, and the liposome is loaded with a drug; the medicine comprises a medicine for promoting cartilage differentiation and an anti-inflammatory traditional Chinese medicine monomer. According to the invention, through a liposome entrapment technology, the stability and sustained release ability of the insoluble traditional Chinese medicine monomer and the cartilage differentiation induction drug are enhanced. The particle size of the liposome is controllable, the liposome is well combined with a methacrylated natural protein network, a drug sustained release bin can be formed in the hydrogel, long-time and local precise release is achieved, the drug utilization efficiency is improved, and systematic toxic and side effects are avoided.

The invention discloses a frontalon tooth healing targeting nano preparation and a preparation process thereof, belongs to the technical field of nano medicines, and aims to solve the problems that the natural regeneration capacity of teeth is limited and the combination of ethnic drugs and modern biotechnology is caused due to the lack of a targeting inhibition means for USAG-1. Comprising an anti-USAG-1 monoclonal antibody, ethnic drug components and a nano-carrier, the anti-USAG-1 monoclonal antibody is connected to the surface of the nano-carrier through covalent bonds, the ethnic drug components are loaded in the nano-carrier through physical action, and the nano-carrier is a polylactic acid-glycolic acid copolymer or chitosan; the anti-USAG-1 monoclonal antibody is used as a targeting ligand, is high in targeting property, can accurately reach a tooth focus, improves the drug utilization rate, enhances the curative effect, integrates multiple ethnic drug components, exerts a synergistic effect, can increase the contact area between the ethnic drug components and a biological membrane, promotes the absorption and transport of the drug, and improves the bioavailability of the drug. And the medicine can better play a treatment role.

The invention discloses a multi-effect traditional Chinese medicine composite navel patch and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The multi-effect traditional Chinese medicine composite navel patch comprises the following components in parts by weight: 22-26 parts of glucomannan, 16-18 parts of sodium periodate, 12-15 parts of carboxymethyl chitosan, 8-12 parts of nano-plastid and 2-3 parts of composite polysaccharide. According to the preparation method, oral administration is replaced by transdermal absorption through a mode of preparing the nano microneedle, gastrointestinal discomfort caused by oral administration is avoided, the medicine utilization rate is increased, medicine absorption is accelerated, meanwhile, the nano-plastid loaded traditional Chinese medicine extract is prepared, the transdermal absorption effect is further enhanced, and the bioavailability is improved. The effective speed of the traditional Chinese medicine extract and the utilization rate of effective components are improved.

The invention discloses a targeted anti-aging microneedle drug delivery system for chronic wound repair as well as a preparation method and application of the targeted anti-aging microneedle drug delivery system. The system is composed of functionalized nanoparticles and a microneedle platform: a nano drug-loading unit which takes a polydopamine nanosphere as a carrier, entraps an anti-aging drug Bem, and modifies the surface of the nano drug-loading unit with a targeting peptide E7; according to the micro-needle delivery unit, hyaluronic acid-nitrogen carboxymethyl chitosan hydrogel is used as a matrix, a nano drug-loading unit and silver ions (Ag) are loaded, a micro-needle array is formed, and minimally invasive transdermal drug delivery is achieved. According to the invention, multiple mechanisms of anti-aging (APCs aging inhibition), antioxidation (ROS removal), antibiosis (Agaction) and immunoregulation (macrophage M2 type polarization promotion) are synergistically exerted, and the bottleneck problems of single intervention target, low drug availability and difficulty in regulating and controlling pathological microenvironment of chronic wounds (such as diabetic foot ulcer) in the traditional therapy are effectively solved.

