6 results about "Hedgehog" patented technology

The present application relates to the application of imperatorin in the preparation of a drug for inhibiting the Hedgehog signal pathway, and discloses that imperatorin can inhibit the Hedgehog signal pathway activated by Shh, inhibit the Hedgehog signal pathway activity activated by SMO overexpression, and inhibit the Hedgehog signal pathway activity activated by SMO drug-resistant mutation, and can obviously inhibit the growth of tumors in vivo caused by abnormal activation of the Hedgehog, and in particular, it is disclosed that imperatorin can inhibit the Hedgehog signal pathway activity activated by SMO drug-resistant mutation, which provides a new strategy for treating tumors caused by abnormal activation of the Hedgehog, and expands the application field of imperatorin.

1. Name of the designed product: decorative lamp (hedgehog). 2. Use of the designed product: for decoration, lighting. 3. Design points of the designed product: shape, pattern. 4. Picture or photo best showing the design points: perspective view.

1. Name of the product in this design: Packaging Box (Hedgehog). 2. Purpose of this design: For packaging products. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: 3D view 1. 5. Other situations requiring explanation: The lid of the box indicated in section A of the usage status diagram is a transparent design.

The application provides a pipeline multi-objective optimization method and device based on a lemming-A star nesting, comprising the following steps: defining a data structure to determine all pipeline properties, discretizing a three-dimensional assembly space based on the pipeline properties, and constructing a preference function; generating an initial lemming population through the preference function, performing three-dimensional space pipeline routing on each lemming in the initial lemming population by using a preset A star algorithm to obtain a total pipeline length and a power assembly envelope volume; constructing a fitness function according to the total pipeline length and the power assembly envelope volume, and calculating the fitness value of each lemming through the fitness function; updating the position of each lemming and forming a new lemming population through an improved lemming algorithm according to the fitness value of each lemming, and outputting the position of the new lemming population to obtain a three-dimensional optimal routing path. The application quickly determines an optimal pipeline routing path, and the pipeline routing path has a small space occupation volume, which is beneficial to the arrangement of a power cabin.

This invention discloses a method and system for correcting structural finite element models based on the Crucian porcupine optimization algorithm, belonging to the field of structural health monitoring technology. It aims to solve the technical problems of slow convergence speed and insufficient accuracy in traditional model correction. The main technical features are: first, acquiring measured modal data of the structure and extracting the calculated modal parameters of the finite element model; second, constructing a weighted objective function that includes the difference between frequency error and modal confidence criteria; finally, using this objective function as a fitness standard, and employing the four defense processes of the Crucian porcupine optimization algorithm to perform global optimization iteration on the model parameters until the convergence condition is met, thus achieving high-precision model parameter updates through intelligent optimization algorithms.

1. Name of the product in this design: Cat Scratching Board (Hedgehog). 2. Purpose of this design: For cats to sharpen their claws and play with. 3. The key design elements of this product are the combination of shape, pattern, and color. 4. The image or photograph that best illustrates the design's key points: 3D view 1. 5. The design for which protection is sought includes color.