92 results about "Drug penetration" patented technology

The invention relates to a solvent-free organic silicon pressure-sensitive adhesive. The organic silicon pressure-sensitive adhesive comprises the following components in part by mass: 100 parts of polydimethylsiloxane of which the end group is alkenyl; 1 to 300 parts of polydimethylsiloxane of which the end group is hydroxyl; 1 to 50 parts of MQ resin, 1 to 30 parts of polyisobutylene, 20 to 200 parts of diluting agent, 0.1 to 5 parts of crosslinking agent and a platinum catalyst capable of curing the organic silicon pressure-sensitive adhesive. The invention also relates to a preparation method of the organic silicon pressure-sensitive adhesive. The organic silicon pressure-sensitive adhesive has the characteristics of high initial tack, long residual action, proper peeling strength, drug penetration and the like, is nontoxic, environmentally-friendly and reusable, and can be prepared into pressure-sensitive adhesive tapes, medical pressure-sensitive adhesive strips and other functional materials requiring the pressure-sensitive performance.

The present invention relates to a laser hair-loss treatment device. The laser hair-loss treatment device of the present invention comprises a cap provided in such a way as to cover the head of the user and comprises a laser assembly which is provided on the inside of the cap and which receives power and irradiates laser light under control by means of a controller. This hair-loss treatment device further comprises: a resilient pad attached to the inside of the cap; a circuit substrate which is attached to one surface of the resilient pad and which is provided with a heat-emitting body for receiving electrical power and emitting heat; vibrating motors which are provided electrically connected to the circuit substrate, and which are respectively provided in positions where they do not positionally interfere with the heat-emitting body, and which also generate vibrations upon receipt of an electrical power-source supply; and laser assemblies which are provided on one side of the vibrating motors, are electrically connected to the circuit substrate, and one end of each of which is attached to the scalp of the user by being provided passing through and projecting from assembly holes formed in the resilient pads. The laser hair-loss treatment device according to the present invention is beneficial in that it can activate hair-root cells in a complex fashion through thermal stimulation using a heat-emitting element and physical stimulation using a vibrational element and optical-pulse stimulation for a laser diode on the scalp of the wearer, and thereby promote hair growth and prevent hair loss. Additionally, the present invention is advantageous in that it can provide enhanced working efficiency in disassembly and assembly since the laser-diode assembly has a straightforward construction, and in that it can multiply laser and drug penetration since the laser irradiation and vibration are transmitted in a state in which the lens and lens cap are attached to the scalp.

Methods and formulations of enhancing the permeability the skin of a subject to a drug are disclosed. The method may include administering a combination of lauryl alcohol and isopropyl myristate as a penetration enhancer to the area of skin to provide synergistically enhanced penetration of the drug.

The amount of penetration into the skin in adhesive patches generally tends to show a certain peak and trough. An adhesive patch is provided in which the drug shows satisfactory penetrability because of a polymer proportion and drug penetration is constant over a certain period. The adhesive patch for external use has a pressure-sensitive adhesive layer containing a drug. It is characterized in that the pressure-sensitive adhesive layer comprises: polyvinylpyrrolidone and / or a copolymer of monomers including vinylpyrrolidone as the main ingredient; and a (meth)acrylic ester copolymer having a basic nitrogen atom and / or cationic nitrogen atom.

A microfluidic device provides high throughput generation and analysis of defined three-dimensional cell spheroids with controlled geometry, size, and cell composition. The cell spheroids of the invention mimic tumor microenvironments, including pathophysiological gradients, cell composition, and heterogeneity of the tumor mass mimicking the resistance to drug penetration providing more realistic drug response. The device is used to test the effects of antitumor agents.

