98 results about "Drug Utilization" patented technology

The invention relates to a layered drug-loading microneedle patch as well as a preparation method and application thereof. The preparation method of the layered drug-loading microneedle patch comprises the following steps: S1, dissolving a drug and a soluble high-molecular polymer in a solvent according to a mass ratio of (2: 1)-(1: 12) to form a needle tip solution, then filling a needle tip cavity of a microneedle mold with the needle tip solution, drying, and removing redundant drug residues on the surface to form a drug-loading needle tip layer; and S2, filling a mold containing the drug-loading needle tip layer with a photocurable polymer, performing ultraviolet curing for 10-30 seconds under the wavelength of 365-405 nm, and then performing demolding to form a substrate layer, thereby obtaining the layered drug-loading microneedle patch. According to the method, one-time filling of the needle tip part is successfully achieved by combining needle tip auxiliary material proportion optimization, meanwhile, the curing process is rapid, the medicine utilization rate and the process stability are remarkably improved, the medicine stability is good, and the method is suitable for industrial production.

The invention discloses composite hydrogel as well as a preparation method and application thereof. The composite hydrogel comprises a hydrogel matrix and a liposome loaded on the hydrogel matrix, the hydrogel matrix comprises a methacrylated natural protein, and the liposome is loaded with a drug; the medicine comprises a medicine for promoting cartilage differentiation and an anti-inflammatory traditional Chinese medicine monomer. According to the invention, through a liposome entrapment technology, the stability and sustained release ability of the insoluble traditional Chinese medicine monomer and the cartilage differentiation induction drug are enhanced. The particle size of the liposome is controllable, the liposome is well combined with a methacrylated natural protein network, a drug sustained release bin can be formed in the hydrogel, long-time and local precise release is achieved, the drug utilization efficiency is improved, and systematic toxic and side effects are avoided.

The invention discloses a targeted anti-aging microneedle drug delivery system for chronic wound repair as well as a preparation method and application of the targeted anti-aging microneedle drug delivery system. The system is composed of functionalized nanoparticles and a microneedle platform: a nano drug-loading unit which takes a polydopamine nanosphere as a carrier, entraps an anti-aging drug Bem, and modifies the surface of the nano drug-loading unit with a targeting peptide E7; according to the micro-needle delivery unit, hyaluronic acid-nitrogen carboxymethyl chitosan hydrogel is used as a matrix, a nano drug-loading unit and silver ions (Ag) are loaded, a micro-needle array is formed, and minimally invasive transdermal drug delivery is achieved. According to the invention, multiple mechanisms of anti-aging (APCs aging inhibition), antioxidation (ROS removal), antibiosis (Agaction) and immunoregulation (macrophage M2 type polarization promotion) are synergistically exerted, and the bottleneck problems of single intervention target, low drug availability and difficulty in regulating and controlling pathological microenvironment of chronic wounds (such as diabetic foot ulcer) in the traditional therapy are effectively solved.

The invention relates to the technical field of atomizers, in particular to an intelligent atomization control system for medicine dosage homogenization, which comprises a temperature feedback control module, a laser granularity measurement module, an airflow fluctuation compensation module, a flow regulation module and a data analysis module. By intelligently controlling the flow, granularity, airflow and temperature of liquid medicine, accurate adjustment of the atomization process can be achieved, it is ensured that medicine is evenly and stably released in the whole treatment process, waste of the liquid medicine is remarkably reduced, the medicine utilization rate is increased, and by monitoring the temperature change in real time, the atomization effect is improved. The flow is adjusted to cope with the influence of temperature fluctuation on the liquid medicine flow characteristic and the atomization effect, medicine conveying stability in different environments is guaranteed, meanwhile, based on particle size control, airflow and flow can be adjusted in time to guarantee consistency of atomized particles, uneven medicine dosage caused by particle size fluctuation is avoided, and through airflow fluctuation compensation, the atomization effect is improved. It can be ensured that the influence on medicine flow is minimized when airflow is unstable, and dosage instability is avoided.

