38 results about "Hedgehog" patented technology

1. The name of the designed product: ornament (hedgehog). 2. The use of the designed product: ornament. 3. The design points of the designed product: the combination of shape, pattern and color. 4. The picture or photo that best shows the design points: perspective view 1. 5. The design claimed contains color. 6. The bottom surface of the designed product is a part that is not easy to see or cannot be seen during use, and the top view is omitted.

1. The name of the design product: hedgehog lamp mold. 2. The use of the design product: mold for making hedgehog-shaped lamp. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view 1.

1. The name of the product of this design: Teether (hedgehog). 2. Purpose of the product of this design: a teether used for baby teething and soothing. 3. The design key point of this appearance design product lies in the shape. 4. The picture or photo that best illustrates the design points: Stereoscopic diagram 1.

The present invention relates to a composition, comprising neuropilin-1 (NRP-1) and / or a compound that maintains or upregulates intestinal epithelial NRP-1 protein levels and promotes Hedgehog (Hh) signaling in the intestinal epithelium for use in the prevention or treatment of a disease that is associated with a weakened intestinal barrier. Furthermore, the present invention relates to an in-vitro method for the detection of a weakened intestinal barrier in a mammal, comprising the steps of providing a sample of the intestinal epithelium from a donor mammal, measuring the protein or mRNA levels of epithelial neuropilin-1 (NRP-1) in epithelium cells isolated from said sample and correlating the observed NRP-1 levels with the levels observed in control samples from healthy donors, wherein lower NRP-1 levels in the sample from the donor mammal compared to the control samples indicate the presence or predisposition of a weakened intestinal barrier in said mammal.

1. Name of the designed product: cat toy (hedgehog). 2. Use of the designed product: the designed product is used for cat playing. 3. Design points of the designed product: in shape. 4. Picture or photo best indicating the design points: perspective view.

1. The name of the design product: hook (small hedgehog). 2. The use of the design product: small hedgehog hook. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

1. The name of the product of this design: Night Light (Little Hedgehog). 2. Purpose of this design product: for lighting and decoration. 3. The design key point of this appearance design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the design points: Stereoscopic diagram 1.

1. Name of the designed product: magnetic ball decompression toy (hedgehog). 2. Use of the designed product: for toys. 3. Design points of the designed product: in shape. 4. Picture or photo that best indicates the design points: reference drawing in use.

1. The name of this design product: Comb (Hedgehog). 2. Purpose of this design product: used for combing hair. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The present application relates to the application of imperatorin in the preparation of a drug for inhibiting the Hedgehog signal pathway, and discloses that imperatorin can inhibit the Hedgehog signal pathway activated by Shh, inhibit the Hedgehog signal pathway activity activated by SMO overexpression, and inhibit the Hedgehog signal pathway activity activated by SMO drug-resistant mutation, and can obviously inhibit the growth of tumors in vivo caused by abnormal activation of the Hedgehog, and in particular, it is disclosed that imperatorin can inhibit the Hedgehog signal pathway activity activated by SMO drug-resistant mutation, which provides a new strategy for treating tumors caused by abnormal activation of the Hedgehog, and expands the application field of imperatorin.

Graphic Design - Life After Humans Hedgehog

The application belongs to the field of biomedical signal processing and human-computer interaction, and discloses a muscle-derived signal gesture recognition method and system based on crown porcupine optimization VMD parameters. The method collects electromyography or muscle magnetic signals during gesture action, and constructs a sample set through sliding window segmentation, data balancing processing and standardization. The crown porcupine optimization algorithm (CPO) is used to adaptively optimize the mode number and penalty factor of variational mode decomposition (VMD), and the gesture classification accuracy is used as the fitness function. Global search and local mining are realized through the four-layer defense of vision, sound, odor and physics of CPO. The intrinsic mode function (IMF) under the optimal parameters is extracted and spliced into a multi-dimensional feature matrix, which is input into a classification model to realize gesture recognition. The application directly optimizes the recognition performance, enhances the feature discriminability, and improves the recognition accuracy and robustness of muscle-derived signals in complex scenes.

1. The name of the design product: ironing eyelash pad (hedgehog). 2. The use of the design product: for ironing eyelash pad. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view 1. 5. Other circumstances that need to be explained: A part of the view is transparent material.

1. Name of the designed product: decorative lamp (hedgehog). 2. Use of the designed product: for decoration, lighting. 3. Design points of the designed product: shape, pattern. 4. Picture or photo best showing the design points: perspective view.