The invention relates to the technical field of atomizers, in particular to an intelligent atomization control system for medicine dosage homogenization, which comprises a temperature feedback control module, a laser granularity measurement module, an airflow fluctuation compensation module, a flow regulation module and a data analysis module. By intelligently controlling the flow, granularity, airflow and temperature of liquid medicine, accurate adjustment of the atomization process can be achieved, it is ensured that medicine is evenly and stably released in the whole treatment process, waste of the liquid medicine is remarkably reduced, the medicine utilization rate is increased, and by monitoring the temperature change in real time, the atomization effect is improved. The flow is adjusted to cope with the influence of temperature fluctuation on the liquid medicine flow characteristic and the atomization effect, medicine conveying stability in different environments is guaranteed, meanwhile, based on particle size control, airflow and flow can be adjusted in time to guarantee consistency of atomized particles, uneven medicine dosage caused by particle size fluctuation is avoided, and through airflow fluctuation compensation, the atomization effect is improved. It can be ensured that the influence on medicine flow is minimized when airflow is unstable, and dosage instability is avoided.

The invention relates to the field of anesthetic quantification, in particular to an anesthetic quantitative conveying device of an anesthesia machine in an operating room, which comprises a table top, a bottom plate, a box body, a quantitative groove and a buffer groove, the bottom plate is fixed at the upper end of the table top, the box body is fixed at the upper end of the bottom plate, the quantitative groove is arranged on one side of the box body, and a piston I is arranged in the quantitative groove; and a lead screw is rotationally installed at the upper end of the first piston, a movable frame is rotationally installed at the end, penetrating through the upper end of the quantitative groove, of the lead screw, a mounting frame is arranged on one side of the quantitative groove, a height-adjustable lifting frame is connected to the mounting frame in an inserted mode, and a buffer groove is formed in the upper end of the lifting frame. The height of the piston can be adjusted by driving the screw rod through the motor, precise quantification is realized by combining infrared distance measurement, negative pressure is formed by utilizing the design of the piston II and the spring of the buffer groove, liquid medicine is prevented from flowing back and dripping, and the operation convenience and the medicine utilization rate are improved; the problem that an existing anesthetic quantifying device for the operating room lacks accurate quantifying and liquid leakage preventing functions is solved.

A medicine hanging bag for aquaculture disinfection relates to the technical field of aquaculture and comprises a bag body, a supporting piece, a sealing ring, a first pull wire and a second pull wire, the supporting piece is arranged at an opening in the lower end of the bag body, the sealing ring is coaxially arranged at an opening in the upper end of the bag body, and the first pull wire and the second pull wire are oppositely arranged on the sealing ring. The first pull wire and the second pull wire are matched to close the sealing ring; the sealing ring, the first pull wire and the second pull wire are arranged in a matched mode, the opening of the bag body can be closed rapidly, binding is convenient, and the working efficiency is improved; the inner bag is arranged in the bag body, so that other medicines or fillers can be conveniently filled in the inner bag, the utilization rate of the hanging bag is improved, the thickness of the medicines in the bag body is reduced, the medicines can be quickly melted conveniently, the utilization rate of the medicines is improved, and medicine waste is reduced.

The invention discloses a magnetic control soft robot and a preparation method, a control system and a control method thereof, and belongs to the technical field of biomedical engineering and soft robots. The magnetic control soft robot comprises a main body framework, a head magnetic sheet, a tail magnetic sheet, a magnetic box, a hollow needle plate and a magnetic foot pad. The magnetic control soft-bodied robot provided by the invention can be orally taken to enter the gastrointestinal tract in the body, an external rotating magnetic field is applied for control, the whole process of'movement-positioning-piercing-drug release 'is completed, in-vivo subcutaneous drug delivery is carried out, the drug utilization efficiency can be improved, and the robot is high in dynamic environment adaptability and can be recycled.

Embodiments of the present disclosure provide a worm injection device, its usage method, and a worm drug carrier, belonging to the field of biotechnology. The worm injection device includes: a worm placement plate, on the injection surface of which circular worm holes are arranged in an array, and each circular worm hole accommodates a worm; an injection assembly, including an injection tube, a push rod, and a needle plate, the needle plate is connected to the injection end of the injection tube, and a plurality of needles are arranged on the needle plate; there is a gap between the needle plate and the worm placement plate, and the injection tube moves towards the worm placement plate so that the needles extend into the circular worm holes, and the drug in the injection tube is injected into the worms in the corresponding worm holes through the needles. Through the processing solution of the present disclosure, the efficiency and accuracy of the worm injection device are improved, batch production of worm drug carriers is realized, and at the same time, it is ensured that the drug can be stored in the worms for feeding livestock and poultry or aquatic organisms, with high drug utilization rate and prevention of water pollution.

