38 results about "Veratrum" patented technology

The invention provides a veratramine degradation product veratrum fluorene aldehyde 1 and derivatives thereof. The invention uses steroidal alkaloid veratramine (A) as raw material and prepares veratrum fluorene aldehyde by oxidative degradation of m-chloroperoxybenzoic acid to obtain 20 derivative compounds of the veratrum fluorene aldehyde 1 after further oxidation, reduction and condensation reaction. The 20 compounds of the invention have good inhibitory activity on cancer cells, wherein the compounds 1, 2, 5, 8, 13 and 17 have good inhibitory activity on cells of human pancreatic cancer cells BxPC-3 and SW1990, small-cell lung cancer cells NCI-H446, human colorectal cancer LOVO and the like, and the inhibitory activity of the compound veratrum fluorene aldehyde 1 is the most significant.

The invention relates to a biological pesticide composition, in particular to a fungus and plant extract pesticide composition. An insecticidal composition containing metarrhizium anisopliae and veratrine is characterized by mainly comprising the metarrhizium anisopliae and the veratrine, wherein the metarrhizium anisopliae and the veratrine are mixed according to the weight ratio being (1-20):(10-2). The metarrhizium anisopliae is metarrhizium anisopliae conidia, and the content is 5-40 billion spores / gram. The veratrine is a pure substance or a mixture containing veratrum total alkali. The insecticidal composition is environmentally friendly, and can expand the insecticidal spectrum of biological pesticides, be higher in insecticidal effect and longer in lasting period, and reduce the use frequency of pesticides.

The invention provides a method for extracting veratrum alkaloid from veratrum by supercritical carbon dioxide, which comprises the following steps of: A. crushing the veratrum, adding 150mL of ammonia into 100g of veratrum powder and soaking for 3 hours, drying at a shade and ventilating place and then sieving with 30 meshes; B. adding the crushed product of the veratrum after alkalized into a supercritical fluid extracting tank, opening a CO2 steel cylinder, starting to extract by taking ethanol as a carrying agent at the temperature of an extractor of 65 to 75 DEG C, at the extracting pressure of 30 to 38 MPa, at the flow rate of CO2 of 40 to 45Kg / h and with the extracting time of 2 to 4 hours, and implementing distillation by a separator and recovering a solvent so as to obtain crude products of veratrum alkaloid. The invention adopts early-phase alkaline treatment, extracts veratrum alkaloid from veratrum by supercritical carbon dioxide, can separate the combined alkaloid and acid which are hard to separate from each other in veratrum by utilizing high pressure and high seepage pressure of CO2, and dissolves out effective ingredients, the yield of the veratrum alkaloid is higher than that of veratrum alkaloid extracted by soaking of organic solvent; in addition, the invention has simple process, stable operation and recycled solvent and has a certain economic benefit and environmental benefit.

The invention aims at proving a traditional Chinese medicine composite used for treating parkinsonism syndrome and a preparation method thereof. The traditional Chinese medicine composite is characterized by comprising the following raw materials of different proportions: veratrum or active materials extracted from the same and liquorice or active materials extracted from the same. The invention also provides a preparation method of the traditional Chinese medicine composite. The traditional Chinese medicine composite is used for treating the parkinsonism syndrome.

The invention discloses a meshy gel material with a three-ring veratrum hydrocarbon derivate as a node and a preparation method thereof. A three-ring veratrum hydrocarbon derivate molecule with a plurality of phenolichydroxyl serves as the node of a network, polyethylene glycol with different molecular weights serves as network lines, and the three-dimensional meshy gel material is prepared by a synthesis method. A rigid three-ring veratrum hydrocarbon derivate structure in a gel material structure can keep the rigidity due to the characteristics of the derivate structure after being dissolved, so the original combination characteristic between a subject and an object can be kept; and a flexible polyethylene glycol part greatly increases the depth of a cavity of a three-ring veratrum hydrocarbon derivate part, and can adapt to the object by changing the shape of the flexible polyethylene glycol part and the affinity of the overall network to various solvents is enhanced, so the gel material is endowed with the capability of gathering special object molecules.

