418 results about "Signal pathway" patented technology

Systems and methods provide adaptive collection of telemetry by an Information Handling System (IHS). Telemetry is identified that is ready for transmission by the IHS. A position of the telemetry is determined within a telemetry chain of telemetry generated by the IHS. A signaling pathway is selected for transmission of the telemetry based on the position of the telemetry within the telemetry chain.

The invention provides a 3D biological printing osteochondral organ based on dynamic mechanical regulation and control, and a construction method and application thereof. Compared with the prior art, the invention innovatively provides a biphasic scaffold optimization modification strategy: firstly, an osteochondral hydrogel scaffold with an accurate layered structure is prepared by adopting a 3D biological printing technology, then a cell mechanical transduction signal channel is activated by a dynamic pressure stimulation system, and cartilage / bone biphasic differentiation of stem cells is directionally regulated and controlled; and by constructing a bionic mechanical microenvironment, the obtained osteochondral organ not only keeps excellent biocompatibility, but also has gradient mechanical properties and a clear spatial layered structure (cartilage layer-bone layer), the directional cartilage formation / osteogenic differentiation efficiency of the osteochondral organ is remarkably improved, and the osteochondral organ has a good application prospect. The problems of spatial heterogeneity construction and accurate regulation and control of cell fate in osteochondral tissue engineering are effectively solved, and the method has important application value in the fields of osteochondral defect repair treatment and mechanical stimulation mechanism research.

The invention discloses a bus network configuration reconfiguration device and method, a main control unit, equipment and a medium. The bus network configuration reconfiguration device comprises an upper computer and reconfiguration equipment corresponding to M node equipment and P communication networks, the reconstruction device comprises a main control unit and a bus switching matrix. The bus switching matrix comprises a node switching matrix and a network switching matrix; the node switching matrix is respectively connected with the network switching matrix and the P communication networks; the network switching matrix is also connected with the M node devices; and the main control unit controls the node switching matrix and / or the network switching matrix to realize switching of the node equipment accessed to the communication network and / or the communication network accessed by the node equipment based on the configuration information sent by the upper computer. According to the embodiment of the invention, the method can achieve the automatic reconstruction of the high-speed bus network configuration, achieves the switching of the node equipment and the communication network through the node switching matrix and the network switching matrix, enables each signal path to have no branch wiring, and improves the signal transmission quality.

The invention discloses a novel substituted heterocyclic compound with GSPTs / CK1a double-target degradation activity, and particularly discloses a compound which has the GSPTs / CK1a double-target degradation activity and is shown in a formula (I) or pharmaceutically acceptable salt, solvate, hydrate, isotope substitute or isomer of the compound. The compound can be used for preventing or treating diseases related to GSPTs / MYC / CK1a / WNT targets or signal pathways.

The invention discloses application of a stem cell exosome in treating depression-like behaviors caused by high-altitude hypoxia, and belongs to the technical field of biomedicine. The stem cell exosome is an exosome derived from human umbilical cord mesenchymal stem cells, and is used for drugs for preventing and / or treating depression-like behaviors caused by high-altitude hypoxia. The exosome can effectively improve depression-like core behavior symptoms caused by high-altitude hypoxia by regulating a brain-intestinal axis; the method starts from remodeling intestinal flora so as to influence the intracerebral metabolite spectrum, and finally plays a role in neuroprotection by regulating and controlling a 5-HT6 / cAMP-PKA key signal channel. In addition, the combination of the hUC-MSC-exo and probiotics shows synergistic interaction potential, and a potential treatment strategy which is novel in mechanism, remarkable in effect and high in safety is provided for the field.

The invention discloses a novel substituted heterocyclic compound with GSPTs / CK1a double-target degradation activity, and particularly discloses a compound which has the GSPTs / CK1a double-target degradation activity and is shown in a formula (I) or pharmaceutically acceptable salt, solvate, hydrate, isotope substitute or isomer of the compound. The compound can be used for preventing or treating diseases related to GSPTs / MYC / CK1a / WNT targets or signal pathways.

Systems, methods, and apparatuses disclosed herein can enable a computing system to connect to a network. These systems, methods, and apparatuses can connect the computing system to the network through multiple network connections. These multiple network connections represent distinct, physically separate signal pathways to improve security. This physical separation, or isolation, from one another creates distinct boundaries between these multiple network connections, for example, to minimize shared resources these systems, methods, and apparatuses. These distinct boundaries can reduce the vulnerability of these systems, methods, and apparatuses to, for example, attacks that exploit shared sources among these systems, methods, and apparatuses, data leakage within these systems, methods, and apparatuses, and / or unauthorized access to these systems, methods, and apparatuses. Moreover, these distinct boundaries can additionally enhance security by improving fault isolation, enforcing access control, and / or supporting secure communication protocols, among others, within these systems, methods, and apparatuses.