The invention relates to the technical field of medicines, in particular to a novel electret microneedle transdermal drug delivery system. The system comprises an isolation layer and a drug-containing pressure-sensitive adhesive layer arranged on the inner side of the isolation layer, wherein an electret layer made from an electret material is arranged on the outer side of the isolation layer; a controlled-release membrane layer is arranged on the inner side of the drug-containing pressure-sensitive adhesive layer; the electret layer, the isolation layer, the drug-containing pressure-sensitive adhesive layer and the controlled-release membrane layer are arranged in sequence from outside to inside to form a reservoir type patch; a microneedle array layer is arranged on the inner side of the reservoir type patch and comprises a microneedle array formed by a plurality of microneedles; each microneedle is 20-50 microns in diameter; and the spacing between every two adjacent microneedles is 1-1.5mm. According to the system, a drug can conveniently penetrate the skin by optimizing microneedle structure and arrangement; and when the system is used, the microneedles act on the skin firstly, the drug quickly penetrates the skin through the needle holes of the microneedles, and the electret layer accelerates drug penetration to achieve a treatment effect.

The invention discloses a cell membrane microcapsule simultaneously loaded with a chemotherapeutic drug and a photodynamic therapeutic drug. Human cells are selected as a raw material for preparing the cell membrane microcapsule; the obtained cell membrane microcapsule is soaked into a digitonin solution to improve the permeability of cell membranes; a chemotherapeutic drug namely doxorubicin hydrochloride and a photodynamic therapeutic drug namely indocyanine green are added sequentially to ensure that the drugs are infiltrated into the cell membrane microcapsule; and calcium ions are used for sealing the cell membranes to obtain the cell membrane microcapsule simultaneously loaded with the chemotherapeutic drug and the photodynamic therapeutic drug. The cell membrane microcapsule can generate active oxygen under the irradiation of laser light of 808nm, and the active oxygen and the chemotherapeutic drug act together to kill tumor cells, so that the cell membrane microcapsule is expected to be used for tumor treatment. The preparation method of the cell membrane microcapsule disclosed by the invention is simple, convenient and controllable, is high in production efficiency and has good application prospects.

Provided is a method for enhanced intraocular drug penetration that comprises the co-administration of ocular therapeutics with agents that increases the permeability of ocular and periocular vessels and ocular epithelial barriers. Due to its unique and novel concept and additive nature, the method of the present invention can be used in combination with previous methods for enhancement of ocular drug penetration.

The present invention relates to an ultrasound contrast agent with drug-encapsulating nanoparticles and a method for preparing the same that increase drug delivery capabilities and drug penetration effects. According to the present invention, exposure to the focussed ultrasound triggers the cavitation of an ultrasound contrast agent, resulting in the local release of drug-encapsulating nanoparticles, which are conjugated onto the surface of the ultrasound contrast agent, and enhanced penetration of nanoparticles and drug delivery capabilities. Moreover, the present invention simultaneously and selectively diagnoses and treats cancers by conjugation cancer-targeting ligands on the surface of nanoparticles.

The invention belongs to the technical field of biological micro-fluidic control, in particular to a bionic multi-organ chip and a preparation method therefor. The chip consists of four layers, and comprises upper layer culture regions and lower layer culture regions; and each layer of cell culture region is provided with a microstructure inside to promote formation of a three-dimensional tissue cell; the upper layer cell culture regions and the lower layer cell culture regions communicate through porous membranes, and thus, substance exchange and drug penetration can be performed. Each culture region on the lower layer is provided with a liquid inlet and a liquid outlet, and the liquid inlet and the liquid outlet are used for cell inoculation and culture medium replacement. The multi-organ chip can culture three or more different types of tissue cells, thus realizing effects and influences of externally applied substances including drugs and the like on different organs, as well as interaction between upper layer tissue cells and lower layer tissue cells. The multi-organ chip can simulate the complex processes of drugs or other substances acting on different human organs of humanbody, and can also simulate disease models involved with multiple human organs.

It is intended to prepare a composition which contains polysaccharide at a high concentration and yet remains in the state of a liquid having low viscosity to thereby provide drugs, eyedrops, foods, cosmetics, toiletry products having a novel texture or function. The composition in the state of a liquid having low viscosity is obtained by heating polysaccharide at a high concentration in a water-containing liquid and then cooling under applying a shear force, which enables the provision of the above-described drugs. The composition is usable as an aqueous drug vehicle which is free from gelling due to temperature changes during storage and easily applied without pouring and / or streaming down. Eyedrops containing agar have an effect of enhancing ocular drug penetration. Eyedrops containing particulate agar maintain a low viscosity and, achieve easy instillation and impart a favorable feel in instillation.

