11 results about "Icariin" patented technology

The application relates to a traditional Chinese medicine material component extraction and separation equipment and method based on shengjing capsules, and belongs to the technical field of medicine material component extraction. The equipment comprises an outer cylinder, the top of the outer cylinder is provided with an annular spray pipe with a spray head, and a mixing assembly and a separation assembly are respectively arranged in the outer cylinder and an upper cylinder; the closed feeding and cavity sealing design ensures the stability of the extraction environment and solvent leakage, and provides a prerequisite guarantee for subsequent high-efficiency mass transfer; on the basis, a driving motor synchronously activates a rotating ring, a disturbance plate and a scraper through multi-stage gear transmission; the disturbance plate implements three-dimensional tumbling and shearing on the materials, breaks the medicine material agglomeration, and promotes uniform penetration of the solvent, and the scraper applies periodic extrusion on the bottom layer materials under the damping elastic support, which not only accelerates cell rupture and release of effective components (such as icariin, ginsenosides, polysaccharides of medlar and the like), but also forms an up-down cooperative mechanical field with the disturbance plate in space, so that the initial dissolution rate is obviously improved.

This invention relates to the field of traditional Chinese medicine extraction technology, specifically disclosing a method for ultrasonic extraction of flavonol glycosides from Epimedium using a eutectic solvent-assisted process. The method involves mixing choline chloride and glycerol, heating to prepare a eutectic solvent; mixing Epimedium leaf powder with a mixture of 70% ethanol and the eutectic solvent; ultrasonic extraction followed by centrifugation and filtration to obtain the Epimedium flavonol glycoside extract. The extraction method provided by this invention is green, efficient, and operates under mild conditions, resulting in good extraction effects. Compared with conventional ethanol ultrasonic extraction, the extracted icariin content is increased by 37.93%, and the total content of the three monomers is increased by 22.99%, providing technical support for the large-scale preparation and further development and utilization of Epimedium flavonol glycosides.

This invention relates to the field of liposome preparation technology, specifically disclosing a liposome co-loaded with icariin and tanshinone B and its preparation method. The liposomes use soybean lecithin and cholesterol as membrane materials, simultaneously encapsulating icariin and tanshinone B, and are prepared using a thin-film hydration-ultrasound method. The liposomes prepared by this invention have an average particle size of 110.49 nm, and the icariin encapsulation efficiency can reach 85.469%. They exhibit relatively uniform particle size distribution, good system stability, and strong controllability of the preparation process. This method can improve the dispersibility and stability of icariin and can serve as a nano-formulation platform for the co-delivery of icariin and tanshinone B.

The application provides a composite fiber scaffold for treating osteoarthritis and promoting tendon-bone healing and a preparation method thereof, and belongs to the technical field of biological medicine. The composite fiber scaffold of the application is a core-shell structure, the shell layer is based on PLGA, and is loaded with platelet exosomes (PLT-Exos) and curcumin; the core is based on gelatin hydrogel, and is loaded with bone morphogenetic protein-2 (BMP-2) and icariin. The scaffold can realize time-controlled release of drugs by coaxial electrospinning technology: the shell layer drug is rapidly released to resist inflammation and regulate the immune microenvironment, and the core drug is slowly released to long-acting promote tendon-bone regeneration. The application is particularly suitable for treating osteoarthritis caused by dislocation of the distal ulno-radiate joint, and can significantly improve the tendon-bone healing quality after ligament reconstruction, and has the advantages of synergistic effect and good biocompatibility.

The application provides a prenyltransferase mutant and application thereof in production of icariin, and belongs to the technical field of bioengineering. The application solves the problem of low icariin yield in the prior art. The prenyltransferase mutant is obtained by mutating any one of the 52th, 131th, 205th and 303th positions of the amino acid shown in SEQ ID NO. 2. The prenyltransferase mutant is mainly used for efficient prenyltransferase and application thereof in synthesis of icariin.

The application discloses a quercetin-eucalyptus oil composition for clearing and protecting lungs, and relates to the technical field of functional food. The composition comprises an active functional component and a three-phase layered targeting delivery system. The active functional component is composed of quercetin 5-20 parts, eucalyptus oil 1-8 parts, bromelain 2-10 parts, dihydromyricetin 10-30 parts, perillaldehyde 1-6 parts, icariin 3-15 parts and ultralow-molecular-weight sodium hyaluronate 1-5 parts in terms of weight fraction. The three-phase layered targeting delivery system comprises three independent embedding units, namely enteric-soluble protective microspheres for wrapping bromelain, nano-mixed micelles for wrapping quercetin, dihydromyricetin and icariin, and slow-release microcapsules for wrapping eucalyptus oil and perillaldehyde. The application solves the problems of component compatibility conflict and component inactivation in traditional compositions by scientifically matching seven active functional components and combining the three-phase layered targeting delivery system, improves the utilization rate of components, can be produced on a large scale, and improves the storage stability of the composition.

