150 results about "Drug penetration" patented technology

The invention discloses a nano hydrogel preparation for packaging small interfering RNA (Ribonucleic Acid) and a preparation method, and belongs to the technical field of nano pesticides. Gold nanoparticles and dendritic mesoporous silica nanoparticles are used as composite carriers to load small interfering RNA, then a pectin solution is used for packaging, and the nano hydrogel preparation is prepared, so that the adhesion of a medicament is greatly enhanced, and rapid permeation and targeted delivery of the medicament are realized.

The invention provides a personalized corneal contact lens microneedle device for treating corneal dilation diseases, which comprises a fixing device and a drug delivery device, the drug delivery device comprises a drug delivery main body and a drug delivery microneedle arranged on the drug delivery main body; the fixing device surrounds the periphery of the drug delivery main body and is concentric with the drug delivery main body and embedded with the drug delivery main body; wherein the fixing device fixes the whole corneal contact lens microneedle device on the surface of a cornea through the fixing microneedle, a biomechanical effect is generated around the cornea to control the corneal curvature progress, and meanwhile, the medicine delivery microneedle is fixed in the center of the cornea; the drug delivery microneedle is used for penetrating through the cornea epithelium to reach the cornea stroma layer, so that the drug on the drug delivery main body permeates into the cornea stroma layer, and finally, the thickness and hardness of the cornea stroma layer are increased in combination with ultraviolet irradiation, and the disease progress is controlled. The treatment mode is safe and efficient, and nano-drugs are not needed.

The invention relates to the technical field of manufacturing of medical instruments, in particular to an intracranial controllable drug balloon dilatation catheter and a drug delivery method for a narrow area of a blood vessel. According to the intracranial controllable medicine balloon dilatation catheter, the inner-layer catheter body is arranged in the outer-layer catheter body in a sleeved mode and fixedly connected with the far end of the outer-layer catheter body; the balloon is assembled on the outer-layer tube body and is provided with a plurality of dosing holes along the circumferential direction; a medicine adhesion layer is compounded on the surface of the balloon section of the outer-layer tube body; the stress releasing pipe is connected to the end, close to the operation end, of the outer-layer pipe body. The Y-shaped tube base is connected to the end, away from the outer-layer tube body, of the stress releasing tube, one connector is connected with an injection device to inject medicine carriers into the balloon, and the other connector is used for a guide wire to penetrate through. When intracranial vascular stenosis is treated, directional drug release can be achieved by means of the drug delivery holes and the drug adhesion layer. The medicine is sprayed to the focus through the administration hole, the medicine is promoted to permeate into the middle layer of the blood vessel wall through the attaching force generated by the balloon expansion, the problems of non-uniform liquid medicine distribution, insufficient permeation and the like are effectively solved, and the local medicine concentration and the treatment effect are improved.

This invention relates to the field of traditional Chinese medicine (TCM) technology, specifically to a nasal massage oil, its preparation method, and its application. The nasal massage oil is prepared from the following TCM raw materials in the indicated weight proportions: 4-6 parts of roasted Xanthium sibiricum, 1.5-3.5 parts of Magnolia biondii, 1.5-3.5 parts of Angelica dahurica, 0.3-0.7 parts of Mentha haplocalyx, 0.8-1.2 parts of Borneol, 2-4 parts of Sinapis alba, 1-3 parts of Artemisia argyi, 1-3 parts of Carthamus tinctorius, 1-3 parts of Cinnamomum cassia, 2-4 parts of Pueraria lobata, and 80-120 parts of sesame oil as a base. This application, through scientific formulation and reasonable proportioning, effectively solves the technical problem that existing nasal massage mediums only provide lubrication and lack targeted TCM conditioning effects, failing to achieve synergistic effects between massage and medication. It achieves an integrated effect of "massage lubrication - drug penetration - TCM conditioning."

The invention discloses a bandage emulsification detection device and method for promoting permeation, and relates to the technical field of emulsification detection, the bandage emulsification detection device comprises a detection table, and a placement plate is fixed below the detection table. According to the bandage emulsification detection device and method for promoting permeation, through the arrangement of the self-sliding mixing mechanism, an emulsifier and a contrast reagent in two mixing cylinders can be conveniently and automatically stirred uniformly under the action of gravity, and under the cooperation of a hybrid power assembly, a mixing rod can continuously jolt up and down in the autorotation process, so that the emulsification detection efficiency is improved. After uniform stirring, the contact liquid discharging mechanism is arranged, so that an emulsifier solution and a contrast reagent solution are conveniently and automatically discharged into corresponding detection containers to be stored and put into a bandage to be soaked and subjected to a contrast test, and the whole process does not need frequent manual operation or electric driving; the use cost can be effectively saved while the detection efficiency is improved, all the mechanisms work cooperatively, and the automation degree is high.