The present invention recognizes that medical devices, such as but not limited to contact lenses, can be made having a coating made at least in part using printing technologies to provide drug storage and drug release structures. The coating preferably includes at least one drug reservoir layer and a least one barrier layer, and can include structures, such as but not limited to capillary structures that alone or in combination modulate the release of the drug from the coating. One aspect of the present invention is a medical device that incorporates a drug in at least one coating. A second aspect of the present invention is a method of making a medical device that incorporates a drug in at least one coating. A third aspect of the present invention is a method of using a medical device of the present invention to treat, prevent from having, prevent from developing, control, reduce the severity, or reduce the progression of a disease, disorder or condition of a subject.

A drug-delivering medical device for delivering a drug to a target site in a body lumen is disclosed. The drug-delivering medical device includes a balloon catheter and an inflatable balloon positioned on the balloon catheter. The inflatable balloon has a hydrophilic surface. One or more portions of the hydrophilic surface are coated with two or more nano-carriers. A nano-carrier of the two or more nano-carriers includes a drug surrounded by an encapsulating medium. As the drug is surrounded by the encapsulating medium, the surface of the nano-carrier is devoid of the drug. When the inflatable balloon is inflated upon coming in proximity to a target site in the body lumen, about 30% to 80% of the two or more nano-carriers are released from the hydrophilic surface within 15-90 seconds.

The present invention relates to an ultrasound contrast medium in which nanoparticles are combined having increased drug delivery capacity and enhanced drug penetration effects, and a preparation method therefor. The ultrasound contrast medium, according to the present invention, comprises drug-loaded nanoparticles combined on the surface thereof, and thus has improved drug delivery capacity and nanoparticle penetration. In addition, the present invention prepares nanoparticles using a cancer target-specific protein, thereby allowing selective diagnosis and treatment of cancer to be simultaneously carried out.

The invention creatively discloses a drug penetration dynamic evaluation method based on a three-dimensional cell model. The method comprises the steps that (1) a three-dimensional somatic cell model and a "penetration dynamics" mathematic model are established, the penetration behavior of an antitumor drug in somatic cells and an accumulation process in all layers of cells are described semi-quantitatively, and fitting is performed to obtain corresponding dynamic parameters; (2) drug concentrations in all layers of cells at different time points after the drug is given according to different concentrations can be subjected to backward prediction based on the obtained dynamic parameters, and the prediction result is highly consistent with an experience result; (3) biological factors influencing characteristic dynamic parameters are analyzed, the penetration behavior of the drug in tumor tissue is speculated according to a plasma drug concentration time course, and the speculation result is highly consistent with an experiment result; and (4) the model and the evaluation method are applied to a second-phase clinical drug INNO-206, and reasons for superiority of the clinical effect of the drug to that of doxorubicin are expounded from the aspect of in-tumor penetration, so that the universality of the method is further verified.

The invention relates to a whitening containing iPS living cell fluid and biological polypeptides. The cosmetic comprises, by mass, 0.1-3% of biological polypeptides, 1-10% of a PS living cell fluid, 0.1-10% of hyaluronic acid, and the balance deionized water. The cosmetic can effectively solve the skin problems caused by pigmentation of chloasma, malar rash, senile plaque and the like, also solves the problem of bad drug penetration or use inconvenience due to short drug carrier retention time, and has a wide application prospect.