The invention relates to the field of anesthetic quantification, in particular to an anesthetic quantitative conveying device of an anesthesia machine in an operating room, which comprises a table top, a bottom plate, a box body, a quantitative groove and a buffer groove, the bottom plate is fixed at the upper end of the table top, the box body is fixed at the upper end of the bottom plate, the quantitative groove is arranged on one side of the box body, and a piston I is arranged in the quantitative groove; and a lead screw is rotationally installed at the upper end of the first piston, a movable frame is rotationally installed at the end, penetrating through the upper end of the quantitative groove, of the lead screw, a mounting frame is arranged on one side of the quantitative groove, a height-adjustable lifting frame is connected to the mounting frame in an inserted mode, and a buffer groove is formed in the upper end of the lifting frame. The height of the piston can be adjusted by driving the screw rod through the motor, precise quantification is realized by combining infrared distance measurement, negative pressure is formed by utilizing the design of the piston II and the spring of the buffer groove, liquid medicine is prevented from flowing back and dripping, and the operation convenience and the medicine utilization rate are improved; the problem that an existing anesthetic quantifying device for the operating room lacks accurate quantifying and liquid leakage preventing functions is solved.

A medicine hanging bag for aquaculture disinfection relates to the technical field of aquaculture and comprises a bag body, a supporting piece, a sealing ring, a first pull wire and a second pull wire, the supporting piece is arranged at an opening in the lower end of the bag body, the sealing ring is coaxially arranged at an opening in the upper end of the bag body, and the first pull wire and the second pull wire are oppositely arranged on the sealing ring. The first pull wire and the second pull wire are matched to close the sealing ring; the sealing ring, the first pull wire and the second pull wire are arranged in a matched mode, the opening of the bag body can be closed rapidly, binding is convenient, and the working efficiency is improved; the inner bag is arranged in the bag body, so that other medicines or fillers can be conveniently filled in the inner bag, the utilization rate of the hanging bag is improved, the thickness of the medicines in the bag body is reduced, the medicines can be quickly melted conveniently, the utilization rate of the medicines is improved, and medicine waste is reduced.

The invention discloses a magnetic control soft robot and a preparation method, a control system and a control method thereof, and belongs to the technical field of biomedical engineering and soft robots. The magnetic control soft robot comprises a main body framework, a head magnetic sheet, a tail magnetic sheet, a magnetic box, a hollow needle plate and a magnetic foot pad. The magnetic control soft-bodied robot provided by the invention can be orally taken to enter the gastrointestinal tract in the body, an external rotating magnetic field is applied for control, the whole process of'movement-positioning-piercing-drug release 'is completed, in-vivo subcutaneous drug delivery is carried out, the drug utilization efficiency can be improved, and the robot is high in dynamic environment adaptability and can be recycled.

The utility model belongs to the technical field of medicine bottles, and particularly relates to a liquid medicine storage device. The technology comprises a bottle body, a bottle cap is in threaded connection with a bottle opening of the bottle body, a partition pipe used for dividing the interior of the bottle body into two cavities is arranged at the bottom in the bottle body, a thin film is arranged at the top of the partition pipe, a vertically-through fixing hole is formed in the bottle cap, a pointed cone used for puncturing the thin film is slidably connected into the fixing hole, and a fixing plate is arranged at the top of the pointed cone. A locking assembly used for fixing the position of the pointed cone is arranged on the bottle cap. According to the utility model, the inside of the bottle body is divided into two cavities for storing medicines through the separation tube, the two cavities are used for storing the two medicines to be mixed, the locking component is used for loosening the constraint on the pointed cone and pressing the pointed cone to move downwards to enable the pointed cone to pierce the thin film, so that the two medicines can be better mixed, the operation is simpler, and the liquid medicine is prevented from being polluted or leaked.

This invention discloses a porous carbon-based dual-drug-loaded nanomaterial for sustained release. The material uses a thermosensitive polymer as a matrix and cellulose nanocrystals modified with cationic surfactants as a reinforcing phase, loading both hydrophilic and hydrophobic drugs. This material can be used to prepare therapeutic drugs for gynecological diseases and infertility, as well as drug delivery devices. Furthermore, this invention provides a uterine scaffold prepared using this material, which can be fabricated using 3D printing technology. Utilizing the PNIPAm hydrogel network and its temperature-responsive properties, hydrophilic drugs can be loaded at low temperatures. The high mechanical strength of CNC machining allows for the loading of hydrophobic drugs while improving the mechanical properties of the hydrogel matrix, thus solving the problems of easy detachment and bleeding in existing technologies.

