Preparation for improving male erectile function and sperm quality and preparation process

Abstract

The invention discloses a preparation for improving male erectile function and sperm quality. The health-care food is characterized by being prepared from the following raw materials in parts by weight: 30-50 parts of herba epimedii extract, 20-40 parts of herba cistanche extract, 15-30 parts of fructus lycii extract, 18-35 parts of semen cuscutae extract, 10-25 parts of herba cynomorii extract, 8-20 parts of maca powder, 6-18 parts of raspberry extract, 0.5-2 parts of lycopene, 1-3 parts of L-carnitine and 0.3-1 part of vitamin B family (vitamin B1, vitamin B2, vitamin B6 and vitamin B12 are mixed according to the mass ratio of 1: 1: 2: 0.5). The herba epimedii extract is selected as a main component, the content of icariin is regulated to be not lower than 60%, the high-content icariin can more effectively promote sex hormone secretion, enhance sexual desire and improve erectile function, the total content of echinacoside and verbascoside in the herba cistanche extract is not lower than 45%, and the herba epimedii extract and the herba cistanche extract have the effect of promoting sex hormone secretion, enhancing sexual desire and improving erectile function. The two components have the effects of tonifying kidney yang and benefiting essence and blood, and can enhance kidney functions.

Description

Technical Field

[0001] This invention belongs to the field of sperm quality technology, specifically a preparation and preparation process for improving male erectile function and sperm quality. Background Technology

[0002] In modern society, male reproductive health issues are receiving increasing attention. With the fast pace of life, increased work pressure, and the influence of unhealthy lifestyle habits, many men face reproductive health problems such as declining sexual function and poor sperm quality. These problems not only affect men's quality of life but also adversely impact fertility, thereby affecting family happiness and social stability.

[0003] Currently, while some products targeting male reproductive health exist on the market, these products often suffer from issues such as limited ingredients, limited efficacy, or unstable quality. Specifically, some products contain only one or a few limited active ingredients, failing to comprehensively improve male reproductive health. For example, some products primarily focus on improving sexual function while neglecting sperm quality improvement; others focus only on tonifying the kidneys and enhancing virility, ignoring the overall health of the reproductive system. Furthermore, some products have deficiencies in extraction processes and formulations, leading to unstable levels of active ingredients, low bioavailability, or inconvenient administration. Summary of the Invention

[0004] In view of the above situation and to overcome the defects of the prior art, the present invention provides an agent and preparation process for improving male erectile function and sperm quality, so as to at least partially solve the above technical problems.

[0005] The technical solution adopted in this invention is as follows:

[0006] This invention proposes a preparation for improving male erectile function and sperm quality, comprising:

[0007] This preparation is made from the following raw materials in parts by weight: 30-50 parts of Epimedium extract, 20-40 parts of Cistanche deserticola extract, 15-30 parts of Lycium barbarum extract, 18-35 parts of Cuscuta chinensis extract, 10-25 parts of Cynomorium songaricum extract, 8-20 parts of maca powder, 6-18 parts of raspberry extract, 0.5-2 parts of lycopene, 1-3 parts of L-carnitine, and 0.3-1 parts of B vitamins (a mixture of vitamin B1, vitamin B2, vitamin B6, and vitamin B12 in a mass ratio of 1:1:2:0.5).

[0008] In one embodiment of the present invention, the content of icariin in the epimedium extract is not less than 60%, and the epimedium extract is prepared by the following method: take epimedium medicinal material, add 8-12 times the amount of 60%-80% ethanol, reflux extract 2-3 times, 1-2 hours each time, combine the extracts, concentrate under reduced pressure to a relative density of 1.10-1.20 (60℃), then purify by passing through a macroporous adsorption resin column, elute with 30%-50% ethanol, collect the eluent, concentrate under reduced pressure and dry to obtain the extract.

