389 results about "Signal pathway" patented technology

Systems and methods provide adaptive collection of telemetry by an Information Handling System (IHS). Telemetry is identified that is ready for transmission by the IHS. A position of the telemetry is determined within a telemetry chain of telemetry generated by the IHS. A signaling pathway is selected for transmission of the telemetry based on the position of the telemetry within the telemetry chain.

The invention discloses a bus network configuration reconfiguration device and method, a main control unit, equipment and a medium. The bus network configuration reconfiguration device comprises an upper computer and reconfiguration equipment corresponding to M node equipment and P communication networks, the reconstruction device comprises a main control unit and a bus switching matrix. The bus switching matrix comprises a node switching matrix and a network switching matrix; the node switching matrix is respectively connected with the network switching matrix and the P communication networks; the network switching matrix is also connected with the M node devices; and the main control unit controls the node switching matrix and / or the network switching matrix to realize switching of the node equipment accessed to the communication network and / or the communication network accessed by the node equipment based on the configuration information sent by the upper computer. According to the embodiment of the invention, the method can achieve the automatic reconstruction of the high-speed bus network configuration, achieves the switching of the node equipment and the communication network through the node switching matrix and the network switching matrix, enables each signal path to have no branch wiring, and improves the signal transmission quality.

The invention discloses a novel substituted heterocyclic compound with GSPTs / CK1a double-target degradation activity, and particularly discloses a compound which has the GSPTs / CK1a double-target degradation activity and is shown in a formula (I) or pharmaceutically acceptable salt, solvate, hydrate, isotope substitute or isomer of the compound. The compound can be used for preventing or treating diseases related to GSPTs / MYC / CK1a / WNT targets or signal pathways.

The invention discloses application of a stem cell exosome in treating depression-like behaviors caused by high-altitude hypoxia, and belongs to the technical field of biomedicine. The stem cell exosome is an exosome derived from human umbilical cord mesenchymal stem cells, and is used for drugs for preventing and / or treating depression-like behaviors caused by high-altitude hypoxia. The exosome can effectively improve depression-like core behavior symptoms caused by high-altitude hypoxia by regulating a brain-intestinal axis; the method starts from remodeling intestinal flora so as to influence the intracerebral metabolite spectrum, and finally plays a role in neuroprotection by regulating and controlling a 5-HT6 / cAMP-PKA key signal channel. In addition, the combination of the hUC-MSC-exo and probiotics shows synergistic interaction potential, and a potential treatment strategy which is novel in mechanism, remarkable in effect and high in safety is provided for the field.

The invention discloses a novel substituted heterocyclic compound with GSPTs / CK1a double-target degradation activity, and particularly discloses a compound which has the GSPTs / CK1a double-target degradation activity and is shown in a formula (I) or pharmaceutically acceptable salt, solvate, hydrate, isotope substitute or isomer of the compound. The compound can be used for preventing or treating diseases related to GSPTs / MYC / CK1a / WNT targets or signal pathways.

Systems, methods, and apparatuses disclosed herein can enable a computing system to connect to a network. These systems, methods, and apparatuses can connect the computing system to the network through multiple network connections. These multiple network connections represent distinct, physically separate signal pathways to improve security. This physical separation, or isolation, from one another creates distinct boundaries between these multiple network connections, for example, to minimize shared resources these systems, methods, and apparatuses. These distinct boundaries can reduce the vulnerability of these systems, methods, and apparatuses to, for example, attacks that exploit shared sources among these systems, methods, and apparatuses, data leakage within these systems, methods, and apparatuses, and / or unauthorized access to these systems, methods, and apparatuses. Moreover, these distinct boundaries can additionally enhance security by improving fault isolation, enforcing access control, and / or supporting secure communication protocols, among others, within these systems, methods, and apparatuses.

The invention belongs to the technical field of biological detection, and particularly relates to a composite system for MCP-1 magnetic particle chemiluminescence detection, application and a product. The composite system comprises a coupling buffer solution and a labeling buffer solution, the coupling buffer solution is composed of MES, NaCl, PEG 4000, PVP K30, Tween-20, glycerin and water, and the pH value of the coupling buffer solution is 5.5-6.5; the immunolabeling buffer solution is composed of boric acid, CAPS, NaCl, cane sugar, PEG 6000, Triton X-100 and water, and the pH value of the immunolabeling buffer solution is 9.0-10.0. The sensitivity of the kit containing the composite system can reach 2.31 pg / mL; the linear relation in the concentration range is good; the accuracy is high; the repeatability is high. The method can be used for researching the pathogenesis of the MCP-1 signal channel participating in diseases, screening MCP-1 inhibition drugs and qualitatively and quantitatively detecting the MCP-1.

