65 results about "Lanosterol" patented technology

A cosmetic composition, preferably an antiperspirant stick, has a carrier liquid which is almost exclusively silicone oil, structured with lanosterol. Instability is avoided by nearly complete exclusion or complete exclusion of silicon-free organic liquids.

The invention relates to a method for separating and extracting cholesterol in lanolin alcohol, which comprises the following steps: carrying out molecular distillation on lanolin alcohol, collecting the light-phase fraction which is refined lanolin alcohol, heating the refined lanolin alcohol in a mixed solvent of methanol and acetone until the refined lanolin alcohol is completely dissolved, and cooling to cooling temperature, wherein the remainder of the filtrate after reduced pressure distillation is the primary concentrate of cholesterol; heating to dissolve the primary concentrate of cholesterol in acetone, cooling to precipitate, filtering, and carrying out reduced pressure distillation on the filtrate to recover the solvent, wherein the balance is the secondary concentrate of cholesterol; heating to dissolve the secondary concentrate of cholesterol in an alcohol solvent, cooling to cooling temperature, keeping the temperature for 6-12 hours, and vacuum-filtering to obtain the white acerose cholesterol crude product; and recrystallizing the cholesterol crude product through a methanol-acetone mixed solvent to obtain the refined cholesterol product. The refined cholesterol product selectively recrystallizes through the solvent to obtain the byproduct lanosterol accounting for 63-70% and the cholesterol product of which the purity is more than 90%.

The invention discloses multiple-plant-extract lip pomade and a preparation method thereof. The multiple-plant-extract lip pomade contains the following raw materials in parts by weight: 19 parts of olive squalane, 14 parts of diisostearyl alcohol malate, 5 parts of dimeric pentaerythritol tri-polyhydroxyl stearate, 5 parts of jojoba esters, 5 parts of tridecanol trimellitate, 5 parts of caprylate/decanoate triglyceride, 5 parts of meadowfoam seed oil, 5 parts of adansonia digitata tree seed oil, 5 parts of phytosterol oleate, 5 parts of C10-30 acid cholesterol/lanosterol mixed ester, 4 partsof polyethylene, 3 parts of candelilla wax, 3 parts of hydrogenated castor oil dimeric linoleate, 3 parts of polyglycerol-2-tri-isostearate, 2.5 parts of beeswax, 2.5 parts of earth wax, 4 parts of humectant, 2 parts of emollient, 2 parts of prunus avium seed oil, 0.5 part of tocopherol and 0.5 part of antioxidant. The multiple-plant-extract lip pomade has very good repairing, moisture preservingand cheilogramma dispelling actions and can be used for durably nourishing and relaxing skin and keeping lip skin healthy.

The fruit veranal oil extracted from plant fruit kernel is composed of 95-99.9% of triglyceride, 0.01-3% of diglyceride, 0.01-0.5% of monoglyceride, 0.1-1.5 % of sitosterol and 0.01-0.5% of cyclolanosterol. Said invention also provides two extrraction methods, medicine composition containing said invented fruit kernel oil and its application. Said invented fruit kernel oil possesses good quality,high yield and reliable therapeutic effect, and its walnut kernel oil venous emulsion and emulsifier are safe, reliable and reasonable in formula, can supplement nutrient energy for body, resist fatigue, can obviously raise immunological function of human body, and possess a certain action for inhibiting animal transplatation tumor Lewis cancer of lung and mouse liver cancer HAC, and have the functions of supplementing kidney, warming lung and loosening the bowel, etc.

The invention discloses natural moisturizing skin cream for the purpose of solving the problems that traditional skin cream is poor in moisturizing performance, strong in irritation, large in viscosity and short in oil-control time. According to the technical scheme, the natural moisturizing skin cream is prepared from, by mass, 29-34 parts of caprylic/capric triglyceride, 1-5 parts of C10-18 fatty acid triglyceride, 0.7-3.8 parts of natural emulsifying agent, 0.3-2 parts of sucrose laurate, 0.1-1.2 parts of ceramide, 1-5 parts of squalane, 0.1-0.6 part of cholesterol and 0.3-2.2 parts of C10-30 acid cholesterol/lanosterol mixed ester. The natural moisturizing skin cream is free of irritation, high in moisturizing performance, small in viscosity and long in oil-control time.