The invention belongs to the technical field of medical apparatus and instrument control, particularly relates to an atomization control system for respiratory nursing, and aims to solve the problems of low medicine deposition efficiency, serious waste and incapability of precise medicine administration caused by the lack of the capability of sensing and responding to the real-time respiratory state of a patient in a traditional atomization device. The system comprises a breathing state real-time monitoring module, an aerosol generation and regulation module, an intelligent control center, a man-machine interaction interface and a cloud data collaboration platform. Breathing parameters are collected through a high-sensitivity sensor, the particle size and the output opportunity of fog drops are dynamically adjusted in combination with a dual-mode ultrasonic atomization technology, and accurate inspiration phase dosing is achieved; a self-adaptive learning engine is arranged in the intelligent control center, the breathing cycle can be predicted, atomization can be started in advance, and the response speed is increased; local closed-loop control and remote personalized management are supported, and the medicine utilization rate and treatment compliance are remarkably improved.

The invention discloses a non-small cell lung cancer intrathoracic precise drug delivery device matched with a pH-responsive metal organic framework drug delivery system, and belongs to the technical field of intrathoracic drug delivery. The device comprises an injector, the injector is fixedly installed on a micro-injection pump, a drug delivery connector is inserted into a connection connector, and the drug delivery connector is connected with a pH-responsive metal organic framework drug delivery system. A needle head is fixedly connected to the end, away from the dosing connector, of the liquid inlet pipe, a protection mechanism is arranged outside the connecting connector and the dosing connector, a butt-joint limiting mechanism is arranged on the side wall of the protection mechanism, and the connecting connector and the dosing connector are fixed to the butt-joint limiting mechanism. Stable power and accurate control are provided for the injector through the micro-injection pump, the dosing requirements of local high concentration and accurate dosage in non-small cell lung cancer treatment are met, curative effect fluctuation caused by manual operation errors is reduced, the connecting joint and the dosing joint are protected and fixed by arranging the protective sleeve and the butt-joint limiting mechanism, and the non-small cell lung cancer dosing device is convenient to use. Liquid medicine leakage caused by loosening of the connector in the dosing process is effectively prevented, and the medicine utilization rate is guaranteed.

This invention provides a chemotherapy catheter for spinal tuberculosis, comprising a catheter with a drug channel, a flexible tube at the front end of the catheter with multiple through holes communicating with the drug channel, and a built-in one-way structure. The one-way structure includes an elastic rubber sheet at one end fixed to the inner wall of the drug channel; multiple elastic rubber sheets are stacked together in a conical shape; and a connector is connected to the rear end of the catheter, with a drug injection end for injecting medication. This invention, by inserting the catheter into the patient's body, injects medication through the drug injection end, which then passes through the drug channel and the one-way structure to prevent backflow, and finally flows out through the multiple through holes, thereby widely dispersing the medication and improving drug utilization.

The present application relates to the technical field of medicine and provides a lanosterol derivative, a preparation method therefor and a use thereof. The structural formula of the lanosterol derivative provided by the present application is as shown in formula I or II. The lanosterol derivative provided by the present application has both lipid solubility and water solubility, and can effectively penetrate into the pathological site in the body, thereby improving the drug utilization rate. The results of embodiments show that the lanosterol derivative provided by the present application has a significantly higher solubility in water than lanosterol or 25-hydroxylanosterol and shows a significant therapeutic effect on a cataract in animal in vivo experiments. Therefore, the derivative has wide prospects in the preparation of drugs for treating eye diseases or conditions.

The application discloses a mesh nebulizer. The nebulization control method of the mesh nebulizer comprises the following steps: acquiring breathing data of a user; determining a breathing state of the user and an end time point of exhalation of each breathing cycle based on the breathing data; the breathing state comprises stable breathing and abnormal breathing; and controlling a running state of a nebulization sheet based on the breathing state and the end time point of exhalation. According to the breathing state of the user and the end time point of exhalation, the running state of the nebulization sheet is accurately controlled, so that the drug utilization rate is improved, and intelligent and personalized nebulization treatment is realized.