The invention is applicable to the technical field of biomedicine, and provides a preparation method and application of a multifunctional nano composite material. The material has good biocompatibility and can be used as a safe preparation for tumor treatment; the preparation is simple, green and pollution-free; the application of the quercetin in anti-tumor immunotherapy is expanded; the probe has excellent fluorescence / computed tomography dual-mode imaging performance, and can be used for determining tumor boundaries and realizing accurate treatment guidance; the nano-material has excellent photo-thermal and photo-thermal enhanced catalytic performance, has the advantages of being minimally invasive, efficient, small in toxic and side effect, controllable and the like, and can effectively treat primary, metastatic or recurrent head and neck squamous cell carcinoma by activating immunity; by inducing tumor cells to release 2 '3'-cGAMP and preventing the 2 '3'-cGAMP from being degraded, a cGAS-STING signal channel is efficiently activated, and finally the anti-tumor immune effect is enhanced.

The invention discloses a polyethylene glycol modified gold and manganese dioxide nano particle and a preparation method and application thereof, and belongs to the technical field of biological medicine, the polyethylene glycol modified gold and manganese dioxide nano particle (GMCN and PEG) has good biocompatibility under neutral physiological conditions, can relieve tumor hypoxia and increase generation of active oxygen in acidic TME, and has a good anti-tumor effect. The radiotherapy sensitivity is improved; and immune cell death is induced. Meanwhile, a cGAS-STING signal channel can be activated, dendritic cell maturation, macrophage M1 polarization and T cell infiltration are promoted, and the immunosuppression state in TME is counteracted. In addition, the GMCN-coated PEG also has an MR-CT bimodal imaging enhancement function, and integration of diagnosis and treatment is realized. The nano sensitizer disclosed by the invention has huge potential in the aspects of improving the radiotherapy curative effect, remodeling the tumor microenvironment, promoting the anti-tumor immunity, enhancing the biomedical imaging and the like.

The invention relates to an establishment method and application of in-vitro intestinal inflammation models of mice of different ages, and relates to the technical field of biology. According to the invention, young, adult, middle-aged and old wild type (WT) and TLR4 gene deletion type (TLR4 <- / ->) mice are selected, colon tissues are cultured in vitro, inflammatory response is induced by using interleukin-1beta (IL-1beta) stimulation, an age-related intestinal inflammation model is constructed, the inflammation phenotype of the mouse model and the activity of a TLR4 / MyD88 / NF-kappa B signaling pathway are determined by comparing WT and TLR4 <- / ->, and the age-related intestinal inflammation model is constructed. The core function of the TLR4 in regulating age-dependent intestinal barrier dysfunction is defined, a regulatory network of the TLR4 in intestinal immune aging and flora-host interaction is disclosed, and an age personalized medical strategy is promoted. According to the invention, an efficient and customizable multi-age in-vitro intestinal inflammation model is constructed, and an innovative platform is provided for mechanism analysis and intervention drug screening of TLR4 targeted therapy and age-related intestinal diseases.

In one embodiment, an apparatus performs receiving, via two different signal pathways, at least two different signals that are associated with different radio wave characteristics; changing the frequency of signal(s) to provide intermediate signal(s) with each having different frequencies; multiplexing the intermediate signals to allow signals to be transmitted together via a single wired connection; receiving a multiplexed signal via the single wired connection, the multiplexed signal including intermediate further signals having different frequencies, the intermediate further signals also being associated with differing radio wave characteristics; and separating the intermediate further signals into separate signals; changing the frequency of the further signals to provide further signals at a transmission frequency; and transmitting the further signals via the two signal pathways.

The invention discloses a culture method for improving proliferation and differentiation capacity of NK (Natural Killer) cells based on angelica sinensis-astragalus membranaceus exosomes, which comprises the following steps: firstly extracting exosomes in angelica sinensis and astragalus membranaceus, then adding the exosomes into an NK cell culture system according to a specific concentration, and regulating and controlling an NK cell signal channel by virtue of active ingredients carried by the exosomes so as to improve the proliferation and differentiation capacity of the NK cells. Therefore, the proliferation rate and differentiation maturity of the NK cells are remarkably improved. Experimental results show that compared with a traditional culture method, the proliferation multiple of the NK cells cultured through the method is increased by 28.99%-33.69%, the proportion of differentiated mature cells is increased by 15.91%-28.30%, and the cell killing activity is not remarkably reduced. The method can be widely applied to the field of immune cell treatment, provides a high-quality NK cell source for clinic, effectively solves the problems of slow cell proliferation rate, low differentiation maturity, easy activity reduction after large-scale culture and the like in traditional NK cell in-vitro culture, and has important clinical application value and industrialization prospect.