The invention provides a method for preparing high-purity veratramine and jervine. The method comprises the steps of: crashing crude veratrum drugs, distilling and extracting alcohol, enriching, eluting (desorbing) and concentrating macroporous absorbent resin, then obtaining veratrum steroid alkaloid, conducting column chromatography purification and recrystalization, drying and obtaining the finished product of monomer. The purity of the veratramine and jervine prepared in the method can reach above 90 percent. The method for preparing high-purity veratramine and jervine has simple process and high yield, and is suitable for industrialized production.

The invention discloses a making method of cyclopamine and application in the medical domain, which comprises the following steps: adopting jervine from Veratrum plant as raw material; reacting jervine and hydrazine hydrate to produce hydrazone in the high-boiling point solvent; denitrifying acted by potassium hydroxide and tert-butanol potassium to form jervine; using carbowax 400 and TEBA as phase transmitting catalyst; connecting tumour cell Hh and Smo protein; dying cancer cell due to non-gene toxicity without influencing normal cell.

The invention relates to the technical field of pesticides, in particular to a preparation method of a Kumquat red spider insecticidal solution. According to the preparation method provided by the invention, the Kumquat red spider insecticidal solution is prepared through the steps of raw material treatment, cellulose degradation, fermentation, filtering and the like and by taking ginkgo biloba exocarp, veratrum, camelpool, calamus as raw materials; and a spreading agent is also added in the insecticidal solution, so that the spreading of the insecticidal solution on the surfaces of plant stems and leaves as well as insects is improved, the residence time of the insecticidal solution is prolonged, and the frequency of spraying is reduced. The preparation method provided by the invention issimple in process and low in cost; the prepared Kumquat red spider insecticidal solution achieves a chemical insecticidal solution level in Kumquat red spider prevention and treatment effects, also has higher continuous prevention and treatment effects and has the advantage of safety when being taken as a botanical insecticide.

The invention relates to a separation method of a natural drug, and discloses a method for separating cyclopamine analogs from Veratrum plants by high-speed counter-current chromatography. The method is characterized in that Veratrum total alkaloid powder is separated and purified by high-speed counter-current chromatography twice, wherein the solvent system of the first high-speed counter-current chromatography is a mixed solvent composed of dichloromethane, methanol and water; and in the second high-speed counter-current chromatography, the jervine fraction obtained by the first high-speed counter-current chromatography is separated and purified as a reflux sample, and the solvent system is a mixed solvent composed of normal hexane, ethyl acetate, methanol and water. The method is simple and quick, and has the advantages of high recovery rate and high purity of the target compound.

The invention discloses a veratrum ISSR-PCR molecular marking method; with veratrum genomic DNA as a template and UBC856 as a primer and with adopting of 20 [mu]L of an ISSR-PCR reaction system, the amplification procedures comprise the steps: carrying out pre-denaturation for 2 min at the temperature of 94 DEG C, carrying out denaturation for 30 s at the temperature of 94 DEG C, annealing for 30s at the temperature of 51.8 DEG C, extending for 30 s at the temperature of 72 DEG C, circulating for 30 times, extending for 2 min at the temperature of 72 DEG C, and preserving at the temperature of 4 DEG C; an ISSR-PCR reaction system comprises 0.5 [mu]mol / L of the primer, 24 ng / 20 [mu]L of the template DNA, 1 U / 20 [mu]L of Taq DNA polymerase, 0.2 mmol / L of dNTP, and 1.0 mmol / L of Mg<2+>. Thereaction system is stable and reliable, is suitable for subsequent genetic diversity analysis and genetic variation process and evolution research of veratrum, and provides reference basis for germplasm resource identification, genetic relationship analysis, genetic map research and the like.

The invention relates to a preparation method of a traditional Chinese medicine composition capable of promoting blood circulation to remove blood stasis, and stopping bleeding and relieving pain. The traditional Chinese medicine composition is prepared from following traditional Chinese medicine bulk drugs: rhizoma paridis, prepared kusnezoff monkshood root, sedum henryi diels, radix psammosilenes, veratrum taliensis Loes.f., Chinese yam, epigeal srephaia root, polygonum runcinatum Buch.-Harn. ex D.Don, rhizoma polygoni paleacei, semen strychni, and datura metel L. seed. The invention also relates to the preparation method and applications of the traditional Chinese medicine composition in clinic. The traditional Chinese medicine composition is reasonable and unique in formula, processing technology, and application; the preparation method is simple; clinical application is wide; and market value is high.

