The invention discloses a compound preparation for treating mouth mucosa lichen planus. The compound preparation is prepared from the following raw materials in part by weight: 16 to 28 parts of common lophatherum herb, 16 to 28 parts of largetrifoliolious bugbane rhizome, 16 to 28 parts of toad coat, 16 to 28 parts of golden thread, 16 to 28 parts of multiflora rose root, 16 to 28 parts of caudate sweetleaf, 12 to 25 parts of villous amomum fruit, 12 to 25 parts of trogopterus dung, 12 to 25 parts of costustoot, 12 to 25 parts of Christina loosestrife herb, 12 to 25 parts of hedgehog fungus, 12 to 25 parts of blister beetle, 6 to 18 parts of notoginseng root, 6 to 18 parts of lotus stamen, 6 to 18 parts of eggplant root, 6 to 18 parts of edible bayberry bark, 6 to 18 parts of calculus bovis factitius, 6 to 18 parts of vitamin C, 1 to 12 parts of axillary choerospondias fruit, 1 to 12 parts of saffron, 1 to 12 parts of ginseng flower, 1 to 12 parts of gleditsia seed, 1 to 12 parts of loquat leaf and 1 to 12 parts of water chestnut. According to the compound preparation, the raw materials are compatible with each other to condition viscera, so the compound preparation has the effects of removing necrotic tissue, promoting tissue regeneration and repairing deformed mucosae quickly.