The invention belongs to the technical field of biological medicine, and particularly relates to application of macrophage LSR gene and / or LSR protein in preparation of drugs and diagnostic products for preventing and / or treating diabetic nephropathy. Research finds that the LSR deletion of macrophages aggravates renal injury by promoting inflammatory response of diabetic nephropathy and increasing lipid renal toxicity; on the contrary, after the LSR expression of the macrophages is recovered, the inflammatory response and lipid droplet deposition of the kidney of the diabetic nephropathy mouse can be effectively reduced, and meanwhile, the kidney injury is improved. Cell experiments show that LSR deletion of macrophages can activate a YAP signal channel to increase secretion of inflammatory factors and reduce low-density lipoprotein uptake at the same time. Therefore, the macrophage LSR can be used as a diabetic nephropathy drug target, a gene therapy target gene and an auxiliary diagnosis marker, and a new theoretical basis and an intervention strategy are provided for prevention and treatment of the disease.

The invention discloses an application of an AMPK (adenosine monophosphate kinase) activator or a PPAR (peroxisome proliferator activated receptor) gamma inhibitor in preparation of a medicine for preventing or treating diabetic osteoporosis. The invention discloses a key effect of a brand new signal channel, namely an AMPK-PPAR gamma-ERS axis, in osteogenic differentiation disorder of diabetes mellitus, and provides a method for preventing and treating diabetic osteoporosis by regulating and controlling the signal axis by taking metformin as a core. The invention provides new guidance for research and development of medicines for treating osteoporosis, and has potential clinical application and mechanism research values.

The invention discloses application of miR-101-3p in preparation of a medicine for treating myocardial fibrosis, and relates to the technical field of medicines. According to the invention, the influence of the miR-101-3p / RAC1 / PAK1 pathway on endothelial cells EndMT is verified by adopting human umbilical vein endothelial cells and utilizing molecular and cell biology means; and constructing an HFrMF mouse model, and verifying the feasibility of intervening the signal channel to alleviate MF. And a thought is provided for clarifying the pathological mechanism of heart failure and exploring a new treatment target.

The application of phlorizin in the medicine for treating and / or preventing lupus nephritis, the molecular formula of phlorizin is C 21 H 24 O 10 , the application promotes the differentiation of regulatory T cells (Treg) by applying phlorizin to up-regulate the PI3K / Akt signal pathway, thereby reducing the symptoms of lupus nephritis, and provides an effective treatment method with less side effects. In the application, the traditional Chinese medicine monomer phlorizin can effectively promote the differentiation of Treg cells, and compared with compound traditional Chinese medicine, the use of single component has more advantages in drug efficacy control and efficacy evaluation. In addition, phlorizin is widely sourced, low in cost and non-toxic, and is very suitable for long-term treatment of lupus nephritis.

The invention discloses an application of isoquercitrin in preparation of a medicine for improving insulin resistance and diabetes-related liver diseases, and belongs to the technical field of medicines. According to the application, a high-glucose and high-fat diet and streptozotocin combined method is adopted to successfully construct a type 2 diabetes mouse model; experiments find that the isoquercitrin can effectively relieve the symptoms of weight loss and water intake increase of T2DM mice, significantly reduce the fasting blood-glucose level and improve abnormal glucose tolerance; the isoquercitrin can reduce the liver index of a T2DM mouse, relieve fatty degeneration of the liver and repair a liver cell structure; by activating a PI3K / AKT signal channel, the isoquercitrin up-regulates the expression levels of PI3K, p-AKT, p-GSK3 and GLUT4 and down-regulates the expressions of GSK3 and PEPCK at the same time, so that the insulin resistance of T2DM mice is effectively improved, the fatty degeneration of the liver is improved, and the isoquercitrin has a protection or repair effect on liver injury.

The invention belongs to the technical field of semiconductor memory packaging, and particularly relates to a memory chip based on two-dimensional material and CMOS circuit 2.5 D integration and a preparation method thereof. According to the chip, a 2.5 D packaging structure is adopted, two-dimensional material ultra-flash memory device core particles and peripheral control circuit core particles prepared by adopting a standard CMOS technology are integrated on an intermediate layer, reliable electric connection is achieved through a metal bump-solder ball interconnection structure, a low-temperature flip-chip technology is adopted in the packaging process, and therefore the reliability of the chip is improved. The design of a multi-layer metal bump laminated structure is matched, and the heat sensitivity and interconnection reliability of the two-dimensional material are considered; and the intermediate layer is further connected with a PCB test board below the intermediate layer to construct signal channels among the core particles and outside the chip. According to the structure, the ultrafast programming / erasing characteristic of the two-dimensional material flash memory and the logic function advantage of the CMOS circuit are fully combined, and a feasible path and technical support are provided for engineering and system-level application of a two-dimensional material ultrafast memory device.