The invention relates to an anticancer medicine which is a lanosterol derivative. The compound has an anticancer effect, and can inhibit the growths of lung cancer cells, liver cells, mammary gland cells, brain cancer cells, and pancreatic cancer cells. The medicine is a compound with a general formula of (I), (II), (III), or (IV). The invention also provides an application of the compound or pharmaceutically acceptable salt thereof in preparing medicines used for treating cancers. The medicine can be used independently, and can be used in combination. Especially, the medicine can be used in combination with gemcitabine or nexavar. The medicine can be used in treating cancers such as lung cancer, liver cancer, pancreatic cancer, breast cancer, brain cancer, and the like.

The invention discloses a lanosterol compound preparation for eyes, particularly a pharmaceutical composition comprising 5-250mM lanosterol compounds and a preparation method of the pharmaceutical composition, and application of the pharmaceutical composition in the aspects of prevention and treatment of ophthalmic diseases.

The invention discloses dromiceius oil lip care balm and preparation method thereof. The lip care balm is prepared from, by weight, 11 parts of dromiceius oil, 11 parts of olive squalane, 10 parts ofC10-30 acid cholesterol/lanosterol mixed ester, 10 parts of hydrogenated castor oil dimer dilinoleate, 8 parts of avocado oil, 8 parts of polyglyceryl-2 triisostearate, 8 parts of aloe oil, 6 parts ofmeadowfoam seed oil, 5 parts of jojoba esters, 5 parts of isononyl isononanoate, 5 parts of simmondsia chinensis seed oil, 4 parts of polyethylene, 3 parts of candelilla wax, 2.5 parts of ozocerite,2.5 parts of beewax, 0.5 part of tocopherol and 0.5 part of an antioxidant. The lip care balm has the functions of repair, moisture preservation, antisepsis and anti-inflammation, the adopted raw materials are mild, free of irritation, free of pigment and free of side effect and cannot make the lip skin generate adverse effects.

The invention discloses a composition capable of preventing water drops from forming on the surface of lip balm and repairing lip injury. The composition comprises emollient and wax. By moderately regulating the emollient and the wax, water drops can be prevented from forming on the surface of the lip balm during the storage of the lip balm, and lip balm transportation and use are facilitated. The composition has the advantages that the composition mainly adopts natural bee wax and C10-30 acid cholesterol/lanosterol mixed ester, is capable of preventing the water drops from forming on the surface of the lip balm, softening, nourishing and moistening the lips and repairing lip injury, and can eliminate the greasiness of the lip balm; the lips can look moistened and nourished after using the lip balm containing the composition, and the cracked and injured lips due to dryness can be repaired and lip desquamating can be cured when a user uses the lip balm containing the composition for a long time.

The invention discloses moisture neck cream and relates to the technical field of a neck skin care product. The moisture neck cream comprises the following components in percentage: 2 percent of sunflower seed oil, 8 percent of jojoba oil, 8 percent of shea butter, 2 percent of macadamia oil, 2 percent of olive oil, 2 percent of soybean oil, 1 percent of lanosterol mixed ester, 10 percent of collagen, 4 percent of emulsifier, 6 percent of antioxidant, 5 percent of neutralizer, 10 percent of skin care silicon oil, 10 percent of seaweed extract, 10 percent of hyaluronic acid, 5 percent of vitamin A, 10 percent of matrixyl and 5 percent of essence. The moisture neck cream adopts the environmental-friendly components, has small side effects, is suitable for people at any age, has no rebound phenomenon, and has strong practicality.