This invention discloses a portable low-temperature plasma device based on a Laval nozzle structure and its application, belonging to the field of plasma technology application technology. Specifically, it includes (1) the construction of the device; and (2) the use of the device for fungal eradication treatment and transdermal drug delivery enhancement treatment. The beneficial effects achieved by this invention are as follows: This invention is the first to apply the Laval nozzle structure to a portable low-temperature plasma device. The results show that the device can effectively improve the plasma jet performance and active particle content, significantly improve the treatment effect of fungal infections of the skin and nails and the transdermal drug penetration efficiency, while solving the problems of large size, reliance on external power supply, and complex operation of traditional plasma devices. Therefore, using this invention for the treatment of fungal infections of the skin and nails and for enhanced transdermal drug delivery has advantages such as ease of operation, high safety, non-invasiveness, and high efficiency, and thus has potential application prospects in the field of skin disease treatment and transdermal drug delivery.

The application belongs to the technical field of biological medicine, and particularly relates to a biomimetic nano delivery system based on MRSA outer vesicle coating and application thereof. The application first couples chitosan oligosaccharide and monocarboxylated curcumin through an amide reaction to synthesize an amphiphilic polymer carrier, then loads vancomycin, daptomycin and other drugs through self-assembly to obtain a drug micelle, and finally coats the drug micelle with MRSA outer vesicle to successfully prepare a targeted biomimetic nano delivery system. The prepared biomimetic nano delivery system has excellent antibacterial effect, can realize targeted delivery and long-acting release of antibacterial drugs at an infection site, and is expected to overcome the bottleneck of drug resistance and insufficient drug penetration in traditional treatment, and provides a potential solution for the treatment of diseases such as periprosthetic infection.

The invention discloses an electrode structure based on liquid ion polar molecules and a use method, and relates to the technical field of electrotherapy, the electrode structure comprises an insulating film, the upper end of the insulating film is provided with a solid-state electrode assembly, and the upper end of the solid-state electrode assembly is provided with a liquid ion polar molecule. The lower end of the insulating film is provided with an affected part auxiliary attaching assembly, the upper end of the insulating film is provided with a liquid inlet auxiliary assembly, the liquid electrode and the affected part can achieve complete surface contact, the contact resistance between the solid electrode and the affected part can be effectively reduced, and accurate local treatment of the affected part by in-vitro liquid can be achieved; the liquid electrode has a drug penetration effect on the skin tissue of the affected part; the liquid electrode can achieve the synergistic effect of various treatment means.

The present invention provides: nanocomposites for temporary photoperforation of a cell membrane, formed by combining (i) gold nanoparticle and (ii) upconverting nanoparticles comprising ytterbium (Yb3+) and erbium (Er3+); and a pharmaceutical composition comprising same. The nanocomposite according to the present invention enables the use of near-infrared region light, which can effectively penetrate tissue, and enables temporary photoperforation through the formation of vapor nanobubbles caused by a momentary increase in temperature, and thus can promote the penetration of molecules (for example, drugs) into the plasma membrane / cell membrane.

A self-powered intelligent adhesive bandage capable of detecting temperature in real time and dosing according to needs is applied to detection and treatment of skin wound infection and can detect the temperature of a wound and surrounding skin in real time and conduct dosing according to needs. According to the intelligent adhesive bandage, the piezoelectric nanometer generator is combined, mechanical energy generated in the daily activity process of a wearer can be converted into electric energy, and the electric energy is used for driving the whole intelligent adhesive bandage to operate. The two temperature measuring units are used for detecting the temperature of the wound and the surrounding skin at the same time, the temperature difference value serves as a relative index for judging whether the wound is infected or not, and the influence of environmental factors on detection is reduced. A three-electrode structure is adopted, on-demand drug delivery is achieved through iontophoresis, and high drug permeability, dosage controllability and drug delivery uniformity are all considered. After the intelligent adhesive bandage is used for treating a mouse with wound infection for three days, the wound recovery rate of the mouse reaches 90.3%, and the realization of temperature detection and on-demand administration is proved. The intelligent adhesive bandage has a good application prospect in detection and treatment of wound infection.