This invention relates to the field of cosmetic compositions, and more specifically to a synergistic anti-aging composition involving energy metabolism and autophagy, its preparation method, and its application. The composition comprises sea buckthorn fruit extract, trehalose, and a cosmetically acceptable polyol carrier. This invention pioneers a betaine-trehalose-NADES extraction system, achieving low-temperature, high-efficiency extraction while preserving the heat-sensitive active ingredients of sea buckthorn. Trehalose possesses both extraction and autophagy activation effects. A selective separation strategy achieves a balance between efficacy, compliance, and process simplicity. The green, circular process reduces costs and is environmentally friendly. Through the synergistic effect of sea buckthorn fruit extract and trehalose, the composition enhances mitochondrial membrane potential, increases ATP production, inhibits excessive activation of the mTOR pathway, and promotes LC3-II conversion, thus synergistically combating skin aging from multiple targets including cellular energy metabolism, signaling pathways, and autophagy.

The invention relates to the technical field of molecular biology and the technical field of gene editing, in particular to pegRNA of a specific target EGFR gene tyrosine 1068 site, a pilot editing system and application. The pegRNA comprises sgRNA (small guide RNA), sgRNA scaffold, an RT (reverse transcription) template and PBS (phosphate buffer solution); wherein the sequence of the pegRNA is as shown in SEQ ID NO. 1; the sequence of the sgRNA is as shown in SEQ ID NO. 2; the sequence of the sgRNA scaffold is as shown in SEQ ID NO. 3; the sequence of the RT template is as shown in SEQ ID NO. 4; the sequence of the PBS is as shown in SEQ ID NO. 5. The tyrosine 1068 site of the EGFR gene is mutated into phenylalanine, so that phosphorylation of the site is blocked, and a protein structure is maintained. The tyrosine 1068 site point mutant with the EGFR gene can be applied to research on preparation of drugs for treating cancers, research on drug resistance and research on screening of compounds of targeted EGFR signal channels.

The invention provides application of AhR in regulation and control of ALDH1A3 and synthesis of retinoic acid. Specifically, the invention provides an application of a reagent in preparation of a product, the reagent is used for regulating and controlling AhR or an AhR signal channel, and the product is used for at least one of the following: regulating and controlling ALDH1A3; regulating and controlling synthesis of retinoic acid; the expression of skin barrier function related genes is regulated and controlled. The inventor provides the application by utilizing the relationship between AhR and ALDH1A3, the relationship between ALDH1A3 and retinoic acid and the relationship between retinoic acid and the skin barrier function, and when an AhR or AhR signal channel is regulated and controlled, the generation of ALDH1A3, retinoic acid synthesis and skin barrier function gene transcription can be regulated and controlled at the same time.

The invention provides application of taurochenodeoxycholic acid in preparation of a medicine for preventing and / or treating Fuchs corneal endothelial dystrophy, and particularly belongs to the technical field of medicine preparation. The invention provides an application of taurochenodeoxycholic acid in preparation of a medicine for preventing and / or treating Fuchs corneal endothelial dystrophy. Test results show that taurochenodeoxycholic acid can realize prevention and / or treatment of corneal endothelial cell injury caused by UVA; the number reduction, activity reduction, oxidative stress, ROS level rise and mitochondrial membrane potential drop of corneal endothelial cells caused by UVA are relieved; mitochondrial biological energy deficiency caused by UVA is relieved; and the prevention and / or treatment of the Fuchs corneal endothelial dystrophy are / is realized by activating a Ca < 2 + > signal channel.

The invention discloses a method for cultivating low-potassium-tolerant rice. The rice OsSPL19 gene is directionally knocked out by using a CRISPER / Cas9 technology, and it is found that a transgenic plant with the OsSPL19 gene knocked out is sensitive to low potassium, the plant is short and small under low potassium treatment, the root is shortened, the potassium ion content of the root and the overground part is obviously reduced, and the potassium ion absorption capacity of the root is obviously reduced. Overexpression of the OsSPL19 gene in rice shows that a plant overexpressed by the OsSPL19 gene is tolerant to low potassium and grows well under a low-potassium condition, the potassium ion content of plant roots and overground parts is obviously increased, and the potassium ion absorption capacity of the roots is obviously enhanced. The result shows that the OsSPL19 gene participates in a rice low-potassium-resistant signal pathway and is a rice low-potassium-resistant gene. According to the invention, guarantee can be provided for improving the low-potassium resistance of the rice and cultivating low-potassium-resistant rice varieties.