The utility model belongs to the technical field of medicine bottles, and particularly relates to a liquid medicine storage device. The technology comprises a bottle body, a bottle cap is in threaded connection with a bottle opening of the bottle body, a partition pipe used for dividing the interior of the bottle body into two cavities is arranged at the bottom in the bottle body, a thin film is arranged at the top of the partition pipe, a vertically-through fixing hole is formed in the bottle cap, a pointed cone used for puncturing the thin film is slidably connected into the fixing hole, and a fixing plate is arranged at the top of the pointed cone. A locking assembly used for fixing the position of the pointed cone is arranged on the bottle cap. According to the utility model, the inside of the bottle body is divided into two cavities for storing medicines through the separation tube, the two cavities are used for storing the two medicines to be mixed, the locking component is used for loosening the constraint on the pointed cone and pressing the pointed cone to move downwards to enable the pointed cone to pierce the thin film, so that the two medicines can be better mixed, the operation is simpler, and the liquid medicine is prevented from being polluted or leaked.

This invention discloses a porous carbon-based dual-drug-loaded nanomaterial for sustained release. The material uses a thermosensitive polymer as a matrix and cellulose nanocrystals modified with cationic surfactants as a reinforcing phase, loading both hydrophilic and hydrophobic drugs. This material can be used to prepare therapeutic drugs for gynecological diseases and infertility, as well as drug delivery devices. Furthermore, this invention provides a uterine scaffold prepared using this material, which can be fabricated using 3D printing technology. Utilizing the PNIPAm hydrogel network and its temperature-responsive properties, hydrophilic drugs can be loaded at low temperatures. The high mechanical strength of CNC machining allows for the loading of hydrophobic drugs while improving the mechanical properties of the hydrogel matrix, thus solving the problems of easy detachment and bleeding in existing technologies.

The present invention provides a nebulizer spacer, comprising a spacer body with a mist outlet provided at the front end of the spacer body. The spacer is characterized in that a rear cover is provided on the inlet provided at the rear end of the spacer body, and a mist inlet, an air inlet, and an air inlet check valve are provided on the rear cover. The air inlet check valve is a spiral air inlet check valve. The main body of the spiral air inlet check valve is annular, with a central opening diameter not less than the diameter of the inner wall of the mist inlet. The spiral air inlet check valve is arranged around the mist inlet, and the thickness of the spiral air inlet check valve gradually decreases from the inner edge to the outer edge. At least three inter-petal openings are provided along the radial direction of the spiral air inlet check valve, forming at least three petals, and each of the petals is provided with a fixing port. The spiral air inlet check valve can reduce the probability of drug mist particles adhering to the inner wall of the spacer, improve drug utilization, refine drug particles, reduce drug diffusion, and increase the delivered dose. Furthermore, the oxygen tube interface provided can achieve simultaneous nebulization while inhaling oxygen, reducing the patient's breath-holding phenomenon.

The invention belongs to the technical field of medical apparatus and instrument control, particularly relates to an atomization control system for respiratory nursing, and aims to solve the problems of low medicine deposition efficiency, serious waste and incapability of precise medicine administration caused by the lack of the capability of sensing and responding to the real-time respiratory state of a patient in a traditional atomization device. The system comprises a breathing state real-time monitoring module, an aerosol generation and regulation module, an intelligent control center, a man-machine interaction interface and a cloud data collaboration platform. Breathing parameters are collected through a high-sensitivity sensor, the particle size and the output opportunity of fog drops are dynamically adjusted in combination with a dual-mode ultrasonic atomization technology, and accurate inspiration phase dosing is achieved; a self-adaptive learning engine is arranged in the intelligent control center, the breathing cycle can be predicted, atomization can be started in advance, and the response speed is increased; local closed-loop control and remote personalized management are supported, and the medicine utilization rate and treatment compliance are remarkably improved.

