115 results about "Echinacoside" patented technology

The tubiflorous desert cistanche preparation containing phenethyl alcohol glycoside contains echinacoside in 10-70 wt% and acteoside in 1-40 wt%. The preparation of the present invention may be applied as active component for preparing medicine treating and preventing senile dementia and for preparing medicine inhibiting platelet aggregation.

The objective of the invention is to provide a photo-aging prophylactic agent for skin with novel ingredients and foods using the photo-aging prophylactic agent for skin, medicaments for mammals including human beings and a skin external agent, as well as feed for mammals. The inventive photo-aging prophylactic agent for skin is characterized by taking extracts of Orobanchaceae plants as effective ingredients. The photo-aging prophylactic agent for skin preferably comprises phenylethanoid glycosides compounds as effective ingredients. Moreover, the photo-aging prophylactic agent for skin preferably comprises at least one of echinacoside and acteoside as the phenylethanoid glycosides compounds. On top of that, the photo-aging prophylactic agent for skin preferably comprises both echinacoside and acteoside as the phenylethanoid glycosides compounds. In addition, the photo-aging prophylactic agent for skin can be employed as medicaments for mammals including human beings, skin external agents, consumptive foods and feed for mammals.

The body of a herbaceous plant, Cistanche tubulosa (Schenk.) Wight, is used to make a medicinal preparation containing phenylethanoid glycosides and comprising 10–70% of echinacoside by weight of the preparation and 1–40% of acteoside by weight of the preparation. The medicinal preparation is used as an active ingredient of medicinal composition for use in prevention of senile dementia, and inhibition of aggregation of blood platelets.

The invention provides a preparation method of a Cistanche tubulosa extract and a skin-whitening anti-aging cosmetic. The preparation method comprises pulverizing, performing crude extraction, centrifugally collecting the obtained crude extract, standing, eluting, and drying to obtain the Cistanche tubulosa extract. The preparation method is simple, and has no pollution. The extract has the content of echinacoside not lower than 25%, the content of verbascoside not lower than 55%, and the content of total glycosides not lower than 80%. Proven by the antioxidant activity test, the Cistanche tubulosa extract has antioxidant, skin whitening and anti-aging effects. The skin-whitening anti-aging cosmetic is prepared by adding the Cistanche tubulosa extract into a cosmetic, is safe and free of stimulation proven by cytotoxicity and safety test, and also has good skin whitening effect.

The invention provides a method that effectively stops and restrains the active ingredients of desertliving cistanche from serious degrading or losing caused by enzyme catalytic reaction initiated during the processing, drying and production technology processes by adopting an improved drying processing manner of the desertliving cistanche. The method is characterized in that: microwave is used for heating and sterilizing enzyme at high temperature, polar molecules contained in the meat stalk cell of fresh desertliving cistanche that is rich in water are led to make high frequency swing, vibration and friction and extrusion between the molecules by using a microwave high frequency electric field so as to lead the temperature inside the cell of the desertliving cistanche and the surface thereof to raise rapidly, thus generating thermal effect that has the function of enzyme sterilization and decoction pieces of the desertliving cistanche is dried rapidly by adopting microwave drying technology, thus effectively preserving the content of the active ingredients of phenylethanoid glycosides, etc. that is rich in the meat stalk of the fresh desertliving cistanche and greatly promoting the quality and medical value of the prepared decoction pieces of the desertliving cistanche. Upon analysis and determination, the content of the active ingredients of the phenylethanoid glycosides, etc. contained in the prepared decoction pieces, which is in the shapes of filiform, elongated flake or granular, of the desertliving cistanche is rich, the content of the main index ingredients of echinacoside and verbascoside monomeric compounds of the prepared decoction pieces of the desertliving cistanche, which used for weighing the quality thereof, is up to 13-24.1 percent (being calculated based on dry substance) and the water content thereof is 1.2-3.8 percent.

The present invention relates to an extraction and separation method for echinacoside and verbascoside in cistanche. The method comprises the following steps: dicing the cistanche and drying the cistanche; adding 75% ethanol into a multi-functional ultrasonic extraction tank to extract for three times; combining extraction liquid and concentrating the extraction liquid until no ethanol exists; filtering and clarifying the extraction liquid and the concentration liquid of the cistanche by using ultrafiltration equipment; performing absorption on the liquid by using a macroporous resin column; firstly washing the liquid with water until the liquid is colorless, then eluting the liquid by using ethanol with certain concentration; collecting an elution solution that contains the echinacoside and the verbascoside; concentrating the elution solution by using an outer circulating vaccum concentrator; carrying out spray-drying on the concentration liquid to obtain the cistanche extract; and carrying out efficient liquid-phase tracing detection on the cistanche extract, wherein the echinacoside accounts for greater than or equal to 25%, and the verbascoside accounts for greater than or equal to 10%. The total content of phenylethanoid glycosides is greater than or equal to 80%, and the yield is 20%.