This invention relates to biomimetic mineralized exosomes for programmed drug penetration in tumors that inhibit cell burial, along with their preparation method and applications. Belonging to the field of novel excipients and dosage forms for pharmaceutical formulations, this invention co-loads the small-molecule chemotherapeutic drugs 10-hydroxycamptothecin and banoanthraquinone into exosomes. Then, through a biomimetic mineralization strategy, aTIM-4 is organically combined with mineralized calcium phosphate particles to obtain biomimetic mineralized exosomes. Under the acidic response of the tumor microenvironment, the calcium phosphate shell dissolves, and the exosome nucleus enters the tumor cells, inducing cell death and generating apoptotic bodies. This programmatically delivers the drug, delivering banoanthraquinone deep into the tumor. Simultaneously, the released aTIM-4 inhibits the cell burial of tumor-associated macrophages, amplifying the programmed drug penetration based on apoptotic bodies. This invention provides a new strategy and more options for overcoming the bottleneck of nanomedicine penetration in tumors, meeting the urgent clinical need for highly effective chemotherapeutic agents.

Drug delivery devices and methods of controlled drug delivery to a patient are provided. The drug delivery device may include one or two microchip elements, each of which has a body portion with one or more drug release apertures in fluid communication with at least one containment reservoir. The drug release apertures are closed off by one or more reservoir caps which can be electrically activated to open the drug release apertures. The drug delivery device also includes (i) a drug formulation disposed in the at least one containment reservoir, and (ii) at least one drug-permeable membrane. In some cases, an outer housing is spaced a distance from an exterior wall of the body portion of the microchip element, the outer housing includes the at least one drug-permeable membrane, and a depot space is defined between the drug-permeable membrane and the exterior wall of the body portion of the microchip element.

The invention relates to an amorolfen liniment, and belongs to the field of external pharmaceutical preparations. By adding a specific type of penetration enhancer into the amorolfen liniment, the amorolfen liniment can realize higher retention volume of the medicine in nails and has higher nail penetration capacity, namely, the penetration speed and degree of the medicine on the nails are obviously increased, the defects in the prior art are overcome, and the amorolfen liniment is suitable for clinical application. And a better choice is provided for clinical treatment of nail fungal infection.

This invention provides an intelligent ultrasonic conductance directional drug penetration therapeutic device. Compared to existing technologies, this invention also includes a drug penetration module that contacts the patient's skin to apply the drug to the patient's skin, an adaptation module that adjusts the drug penetration efficiency of the drug penetration module according to the patient's skin location, and a fixation module for adapting the drug penetration module to different skin locations. This invention integrates ultrasonic treatment, drug delivery, infrared sensing, and compress clamping functions, achieving a combined application of multiple treatment methods. Utilizing ultrasonic technology, it allows drugs to penetrate the patient's skin more easily, thereby improving drug utilization.

The invention discloses an intelligent ultrasonic transdermal drug delivery device which comprises a skin state acquisition module used for acquiring initial skin parameters of a patient when transdermal drug delivery is performed on the patient through the device; the adjustable power ultrasonic transmitting module is used for irradiating the skin of the patient; the ultrasonic response substance loading module is used for loading a mixed solution of an ultrasonic response substance and a medicine; the feedback parameter monitoring module is used for monitoring the cavitation intensity, the skin temperature field and the drug entry amount of ultrasonic transdermal drug delivery in real time and transmitting the cavitation intensity, the skin temperature field and the drug entry amount to the intelligent regulation and control module; the intelligent regulation and control module is used for receiving the initial skin parameters, determining initial parameters of transdermal drug delivery, and dynamically regulating the initial parameters according to the cavitation intensity, the skin temperature field and the drug entry amount and a preset period; according to the application, a monitoring feedback and intelligent regulation and control module is established, and the ultrasonic cavitation effect is enhanced by adjusting ultrasonic parameters and introducing an ultrasonic responder, so that the skin injury is avoided while the permeation efficiency and depth are improved.

The invention belongs to the technical field of biological medicine, and particularly relates to a bionic nanometer delivery system based on MRSA outer vesicle coating and application of the bionic nanometer delivery system. Chitosan oligosaccharide and monocarboxylated curcumin are coupled through an amide reaction to synthesize an amphiphilic polymer carrier, then drugs such as vancomycin and daptomycin are entrapped through self-assembly to obtain drug micelles, and finally the drug micelles are coated with MRSA outer vesicles to successfully prepare the targeted bionic nano delivery system. The bionic nano delivery system prepared by the invention has an excellent antibacterial effect, can realize targeted delivery and long-acting release of an antibacterial drug at an infected part, is expected to overcome the bottlenecks of drug resistance and insufficient drug permeation in traditional treatment, and provides a potential solution for treatment of diseases such as periprosthetic infection and the like.