The invention belongs to the technical field of biological detection, and particularly relates to a composite system for MCP-1 magnetic particle chemiluminescence detection, application and a product. The composite system comprises a coupling buffer solution and a labeling buffer solution, the coupling buffer solution is composed of MES, NaCl, PEG 4000, PVP K30, Tween-20, glycerin and water, and the pH value of the coupling buffer solution is 5.5-6.5; the immunolabeling buffer solution is composed of boric acid, CAPS, NaCl, cane sugar, PEG 6000, Triton X-100 and water, and the pH value of the immunolabeling buffer solution is 9.0-10.0. The sensitivity of the kit containing the composite system can reach 2.31 pg / mL; the linear relation in the concentration range is good; the accuracy is high; the repeatability is high. The method can be used for researching the pathogenesis of the MCP-1 signal channel participating in diseases, screening MCP-1 inhibition drugs and qualitatively and quantitatively detecting the MCP-1.

The invention is applicable to the technical field of biomedicine, and provides a preparation method and application of a multifunctional nano composite material. The material has good biocompatibility and can be used as a safe preparation for tumor treatment; the preparation is simple, green and pollution-free; the application of the quercetin in anti-tumor immunotherapy is expanded; the probe has excellent fluorescence / computed tomography dual-mode imaging performance, and can be used for determining tumor boundaries and realizing accurate treatment guidance; the nano-material has excellent photo-thermal and photo-thermal enhanced catalytic performance, has the advantages of being minimally invasive, efficient, small in toxic and side effect, controllable and the like, and can effectively treat primary, metastatic or recurrent head and neck squamous cell carcinoma by activating immunity; by inducing tumor cells to release 2 '3'-cGAMP and preventing the 2 '3'-cGAMP from being degraded, a cGAS-STING signal channel is efficiently activated, and finally the anti-tumor immune effect is enhanced.

The invention discloses a polyethylene glycol modified gold and manganese dioxide nano particle and a preparation method and application thereof, and belongs to the technical field of biological medicine, the polyethylene glycol modified gold and manganese dioxide nano particle (GMCN and PEG) has good biocompatibility under neutral physiological conditions, can relieve tumor hypoxia and increase generation of active oxygen in acidic TME, and has a good anti-tumor effect. The radiotherapy sensitivity is improved; and immune cell death is induced. Meanwhile, a cGAS-STING signal channel can be activated, dendritic cell maturation, macrophage M1 polarization and T cell infiltration are promoted, and the immunosuppression state in TME is counteracted. In addition, the GMCN-coated PEG also has an MR-CT bimodal imaging enhancement function, and integration of diagnosis and treatment is realized. The nano sensitizer disclosed by the invention has huge potential in the aspects of improving the radiotherapy curative effect, remodeling the tumor microenvironment, promoting the anti-tumor immunity, enhancing the biomedical imaging and the like.

The invention belongs to the technical field of medicine, and particularly relates to a PI3K gamma inhibitor, a preparation method thereof and application of the PI3K gamma inhibitor in medicine. The invention provides a PI3K gamma inhibitor as shown in a formula (Ia), (IIa), (Ib) or (IIb) as well as a composition and application thereof. The compound can be used for treating or preventing diseases or symptoms related to abnormal expression of a PI3K gamma signaling pathway. # imgabs0 #

The invention relates to an establishment method and application of in-vitro intestinal inflammation models of mice of different ages, and relates to the technical field of biology. According to the invention, young, adult, middle-aged and old wild type (WT) and TLR4 gene deletion type (TLR4 <- / ->) mice are selected, colon tissues are cultured in vitro, inflammatory response is induced by using interleukin-1beta (IL-1beta) stimulation, an age-related intestinal inflammation model is constructed, the inflammation phenotype of the mouse model and the activity of a TLR4 / MyD88 / NF-kappa B signaling pathway are determined by comparing WT and TLR4 <- / ->, and the age-related intestinal inflammation model is constructed. The core function of the TLR4 in regulating age-dependent intestinal barrier dysfunction is defined, a regulatory network of the TLR4 in intestinal immune aging and flora-host interaction is disclosed, and an age personalized medical strategy is promoted. According to the invention, an efficient and customizable multi-age in-vitro intestinal inflammation model is constructed, and an innovative platform is provided for mechanism analysis and intervention drug screening of TLR4 targeted therapy and age-related intestinal diseases.