A method for extracting cholesterol from lanosterol by supercritical CO2 is carried out by putting lanosterol and laminating agent into extractor, delivering CO2 into extractor by compressing pump, adjusting CO2 extractor pressure and temperature, controlling CO2 flow speed, extracting to obtain CO2 with solute, decompressing CO2 with solute, separating to obtain cholesterol and lanosterol, dissolving for cholesterol by solvent, lowering temperature and crystallizing to obtain high-content final product. It's simple and inodorous, has better purity and light color.

The present invention provides a variable color transparent lip balm, consisting of following components by weight percent: 4.0 to 5.0% by weight of dibutyl lauroyl glutamide, 2.0 to 3.0% by weight of polyamide-3, 15.0 to 20.0% by weight of bis-stearyl ethylenediamine/neopentyl glycol/stearyl hydrogenated dimer dilinoleate copolymer, 46.65 to 49.60% by weight of C12-15 alkyl benzoate, 1.0 to 3.0% by weight of heptyl undecylenate, 9.0 to 11.0% by weight of C10-30 cholesterol/lanosterol esters, 10.0 to 15.0% by weight of hydrogenated C6-20 polyolefin, 1.5 to 2.5% by weight of dextrin isostearate, 0.05 to 0.1% by weight of eosin yellowish and 0 to 0.8% by weight of excipient. The transparent lip balm of the present invention has good transparency, and excellent variable color effect.

The present invention relates to a method of producing vicinal diols from a compound, the method characterised by the step of reacting the compound with a moderately strong acid in the presence one or more reagents capable of supplying hydroxyl groups wherein the moderately strong acid is a strongly reducing agent, but has a conjugate base that is a weak nucleophile. In preferred embodiments the moderately strong acid is hypophosphorous acid and the reagent(s) capable of supplying hydroxyl groups is 2-propanol in water, where 2-propanol is water soluable and organic. This method is particularly applicable to the production of vicinal diols of steroids, including lanosterol. Once vicinal diols of lanosterol diols are formed they are then capable of being further reacted to produce high purity lanosterol.

A color-changeable lip protector having a repairing effect is disclosed. The lip protector includes following raw materials: tridecyl trimellitate, triethylhexanoin, diisostearyl malate, cholesterol/lanosterol C10-C30 acid esters, C12-C15 alcohol benzoate, meadowfoam seed oil, shea butter, a thickening agent, hydrogenated polyisobutene, functional active components, an antioxidant and a coloring agent. The functional active components include safflower seed oil, Spilanthes paniculata flower/leaf/stem extract, Astragalus membranaceus extract, ubiquinone and tocopherol. A preparing method of thelip protector is also disclosed. The lip protector has repairing and inflammation diminishing effects, can repair dry lines, dryness, coarseness and other lip problems, and is capable of protecting and nourishing lips, fading lip lines, making lips glossy, and making lips full. The color changes along with pH values, temperature and water contents of lips.

The invention discloses lanolin oil moisturizing cream and a preparation method thereof. The lanolin oil moisturizing cream includes a solvent, a moisturizing agent, a conditioning agent, a skin moistening agent, an anti-oxidizing agent, an emulsifier and a preservative. The solvent is pure water. The moisturizing agent includes glycerin, propylene glycol, aloe vera leaf extract and panthenol. The conditioning agent includes acetylazed C10-40 hydroxyalkyl acid (cholesterol/lanosterol) esters, phytosterols and ceramide 1. The skin moistening agent includes lanolin, shea butter and polydimethylsiloxane. The anti-oxidizing agent includes tocopherol (vitamin E). The emulsifier comprises cetearyl glucoside. The moisturizing cream is finely prepared from the lanosterol so that a more effective moisturizing and repairing effect is achieved. The moisturizing cream can effectively prevent and repair dryness, coarse and chap on skin of babies, and is pure and fine. By means of addition of the phytosterols, the ceramide 1 and the vitamin E and the like natural organic components, the moisturizing cream is high in moisturizing and repairing effects and can improve shield and protection on baby skin.