The invention provides a system integration technology through cell disruption, slurry extraction, membrane separation and macroporous resin adsorption and chromatography separation and purification, high temperature enzyme deactivation and spray drying and the like, which achieves a technical process that from the time fresh cistanche raw materials are fed until obtaining active matters such as monomeric compounds which are rich in echinacoside and verbascoside and the like in 30 to 80 minutes, and the invention effectively overcomes a technical defect that active components such as benzyl carbinol glycosides compounds are normally seriously degraded and lost, which are caused by an enzymatic reaction which is initiated by an imperfect dry treatment method of cistanche, and the invention obviously improves the medical value of cistanche. In the active maters of cistanche which are obtained ( calculating by dry matter), the productivity of echinacoside monomeric compound reaches to 9.8% to 19.6%, and the yield of verbascoside monomeric compound reaches to 2.0% to 7.5%. The content of echinacoside monomeric compound in active matters of cistanche which are obtained reaches to 15% to 49.6%, and the content of verbascoside monomeric compound reaches to 5% to 26.7%.

The invention provides application of echinacoside or acteoside in preparation of angiogenesis inhibitor medicines. Tests prove that angiogenesis echinacoside and acteoside can be used for effectively inhibiting reproduction of vascular endothelial cells, can be used as angiogenesis inhibitors for treating tumors, diabetic retinopathy, rheumatoid arthritis, prostatic hyperplasia or psoriasis and other angiogenesis dependent diseases and have a wide market prospect.

The invention provides a cistanche deserticola medicinal material processing method including the following steps: 1) impurities in a fresh Cistanche deserticola medicinal material are removed, sediment is rapidly flushed away with water, the fresh Cistanche deserticola medicinal material is cut into thick slices; 2) high temperature enzyme killing process of the thick slices obtained in step 1 is performed for 1 and 15min; 3) after heat treatment the thick slices are lyophilized. Cistanche deserticola decoction pieces processed by the method are white in color, beautiful in appearance and dry in texture, and the content of main effective constituents of echinacoside and verbascoside is 10 times greater than that of a natural drying method.

The invention provides a healthcare product containing cistanche tubulosa extract and a preparation method thereof. The healthcare product contains a cistanche tubulosa extract, a wolfberry extract and auxiliary materials in weight percentage; the cistanche tubulosa extract contains echinacoside as an active ingredient. Fine powders of the screened cistanche tubulosa extract, wolfberry extract and auxiliary materials are mixed uniformly to obtain dispersed healthcare products; the dispersed healthcare products are pressed to obtain tablet cores and then are coated to obtain healthcare tablets. According to the invention, raw materials capable of enhancing immunity and relieving physical fatigue are selected to prepare the healthcare product with functions of enhancing immunity and relieving physical fatigue; the healthcare product is good in stability and plays a role of enhancing the body resistance to diseases and delaying and relieving fatigue, so that the healthcare product raises the health level of people, improves the quality of life and work, and has a certain degree of social and economic benefits. The healthcare product is suitable for people with low immunity and unsuitable for children.

The present invention discloses an echinacea purpurea extract. The echinacea purpurea extract comprises 2.4 to 3.1% of caftaric acid, 4.4 to 5.7% of chicoric acid and 1.5 to 2.0% of echinacoside based on the weight percentages of all ingredients accounting for the dry weight of the extract. The present invention also discloses a preparing method of echinacea purpurea extract and a detection method for phenols ingredient content in echinacea purpurea extract. The phenols ingredient content in the echinacea purpurea extract all meet the requirements of the active ingredient content specification of echinacea purpurea in United State Pharmacopeia 30 (USP 30). The phenols ingredient content is increased by 4 to 6% than that of echinacea purpurea extract sold on market. The preparing method has the advantages of simple technique, low cost, low energy consumption and easy industrialization.