The application discloses application of PGD2 in promoting rumen development of young ruminants, and application of PGD2 in young ruminants promotes proliferation and differentiation of rumen wall cells, and further promotes rumen development and improves the digestive and absorptive capacity of the rumen. 2+ It is found that PGD2 can promote rumen development by activating Ca signal pathways, promoting expression of CAMK2A protein, promoting cell cycle progression, promoting rumen development, and ensuring animal health. Therefore, PGD2 can be used for preparing a medicine for promoting rumen development of young ruminants.

The invention discloses an application of a coix seed extract in preparation of a medicine for preventing and treating acute lung injury. The semen coicis extract is obtained by performing reflux extraction on semen coicis by using ethanol, recovering an extraction solvent by using a rotary evaporator and then performing evaporation concentration by using a water bath. The coix seed extract can obviously increase the thymus index, improve the pathological injury of lung tissues, reduce the level of inflammatory factors in serum and lung tissues, possibly inhibit the expression of NLRP3, Caspase-1 and GSDMD-N in NLRP3 signal channel key proteins in the lung tissues, inhibit the NLRP3 signal channel, inhibit inflammation and pyroptosis, and play a role in protecting ALI. The coix seed extract can inhibit the activation of an NLRP3 signal channel and play a role in treating the acute lung injury disease.

The invention belongs to the field of molecular biology, particularly relates to the field of tumor treatment, and particularly relates to application of a TRK inhibitor LYS-8 in preparation of a medicine for treating malignant tumors, particularly pancreatic cancer. LYS-8 is a small molecule TRK inhibitor with a novel structure, and research finds that LYS-8 can significantly inhibit TRK kinase activity and down-regulate downstream PI3K-AKT and other signal channels. Experimental results show that the inhibition effect of LYS-8 in pancreatic cancer cells is obviously superior to that of colorectal cancer cells, and the IC50 value of LYS-8 is lower; in an animal model, the tumor inhibition rate of LYS-8 on pancreatic cancer reaches about 70%, and the inhibition rate on colorectal cancer is about 56%, which is obviously superior to that of a colorectal cancer model. The invention reveals that LYS-8 has an unexpected curative effect advantage on pancreatic cancer, and a new drug choice is provided for targeted therapy of pancreatic cancer.

The invention discloses an application of rhBMP9 in preparation of a medicine for treating idiopathic pulmonary fibrosis related pulmonary arterial hypertension, the rhBMP9 protects pulmonary vascular endothelial cells, inhibits endothelial cell apoptosis and improves pulmonary vascular remodeling by up-regulating BMP9 / BMPR2 / SMAD signal pathways so as to treat IPF-PH, the invention further provides various dosage forms and administration routes of the rhBMP9 medicine, and the rhBMP9 medicine can be used for preparing the medicine for treating the idiopathic pulmonary fibrosis related pulmonary arterial hypertension. According to the application of the rhBMP9 and the drug combination scheme of the rhBMP9 and other IPF treatment drugs, animal experiments show that the rhBMP9 can remarkably improve hemodynamic parameters and lung tissue pathological changes of an IPF-PH model, and a new strategy is provided for clinical treatment of IPF-PH.

The invention discloses an application of indole-3-pyruvic acid in preparation of an NF-kappa B signal channel activator. The research on the influence of the indole-3-pyruvic acid on NF-kappa B signal channels in breast cancer cells and killer T cells (CD8 + T cells, Tc) proves that the indole-3-pyruvic acid can activate the NF-kappa B signal channels in the breast cancer cells and the CD8 + T cells, so that the indole-3-pyruvic acid can be used for preparing the medicine for improving the tumor immunosuppressive microenvironment.

The application belongs to the technical field of molecular biology and medicine, and discloses a methylation marker for detecting the benignity and malignancy of thyroid nodules and an application. 780 new methylation sites are identified, 273 tumor occurrence and development related genes are associated, and the Fc gamma R-mediated phagocytosis signal pathway is involved. The methylation marker for detecting the benignity and malignancy of thyroid nodules comprises multiple genes and multiple methylation sites. The methylation level of multiple genes and multiple sites is detected, the problem of low and unstable methylation signal of single gene or single site is overcome, and thus the sensitivity and specificity of detection are improved.