The utility model relates to the technical field of unmanned aerial vehicles, in particular to a centrifugal sprayer for an unmanned aerial vehicle, which comprises a barrel, a water inlet channel is arranged in the barrel, a hose is arranged in the water inlet channel, one end of the hose is used for extending out of the water inlet channel to be connected with a water pipe, and a nozzle for spraying liquid medicine is arranged at the other end of the hose. The hose is used for introducing liquid medicine into the nozzle, the nozzle is rotationally connected with the barrel, a motor is further arranged in the barrel and fixedly connected with the barrel, a rotating shaft of the motor is fixedly connected with the nozzle, and a plurality of atomizers used for atomizing the sprayed liquid medicine are arranged on the nozzle. The nozzle is rotationally connected with the barrel, the motor drives the nozzle to rotate, and the motor can rotate the nozzle, so that the liquid medicine is centrifugally thrown out, the liquid medicine can be sprayed uniformly, and the coverage range is wider. The atomizer further improves the atomization effect of the liquid medicine, so that the liquid medicine is finer and easy to diffuse, and the medicine utilization rate and the treatment efficiency are improved.

The invention relates to an ibuprofen-containing transdermal patch as well as a preparation method and application thereof. The ibuprofen-containing transdermal patch comprises a polymer matrix layer, the polymer matrix layer comprises ibuprofen, a compound at least containing one amino group and a pressure-sensitive adhesive, and based on the weight of the polymer matrix layer, the ibuprofen accounts for 10-30% by weight, the compound at least containing one amino group accounts for 0.1-5% by weight, and the pressure-sensitive adhesive accounts for 0.1-5% by weight. The weight content of the pressure-sensitive adhesive is 45%-84%, the pressure-sensitive adhesive is composed of a silicone pressure-sensitive adhesive and an acrylate pressure-sensitive adhesive, and the weight ratio of the silicone pressure-sensitive adhesive to the acrylate pressure-sensitive adhesive is 1: 1-15: 1. According to the transdermal patch, the penetration capacity of ibuprofen is remarkably improved, particularly, the early-stage medicine penetration rate is higher, the medicine utilization rate is greatly improved, meanwhile, the patch is good in application performance, free of skin irritation, free of crystallization in the long-term storage process, good in stability and capable of better meeting the clinical medication requirement.

The present application relates to the technical field of medicine, and provides a lanosterol derivative, a preparation method and application thereof.The structural formula of the lanosterol derivative provided by the present application is shown as formula I or formula II.The lanosterol derivative provided by the present application has both fat solubility and water solubility, can effectively penetrate into the pathological site in the body, and improves the drug utilization degree;the results of examples show that the solubility of the lanosterol derivative provided by the present application in water is obviously higher than that of lanosterol or 25-hydroxy lanosterol, and the lanosterol derivative shows obvious cataract treatment effect in animal body experiments, and has a broad prospect in the preparation of drugs for treating eye diseases or conditions.

The application discloses a drug design method and device based on topological data analysis, equipment and medium, relates to the technical field of computer-aided drug design, and the method comprises the steps of obtaining a plurality of three-dimensional structure conformations of a target protein, determining the binding pocket region of each three-dimensional structure conformation, and constructing a conformation set; calculating a topological descriptor representing the topological relationship between atoms based on the atomic coordinates of the binding pocket region of each three-dimensional structure conformation, and converting the topological descriptor into a corresponding conformation feature vector; performing a pooling operation on the conformation feature vector corresponding to each three-dimensional structure conformation to generate a unified topological feature representation representing the common topological feature mode of the target protein binding pocket under a plurality of three-dimensional structure conformations; and screening or generating candidate drugs based on the unified topological feature representation. The common topological invariant information of a plurality of conformations is used to represent the flexible protein binding pocket, the screening omission caused by single conformation representation is reduced, and the representation accuracy and the calculation efficiency are considered.