The invention discloses a non-small cell lung cancer intrathoracic precise drug delivery device matched with a pH-responsive metal organic framework drug delivery system, and belongs to the technical field of intrathoracic drug delivery. The device comprises an injector, the injector is fixedly installed on a micro-injection pump, a drug delivery connector is inserted into a connection connector, and the drug delivery connector is connected with a pH-responsive metal organic framework drug delivery system. A needle head is fixedly connected to the end, away from the dosing connector, of the liquid inlet pipe, a protection mechanism is arranged outside the connecting connector and the dosing connector, a butt-joint limiting mechanism is arranged on the side wall of the protection mechanism, and the connecting connector and the dosing connector are fixed to the butt-joint limiting mechanism. Stable power and accurate control are provided for the injector through the micro-injection pump, the dosing requirements of local high concentration and accurate dosage in non-small cell lung cancer treatment are met, curative effect fluctuation caused by manual operation errors is reduced, the connecting joint and the dosing joint are protected and fixed by arranging the protective sleeve and the butt-joint limiting mechanism, and the non-small cell lung cancer dosing device is convenient to use. Liquid medicine leakage caused by loosening of the connector in the dosing process is effectively prevented, and the medicine utilization rate is guaranteed.

This invention provides a chemotherapy catheter for spinal tuberculosis, comprising a catheter with a drug channel, a flexible tube at the front end of the catheter with multiple through holes communicating with the drug channel, and a built-in one-way structure. The one-way structure includes an elastic rubber sheet at one end fixed to the inner wall of the drug channel; multiple elastic rubber sheets are stacked together in a conical shape; and a connector is connected to the rear end of the catheter, with a drug injection end for injecting medication. This invention, by inserting the catheter into the patient's body, injects medication through the drug injection end, which then passes through the drug channel and the one-way structure to prevent backflow, and finally flows out through the multiple through holes, thereby widely dispersing the medication and improving drug utilization.

The present application relates to the technical field of medicine and provides a lanosterol derivative, a preparation method therefor and a use thereof. The structural formula of the lanosterol derivative provided by the present application is as shown in formula I or II. The lanosterol derivative provided by the present application has both lipid solubility and water solubility, and can effectively penetrate into the pathological site in the body, thereby improving the drug utilization rate. The results of embodiments show that the lanosterol derivative provided by the present application has a significantly higher solubility in water than lanosterol or 25-hydroxylanosterol and shows a significant therapeutic effect on a cataract in animal in vivo experiments. Therefore, the derivative has wide prospects in the preparation of drugs for treating eye diseases or conditions.

The application discloses a mesh nebulizer. The nebulization control method of the mesh nebulizer comprises the following steps: acquiring breathing data of a user; determining a breathing state of the user and an end time point of exhalation of each breathing cycle based on the breathing data; the breathing state comprises stable breathing and abnormal breathing; and controlling a running state of a nebulization sheet based on the breathing state and the end time point of exhalation. According to the breathing state of the user and the end time point of exhalation, the running state of the nebulization sheet is accurately controlled, so that the drug utilization rate is improved, and intelligent and personalized nebulization treatment is realized.

The present invention relates to a Chinese herbal volatile oil, a preparation method and application thereof, and Chinese herbal granules, and relates to the technical field of Chinese medicine. The preparation method comprises the following steps: adding the raw materials of the Ling Gui Shu Gan Tang prescription to water, and then performing ultrasound-assisted pulsed electric field pretreatment to obtain a mixture; decocting the mixture and collecting drug vapor condensate to obtain drug vapor condensate and a decoction; extracting the drug vapor condensate through a volatile oil extractor and collecting volatile oil to obtain the Chinese herbal volatile oil. Targeting the classic prescription Ling Gui Shu Gan Tang, the present invention introduces ultrasound-assisted pulsed electric field pretreatment based on the existing technology, utilizing the composite field formed by the cavitation effect of ultrasound and the electroporation effect of the pulsed electric field to promote the dissolution of the drug's active ingredients, thereby improving drug utilization and work efficiency; at the same time, the present invention finds that the obtained extract has good anti-osteoporosis activity, a discovery that opens up a new clinical application field for the classic prescription Ling Gui Shu Gan Tang.