The present invention provides a production method of cynamorlum extract full of active ingredients as echinacoside and veroascose glucoside monomeric compounds with high yield extracted from fresh cynamorlum succulent stem. The production method is implemented through systematic integrated technology of cytoclasis, serous extraction, membrane separation, high-temperature enzyme sterilization, spraying and drying, and other processes, so as to realize the manufacturing process from feeding the fresh cynamorlum to obtaining powdery or granular cynamorlum extract with high yield within 15 to 60 minutes. The present invention effectively inhibits, blocks and overcomes the technical defect of serious degradation and loss of active ingredients of echinacoside and veroascose glucoside monomeric compounds caused by enzyme catalysis reaction of poor drying method of cynamorlum. The major index ingredients of the obtained powdery or granular cynamorlum extract for measuring the cynamorlum quality are echinacoside and veroascose glucoside monomeric compounds, the productive rate of which is up to 15 to 23.4 percent (calculated in dry materials).

The invention relates to a method for separating and preparing echinacoside in herba cistanche. The method comprises the following steps of: dissolving an ethanol extractive of a herba cistanche medicinal material in water; adopting polyamide column chromatography and eluting with water and ethanol; recovering a solvent, decompressing and concentrating; purifying by adopting intermediate-pressure preparative chromatography, wherein a chromatographic column is a C18 column, methanol and 0.5 percent acetic acid aqueous solution are used as an eluant, and the volume ratio of the methanol to the 0.5 percent acetic acid aqueous solution is (1-2.5):(4-1.5); HPLC monitoring; collecting a sample containing the echinacoside and drying by distillation; separating the sample containing the echinacoside by adopting a high speed counter current chromatograph; arranging a solvent system containing n-butyl alcohol, ethylacetate, ethanol and water in a liquid separating funnel; and sufficiently shaking the solvent and then standing still for 12 hours for layering, wherein an upper phase is used as a fixed phase, a lower phase is used as a flowing phase, and the volume ratios of the n-butyl alcohol to the ethylacetate to the ethanol to the water is (1-5):(1-5):(0.2-1):(5-10). The method is used for preparing the echinacoside, and the purity of the prepared echinacoside is higher than 98 percent.

The invention relates to an application of echinacoside in the preparation of drugs for treating Parkinson's disease. The invention discloses that echinacoside has a remarkable protective effect against the MMP+ mediated cell injury. The echinacoside can be used to prepare drugs for the treating Parkinson's disease and offers a new treatment for people with the Parkinson's disease.

The invention belongs to the field of traditional Chinese medicine extraction, and especially relates to a preparation method of high purity cistanche phenyl ethanol glycosides and an application of high purity cistanche phenyl ethanol glycosides in the preparation of drugs for treating pulmonary fibrosis. The preparation method extracts two high purity cistanche phenyl ethanol glycosides from cistanche. The invention specifically discloses a preparation method and applications of high purity cistanche phenyl ethanol glycosides. Three resin columns are used together; Amberlite XAD16HP macroporous resin is used to remove impurities such as sugar; Amberlite FPC22Na (macroporous strongly acidic styrene resin) and D201 (strong alkali I type anion exchange resin) are used to effectively removepigments and components that are not phenyl ethanol glycosides; three resins are screened from a plurality of resins, the extracted cistanche phenyl ethanol glycosides have a light yellow color; the content of total phenyl ethanol glycosides is more than 95% (weight ratio), the content of echinacoside and verbascoside is more than 85% (weight ratio), and the phenyl ethanol extract has a good effect on preventing pulmonary fibrosis.

The invention provides a plateau sunscreen cream containing a natural product--echinacoside. A preparation method for the plateau sunscreen cream comprises the following steps: separately heating oil phase components (including stearic acid, monoglyceride stearate, Vaseline, nanometer zinc oxide and octyl methoxycinnamate) and water phase components (including triethanolamine, glycerin, azone, echinacoside, ethylparaben, vitamin C and deionized water) to 80 DEG C; adding a molten oil phase into a water phase and carrying out stirring at a high speed; cooling a cream body to 40 DEG C and carrying out homogenization and degassing; and continuing slow stirring until the cream body is formed after complete emulsification and condensing the cream body to obtain the plateau sunscreen cream containing echinacoside. The plateau sunscreen cream provided by the invention has good protection effect when applied to treatment or prevention of skin injury caused by high-intensity plateau ultraviolet rays.

The invention provides a new application of echinacoside. Natural micromolecule active compound echinacoside has selective peculiar protection effect on injury of nerve cells, the echinacoside can activate TrkA/B receptors, and the nerve protection effect of the echinacoside can be reversed by restraining the receptors from being activated through Trk receptor specificity inhibitors. Vein medication of the echinacoside can generate obvious nerve protection effect, and simultaneously long-time vein medication causes no obvious liver and renal toxicity.