The invention provides a sunscreen transparent lipstick which is prepared from the following components in percentage by weight: 90.1wt% of first component and 0.9wt% of second component, wherein the first component is a mixture of the following components: a mixture of dibutyl lauroyl glutamine, polyamide-3 and a bis-stearyl ethidene diamine/neopentyl glycol/stearyl alcohol hydrodimerized linoleate copolymer, C12-15 cholesteryl benzoate, heptyl undecylenate, benzophenone-3, ethylhexyl salicylate, homosalate, C10-30 acid cholesterol/lanosterol mixed ester, hydrogenated C6-20 polyolefin and dextrin isostearate; the second component is an auxiliary additive. The lipstick provided by the invention can pass through a three-month stability test, and is clear and transparent in appearance, good in sunscreen effect, high in melting point, good in moistening degree and difficult to break off.

The invention provides compositions and methods for treating neurological disorders, such as amyotrophic lateral sclerosis, frontotemporal degeneration, and Alzheimer's disease, among others. Using the compositions and methods described herein, a patient having a neurological disorder, such as a neurological disorder associated with TAR-DNA binding protein (TDP)-43 aggregation, may be administered an inhibitor of cytochrome P450 (CYP450) isoform 51A1 (CYP51A1), also referred to herein as lanosterol 14-alpha demethylase, so as to treat an underlying etiology of the disorder and/or to alleviate one or more symptoms of the disease. The inhibitor of CYP51A1 may be a small molecule, anti-CYP51A1 antibody or antigen-binding fragment thereof, or a compound, such as an interfering RNA molecule, that attenuates CYP51A1 expression. Patients that may be treated using the compositions and methods described herein include those that express a mutant TDP-43 isoform containing a mutation associated with TDP-43-promoted aggregation and toxicity.

The invention discloses a lip-care composition and a preparation method thereof. The lip-care composition comprises effective components including, by weight, 50-80 parts of C10-30 acid cholesterol/lanosterol mixed ester, 1-40 parts of vegetable oil and 5-25 parts of wax. The preparation method of the lip-care composition includes steps: mixing, to be specific, heating and dissolving wax, adding vegetable oil, mixing, heating to 75-90DEG C, and keeping the temperature for at least 30min to obtain a premix; mixed ester adding, namely adding the C10-30 acid cholesterol/lanosterol mixed ester into the premix, and mixing to obtain the lip-care composition. Due to high content of the C10-30 acid cholesterol/lanosterol mixed ester, the chemical structure of the lip-care composition is similar tothat of skin sebum, high hydrophilicity is realized, a stratum corneum not sticky to human skin is formed on the skin, regulation of skin moisture content and skin barrier function can be realized, and a high value in dry skin care is achieved.

The invention relates to a construction method of an escherichia coli bacterial strain for generating lanosterol. The construction method comprises the steps of optimizing a codon of squalene epoxidase of methylococcus capsulatus according to an escherichia coli codon, and performing PCR amplification to obtain a squalene epoxidase genetic fragment; performing PCR amplification to obtain NADPH-cytochrome P450 reductase, and lanosterol synthetase genetic fragments, performing merging to obtain a DNA fragment SE-CPR-LS, cloning the SE-CPR-LS fragment to a vector pet21c by a restriction enzyme cutting connection method, and constructing an expression vector pet21c-SE-CPR-LS; cloning the squalene synthase genetic fragment to the vector pACYCduet-1 by a homologous recombination method, and constructing an expression vector pACYCduet-SS; and transforming the vectors pet21c-SE-CPR-LS and pACYCduet-SS into escherichia coli competence cells, so as to obtain the escherichia coli bacterial strainfor generating lanosterol. Through an exogenous plasmid transforming method, an escherichia coli BL21(DE3) system is improved, so that synthesis of the lanosterol can be realized; and through a codonoptimization technique, the expression level of exogenous genes in an escherichia coli system can be increased.