The utility model relates to the technical field of unmanned aerial vehicles, in particular to a centrifugal sprayer for an unmanned aerial vehicle, which comprises a barrel, a water inlet channel is arranged in the barrel, a hose is arranged in the water inlet channel, one end of the hose is used for extending out of the water inlet channel to be connected with a water pipe, and a nozzle for spraying liquid medicine is arranged at the other end of the hose. The hose is used for introducing liquid medicine into the nozzle, the nozzle is rotationally connected with the barrel, a motor is further arranged in the barrel and fixedly connected with the barrel, a rotating shaft of the motor is fixedly connected with the nozzle, and a plurality of atomizers used for atomizing the sprayed liquid medicine are arranged on the nozzle. The nozzle is rotationally connected with the barrel, the motor drives the nozzle to rotate, and the motor can rotate the nozzle, so that the liquid medicine is centrifugally thrown out, the liquid medicine can be sprayed uniformly, and the coverage range is wider. The atomizer further improves the atomization effect of the liquid medicine, so that the liquid medicine is finer and easy to diffuse, and the medicine utilization rate and the treatment efficiency are improved.

This invention provides an intelligent ultrasonic conductance directional drug penetration therapeutic device. Compared to existing technologies, this invention also includes a drug penetration module that contacts the patient's skin to apply the drug to the patient's skin, an adaptation module that adjusts the drug penetration efficiency of the drug penetration module according to the patient's skin location, and a fixation module for adapting the drug penetration module to different skin locations. This invention integrates ultrasonic treatment, drug delivery, infrared sensing, and compress clamping functions, achieving a combined application of multiple treatment methods. Utilizing ultrasonic technology, it allows drugs to penetrate the patient's skin more easily, thereby improving drug utilization.

The invention relates to an ibuprofen-containing transdermal patch as well as a preparation method and application thereof. The ibuprofen-containing transdermal patch comprises a polymer matrix layer, the polymer matrix layer comprises ibuprofen, a compound at least containing one amino group and a pressure-sensitive adhesive, and based on the weight of the polymer matrix layer, the ibuprofen accounts for 10-30% by weight, the compound at least containing one amino group accounts for 0.1-5% by weight, and the pressure-sensitive adhesive accounts for 0.1-5% by weight. The weight content of the pressure-sensitive adhesive is 45%-84%, the pressure-sensitive adhesive is composed of a silicone pressure-sensitive adhesive and an acrylate pressure-sensitive adhesive, and the weight ratio of the silicone pressure-sensitive adhesive to the acrylate pressure-sensitive adhesive is 1: 1-15: 1. According to the transdermal patch, the penetration capacity of ibuprofen is remarkably improved, particularly, the early-stage medicine penetration rate is higher, the medicine utilization rate is greatly improved, meanwhile, the patch is good in application performance, free of skin irritation, free of crystallization in the long-term storage process, good in stability and capable of better meeting the clinical medication requirement.

The present application relates to the technical field of medicine, and provides a lanosterol derivative, a preparation method and application thereof.The structural formula of the lanosterol derivative provided by the present application is shown as formula I or formula II.The lanosterol derivative provided by the present application has both fat solubility and water solubility, can effectively penetrate into the pathological site in the body, and improves the drug utilization degree;the results of examples show that the solubility of the lanosterol derivative provided by the present application in water is obviously higher than that of lanosterol or 25-hydroxy lanosterol, and the lanosterol derivative shows obvious cataract treatment effect in animal body experiments, and has a broad prospect in the preparation of drugs for treating eye diseases or conditions.