The invention belongs to the technical field of agricultural crop fertilization, and in particular relates a special spraying agent for herba centipedae. The special spraying agent for the herba centipedae comprises a component A and a component B, wherein the component A and the component B are added to water which is 200 to 300 times of the total weight after mixed according to the weight ratioof 1: 1 and then stirred uniformly, so that the special spraying agent for the herba centipedae can be obtained; the component A is obtained by mainly fermenting raw materials such as coffee grounds,tea seed cakes, bean pulp, zymocyte and the like and then adding lemon citrus enzyme, a veratrum extracting solution and the like, and contains rich organic nitrogen phosphorus and potassium elementsand substances of a large amount of small molecule amino acids, polysaccharides, vitamins, and mineral nutrient elements, beneficial bacteria and the like; the component A is matched with the substances of bone powder, rubus suatrssimus, trace elements and the like in the component B, thereby being comprehensive in nutrition and rich in various nutrients and medium and trace elements which can quickly supplement the nutrients needed for the herba centipedae; in addition, the special spraying agent for the herba centipedae has good fertilizer efficiency and a long-lasting effect, thereby beingcapable of effectively improving the yield and quality of the herba centipedae.

The invention provides an external use drug for treating climacteric syndrome and further discloses a preparation method of the external use drug. The external use drug for treating the climacteric syndrome is good in therapeutic effect and convenient to take. The technical point is that the external use drug for the treating climacteric syndrome is composed, by weight, of 3%-6% of angelica sinensis, 1%-3% of ligusticum, 1%-3% of ligusticum wallichii, 3%-6% of Chinese yam, 1%-3% of veratrum album, 2%-5% of chasteberry, 3%-6% of soybean, 3%-7% of polyethylene glycol, 1%-3% of twain-80, 1%-3% of potassium hydroxide, 2%-4% of carbomer 2020,1%-3% of hydroxyethylcellulose, 10%-18% of ethanol,1%-3% of jiema bp and 30%-45% of deionized water. The external use drug belongs to the technical field of traditional Chinese medicine preparation.

The invention discloses a veratrine plant source compound bactericide and application thereof. The veratrine plant source compound bactericide is prepared from the following raw materials in percentage by weight: 0.1 to 10 percent of veratrine, 1 to 20 percent of a willow bark extract and the balance of auxiliaries, wherein the veratrine is a total veratrine-containing pure product, a mixture or a veratrum plant extract. The veratrine plant source compound bactericide is microemulsion, water aqua or wettable powder. The bactericide disclosed by the invention does not contain any chemical pesticidal components, easily degrades in an environment, and is safe to human, livestock and the environment; pathogenic bacteria cannot resist the veratrine plant source compound bactericide; meanwhile, the veratrine plant source compound bactericide has the advantages of high stability, high efficiency and low cost. The bactericide can be used for preventing and treating one or more of diseases of crops, such as brown rot, gray mold, soft rot, pear scab, bacterial shot hole, downy mildew, phytophthora root rot, powdery mildew, late blight and dry rot, and also used for preventing and treating other plant diseases.

The invention discloses a traditional Chinese medicine composition for preventing and treating dermatomycoses. The traditional Chinese medicine composition is prepared by using Sichuan pepper and / or zanthoxylum armatum fruits, radix sophorae flavescentis and veratrum nigrum roots as effective pharmaceutical ingredients, and co-formed with pharmaceutically acceptable auxiliary additive ingredients.According to the parts by weight, a proportion of each ingredient of crude drugs of the Sichuan pepper and / or the zanthoxylum armatum fruits to the radix sophorae flavescentis to the veratrum nigrumroots is (0.01 to 1.0) to (1.0 to 5.0) to (0.3-3). The traditional Chinese medicine composition has the remarkable synergistic interaction effect to the prevention and treatment of the dermatomycoses,especially dermatosis caused by dermatophytes, and apparent toxic and side effects are not existent.