The invention relates to the technical field of physical therapy products, in particular to a traditional Chinese medicine composition for treating muscle fascia injury and a special muscle effect patch structure. The traditional Chinese medicine composition comprises the following raw materials: premna fulva, safflower, corydalis tuber, garden balsam stem, corydalis amabilis, lycopodium clavatum, ground beetle, cassia twig, borneol and white spirit. The special muscle effect patch structure comprises a fixing area and a cross-shaped structure formed by connecting four anchoring parts, the anchoring parts are connected with the fixing area, a medicine ball is connected to the center of the fixing area, and a plurality of medicine outlet holes are formed in the wall face of the medicine ball with liquid absorption filler inside. The surface of the targeting part is provided with a bonding layer used for being adhered to the skin, the bonding layer is connected with release paper, and the release paper is provided with a protruding film matched with the medicine balls. Through the unique structural design and cooperation of the fixing area, the anchoring part, the targeting part, the medicine ball and the like, muscles are relaxed in a physical mode, dynamic and active medicine permeation and physical pressing are achieved, and the pressing and rebounding effects of manual massage are simulated, so that transdermal delivery of medicine components is better achieved.

The invention relates to the technical field of intelligent hot compress bags and control methods, in particular to an intelligent hot compress bag capable of preventing scalds and promoting medicine permeation and a control method, the intelligent hot compress bag comprises a skin contact layer, a medicine active layer, a phase change temperature control layer and a heat source layer which are sequentially arranged from the skin contact side to the inner side, and a four-stage collaborative system is integrated. Dense temperature sensing assemblies are arranged in a hot compress area, the temperature change of each position of the skin surface is captured in real time, the scalding risk caused by a local temperature monitoring blind area of a traditional hot compress bag is avoided, and the safe temperature standard is set in a personalized mode in combination with the characteristics of different people and different hot compress parts; when it is detected that the temperature exceeds the safety range, the system can rapidly start multiple protections of acousto-optic reminding, heat source output adjustment and even power supply cut-off, damage of high temperature to the skin is blocked in time even in the scenes of unattended real-time monitoring such as user sleep and nurse patrol gaps, and safety and reliability in various use scenes are ensured.

The invention belongs to the field of biological pharmacy, and relates to an anti-tumor nano-drug, in particular to a tumor-targeted anti-tumor nano-drug HPCR as well as a preparation method and application thereof. An immune checkpoint inhibitor anti-PD-L1, a chemotactic factor CCL5 and rutin with an ACE2 activation effect are respectively grafted to HA through a chemical synthesis method to synthesize HA-anti-PD-L1, HA-CCL5 and HA-RT, then the HA-anti-PD-L1, HA-CCL5 and HA-RT are synthesized into the anti-tumor nano-drug HPCR through a film hydration method, and in-vivo experiments prove that the drug has an excellent anti-tumor effect; the medicine has good T cell activation effect, T cell recruitment effect, tumor matrix elimination, T cell infiltration increase and medicine permeation effects, and provides a new method and a new thought for tumor treatment.

This invention relates to the field of medical device control technology, and discloses a method and system for adaptive control of anesthesia puncture pressure based on tissue stiffness feedback. The method controls a fluid drive unit to operate in microcycles, dividing each microcycle into an active loading segment and a passive relaxation segment. In the active loading segment, pressure peak value and rise rate indices characterizing tissue stiffness are extracted, and a heterogeneity factor is calculated. In the passive relaxation segment, pressure decay indices characterizing tissue permeability are extracted. A multidimensional state vector is constructed by fusing stiffness and permeability characteristics to determine the physical condition. Based on the determined physical condition, the control target is retrieved, and execution parameters such as the duration of the active loading segment in the next cycle are dynamically adjusted using a closed-loop controller. By time-divisionally detecting the solid and fluid dynamic properties of the tissue, dense tissue and obstructive conditions are effectively distinguished, achieving real-time adaptive matching of injection parameters and tissue characteristics, thus reducing the risk of tissue damage while ensuring drug penetration efficiency.