[0009] In one embodiment of the present invention, the total content of echinacoside and verbascoside in the Cistanche deserticola extract is not less than 45%. The preparation method of the Cistanche deserticola extract is as follows: Cistanche deserticola is pulverized into coarse powder, 10-15 times the amount of water is added, and the mixture is soaked for 2-4 hours. Then, it is decocted 2-3 times, each time for 1.5-2.5 hours. The decoctions are combined, filtered, and the filtrate is concentrated to a relative density of 1.15-1.25 (60°C). Ethanol is added to make the alcohol content reach 70%-80%. The mixture is allowed to stand for 12-24 hours, filtered, and the ethanol is recovered from the filtrate. The filtrate is then concentrated and dried to obtain the final product.

[0010] In one embodiment of the present invention, the content of wolfberry polysaccharide in the wolfberry extract is not less than 35%, and the preparation process of the wolfberry extract is as follows: take wolfberries, add 6-10 times the amount of water, use ultrasonic-assisted extraction, the ultrasonic power is 200-400W, the extraction time is 30-60 minutes, extract 2-3 times, combine the extracts, filter, concentrate the filtrate to a relative density of 1.05-1.15 (60℃), then add ethanol to make the alcohol content reach 60%-70%, let stand for 8-16 hours, filter, recover the ethanol from the filtrate, concentrate and dry to obtain wolfberry extract.

[0011] In one embodiment of the present invention, the content of hyperoside in the dodder extract is not less than 25%, and the preparation steps of the dodder extract are as follows: wash the dodder medicinal material, add 8-12 times the amount of 50%-70% ethanol, heat and reflux for 1.5-2.5 hours, extract twice, combine the extracts, concentrate under reduced pressure to a relative density of 1.12-1.22 (60℃), purify using membrane separation technology with a membrane pore size of 0.1-0.5μm, collect the permeate, concentrate and dry to obtain the dodder extract.

[0012] In one embodiment of the present invention, the total flavonoid content in the Cynomorium extract is not less than 30%, and the preparation method of the Cynomorium extract is as follows: take Cynomorium medicinal material, add 10-15 times the amount of water, extract 2-3 times at 80-100℃, each extraction time is 1-2 hours, combine the extracts, filter, concentrate the filtrate to a relative density of 1.18-1.28 (60℃), add ethanol to make the alcohol content reach 75%-85%, let stand for 10-20 hours, filter, recover the ethanol from the filtrate, concentrate and dry to obtain Cynomorium extract.

[0013] In one embodiment of the present invention, the preparation process of the agent for improving male erectile function and sperm quality includes the following steps:

[0014] Step 1: Mix the Epimedium extract, Cistanche deserticola extract, Lycium barbarum extract, Cuscuta chinensis extract, Cynomorium songaricum extract, maca powder, and raspberry extract evenly according to the formula ratio to obtain a mixed powder;

[0015] Step 2: Add lycopene, L-carnitine, and B vitamins to an appropriate amount of cooking oil, stir well, and obtain the oil phase;

[0016] Step 3: Add the mixed powder to the oil phase and stir thoroughly to ensure the raw materials are fully mixed. Then add appropriate excipients, such as microcrystalline cellulose and starch, to make a soft material.

[0017] Step 4: Pelletize the soft material using a granulator, dry it, and granulate it.

[0018] Step 5: Compress the granulated granules into tablets to obtain tablet formulations; or fill them into capsules to obtain capsule formulations.

[0019] The beneficial effects of the technical solution of this invention are as follows:

[0020] This invention selects Epimedium extract as the main component, specifying that the icariin content is no less than 60%. A high content of icariin can more effectively promote sex hormone secretion, enhance libido, and improve erectile function. The total content of echinacoside and verbascoside in Cistanche deserticola extract is no less than 45%. These two components have the effects of tonifying kidney yang and nourishing essence and blood, which can enhance kidney function, improve sperm motility and quality, and improve male reproductive health overall. They work synergistically with Epimedium extract to enhance the overall efficacy of the preparation. The content of Lycium barbarum polysaccharides in Lycium barbarum extract is no less than 35%. Lycium barbarum polysaccharides have various biological activities such as immunomodulation and antioxidation, which can improve the overall condition of the body, provide a good internal environment for the reproductive system, and also help improve sperm count and quality, thus enhancing male reproductive capacity.