The invention provides a veratramine degradation product veratrum fluorene aldehyde 1 and derivatives thereof. The invention uses steroidal alkaloid veratramine (A) as raw material and prepares veratrum fluorene aldehyde by oxidative degradation of m-chloroperoxybenzoic acid to obtain 20 derivative compounds of the veratrum fluorene aldehyde 1 after further oxidation, reduction and condensation reaction. The 20 compounds of the invention have good inhibitory activity on cancer cells, wherein the compounds 1, 2, 5, 8, 13 and 17 have good inhibitory activity on cells of human pancreatic cancer cells BxPC-3 and SW1990, small-cell lung cancer cells NCI-H446, human colorectal cancer LOVO and the like, and the inhibitory activity of the compound veratrum fluorene aldehyde 1 is the most significant.

The invention provides a preparation method of veratrum alkaloid, and belongs to the field of organic chemistry. The preparation method is as follows: the veratrum alkaloid is prepared through a series of steps of leaching, extraction, column chromatography, crystallization, and the like by taking a veratrum medicinal material as a raw material, and the content of the veratrum alkaloid achieves 80%-98%. The preparation process provided by the invention is safe and reasonable; because a heating procedure is not adopted in the preparation process of the veratrum alkaloid, the condition that the veratrum alkaloid is sufficiently extracted and separated is ensured farthest, and the damage of the active components of a product and the generation of a by-product due to a heating condition are reduced, so that the yield and safety of the product are enhanced. The process provided by the invention has the advantages of good stability and repeatability, controllability in quality and very high practicability through the verification of batched industrialized production.

The invention provides an anti-wrinkling and antibacterial cotton fabric finishing agent. The anti-wrinkling and antibacterial cotton fabric finishing agent comprises the following components in partsby weight: 4-16 parts of an ethanol extract of veratrum, 3-12 parts of a 50wt% ethanol water extract of rhizoma anemarrhenae, 2-8 parts of a water extract of paris polyphylla, 5-13 parts of methyl carbamate, 6-12 parts of cyclopentane tetracarboxylic acid, 3-8 parts of furfural resin, 3-9 parts of a penetrant, 3-9 parts of a cross-linking agent, 2-7 parts of a catalyst and 10-20 parts of water. after the anti-wrinkling and antibacterial cotton fabric finishing agent provided by the invention finishes pure cotton fabric, the anti-wrinkling performance of the cotton fabric is greatly improved,propagation of staphylococcus aureus and escherichia coli can be inhibited very well, and the treated fabric has the advantages of a comfortable hand feel, high efficiency, safety and the like.

The invention discloses Hami melon vinegar. The Hami melon vinegar is prepared through the following steps: Hami melon flesh is selected, washed, subjected to enzyme killing and milled with a colloid mill, and pulp is prepared and subjected to enzymolysis with a complex enzyme; then Veratrum root and rhizome, largehead atractylodes rhizome, manchurian wildginger and common anemarrhena rhizome are mixed and ground, distilled water is added, cellulase is added for enzymolysis, and traditional Chinese medicine enzymatic hydrolysate is obtained; the pulp subjected to enzymolysis and the traditional Chinese medicine enzymatic hydrolysate are mixed and sterilized, activated acetic acid bacteria are added, the mixture is fermented in a sealed manner at the temperature of about 30 DEG C for 20 days; the fermented mixture is fed to an ageing tank and subjected to post-maturation ageing for 20-25 days, filtering, filling and sterilization, and a finished product is prepared. The Hami melon vinegar has good taste and has a good treatment effect on mycoplasma pneumonia in children.