The invention discloses an intelligent regulation and control system for heat separation synergistic targeted transdermal drug delivery, and relates to the technical field of crossing of modernization of traditional Chinese medicine and intelligent medical equipment. The driving module is integrated in the application unit, the pressure unit generates periodic pressure changes, the temperature control unit is used for heating liquid medicine, and the electric field unit is used for establishing an electric field in a medicine cavity. The intelligent control box is used for receiving signals of the sensor and controlling the pressure unit, the temperature control unit and the electric field unit to cooperatively work in stages, and through the progressive force-heat-ionization triple synergistic effect, the defects that in the prior art, the infiltration promotion means is single, and the synergism is insufficient are effectively overcome; the medicine permeation efficiency and depth are obviously improved; by means of the multi-electrode system capable of being independently regulated and controlled, dynamic directional gathering and long-acting maintaining of the medicine in a subcutaneous focus area are achieved, and the problems that a traditional method is poor in targeting performance and fast in medicine dispersion are solved.

The present invention provides drug delivery devices and methods for controlled drug delivery to a patient. The drug delivery devices can include one or two microchip elements, each having a body portion with one or more drug release apertures in fluid communication with at least one contained reservoir. The drug release apertures are closed by one or more reservoir covers that can be electrically activated to open the drug release apertures. The drug delivery devices further include (i) a drug formulation disposed in the at least one contained reservoir, and (ii) at least one drug permeable membrane. In some cases, an outer housing is spaced apart from an outer wall of the body portion of the microchip element, the outer housing includes the at least one drug permeable membrane, and defines a reservoir space between the drug permeable membrane and the outer wall of the body portion of the microchip element.

The invention relates to a needle solution for a double-drug-loading self-emulsifying drug release system and a preparation method thereof.The needle solution is obtained by mixing an SE solution and a water phase, and the SE solution is prepared from an oil phase solution obtained by dissolving a water-insoluble drug 1 in an oil ester organic solvent and a hydrotropy solution, the hydrotropy solution is a mixed solution of an emulsifier and a co-emulsifier; the water phase is an aqueous solution obtained by dissolving a water-soluble medicine 2 into water, and HA, Dex or Chs are added into the aqueous solution. The invention also relates to a drug-loaded soluble microneedle obtained from the needle solution, and also provides an application of the double drug-loaded soluble microneedle in preparation of drugs for treating gouty arthritis. The double-drug-loading microneedle prepared by the invention can obviously improve the corrosion speed in the skin and quickly release the drug, can play a role in promoting the drug permeation after being combined with the ultrasonic action, and can play a role in controlled release by controlling the demulsification release of the drug by utilizing the mechanical action of the ultrasonic.

The present invention discloses a spatiotemporally controllable drug delivery system targeting the tumor extracellular matrix and its application. The delivery system includes: i) nanoparticles loaded with drugs using a metal polyphenol network modified with polyvinylpyrrolidone as a carrier; and ii) a metal ion chelator; the nanoparticles are used for targeted tumor delivery of drugs; the metal ion chelator is used to disassemble the nanoparticles when they reach the tumor extracellular matrix to release the drugs, thereby degrading the tumor extracellular matrix, enhancing blood perfusion, relieving tumor hypoxia, promoting drug penetration and T cell infiltration to reshape the tumor microenvironment. The present invention provides a novel delivery strategy for drugs targeting the tumor extracellular matrix, effectively overcoming the problem of insufficient treatment such as PDT caused by the TME. It provides new ideas for drug delivery targeting the tumor extracellular matrix and the treatment of various solid tumors.

The invention discloses an intelligent meibomian gland targeted therapy system based on multi-mode biological feedback, which comprises an intelligent thermal therapy module, a targeted drug penetration module, a bionic massage module, a multi-mode monitoring module and an AI central controller, and is characterized in that the AI central controller is electrically connected with the intelligent thermal therapy module, the targeted drug penetration module, the bionic massage module and the multi-mode monitoring module; the control module is used for receiving real-time monitoring data of the multi-mode monitoring module, generating a control instruction, dynamically regulating and controlling heating parameters of the intelligent thermal therapy module, drug delivery parameters of the targeted drug penetration module and massage parameters of the bionic massage module, and forming a closed-loop feedback system based on the thickness of a tear film lipid layer and a gland image; through closed-loop control of the graphene heating film and the infrared temperature sensor, the temperature fluctuation is small, the precision is far better than that of traditional equipment, and the cornea burning risk is thoroughly avoided.

