Method of preparing cyclopamine from jervine

A technology of cyclopamine and mephenamine, which is applied in the field of medicine and can solve problems such as low content, low yield, and harsh reaction conditions
CN101016329AInactive Publication Date: 2007-08-15SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Publication Date
2007-08-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a making method of cyclopamine and application in the medical domain, which comprises the following steps: adopting jervine from Veratrum plant as raw material; reacting jervine and hydrazine hydrate to produce hydrazone in the high-boiling point solvent; denitrifying acted by potassium hydroxide and tert-butanol potassium to form jervine; using carbowax 400 and TEBA as phase transmitting catalyst; connecting tumour cell Hh and Smo protein; dying cancer cell due to non-gene toxicity without influencing normal cell.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method of cyclopamine, in particular to a method for preparing cyclopamine from a plant of the genus Veratrum, and the cyclopamine is used in the treatment of Applications in tumors expressing the Hh signaling pathway, such as pancreatic cancer, medulloblastoma, and small cell lung cancer. Background technique

[0002] The Hedgehog (Hh) signaling pathway was first discovered in Drosophila, and it is a signaling pathway that triggers the development of Drosophila larvae. Further studies have shown that the Hh signaling pathway includes Patched (Ptc) protein, Smoothened (Smo) protein, Ci (Gli) protein, Cos2 protein, Fused kinase, protein SuFu complex, and the target gene. Hh protein is a secreted protein, which obtains activity through its own modification; Patched protein is the receptor of Hh signal protein; Smo protein is the converter of Hh signal. ...

Claims

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