[0021] This invention utilizes the fact that the dodder seed extract contains no less than 25% hyperoside, which has antioxidant and anti-inflammatory effects, can protect reproductive cells from damage by harmful free radicals, maintain the normal function of the reproductive system, and improve sperm survival rate and fertilization ability. The cynomorium extract contains no less than 30% total flavonoids, which have the effects of tonifying the kidney and strengthening yang, and regulating endocrine function, thus forming a multi-target and multi-pathway pharmacological mechanism.

[0022] This invention utilizes maca powder, which is rich in various nutrients and can enhance physical strength and improve fertility; raspberry extract, which has the effect of tonifying the kidneys, strengthening sperm, and reducing urination; and the synergistic effect of these two extracts with other extracts to comprehensively improve male reproductive health. Lycopene has a powerful antioxidant effect and can protect reproductive cells from oxidative damage; L-carnitine participates in sperm energy metabolism and improves sperm motility; and B vitamins provide necessary nutritional support for the body's metabolism and maintain the normal physiological function of the reproductive system.

[0023] This invention utilizes ethanol reflux extraction to fully extract the active ingredients from Epimedium, thereby improving extraction efficiency. Purification via macroporous adsorption resin column effectively removes impurities, increases the content of icariin, and ensures the quality and efficacy of the extract. Reduced-pressure concentration and drying processes maximize the preservation of the active ingredients' activity, resulting in higher bioavailability. After coarsely pulverizing the Cistanche deserticola, soaking it in water before decoction facilitates the full dissolution of active ingredients. Adding ethanol to precipitate impurities improves the purity of the extract and ensures the content of echinacoside and verbascoside. Proper control of the concentration and drying processes preserves the activity of the active ingredients, providing high-quality raw materials for formulations.

[0024] This invention employs ultrasonic-assisted extraction, utilizing the cavitation and mechanical effects of ultrasound to accelerate the dissolution of active ingredients, improve extraction efficiency, and shorten extraction time. Adding ethanol to precipitate impurities yields a high-purity Lycium barbarum extract, ensuring the content of Lycium barbarum polysaccharides and maximizing their efficacy in formulations. Ethanol reflux extraction fully extracts hyperoside, the active ingredient from Cuscuta chinensis. Membrane separation technology with a pore size of 0.1-0.5 μm effectively removes large molecular impurities, improving the purity and quality of the extract while avoiding high-temperature damage to the active ingredients, thus preserving the content and activity of hyperoside. Adding ethanol to precipitate impurities further enhances the purity of the extract and ensures the total flavonoid content. The optimized concentration and drying processes retain the activity of the active ingredients, allowing the Cynomorium songaricum extract to exert its optimal medicinal effect in formulations.

[0025] This invention ensures the uniform distribution of various components in the preparation by uniformly mixing various extracts, maca powder, and raspberry extract according to the formula ratio to obtain a mixed powder. This ensures that each tablet (capsule) contains a relatively stable content of active ingredients, guaranteeing the stability of the preparation quality and the consistency of efficacy. Lycopene, L-carnitine, and B vitamins are added to an appropriate amount of edible oil and stirred evenly to obtain the oil phase.

[0026] The mixed powder is added to the oil phase and thoroughly stirred to ensure complete mixing of the raw materials. Then, appropriate excipients such as microcrystalline cellulose and starch are added to form a soft mass. Microcrystalline cellulose and starch, acting as fillers and disintegrants, regulate the properties of the soft mass, giving it good compressibility and formability, while ensuring the disintegration and release properties of the formulation in vivo, thus facilitating the release and absorption of the active ingredient. The soft mass is then granulated using a granulator, dried, and sized. The granulation process improves the flowability and compressibility of the material, resulting in uniform particle size, which facilitates subsequent tableting or capsule filling. The drying process removes moisture from the granules, preventing deterioration of the formulation during storage. The sized granules are then compressed into tablets or filled into capsules. Tablets and capsules offer advantages such as convenient administration, accurate dosage, and stable quality, meeting the needs of different patients. Furthermore, a suitable formulation format also facilitates the release and absorption of the active ingredient in vivo, improving the bioavailability and efficacy of the formulation.