The invention relates to the technical field of biological pharmacy, and particularly discloses targeting drug-loaded nanoparticles for treating rheumatoid arthritis (RA) as well as a preparation method and application thereof, and the technical key points are as follows: on the basis that a GLP-1R agonist (such as liraglutide) is proved to be capable of effectively relieving rheumatoid arthritis symptoms, the targeting drug-loaded nanoparticles can be used for treating rheumatoid arthritis; gLP-1RA is wrapped by the silk fibroin nanoparticles to prepare the drug-loaded nanoparticles, and the drug-loaded nanoparticles can effectively improve the stability of GLP-1RA, prolong retention time in vivo and improve the curative effect of the drug; the drug-loaded nanoparticles and the type II collagen targeting peptide (WYRGRL) are crosslinked, so that the drug-loaded nanoparticles target the articular cartilage, the drug is gathered on the articular cartilage to be attached, the local concentration of the drug and the availability of the drug are further improved, and the curative effect of inhibiting the progress of RA is further enhanced; for lesion facet joints in RA, the treatment scheme of micro-needle administration can realize slow release of drugs, and the micro-needle is convenient to use and is suitable for patients to use at home.

The invention belongs to the technical field of medical instruments, and discloses an automatic hot compress device for traditional Chinese medicine, which comprises a box body, a top cover and a bottom frame, a partition plate is arranged in the box body and used for vertically dividing an inner cavity of the box body into a storage cavity and a medicine steam cavity, the storage cavity is used for storing medicine bags, and a plurality of air holes are formed in the partition plate. The top cover is hermetically arranged at the top of the box body, a heating assembly is arranged on the bottom surface of the top cover, a pressure adjusting assembly is arranged on the top surface of the top cover, and the pressure adjusting assembly is communicated with the medicine steam cavity and used for adjusting the pressure in the box body; the bottom frame is hermetically arranged at the bottom of the box body, a flexible breathable film is arranged in the bottom frame, the flow resistance of the flexible breathable film is smaller than that of the partition plate, and a flexible rubber ring is arranged on the bottom surface of the bottom frame and used for fitting the skin of a patient; the flexible breathable film and the flexible rubber ring make contact with the skin of a patient to form sealing, the heating assembly heats the medicine bag to generate medicine steam with medicine components, the pressure in the box body is adjusted through reciprocating action of the pressure adjusting assembly, the medicine steam is directionally conveyed, and the medicine utilization rate and the treatment effect are improved.

The invention belongs to the field of biological material preparation, and particularly relates to degradable drug-loading hydrogel and a preparation method thereof.Acrylate groups are introduced into 6s-PLA, 6s-PLA-HA is synthesized, a hydrogel material is synthesized through a photopolymerization method, then cefprozil serves as a model drug, and drug loading is conducted on the hydrogel through the supercritical impregnation technology. The composite material is self-prepared six-arm star-shaped polylactic acid (6s-PLA), the 6s-PLA is terminated by using acryloyl chloride to synthesize 6s-PLA-HA, PLA-PEG hydrogel is prepared by using a photopolymerization method, and a hydrogel material loaded with cefprozil is prepared by using a supercritical carbon dioxide impregnation technology. The material has the advantages of being excellent in mechanical property, non-toxic, good in biological safety, non-irritant, easy to process and form, degradable, anti-inflammatory and the like, and is expected to be widely applied to the field of biomedical materials.

This invention belongs to the field of DNA hydrogel technology, specifically relating to a VEGF-responsive, on-demand release smart DNA hydrogel of glycyrrhizin, its preparation method, and its applications. This invention constructs a VEGF-responsive smart DNA hydrogel, efficiently encapsulating glycyrrhizin within a three-dimensional gel network, utilizing the high expression of VEGF in the tumor microenvironment to trigger on-demand drug release. This invention achieves precise on-demand release of glycyrrhizin, significantly improving drug utilization efficiency and reducing systemic toxicity. Simultaneously, the VEGF aptamer introduced into the system can specifically bind to and neutralize free VEGF, blocking angiogenesis, cutting off tumor nutrient supply, and further inhibiting tumor proliferation and progression, achieving a synergistic effect of intelligent drug delivery and anti-angiogenesis.