In one embodiment, an apparatus performs receiving, via two different signal pathways, at least two different signals that are associated with different radio wave characteristics; changing the frequency of signal(s) to provide intermediate signal(s) with each having different frequencies; multiplexing the intermediate signals to allow signals to be transmitted together via a single wired connection; receiving a multiplexed signal via the single wired connection, the multiplexed signal including intermediate further signals having different frequencies, the intermediate further signals also being associated with differing radio wave characteristics; and separating the intermediate further signals into separate signals; changing the frequency of the further signals to provide further signals at a transmission frequency; and transmitting the further signals via the two signal pathways.

The invention discloses a culture method for improving proliferation and differentiation capacity of NK (Natural Killer) cells based on angelica sinensis-astragalus membranaceus exosomes, which comprises the following steps: firstly extracting exosomes in angelica sinensis and astragalus membranaceus, then adding the exosomes into an NK cell culture system according to a specific concentration, and regulating and controlling an NK cell signal channel by virtue of active ingredients carried by the exosomes so as to improve the proliferation and differentiation capacity of the NK cells. Therefore, the proliferation rate and differentiation maturity of the NK cells are remarkably improved. Experimental results show that compared with a traditional culture method, the proliferation multiple of the NK cells cultured through the method is increased by 28.99%-33.69%, the proportion of differentiated mature cells is increased by 15.91%-28.30%, and the cell killing activity is not remarkably reduced. The method can be widely applied to the field of immune cell treatment, provides a high-quality NK cell source for clinic, effectively solves the problems of slow cell proliferation rate, low differentiation maturity, easy activity reduction after large-scale culture and the like in traditional NK cell in-vitro culture, and has important clinical application value and industrialization prospect.

The invention belongs to the technical field of biological medicine, and particularly relates to application of macrophage LSR gene and / or LSR protein in preparation of drugs and diagnostic products for preventing and / or treating diabetic nephropathy. Research finds that the LSR deletion of macrophages aggravates renal injury by promoting inflammatory response of diabetic nephropathy and increasing lipid renal toxicity; on the contrary, after the LSR expression of the macrophages is recovered, the inflammatory response and lipid droplet deposition of the kidney of the diabetic nephropathy mouse can be effectively reduced, and meanwhile, the kidney injury is improved. Cell experiments show that LSR deletion of macrophages can activate a YAP signal channel to increase secretion of inflammatory factors and reduce low-density lipoprotein uptake at the same time. Therefore, the macrophage LSR can be used as a diabetic nephropathy drug target, a gene therapy target gene and an auxiliary diagnosis marker, and a new theoretical basis and an intervention strategy are provided for prevention and treatment of the disease.

To provide: means for enhancing the fungal resistance of polar using genetic engineering means by exploring infections, disease-resistant genes and internal signal pathways related to poplar against S. musiva infection: and means for improving the disease resistance of poplar by exploring the related mechanisms.SOLUTION: A PtMAPK3-1 gene is a poplar MAPK cascade gene family member and plays an important role in stress resistance and a disease resistance process of poplar. According to the invention, it is discovered that through construction of an expression vector and agrobacterium tumefaciens transgenic overexpression MAPK3-1, accumulation of ROS in a poplar body after overexpression PagMAPK3-1 is infected by S.musiva provides nutrition for further infection and reproduction of pathogenic fungi in a plant body, and the PagMAPK3-1 in a K8 poplar plays a negative regulation role in poplar disease resistance reaction. The invention provides a molecular marker for screening disease-resistant poplar varieties, and also provides a regulation and control means for improving the disease resistance of poplar.SELECTED DRAWING: Figure 5

To provide means of suppressing immune checkpoints based on signaling pathways independent of the PD1 pathway, and to provide methods for in silico search for genes belonging to signaling pathways independent of the PD1 pathway.SOLUTION: Provided are an immune checkpoint inhibitor and anticancer drug resistance suppressant, including a kynureninase inhibitor. Also provided are a method for predicting the prognosis of a cancer patient or the sensitivity of a cancer patient to an anticancer drug based on kynureninase activity, and a method for screening genes related to immune checkpoints based on mutual information.SELECTED DRAWING: None

Systems and methods include a remote access controller of an IHS (Information Handling System) that provides remote management of the IHS. The remote access controller initiates an update of firmware used to operate a hardware component of the IHS by transmitting a firmware image to the hardware component via a first signaling pathway connecting the remote access controller to the hardware component. The remote access controller detects a failure in transmission of the firmware image to the hardware component via the first signaling pathway and identifies a second signaling pathway connecting the remote access controller to the hardware component. The remote access controller resumes transmission of the firmware image to the hardware component via the second signaling pathway and the firmware used to operate the hardware component is updated using the transmitted firmware image.