The invention relates to an ultrasonic treatment device and a method mediated by microbubbles for opening prostate barrier. The ultrasonic treatment device comprises an ultrasonic treatment unit and microbubbles, and the ultrasonic treatment device is characterized in that direct-current high voltage is used to generate high pulse, a high pulse switch functional tube is used as a control unit, the direct-current high voltage is supplied to an ultrasonic power oscillator by means of high pulse, and pulse signals are sent out. The treatment unit is capable of transmitting an intermittent pulse type ultrasonic energy form low in average sound intensity and high in peak sound pressure. In coordination with intravenous microbubble injection, microbubble ultrasonic cavitation in blood circulation is induced under pulse type ultrasonic transmission, the prostate barrier is opened noninvasively under microbubble sonoporation, drug penetration into prostate tissue cells is promoted, a novel way of noninvasive prostate drug treatment is developed, drug effect is given to fullest play, drug application time is shortened, and treatment cost is saved.

The invention provides a product for preventing and treating cervical lesions and wounds, comprising an application wall whose inner surface is similar to that of the cervicovaginal portion or / and the surface of the cervical canal. The application wall is loaded with magnetic materials or infrared emitting materials or negative ion emitting materials. At least one kind of material, and the sticking wall can be loaded with medicines for preventing and treating cervical lesions and wounds. The product provided by the invention has the functions of magnetic therapy, infrared therapy, negative ion local cleaning, and targeted drug delivery, and acts on drug molecules through magnetic fields and infrared rays to increase the activity of drug components, improve drug penetration and curative effect. The product of the invention can quickly and thoroughly treat cervical lesions and wounds.

The invention discloses a W / O / W-type composite nano-emulsion gel transdermal preparation containing polypeptide drugs and a preparation method thereof. The preparation method of the W / O / W-type composite nano-emulsion gel transdermal preparation containing the polypeptide drugs comprises the following steps: dissolving the polypeptide drugs with a PBS buffer, adding an emulsifier A, carrying out uniform stirring, and dropwise adding an oil phase while stirring at room temperature until a clear and transparent mixture is obtained so as to obtain a W / O-type nano-emulsion containing the polypeptide drugs; using the W / O-type nano-emulsion as an oil phase, adding an emulsifier B and a co-emulsifier, carrying out uniform stirring, and dropwise adding a PBS buffer while stirring at room temperature until a clear and transparent mixture is obtained so as to obtain a W / O / W-type composite nano-emulsion containing the polypeptide drugs; and then, adding a gel matrix material into the W / O / W-type composite nano-emulsion containing the polypeptide drugs, after full swelling is reached, adjusting the pH value to 6.5, and carrying out gentle stirring until gel is naturally formed so as to obtain the W / O / W-type composite nano-emulsion gel transdermal preparation containing the polypeptide drugs. The preparation method of the W / O / W-type composite nano-emulsion gel transdermal preparation containing the polypeptide drugs is simple in process, mild in conditions, beneficial for maintaining activity of polypeptide drugs and feasible for industrial production; and the prepared composite nano-emulsion is small in particle size, high in permeability and easy for drug penetration.

Disclosed is drug delivery system for effectively administering a drug into a human or animal body tissue. The microjet drug delivery system includes (a) a microjet injector including: a pressure chamber partially sealed by an elastic membrane and containing a pressure-inducing liquid fluid-tightly filled therein; and a drug chamber adjacent to the pressure chamber, wherein the elastic membrane is disposed between the pressure and drug chambers, wherein the drug solution is contained in the drug chamber, wherein the drug chamber has a micro-nozzle partially defined in a wall thereof for ejecting the drug solution out of the drug chamber; (b) a laser generator for generating a laser beam and emitting the laser beam out of the laser generator, wherein the laser generator is configured by irradiating the laser beam into the pressure-inducing liquid in the microjet injector, thereby generating a bubble in the pressure-inducing liquid; and (c) a fractional laser filter module configured for splitting the laser beam incident from the laser generator into a plurality of fractional laser beams, each beam has a reduced diameter, and for irradiating the fractional laser beams. According to the microjet drug delivery system, the pre-ablating of the skin with the fractional laser beams to partially remove the stratum corneum may enable the drug microjet based injection to allow the drug to be effectively invaded into a skin tissue at the portion where the stratum corneum is partially removed and relatively softened.