The invention relates to the technical field of biomedical engineering, and particularly discloses a portable insulin administration device which comprises a noninvasive blood glucose detection module, an insulin administration module, an insulin administration module and an insulin administration module which are sequentially arranged from bottom to top, and the noninvasive blood glucose detection module is used for monitoring the blood glucose concentration of a human body based on a counter-ion electroosmosis technology; the drug loading module is used for loading drugs, and the drugs comprise insulin; the transdermal drug delivery module is connected with the drug carrying module and used for applying pulse voltage to the skin to enhance the transdermal permeation efficiency of the skin when the monitored blood glucose concentration value is larger than a preset threshold value and driving the drug in the drug carrying module to permeate into the corium layer. The equipment monitors the blood sugar concentration of a human body in real time by adopting a counter-ion electroosmosis technology, realizes transdermal delivery of insulin through an electroporation technology, combines two functions of blood sugar concentration monitoring and insulin delivery, realizes integrated closed-loop control of symptom diagnosis and treatment, and can realize the two functions in a completely non-invasive manner, so that the operation is simple and convenient. The skin of a patient is not damaged.

The invention provides a bowl-shaped Janus mesoporous silica nano motor and a preparation method and application thereof, and belongs to the technical field of novel biomedical materials and eye disease treatment. The preparation method comprises the following steps: preparing ZIF-8 amp by taking a ZIF-8 nanocube as a seed and taking tetraethoxysilane as a silicon source; the preparation method comprises the following steps: preparing an mSiO2 anisotropic nano hybrid, performing amino functional modification, etching to remove a ZIF-8 core to obtain amino functional bowl-shaped mesoporous silicon dioxide, and passing through B-mSiO2amp; and asymmetrically and covalently grafting catalase on the outer surface of the Janus mesoporous silica nano-motor through amino active sites on the surface of NH2 to obtain the bowl-shaped Janus mesoporous silica nano-motor. The nano-motor prepared by the invention can realize directional autonomous movement in the presence of H2O2 at an infected part, effectively enhances the penetrating ability of a drug across a corneal barrier, goes deep into corneal stroma and a bacterial biofilm, and solves the problem of low delivery efficiency of a traditional drug.

The invention relates to an application of a traditional Chinese medicine inunction prescription for nourishing liver and kidney as a medicine for treating polymyalgia rheumatic, and belongs to the field of traditional Chinese medicine preparations for treating polymyalgia rheumatic. In the traditional Chinese medicine inunction prescription, polygonum cuspidatum, kalimeris indica root and ramulus mori are used as monarch drugs for dispelling wind, eliminating dampness and easing joint movement; the pedicularis and the radix angelicae have the effects of dispelling wind and relieving pain, enhancing local blood circulation and promoting drug absorption, the borneol, the gypsum and the nightshade assist the monarch drug to enhance the anti-inflammatory effect, and the discolor cinquefoil herb and the bulbus tulip bulb have the effects of clearing away heat and toxic materials and relieving swelling and pain and are all ministerial drugs; the manyleaf paris rhizome and the artemisia anomala are used for assisting the monarch drugs to dissipate blood stasis, relieve pain and promote blood circulation to subdue swelling, and the pepper, the croton and the far infrared ceramic powder are used for anesthesia, analgesia and enhancement of drug permeability and are used as adjuvant drugs; rhododendron molle and periploca forrestii schltr harmonize the medicines, enhance the overall curative effect and serve as conductant medicines together. Therefore, according to the traditional Chinese medicine inunction prescription provided by the invention, dialectical treatment is performed from the perspective of nourishing the liver and the kidney, and the treatment effect is relatively good.

The invention provides an ultrasonic-responsive lipid drug carrier capable of transdermal drug delivery and a preparation method thereof, and the method comprises the following steps: dissolving lipid and a surfactant in an organic solvent, then carrying out rotary evaporation to remove the organic solvent and form a lipid film, then adding an aqueous solution to hydrate the film, and finally adding an ultrasonic-responsive substance to obtain the ultrasonic-responsive lipid drug carrier capable of transdermal drug delivery. The ultrasonic responsive lipid drug carrier capable of realizing transdermal drug delivery is obtained. The lipid drug carrier disclosed by the invention is nanoscale, has good deformability and ultrasonic responsiveness, and is suitable for skin delivery and deep administration of water-soluble or fat-soluble drugs. The lipid drug carrier is combined with ultrasound, so that a drug delivery system capable of noninvasively realizing deep transdermal drug delivery can be formed, and the problems of low drug delivery efficiency, poor safety, insufficient drug penetration depth and the like in the prior art can be effectively solved.