The invention relates to the field of drug utilization value analysis, and particularly discloses a data stream-based drug utilization value analysis system, which comprises a data layer, an application layer and a user layer, according to the method, the multi-source drug data stream is constructed and stored in the multi-source drug database, and based on systematic management of drug information, drug use errors caused by drug name confusion, dosage errors and dosage form confusion can be reduced, the drug use safety is improved, and the method is beneficial to quickly and accurately retrieving and querying specific types of drug information; by integrating the elderly physiological features and the drug feature information, the drug utilization value analysis model is constructed, the elderly physiological features and the drug features are comprehensively considered, the utilization value of the drug on the elderly can be comprehensively evaluated, and the influence of the drug on the elderly patient can be predicted more accurately.

The invention discloses a pharmaceutical composition for treating rheumatoid arthritis as well as a preparation method, a traditional Chinese medicine preparation and application thereof, and belongs to the technical field of pharmaceutical compositions. The technical problem to be solved is to provide a preparation method of a pharmaceutical composition with higher drug utilization rate aiming at the current situation that a heat-clearing and blood-activating formula in the prior art is high in active ingredient loss and low in drug utilization rate. The key point of the technical scheme is that the preparation method of the pharmaceutical composition comprises the following steps: (1) mixing rhizoma smilacis glabrae, rhizoma atractylodis stir-fried with bran, rhizoma dioscoreae septemlobae and caulis sinomenii, adding water, soaking, performing enzyme extraction, performing solid-liquid separation, and concentrating enzymatic hydrolysate to obtain enzymatic hydrolysate; (2) mixing honeysuckle, cortex phellodendri and radix paeoniae rubra, performing alcohol extraction, performing solid-liquid separation, combining filtrate, and concentrating an alcohol extract to obtain an alcohol extract; (3) mixing the vinegar-processed curcuma zedoary, salvia miltiorrhiza and astragalus membranaceus with water, performing water extraction, performing solid-liquid separation, combining filtrate, and concentrating a water extracting solution to obtain a water extract; and (4) mixing the enzymolysis paste, the alcohol extraction extract and the water extraction extract, and drying.

The application discloses a compound inhalation powder aerosol and a preparation method thereof. The compound inhalation powder aerosol comprises apremilast or a pharmaceutically acceptable salt thereof and an efficacy enhancing substance, wherein the efficacy enhancing substance is nintedanib or a pharmaceutically acceptable salt thereof; and the amount of the efficacy enhancing substance is 0.1-10 times the amount of the apremilast or the pharmaceutically acceptable salt thereof. In the compound inhalation powder aerosol, the drug exposure of apremilast is greatly improved under the action of nintedanib, and a significant enhancement effect is exhibited. Meanwhile, nintedanib further improves efficacy. The powder aerosol is used for pulmonary inhalation administration, and apremilast or the pharmaceutically acceptable salt thereof and nintedanib or the pharmaceutically acceptable salt thereof are used for treating lung diseases, so that the drugs can be directly delivered to effective sites, the administration dose can be further effectively reduced or the drug utilization rate can be improved, the deposition rate can be improved, and the treatment effect can be greatly improved.

This invention discloses an injectable bone repair material and its preparation method, belonging to the field of biomaterials technology. The material is composed of grafted chitosan obtained by reacting N-formylglycine, allyl lactate, and S-allyl cysteine ​​with chitosan. The grafted chitosan, methacrylamide gelatin, and icariin-naringenin liposomes are then photocured to form a stable three-dimensional interpenetrating network hydrogel. The preparation method includes: first synthesizing grafted chitosan, then preparing icariin-naringenin liposomes, and finally mixing the grafted chitosan solution, methacrylamide gelatin solution, and liposomes, adding a photoinitiator, and then ultrasonically degassing and ultraviolet curing to obtain the finished product. This material utilizes thioether bonds to achieve intelligent drug release in response to reactive oxygen species, and liposome encapsulation improves drug utilization. The dual-network structure endows it with excellent injectability, mechanical strength, and biocompatibility, effectively adapting to irregular bone defects and promoting bone regeneration.

