91 results about "Drug penetration" patented technology

The invention relates to a solvent-free organic silicon pressure-sensitive adhesive. The organic silicon pressure-sensitive adhesive comprises the following components in part by mass: 100 parts of polydimethylsiloxane of which the end group is alkenyl; 1 to 300 parts of polydimethylsiloxane of which the end group is hydroxyl; 1 to 50 parts of MQ resin, 1 to 30 parts of polyisobutylene, 20 to 200 parts of diluting agent, 0.1 to 5 parts of crosslinking agent and a platinum catalyst capable of curing the organic silicon pressure-sensitive adhesive. The invention also relates to a preparation method of the organic silicon pressure-sensitive adhesive. The organic silicon pressure-sensitive adhesive has the characteristics of high initial tack, long residual action, proper peeling strength, drug penetration and the like, is nontoxic, environmentally-friendly and reusable, and can be prepared into pressure-sensitive adhesive tapes, medical pressure-sensitive adhesive strips and other functional materials requiring the pressure-sensitive performance.

The present invention relates to a laser hair-loss treatment device. The laser hair-loss treatment device of the present invention comprises a cap provided in such a way as to cover the head of the user and comprises a laser assembly which is provided on the inside of the cap and which receives power and irradiates laser light under control by means of a controller. This hair-loss treatment device further comprises: a resilient pad attached to the inside of the cap; a circuit substrate which is attached to one surface of the resilient pad and which is provided with a heat-emitting body for receiving electrical power and emitting heat; vibrating motors which are provided electrically connected to the circuit substrate, and which are respectively provided in positions where they do not positionally interfere with the heat-emitting body, and which also generate vibrations upon receipt of an electrical power-source supply; and laser assemblies which are provided on one side of the vibrating motors, are electrically connected to the circuit substrate, and one end of each of which is attached to the scalp of the user by being provided passing through and projecting from assembly holes formed in the resilient pads. The laser hair-loss treatment device according to the present invention is beneficial in that it can activate hair-root cells in a complex fashion through thermal stimulation using a heat-emitting element and physical stimulation using a vibrational element and optical-pulse stimulation for a laser diode on the scalp of the wearer, and thereby promote hair growth and prevent hair loss. Additionally, the present invention is advantageous in that it can provide enhanced working efficiency in disassembly and assembly since the laser-diode assembly has a straightforward construction, and in that it can multiply laser and drug penetration since the laser irradiation and vibration are transmitted in a state in which the lens and lens cap are attached to the scalp.

Provided are compositions relating to novel MDR1 polymorphisms, including nucleic acids, polypeptides, and recombinant cells, as well as methods for detection of MDR1 polymorphisms in biological samples and elucidation of the influence of MDR1 polymorphisms on MDR1 protein function. Also provided are a rat MRP1 cDNA and protein, stable cell lines expressing the rat MRP1 protein, and methods of assessing drug penetration or disposition in a cell line expressing a recombinant mammalian MRP1 or MDR1 protein, or a homolog thereof.

Provided is a method for enhanced intraocular drug penetration that comprises the co-administration of ocular therapeutics with agents that increases the permeability of ocular and periocular vessels and ocular epithelial barriers. Due to its unique and novel concept and additive nature, the method of the present invention can be used in combination with previous methods for enhancement of ocular drug penetration.

A drug-delivering medical device for delivering a drug to a target site in a body lumen is disclosed. The drug-delivering medical device includes a balloon catheter and an inflatable balloon positioned on the balloon catheter. The inflatable balloon has a hydrophilic surface. One or more portions of the hydrophilic surface are coated with two or more nano-carriers. A nano-carrier of the two or more nano-carriers includes a drug surrounded by an encapsulating medium. As the drug is surrounded by the encapsulating medium, the surface of the nano-carrier is devoid of the drug. When the inflatable balloon is inflated upon coming in proximity to a target site in the body lumen, about 30% to 80% of the two or more nano-carriers are released from the hydrophilic surface within 15-90 seconds.

The present invention relates to an ultrasound contrast medium in which nanoparticles are combined having increased drug delivery capacity and enhanced drug penetration effects, and a preparation method therefor. The ultrasound contrast medium, according to the present invention, comprises drug-loaded nanoparticles combined on the surface thereof, and thus has improved drug delivery capacity and nanoparticle penetration. In addition, the present invention prepares nanoparticles using a cancer target-specific protein, thereby allowing selective diagnosis and treatment of cancer to be simultaneously carried out.

A microfluidic device provides high throughput generation and analysis of defined three-dimensional cell spheroids with controlled geometry, size, and cell composition. The cell spheroids of the invention mimic tumor microenvironments, including pathophysiological gradients, cell composition, and heterogeneity of the tumor mass mimicking the resistance to drug penetration providing more realistic drug response. The device is used to test the effects of antitumor agents.