The use of formononetin (FMN) in reducing imiquimod (IMQ)-induced inflammatory cytokine expression by means of inhibiting an interferon (IFN) signaling pathway. The FMN can be used for the prevention and treatment of inflammatory skin diseases and the reduction of disease recurrence in the future. Using animal experiments combined with transcriptomics, it is found that the action of FMN on an IMQ-induced mouse model significantly improves inflammatory skin lesion symptoms, and inhibits pathological phenotypes such as the PASI score and epidermal hyperplasia in mice.

The invention discloses an application of an AMPK (adenosine monophosphate kinase) activator or a PPAR (peroxisome proliferator activated receptor) gamma inhibitor in preparation of a medicine for preventing or treating diabetic osteoporosis. The invention discloses a key effect of a brand new signal channel, namely an AMPK-PPAR gamma-ERS axis, in osteogenic differentiation disorder of diabetes mellitus, and provides a method for preventing and treating diabetic osteoporosis by regulating and controlling the signal axis by taking metformin as a core. The invention provides new guidance for research and development of medicines for treating osteoporosis, and has potential clinical application and mechanism research values.

The invention discloses application of miR-101-3p in preparation of a medicine for treating myocardial fibrosis, and relates to the technical field of medicines. According to the invention, the influence of the miR-101-3p / RAC1 / PAK1 pathway on endothelial cells EndMT is verified by adopting human umbilical vein endothelial cells and utilizing molecular and cell biology means; and constructing an HFrMF mouse model, and verifying the feasibility of intervening the signal channel to alleviate MF. And a thought is provided for clarifying the pathological mechanism of heart failure and exploring a new treatment target.

The application of phlorizin in the medicine for treating and / or preventing lupus nephritis, the molecular formula of phlorizin is C 21 H 24 O 10 , the application promotes the differentiation of regulatory T cells (Treg) by applying phlorizin to up-regulate the PI3K / Akt signal pathway, thereby reducing the symptoms of lupus nephritis, and provides an effective treatment method with less side effects. In the application, the traditional Chinese medicine monomer phlorizin can effectively promote the differentiation of Treg cells, and compared with compound traditional Chinese medicine, the use of single component has more advantages in drug efficacy control and efficacy evaluation. In addition, phlorizin is widely sourced, low in cost and non-toxic, and is very suitable for long-term treatment of lupus nephritis.

The invention relates to the field of traditional Chinese medicine, in particular to a construction method for an individualized traditional Chinese medicine intelligent prescription evaluation model, a medicine evaluation method, a processor and electronic equipment or device. The curative effect of different traditional Chinese medicine combinations on the patient is evaluated by reversing the degree of a peripheral blood mononuclear cell imbalance pathway of the patient through the traditional Chinese medicine combinations. According to the method, the traditional Chinese medicine composition is evaluated in a targeted manner or a personalized intelligent formula is prepared on the basis of the signal path enrichment condition of the peripheral blood mononuclear cells of the patient in the current disease state. According to different disease states of patients, targeted existing traditional Chinese medicine compositions are dynamically screened in real time or new effective prescriptions are intelligently designed. According to the method, a quantification method is adopted, and real-time and dynamic composition and evaluation of the traditional Chinese medicine or the composition are achieved according to the disease state of a patient.

The invention discloses an application of isoquercitrin in preparation of a medicine for improving insulin resistance and diabetes-related liver diseases, and belongs to the technical field of medicines. According to the application, a high-glucose and high-fat diet and streptozotocin combined method is adopted to successfully construct a type 2 diabetes mouse model; experiments find that the isoquercitrin can effectively relieve the symptoms of weight loss and water intake increase of T2DM mice, significantly reduce the fasting blood-glucose level and improve abnormal glucose tolerance; the isoquercitrin can reduce the liver index of a T2DM mouse, relieve fatty degeneration of the liver and repair a liver cell structure; by activating a PI3K / AKT signal channel, the isoquercitrin up-regulates the expression levels of PI3K, p-AKT, p-GSK3 and GLUT4 and down-regulates the expressions of GSK3 and PEPCK at the same time, so that the insulin resistance of T2DM mice is effectively improved, the fatty degeneration of the liver is improved, and the isoquercitrin has a protection or repair effect on liver injury.