1. Name of the product in this design: Toy (Hedgehog Bluetooth Microphone). 2. Intended use of this design: for toys. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

1. The name of this design product: Night Light (Apple Hedgehog). 2. Purpose of this design product: night light. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The application discloses a traffic signal timing optimization method based on an improved crown porcupine algorithm, and the method comprises the following steps: 1) collecting information of a traffic signal intersection; 2) establishing a traffic signal timing optimization model of the intersection; 3) setting a constraint condition of the traffic signal timing optimization model; 4) converting a multi-objective optimization problem of the traffic signal timing optimization model of the intersection into a single-objective optimization problem, and then combining the model constraint to solve the model to obtain a traffic signal timing scheme of the intersection in a current period. The traffic signal timing optimization method uses the improved crown porcupine algorithm to solve a target function, and optimizes a scheme of an optimal solution, and the application can effectively improve the feasibility and excellence of the intersection signal timing scheme.

This item is a hedgehog-shaped ornament housed in a box, and the hedgehog itself can be taken in and out of the box.

Provided is a conformation-specific antigen binding domain (ABD) specific for the Hedgehog receptor Patched1, which may be provided in the form of a nanobody. This nanobody potently activates the Hedgehog pathway in vitro and in vivo by stabilizing an alternative conformation of a Patched1 “switch helix”. This ABD or nanobody is water soluble, i.e. does not require lipid modifications for its activity, facilitating mechanistic studies of Hedgehog pathway activation and therapeutic use.

1. The name of this design product: Ornament (Hedgehog). 2. Purpose of this design product: for decorative ornaments. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

1. The name of the design product: ornament mold (hedgehog reading XC-5384). 2. The use of the design product: mold for making ornaments. 3. The design features of the design product: the combination of shape and pattern. 4. The picture or photo that best indicates the design features: perspective view 1.

1. Name of the product in this design: Packaging Box (Hedgehog). 2. Purpose of this design: For packaging products. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: 3D view 1. 5. Other situations requiring explanation: The lid of the box indicated in section A of the usage status diagram is a transparent design.

1. The name of the design product: small night light (hedgehog). 2. The use of the design product: the design product is used for small night light. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

1. Name of the designed product: Itchy scratch (hedgehog). 2. Use of the designed product: for scratching. 3. Design points of the designed product: in shape. 4. Picture or photo best indicating the design points: perspective view 1.

1. Name of the product in this design: Toy (ziggy - Hedgehog Elf). 2. Purpose of this design: For use in a toy. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

1. Name of the designed product: night lamp (hedgehog). 2. Use of the designed product: the designed product is used for night lamp. 3. Design points of the designed product: combination of shape and pattern. 4. Picture or photo showing the design points: perspective view.

The application provides a pipeline multi-objective optimization method and device based on a lemming-A star nesting, comprising the following steps: defining a data structure to determine all pipeline properties, discretizing a three-dimensional assembly space based on the pipeline properties, and constructing a preference function; generating an initial lemming population through the preference function, performing three-dimensional space pipeline routing on each lemming in the initial lemming population by using a preset A star algorithm to obtain a total pipeline length and a power assembly envelope volume; constructing a fitness function according to the total pipeline length and the power assembly envelope volume, and calculating the fitness value of each lemming through the fitness function; updating the position of each lemming and forming a new lemming population through an improved lemming algorithm according to the fitness value of each lemming, and outputting the position of the new lemming population to obtain a three-dimensional optimal routing path. The application quickly determines an optimal pipeline routing path, and the pipeline routing path has a small space occupation volume, which is beneficial to the arrangement of a power cabin.

1. The name of the product of this design: Toy electronic piano (hedgehog). 2. The purpose of this design product: children playing. 3. The design key point of this appearance design product lies in the shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The present invention relates to a composition, comprising neuropilin-1 (NRP-1) and / or a compound that maintains or upregulates intestinal epithelial NRP-1 protein levels and promotes Hedgehog (Hh) signaling in the intestinal epithelium for use in the prevention or treatment of a disease that is associated with a weakened intestinal barrier. Furthermore, the present invention relates to an in-vitro method for the detection of a weakened intestinal barrier in a mammal, comprising the steps of providing a sample of the intestinal epithelium from a donor mammal, measuring the protein or mRNA levels of epithelial neuropilin-1 (NRP-1) in epithelium cells isolated from said sample and correlating the observed NRP-1 levels with the levels observed in control samples from healthy donors, wherein lower NRP-1 levels in the sample from the donor mammal compared to the control samples indicate the presence or predisposition of a weakened intestinal barrier in said mammal.