This invention discloses a high-pressure synergistic extraction process for the combined active ingredients of mulberry leaf and epimedium, and a process for preparing functional granules. The process includes raw material pretreatment, high-pressure extraction, concentration, compounding, softening, granulation, and drying. Through the scientific combination of mulberry leaf and epimedium, the cold nature of mulberry leaf is neutralized to reduce gastrointestinal irritation, while the precise ratio avoids the risk of excessive heat caused by excessive epimedium intake, achieving a product with "synergistic effects of cold and heat, safe and mild," thus broadening the target population. The high-pressure room-temperature extraction technology shortens the extraction time by more than 80% and reduces energy consumption by 50% compared to traditional solvent extraction, significantly improving production efficiency. Simultaneously, the pure water solvent system is residue-free and pollution-free, ensuring product safety and conforming to green production principles. The flavonoids and DNJ, among other hypoglycemic active ingredients in mulberry leaf, synergistically interact with components such as icariin in epimedium, extending the product's efficacy from single-function hypoglycemia to multi-dimensional health benefits, meeting the diverse health needs of consumers.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to application of a medicine preparation containing icariin in tumor cachexia. The medicine preparation containing icariin comprises first icariin-containing granules, second icariin-containing granules and additional molding accessories. The first icariin-containing granules comprise icariin, a solid dispersion carrier, a lipid solubilization component and a surface active component. The second icariin-containing granules further comprise an intestinal segment release adjusting accessory on the basis of the above components. The first icariin-containing granules and the second icariin-containing granules are combined in a predetermined mass ratio, and are prepared into tablets, capsules, granules or pills. The two types of icariin-containing granules form a release process in which the front release is connected with the rear release, simultaneously reduce the precipitation tendency of icariin in the release medium, improve the consistency of the distribution and release behavior of the active ingredients in the administration unit, and provide a stable preparation basis for oral intervention in tumor cachexia.

This invention discloses a linseed lignan-icariin compound solid beverage for the prevention or adjuvant treatment of osteoporosis and its preparation method, belonging to the field of functional food processing technology. The main active ingredient is a compound extract of linseed lignan and icariin, supplemented with sorbitol, maltodextrin, and β-cyclodextrin. Flaxseed and epimedium are mixed at a specific mass ratio, extracted using subcritical fluid technology, and purified with macroporous resin to obtain the compound extract; then encapsulated with β-cyclodextrin, and finally mixed with excipients and shaped. This method achieves efficient simultaneous extraction and stabilization of the active ingredients, with a simple process, resulting in a product with good solubility, good taste, and high stability. In vitro, this compound solid beverage effectively promotes osteoblast activity, inhibits osteoclast formation, regulates intestinal flora, and increases the production of beneficial metabolites such as short-chain fatty acids, indicating that it can enhance bone density through multiple pathways and can be used in the preparation of products for the prevention or adjuvant treatment of osteoporosis.

The present application relates to a kind of double crosslinking intelligent response hydrogel, the double crosslinking intelligent response hydrogel includes drug-loaded nanoparticles and hydrogel network;The drug-loaded nanoparticles include mesoporous polydopamine, triphenylphosphine and drug, and the drug includes Icaritin;The hydrogel network includes mussel mucin, oxidized dextran and methacrylated silk fibroin.Preparation method includes the following steps: the preparation of mesoporous polydopamine;The preparation of nanoparticle;Nanoparticle drug loading;The preparation of oxidized dextran;The preparation of methacrylated silk fibroin and the preparation of double crosslinking intelligent response hydrogel.The double crosslinking intelligent response hydrogel of the present application can realize kidney cell mitochondria precise targeting, controllable drug release and have fast hemostasis and tissue filling function, and give consideration to the demand of drug intervention iron death and postoperative tissue repair.

The present invention discloses a quercetin-eucalyptus-oil composition for clearing and protecting the lungs, relating to the technical field of functional foods. The composition comprises active functional components and a three-phase layered targeted-delivery system. The active functional components comprise, in parts by weight, 5-20 parts quercetin, 1-8 parts eucalyptus oil, 2-10 parts bromelain, 10-30 parts dihydromyricetin, 1-6 parts perillaldehyde, 3-15 parts icariin, and 1-5 parts ultra-low-molecular-weight sodium hyaluronate. The three-phase layered targeted-delivery system comprises three independent encapsulation units, namely enteric-protective microspheres encapsulating bromelain, nano mixed micelles encapsulating quercetin, dihydromyricetin, and icariin, and sustained-release microcapsules encapsulating eucalyptus oil and perillaldehyde. By scientifically combining the seven active functional components with the three-phase layered targeted-delivery system and by improving the preparation process, the present invention solves the problems of component incompatibility and easy inactivation in conventional compositions, improves ingredient utilization, enables large-scale production, and enhances the storage stability of the composition.