The invention discloses a traditional Chinese medicine composition for treating chronic gastroenteritis, which belongs to the field of traditional Chinese medicines. In order to overcome the deficiencies in the prior art, the present invention provides a traditional Chinese medicine composition capable of alleviating inflammation in patients with chronic gastroenteritis, and alleviating the secondary pain and inflammatory reaction caused by it, which is prepared from the following raw materials: Veratrum, Rhizoma Chuanxiong , white peony, citrus aurantium, Atractylodes atractylodes, Angelica, Codonopsis, Gynostemma, Acanthopanax, Salvia, Poria, Rehmannia, Radix Puerariae, Asarum, Mint, Cocklebur, Ligustrum lucidum, Epimedium, Sophora japonica, Cornus officinalis, Woody , Cuscuta, Purslane, Astragalus, Licorice. Pharmacological experiments and clinical experiments have confirmed that it has a significant effect on treating chronic gastroenteritis, so it has broad medical promotion value.

The invention discloses a preparation method of an anticancer health product. The preparation method of the anticancer health product comprises the following step of weighing and obtaining dextrin, maca, ganoderma lucidum, rhus chinensis, raspberry fruits, donkey-hide gelatin, ligusticum chuanxiong, a fructus momordicae extract, Chinese wolfberry fruits, golden cypress, antelope horns, veratrum roots, radix clematidis, bombyx batryticatus and magnesium stearate. The anticancer health product has the effects of activating meridians so as to stop pain, conteracting toxic substances so as to remove stasis, nourishing and tonifying vitality of the spleen and the stomach, benefiting Qi, and promoting hematopoiesis; moreover, the anticancer health product also has the functions of enhancing energy, improve fertility, treating climacteric syndrome, rheumatism and anaemia, dispersing stagnated liver Qi so as to relieve Qi stagnation, clearing away heat, detoxifying, activating the circulation of the blood so as to dissipate blood stasis, resisting cancer and eliminating stagnation, reducing swelling and stopping pain, benefiting Qi, and nourishing the blood. Synergistic effects are produced between the ingredients in the prescription, and thus, the prescription has the effect of resisting cancer, resisting leukemia and so on; moreover, the prescription has obvious curative effects of treating acute myocardial ischemia, dilating blood vessels, lowering blood pressure, resisting bacterial, and resisting tumors. The anticancer health product is free of obvious toxic and side effects, and is free of side effects to the human body after long-term taking; and thus, the anticancer health product can be widely produced and continuously used for replacing existing materials.

The invention discloses a traditional Chinese medicine composition for treating osteoporosis and sciatica, belonging to the technical field of traditional Chinese medicines. It is prepared from the following raw materials in parts by weight: 8-20 parts of Veratrum, 5-15 parts of Rhizoma Chuanxiong, 5-15 parts of Radix Paeoniae Alba, 3-10 parts of Ye Ma Zhui, 10-25 parts of Angelica dahurica, 5-15 parts of Sarcorrhizae, Achyranthes bidentata 10-20 parts, Pearl grass 3-10 parts, Bupleurum 10-20 parts, Salvia miltiorrhiza 5-15 parts, Poria cocos 8-20 parts, Rehmannia glutinosa 5-12 parts, Pueraria 10-20 parts, Asarum 3-10 parts 5-15 parts of mint, 3-10 parts of cocklebur, 3-10 parts of Ligustrum lucidum, 5-12 parts of epimedium, 10-15 parts of medlar, 10-20 parts of dogwood, 3-10 parts of windproof, Cuscuta 5-15 parts, beef bone powder 5-15 parts, astragalus 5-25 parts, licorice 10-20 parts. Pharmacological experiments and clinical experiments have confirmed that it has a significant effect on treating osteoporosis and sciatica, and has broad medical promotion value.

The invention relates to a preparation method of a traditional Chinese medicine composition capable of promoting blood circulation to remove blood stasis, and stopping bleeding and relieving pain. The traditional Chinese medicine composition is prepared from following traditional Chinese medicine bulk drugs: rhizoma paridis, prepared kusnezoff monkshood root, sedum henryi diels, radix psammosilenes, veratrum taliensis Loes.f., Chinese yam, epigeal srephaia root, polygonum runcinatum Buch.-Harn. ex D.Don, rhizoma polygoni paleacei, semen strychni, and datura metel L. seed. The invention also relates to the preparation method and applications of the traditional Chinese medicine composition in clinic. The traditional Chinese medicine composition is reasonable and unique in formula, processing technology, and application; the preparation method is simple; clinical application is wide; and market value is high.