The invention discloses an all-in-one eye cream and a preparation method. The eye cream comprises deionized water, cis-butanediol, hydrogenated polyisobutene, dicaprylyl carbonate, isononyl isononanoate, glycerol, polydimethylsiloxane, dimethiconol, mycose, bio-saccharide gum-1, cetearyl alcohol olivate, sorbitan olivate, palmitoyl tripepitde-5, shaddock extract, Equisetum arvense extract, ascorbyl methylsilanol pectinate, methylsilanol hydroxyproline aspartate, dimethylsilanol hyaluronate, cetostearyl alcohol, cetearyl glucoside, C10-30 cholesterol/lanosterol esters, shea butter, Dipalmitoyl Hydroxyproline, sodium acrylate/sodium acryloyldimethyl taurate copolymer, polysorbate-80, isocetane, phenoxyethanol and the like. The eye cream can solve a variety of eye skin problems such as periorbital puffiness, black rim of eye and eye wrinkles.

Disclosed are a lanosterol prodrug compound, a pharmaceutically acceptable salt and an isomer thereof, and a pharmaceutical composition comprising the lanosterol prodrug compound and the use thereof in the preparation of a drug for treating cataracts. The lanosterol prodrug compound has a better permeability than lanosterol.

This disclosure concerns nucleic acid molecules and methods of use thereof for control of pathogens through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in pathogens. The disclosure also concerns methods for applying dsRNA through formulations and/or transgenic plants that express nucleic acid molecules useful for the control of pathogens, and the plant cells and plants obtained thereby.

The invention discloses an engineering strain for biosynthesizing mogrol by taking glucose as a substrate as well as construction and application of the engineering strain, and belongs to the technical field of biology. A chassis yeast engineering bacterium is constructed by enhancing squalene oxidation module expression, improving an MVA metabolic pathway and knocking out a lanosterol competition pathway, heterologous protein cucurbitadienol synthase, epoxide hydrolase and cell P450 enzyme are expressed on the basis of the chassis bacterium, and the yeast engineering bacterium for biosynthesis of mogrol is constructed. According to the method, mogrol can be synthesized from the beginning, the environment is not polluted, the yield is high, the cost is low, and a basis is provided for industrial production of mogrol.The finally produced mogrol reaches 1.2 g/L, which is the highest level reported at present.

The invention relates to a method for separating lanosterol and dihydrolanosterol. The method comprises the following steps: dissolving a lanosterol and dihydrolanosterol mixture crude product in a solvent to prepare a raw material solution; adding a complexing agent into the raw material solution to carry out complexation reaction, and after the reaction is finished, cooling, crystallizing and separating to obtain a complex crystal and a complexation mother solution; decomplexing the complex crystal to obtain a complex crude product, and recrystallizing to obtain a lanosterol pure product; and recrystallizing the complexing mother liquor to obtain a pure product of the dihydrolanosterol. Separation of lanosterol and dihydrolanosterol can be effectively achieved through a complexing crystallization method, and the method has the advantages of being high in separation purity, high in yield, simple in process, low in cost, environmentally friendly and the like.

The invention discloses a lip balm with deep moisturizing effect and a preparation method thereof. The lip balm is prepared from, by mass, 3-10% of C10-30 cholesterol/lanosterol mixed ester, 0.1-0.5%of shea butter extracts, 0.1-2% of oat kernel oil and 0.1-0.5% of a sodium hyaluronate mixture; the sodium hyaluronate mixture is prepared from, by mass, 30% of sodium hyaluronate, 5% of hydrogenatedcastor oil and 65% of castor seed oil. Accordingly, the raw materials are food-grade materials, and by means of the synergistic effect of the ingredients of C10-30 cholesterol/lanosterol mixed ester,sodium hyaluronate mixture, shea butter extracts and oat kernel oil, the skin of the lips can be effectively nourished and moistened for a long time. According to the lip balm, the preparation methodis simple and rapid, and the effective deep moisturizing lip balm can be provided for consumers.