The application discloses a drug design method and device based on topological data analysis, equipment and medium, relates to the technical field of computer-aided drug design, and the method comprises the steps of obtaining a plurality of three-dimensional structure conformations of a target protein, determining the binding pocket region of each three-dimensional structure conformation, and constructing a conformation set; calculating a topological descriptor representing the topological relationship between atoms based on the atomic coordinates of the binding pocket region of each three-dimensional structure conformation, and converting the topological descriptor into a corresponding conformation feature vector; performing a pooling operation on the conformation feature vector corresponding to each three-dimensional structure conformation to generate a unified topological feature representation representing the common topological feature mode of the target protein binding pocket under a plurality of three-dimensional structure conformations; and screening or generating candidate drugs based on the unified topological feature representation. The common topological invariant information of a plurality of conformations is used to represent the flexible protein binding pocket, the screening omission caused by single conformation representation is reduced, and the representation accuracy and the calculation efficiency are considered.

The EG017 gel composition provided by the invention is moderate in viscosity, high in in-vitro release rate and high in stability, and can be used for remarkably improving the use compliance and the treatment effect of androgen alopecia patients. The gel provided by the invention is free from thick, heavy, sticky and greasy feelings and good in refreshing degree; the medicine can be kept for a long time at a medicine application part, medicine absorption is enhanced, and the medicine utilization degree is improved; and a patient can easily insist on taking the medicine.

The invention relates to the technical field of biological pharmacy, and particularly discloses targeting drug-loaded nanoparticles for treating rheumatoid arthritis (RA) as well as a preparation method and application thereof, and the technical key points are as follows: on the basis that a GLP-1R agonist (such as liraglutide) is proved to be capable of effectively relieving rheumatoid arthritis symptoms, the targeting drug-loaded nanoparticles can be used for treating rheumatoid arthritis; gLP-1RA is wrapped by the silk fibroin nanoparticles to prepare the drug-loaded nanoparticles, and the drug-loaded nanoparticles can effectively improve the stability of GLP-1RA, prolong retention time in vivo and improve the curative effect of the drug; the drug-loaded nanoparticles and the type II collagen targeting peptide (WYRGRL) are crosslinked, so that the drug-loaded nanoparticles target the articular cartilage, the drug is gathered on the articular cartilage to be attached, the local concentration of the drug and the availability of the drug are further improved, and the curative effect of inhibiting the progress of RA is further enhanced; for lesion facet joints in RA, the treatment scheme of micro-needle administration can realize slow release of drugs, and the micro-needle is convenient to use and is suitable for patients to use at home.

The invention discloses a preparation method of lung and mitochondria dual-targeting nanoparticles, which utilizes a nanotechnology to efficiently load and accurately deliver an anti-inflammatory drug, reduces the frequency and dosage of medication, and reduces the side effects of the drug on patients. LSALTPSPSWLKYKAL is used for modifying lipidosome, and the LSA targeting peptide competitively inhibits aggregation of neutrophile granulocytes by being combined with a DPEP1 receptor, so that the effect of targeting the lung to deliver drugs can be achieved, aggregation of neutrophile granulocytes can be relieved, and lung injury can be accurately treated. The lipidosome core layer wraps the tannic acid cerium metal nanoparticles, not only has the mitochondrial targeting characteristic of tannic acid, but also can achieve the anti-oxidation effect through the change of the cerium metal valence, thereby reducing the generation of mitochondrial active oxygen, relieving the tissue oxidative stress and protecting mitochondria. The polyethylene glycol modified lipidosome can reduce the in-vivo clearance rate of the lipidosome, prolong the half-life period of the medicine and increase the compatibility with the body, and the surface modification utilizes the characteristics of diseases to carry out controllable release and increase the availability of the medicine. According to the invention, the progress of a drug delivery technology is promoted, and a new thought and a technical platform are provided for organelle targeted therapy.