Provided in the present invention is a pharmaceutic osmotic pump preparation comprising a tablet core, wherein the tablet core contains drugs (or pharmaceutically active ingredients) and materials forming a chamber structure; and a coating film coating the tablet core where a drug release hole is set; wherein when the pharmaceutic osmotic pump preparation releases drugs in water or an aqueous medium, the materials forming the chamber structure lead to the formation of a superfine chamber structure in the coating film, and the total volume of the superfine chamber structure Vb gradually increases over the releasing time, but the releasing rate R (or release amount A) of the pharmaceutically active ingredients is proportional to Vb. The osmotic pump preparation of the present invention is suitable for water-soluble drugs and water-insoluble drugs, and especially is suitable for the controlled release of low solubility drugs or pH dependent drugs.

The invention discloses a cation-modified pilocarpine hydrochloride flexible nano-liposome eye-drops preparation and a preparation method thereof. The preparation method comprises the following steps:(1) adding lecithin and cholesterol into chloroform, and performing ultrasonic treatment to obtain suspension; and dissolving pilocarpine hydrochloride and a penetration enhancer in methanol to obtain a solution I; (2) uniformly mixing the suspension and the solution I, and removing an organic solvent to obtain a uniform lipid membrane; (3) dissolving a softener into purified water to obtain a solution II, and dissolving the lipid membrane into the solution II so as to obtain primary mixed emulsion; (4) performing ultrasonic treatment on the primary mixed emulsion, and adding into a warm bathso as to obtain a pilocarpine hydrochloride flexible nano-liposome preparation; and (5) dissolving a cationic material into the purified water to obtain a solution III, stirring the pilocarpine hydrochloride flexible nano-liposome preparation, dropping the solution III, and stirring, thereby obtaining the eye-drops preparation in the invention. The preparation disclosed by the invention has hugemembrane surface area and high adhesion, and the drug penetration is increased. The eye-drops preparation has excellent biocompatibility and low eye irritation.

According to the invention, essential oil of alpinia oxyphylla miq. is taken as a major research object, and the effect of the essential oil on promoting drug transdermal permeation is investigated. On the basis of systematic investigation, both fruit essential oil and leaf essential oil of the alpinia oxyphylla miq. are relatively strong in penetration enhancing effect; and when the concentration of the essential oil is 3%, the penetration enhancing effect of the fruit essential oil and the leaf essential oil on drugs is obviously better than that of a common skin penetration enhancer, namely azone. Based upon GC-MS analysis, as for major ingredients, the fruit essential oil and the leaf essential oil are different in contents of alkane terpene and oxy-terpene ingredients; therefore, the fruit essential oil and the leaf essential oil keep a certain difference in drug penetration enhancing effect. In addition, the result of a skin irritation test proves that the fruit essential oil and the leaf essential oil, at an appropriate concentration, can avoid any erythema or edema in animal skin. Therefore, the essential oil of the alpinia oxyphylla miq., with the significant penetration enhancing effect and safety to the skin, has a broad development and application prospect in the fields of drug delivery and cosmetics.

A compound antithyroid gel for external application comprises an antithyroid drug, adrenal glucocorticoid, and a drug penetration enhancer. When in use, the gel is directly and externally applied to skin at the anterior cervical thyroid site. The drug directly penetrates into thyroid through skin to treat hyperthyroidism; the using amount of the drug is less; the curative effect is quick; and no systemic drug side effect is caused to human body. When the compound antithyroid gel of the invention is used for the treatment of hyperthyroidism, the repeated incidence and recurrence incidence of hyperthyroidism are low; the treatment effect is improved; and patient pain is relieved. The compound antithyroid gel is a safer and more effective drug for treating hyperthyroidism.