The invention relates to a veratrum album alcohol oligomer stilbene compounds and their preparing process, pharmaceutical compositions containing them, and their use as medicaments, especially as medicaments for treating chronic infectious arthritis, asthma and allergic inflammation.

The invention provides a method for preparing high-purity veratramine and jervine. The method comprises the steps of: crashing crude veratrum drugs, distilling and extracting alcohol, enriching, eluting (desorbing) and concentrating macroporous absorbent resin, then obtaining veratrum steroid alkaloid, conducting column chromatography purification and recrystalization, drying and obtaining the finished product of monomer. The purity of the veratramine and jervine prepared in the method can reach above 90 percent. The method for preparing high-purity veratramine and jervine has simple process and high yield, and is suitable for industrialized production.

The invention discloses a traditional Chinese medicinal composition for treating hypochondriac pain due to damp-heat in liver and gallbladder. The traditional Chinese medicinal composition for treating the hypochondriac pain due to damp-heat in liver and gallbladder is characterized by being prepared from the following medicinal materials in parts by weight: 10 parts of corydalis adunca maxim, 15 parts of swertia mileensis, 8 parts of hippuris vulgaris, 10 parts of field melasma herb, 15 parts of bauhinia seeds, 18 parts of fructus schisandrae, 15 parts of gelsemium elegan, 8 parts of emblic leafflower fruit, 5 parts of liquorice, 4 parts of citrus aurantium, 12 parts of hypericum patulum, 8 parts of semen aesculi, 10 parts of salvia chinensis, 12 parts of thladiantha dubia, 10 parts of sunflower root, 10 parts of amomum xanthioides, 15 parts of panicum repens root, 18 parts of desmodium sinuatum, 8 parts of compound leaf veratrum, 8 parts of tupidanthus calyptratus hook, 12 parts of dill seedlings and 8 parts of emmenopterys henryi. The traditional Chinese medicinal composition disclosed by the invention can be used for effectively treating the hypochondriac pain due to damp-heat in liver and gallbladder, and application on multiple patients over the years shows that effective rate can be 98%, treatment effect is good, and no recurrence is caused after the hypochondriac pain due to damp-heat in liver and gallbladder is healed.

The invention relates to a biological pesticide composition, in particular to a fungus and plant extract pesticide composition. An insecticidal composition containing metarrhizium anisopliae and veratrine is characterized by mainly comprising the metarrhizium anisopliae and the veratrine, wherein the metarrhizium anisopliae and the veratrine are mixed according to the weight ratio being (1-20):(10-2). The metarrhizium anisopliae is metarrhizium anisopliae conidia, and the content is 5-40 billion spores / gram. The veratrine is a pure substance or a mixture containing veratrum total alkali. The insecticidal composition is environmentally friendly, and can expand the insecticidal spectrum of biological pesticides, be higher in insecticidal effect and longer in lasting period, and reduce the use frequency of pesticides.

The present invention discloses an anticancer medicine. It is made up by using 0.3-10 g of veratrum root, 8-20g of dried toad, 10-30g of Chinese catalpa bark and 10-20g of doellingeria scaber through the processes of mixing and decocting. Said invention has the obvious therapeutic effect for preventing and curing cancer of lung, mammary cancer and various malignant tumors.

The invention provides an external use drug for treating climacteric syndrome and further discloses a preparation method of the external use drug. The external use drug for treating the climacteric syndrome is good in therapeutic effect and convenient to take. The technical point is that the external use drug for the treating climacteric syndrome is composed, by weight, of 3%-6% of angelica sinensis, 1%-3% of ligusticum, 1%-3% of ligusticum wallichii, 3%-6% of Chinese yam, 1%-3% of veratrum album, 2%-5% of chasteberry, 3%-6% of soybean, 3%-7% of polyethylene glycol, 1%-3% of twain-80, 1%-3% of potassium hydroxide, 2%-4% of carbomer 2020,1%-3% of hydroxyethylcellulose, 10%-18% of ethanol,1%-3% of jiema bp and 30%-45% of deionized water. The external use drug belongs to the technical field of traditional Chinese medicine preparation.