The invention provides a traditional Chinese medicine hydrogel and a preparation method thereof, the traditional Chinese medicine hydrogel comprises the following raw materials by weight: 20-30 parts of polyvinyl alcohol, 3-8 parts of epoxy modified polyvinyl alcohol, 20-30 parts of hyaluronic acid, 5-10 parts of a traditional Chinese medicine composition extract, 1-5 parts of star hyperbranched polylysine, and 200-300 parts of water. The traditional Chinese medicine hydrogel provided by the invention has the properties of antibacterial property, low sensitization, high drug utilization rate and high curative effect, star-shaped hyperbranched polylysine is introduced as a functional modifier, the star-shaped hyperbranched polylysine and the traditional Chinese medicine composition generate an antibacterial synergistic effect, and a hydrophobic drug is loaded through a hyperbranched three-dimensional structure of the star-shaped hyperbranched polylysine; the antibacterial property, the drug loading capacity and the slow release performance of the hydrogel are remarkably improved, so that the purposes of high curative effect and low sensitization are achieved. Epoxy modified polyvinyl alcohol is also added, so that the stability of the hydrogel is further improved, the drug release performance is regulated and controlled, and the drug utilization rate is improved.

The present application relates to a kind of soluble microneedle patch of semaglutide peptide and its preparation method and purposes.The soluble microneedle patch of semaglutide peptide includes drug-loaded needle tip layer and back plate layer;Wherein, the drug-loaded needle tip layer includes semaglutide and needle tip layer matrix material;With the total weight of the drug-loaded needle tip layer 100% as 100%, the weight percentage of semaglutide is 85%~99%, and the weight percentage of the needle tip layer matrix material is 1%~15%.The needle type of the soluble microneedle patch of semaglutide is excellent, and the mechanical strength and skin puncture performance are superior, and the safety is high, and drug release and penetration rate are fast, and drug penetration rate is high, with excellent drug utilization and bioavailability;Its preparation method is simple, and controllability is good, and it is suitable for large-scale production.In addition, the soluble microneedle patch of semaglutide is convenient and fast, and patient compliance is high, with wide clinical application prospect.

This invention discloses a cinnamic acid-black phosphorus nanocomposite targeting Aβ, its preparation method, and its application. The composition uses 4-(dimethylamino)cinnamic acid as the Aβ-targeting group and consists of a drug-loaded host (BP, black phosphorus nanosheets), a modifying material C18-PEG-NH2 (amino polyethylene glycol stearic acid), a targeting material Tar (4-(dimethylamino)cinnamic acid), and a therapeutic material Cur (curcumin). The preparation method includes the following steps: (1) preparation of PEG-Tar, (2) preparation of PEG-Tar@Cur, and (3) preparation of the BP-PEG-Tar@Cur composition. This invention utilizes black phosphorus nanosheets to load Curcumin, whose excellent specific surface area significantly increases the drug loading capacity. Furthermore, by using 4-(dimethylamino)cinnamic acid as a group targeting Aβ, diffuse distribution of the drug in the brain is avoided, greatly improving the drug utilization rate of Curcumin. The synthesis process of this invention is simple, highly reproducible, and easy to scale up for industrial application, and it has a positive effect in the treatment of Alzheimer's disease.

The invention provides a lacrimal passage indwelling administration wearable device and a use method. The problems that in the field of ophthalmology medical treatment, an existing lacrimal passage indwelling medical device is low in medicine utilization rate, a lacrimal passage is prone to bonding, and administration pressure controllability is poor are solved. The lacrimal passage indwelling administration wearable equipment comprises a circulating flow pipeline, the circulating flow pipeline comprises a three-way pipe, an indwelling pipeline and a backflow pipeline, the three-way pipe comprises a first communicating pipe, a second communicating pipe and a third communicating pipe, one ends of the first communicating pipe, one end of the second communicating pipe and one end of the third communicating pipe are communicated, and the two ends of the backflow pipeline are connected with the first communicating pipe and the second communicating pipe correspondingly; the indwelling pipeline comprises a medicine slow-release pipe and a circulating pipe of which one ends are communicated with each other, and the other end of the medicine slow-release pipe is connected with the third communicating pipe; the third communicating pipe is arranged in the lacrimal ductule of the patient, the medicine slow-release pipe is arranged in the lacrimal sac, and the other end of the circulating pipe penetrates out of the body from the nasal meatus of the patient and is connected into the backflow pipeline to form a medicine flowing loop; the invention discloses a head-mounted support and a drug delivery assembly arranged on the head-mounted support.