The invention belongs to the technical field of semiconductor memory packaging, and particularly relates to a memory chip based on two-dimensional material and CMOS circuit 2.5 D integration and a preparation method thereof. According to the chip, a 2.5 D packaging structure is adopted, two-dimensional material ultra-flash memory device core particles and peripheral control circuit core particles prepared by adopting a standard CMOS technology are integrated on an intermediate layer, reliable electric connection is achieved through a metal bump-solder ball interconnection structure, a low-temperature flip-chip technology is adopted in the packaging process, and therefore the reliability of the chip is improved. The design of a multi-layer metal bump laminated structure is matched, and the heat sensitivity and interconnection reliability of the two-dimensional material are considered; and the intermediate layer is further connected with a PCB test board below the intermediate layer to construct signal channels among the core particles and outside the chip. According to the structure, the ultrafast programming / erasing characteristic of the two-dimensional material flash memory and the logic function advantage of the CMOS circuit are fully combined, and a feasible path and technical support are provided for engineering and system-level application of a two-dimensional material ultrafast memory device.

This invention relates to the field of cosmetic compositions, and more specifically to a synergistic anti-aging composition involving energy metabolism and autophagy, its preparation method, and its application. The composition comprises sea buckthorn fruit extract, trehalose, and a cosmetically acceptable polyol carrier. This invention pioneers a betaine-trehalose-NADES extraction system, achieving low-temperature, high-efficiency extraction while preserving the heat-sensitive active ingredients of sea buckthorn. Trehalose possesses both extraction and autophagy activation effects. A selective separation strategy achieves a balance between efficacy, compliance, and process simplicity. The green, circular process reduces costs and is environmentally friendly. Through the synergistic effect of sea buckthorn fruit extract and trehalose, the composition enhances mitochondrial membrane potential, increases ATP production, inhibits excessive activation of the mTOR pathway, and promotes LC3-II conversion, thus synergistically combating skin aging from multiple targets including cellular energy metabolism, signaling pathways, and autophagy.

The invention relates to the technical field of molecular biology and the technical field of gene editing, in particular to pegRNA of a specific target EGFR gene tyrosine 1068 site, a pilot editing system and application. The pegRNA comprises sgRNA (small guide RNA), sgRNA scaffold, an RT (reverse transcription) template and PBS (phosphate buffer solution); wherein the sequence of the pegRNA is as shown in SEQ ID NO. 1; the sequence of the sgRNA is as shown in SEQ ID NO. 2; the sequence of the sgRNA scaffold is as shown in SEQ ID NO. 3; the sequence of the RT template is as shown in SEQ ID NO. 4; the sequence of the PBS is as shown in SEQ ID NO. 5. The tyrosine 1068 site of the EGFR gene is mutated into phenylalanine, so that phosphorylation of the site is blocked, and a protein structure is maintained. The tyrosine 1068 site point mutant with the EGFR gene can be applied to research on preparation of drugs for treating cancers, research on drug resistance and research on screening of compounds of targeted EGFR signal channels.

The invention provides application of AhR in regulation and control of ALDH1A3 and synthesis of retinoic acid. Specifically, the invention provides an application of a reagent in preparation of a product, the reagent is used for regulating and controlling AhR or an AhR signal channel, and the product is used for at least one of the following: regulating and controlling ALDH1A3; regulating and controlling synthesis of retinoic acid; the expression of skin barrier function related genes is regulated and controlled. The inventor provides the application by utilizing the relationship between AhR and ALDH1A3, the relationship between ALDH1A3 and retinoic acid and the relationship between retinoic acid and the skin barrier function, and when an AhR or AhR signal channel is regulated and controlled, the generation of ALDH1A3, retinoic acid synthesis and skin barrier function gene transcription can be regulated and controlled at the same time.

The invention provides application of taurochenodeoxycholic acid in preparation of a medicine for preventing and / or treating Fuchs corneal endothelial dystrophy, and particularly belongs to the technical field of medicine preparation. The invention provides an application of taurochenodeoxycholic acid in preparation of a medicine for preventing and / or treating Fuchs corneal endothelial dystrophy. Test results show that taurochenodeoxycholic acid can realize prevention and / or treatment of corneal endothelial cell injury caused by UVA; the number reduction, activity reduction, oxidative stress, ROS level rise and mitochondrial membrane potential drop of corneal endothelial cells caused by UVA are relieved; mitochondrial biological energy deficiency caused by UVA is relieved; and the prevention and / or treatment of the Fuchs corneal endothelial dystrophy are / is realized by activating a Ca < 2 + > signal channel.