The invention discloses a medicine for treating mastitis and a preparation method thereof, applicable to treatment of mastitis patients. The medicine for treating mastitis disclosed by the invention is prepared by combining eleven traditional Chinese herbal medicinal materials including safflower, coptis chinensis, myrrh, radix ampelopsis, herba lycopi, radix sophorae flavescentis, spica prunellae, lonicera japonica, folium artemisiae argyi, camphor and menthol. The medicine disclosed by the invention is directly sprayed onto diseased parts of patients, is high in drug penetration and obviousin medicinal effect and does not have irritation or toxic or side effect, and irritation and other side effects of oral medicines on the human body are avoided. The treatment cycle can be shortened, and the medicine achieves an obvious therapeutic effect.

The invention brings forward a Chinese herbal paste for treating a superficial cancer. The Chinese herbal paste is prepared by weighing 5 to 30 g of gecko, 5 to 30 g of dysoma pleiantha, 5 to 30 g of Marsdenia tenacissima, 5 to 30 g of euphorbia, 5 to 30 g of frankincense, 5 to 30 g of myrrh, 5 to 30 g of leech and 5 to 30 g of borneol, crushing the above-mentioned materials into powder, adding the obtained powder into cream, carrying out uniform stirring, then carrying out homogenizing with a homogenizer, smearing an obtained substance on a ventilating cloth and covering the substance with a plastic film or a wax film so as to obtain the Chinese herbal paste. The Chinese herbal paste is applied on the skin or corresponding acupuncture points of a patient and realizes treatment of a superficial cancer or alleviation of pains through drug penetration and diffusion on the skin. According to results of clinical practice, the curative effective rate of the paste is 98% and the action rate of the paste is 80%. The Chinese herbal paste provided by the invention is applicable as an externally-applied drug for treating superficial cancers.

The invention discloses a hoof care spray to effectively kill and inhibit the infectious pathogens of hoof diseases and promote healing of hoof wound. The main raw materials comprise a Chinese herbal medicine extract capable of effectively preventing and treating a variety of hoof diseases and improving immunity and disease resistance of cows, and an aloe extract with strong adhesion and for promoting drug penetration and effectively repairing cuticle; and a plant extract capable of changing the structure of the cuticle of the cow hoof and promoting the effective ingredient such as the Chinese herbal medicine extract and aloe to quickly penetrate into the deep skin for absorption is added. The ultrasonic dispersion, dissolution, high pressure homogenization and hot and cold processing technology are combined organically. The hoof care spray is not only scientifically compounded with an efficient bonded modified dietary fiber, but also is supplemented with trehalose, tannins, water-soluble chitosan, carrageenan and natural antioxidant to protect the active ingredients from oxidation and improve physical and chemical stability of hoof care spray. The ultimately prepared hoof care spray has the advantages of strong stability, safety, high efficiency, no antibiotic or chemical toxic substances.

A microfluidic device provides high throughput generation and analysis of defined three-dimensional cell spheroids with controlled geometry, size, and cell composition. The cell spheroids of the invention mimic tumor microenvironments, including pathophysiological gradients, cell composition, and heterogeneity of the tumor mass mimicking the resistance to drug penetration providing more realistic drug response. The device is used to test the effects of antitumor agents.

The invention discloses a resveratrol ointment capable of curing pathological scars, a preparation method and application. The resveratrol ointment comprises the following components: hydroxypropyl-beta-cyclodextrin, purified water, resveratrol, anhydrous ethanol, stearic acid, glyceryl monostearate, hexadecanol, octadecanol, albolene, lanolin, glycerin, triethanolamine, tween-80, methylparaben, ethylparaben, and borneol. Propyl-beta-cyclodextrin for resveratrol is wrapped into a clathrate with good stability, the smell of propyl-beta-cyclodextrin itself is utilized to cover up the objectionable odor of drugs so as to minimize the irritation of drugs, then the resveratrol clathrate is added into an emulsification matrix containing borneol to promote drug penetration into the subcutaneous tissue so as to play a pharmacological role better, the efficacy of resveratrol is maximized, under the premise of enhancing the efficacy, the resveratrol adding amount is lowered, and the toxic and side effect can be greatly reduced. With a total effective rate of 87.75%, the resveratrol ointment has the characteristics of no recurrence and no adverse symptom.