Resveratrol ointment capable of curing pathological scars, preparation method and application

Abstract

The invention discloses a resveratrol ointment capable of curing pathological scars, a preparation method and application. The resveratrol ointment comprises the following components: hydroxypropyl-beta-cyclodextrin, purified water, resveratrol, anhydrous ethanol, stearic acid, glyceryl monostearate, hexadecanol, octadecanol, albolene, lanolin, glycerin, triethanolamine, tween-80, methylparaben, ethylparaben, and borneol. Propyl-beta-cyclodextrin for resveratrol is wrapped into a clathrate with good stability, the smell of propyl-beta-cyclodextrin itself is utilized to cover up the objectionable odor of drugs so as to minimize the irritation of drugs, then the resveratrol clathrate is added into an emulsification matrix containing borneol to promote drug penetration into the subcutaneous tissue so as to play a pharmacological role better, the efficacy of resveratrol is maximized, under the premise of enhancing the efficacy, the resveratrol adding amount is lowered, and the toxic and side effect can be greatly reduced. With a total effective rate of 87.75%, the resveratrol ointment has the characteristics of no recurrence and no adverse symptom.

Description

technical field [0001] The invention relates to an ointment and a preparation method, in particular to a resveratrol ointment capable of curing pathological scars, a preparation method and application thereof, belonging to biotechnology and new medicine. Background technique [0002] Pathological scars include hypertrophic scars and keloids, which are characterized by proliferation of dermal fibroblasts and excessive production of extracellular matrix (collagen types I and III, mucin and mucopolysaccharides, etc.), and are a kind of hyperplastic disease of skin connective tissue . This disease often occurs after burns, surgical operations and trauma, which not only affects the appearance, but can even cause serious dysfunction and bring serious harm to the physical and mental health of patients. Therefore, the prevention and treatment of pathological scars is an important topic in the field of skin surgery and burn plastic surgery. [0003] At present, there are many treat...

AI Technical Summary

Problems solved by technology

In China, traditional Chinese medicine has a long history of preventing and treating diseases, and many valuable experiences and methods are worthy of further exploration. Resveratrol is a polyphenolic compound present in Chinese herbal medicine plants such as Polygonum cuspidatum, Veratrum, and Cassia. 2009 The article "Experimental Research on the Inhibitory Mechanism of Resveratrol on the Growth of Human Skin Cancer Cell Line a431" published in the Journal of Capital Medical University in 2011 revealed that resveratrol has anti-inflammatory, anti-oxidation, inhibition of platelet aggregation, improvement of microcirculation, protection Mitochondrial function and other biological activities and pharmacological effects, studies have shown that it can inhibit cell proliferation and induce apoptosis through various ways, so it has the effect of fighting proliferative diseases, so it can be considered as a drug against proliferative diseases However, due to its poor solubility and stability, it needs to be added in a sufficient amount to achieve the medicinal effect, but resveratrol is highly irritating and has certain toxic and side effects, which limits its application Based on the human body and efficacy, clinical trials have shown that the effect of anti-proliferative diseases is not good

At present, there is no medicine that can effectively cure pathological scars fundamentally.

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