[0027] Additional aspects and advantages of the invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. Attached Figure Description

[0028] The above and / or additional aspects and advantages of the present invention will become apparent and readily understood from the following description of the embodiments taken in conjunction with the accompanying drawings, wherein:

[0029] Figure 1 This is a schematic diagram illustrating the preparation process of the formulation for improving male erectile function and sperm quality proposed in this embodiment of the invention. Detailed Implementation

[0030] Embodiments of the present invention are described in detail below, examples of which are illustrated in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and intended to explain the present invention, and should not be construed as limiting the present invention.

[0031] The following describes, with reference to the accompanying drawings, an embodiment of the present invention, an agent for improving male erectile function and sperm quality, and its preparation process.

[0032] like Figure 1As shown, this embodiment of the invention provides a preparation for improving male erectile function and sperm quality, comprising: the preparation is made from the following raw materials in parts by weight: 30-50 parts of Epimedium extract, 20-40 parts of Cistanche deserticola extract, 15-30 parts of Lycium barbarum extract, 18-35 parts of Cuscuta chinensis extract, 10-25 parts of Cynomorium songaricum extract, 8-20 parts of maca powder, 6-18 parts of raspberry extract, 0.5-2 parts of lycopene, 1-3 parts of L-carnitine, and 0.3-1 parts of B vitamins (a mixture of vitamin B1, vitamin B2, vitamin B6, and vitamin B12 in a mass ratio of 1:1:2:0.5).

[0033] In one possible implementation, the content of icariin in the epimedium extract is not less than 60%. The epimedium extract is prepared by the following method: take epimedium medicinal material, add 8-12 times the amount of 60%-80% ethanol, reflux extract 2-3 times, 1-2 hours each time, combine the extracts, concentrate under reduced pressure to a relative density of 1.10-1.20 (60℃), then purify by passing through a macroporous adsorption resin column, elute with 30%-50% ethanol, collect the eluent, concentrate under reduced pressure and dry to obtain the extract.

[0034] In one possible implementation, the total content of echinacoside and verbascoside in the Cistanche deserticola extract is not less than 45%. The preparation method of Cistanche deserticola extract is as follows: Cistanche deserticola is pulverized into coarse powder, 10-15 times the amount of water is added, and the mixture is soaked for 2-4 hours. Then, it is decocted 2-3 times, each time for 1.5-2.5 hours. The decoctions are combined, filtered, and the filtrate is concentrated to a relative density of 1.15-1.25 (60℃). Ethanol is added to make the alcohol content reach 70%-80%. The mixture is allowed to stand for 12-24 hours, filtered, and the ethanol is recovered from the filtrate. The filtrate is then concentrated and dried to obtain the final product.

[0035] In one possible implementation, the content of wolfberry polysaccharides in the wolfberry extract is not less than 35%, and the preparation process of the wolfberry extract is as follows: take wolfberries, add 6-10 times the amount of water, use ultrasonic-assisted extraction, the ultrasonic power is 200-400W, the extraction time is 30-60 minutes, extract 2-3 times, combine the extracts, filter, concentrate the filtrate to a relative density of 1.05-1.15 (60℃), then add ethanol to make the alcohol content reach 60%-70%, let stand for 8-16 hours, filter, recover the ethanol from the filtrate, concentrate and dry to obtain the wolfberry extract.

[0036] In one possible implementation, the content of hyperoside in the dodder extract is not less than 25%. The preparation steps of the dodder extract are as follows: wash the dodder herb, add 8-12 times the amount of 50%-70% ethanol, heat and reflux for 1.5-2.5 hours, extract twice, combine the extracts, concentrate under reduced pressure to a relative density of 1.12-1.22 (60℃), purify using membrane separation technology with a membrane pore size of 0.1-0.5μm, collect the permeate, concentrate and dry to obtain the dodder extract.

[0037] In one possible implementation, the total flavonoid content in the Cynomorium extract is not less than 30%. The preparation method of the Cynomorium extract is as follows: take Cynomorium medicinal material, add 10-15 times the amount of water, extract 2-3 times at 80-100℃, each extraction time is 1-2 hours, combine the extracts, filter, concentrate the filtrate to a relative density of 1.18-1.28 (60℃), add ethanol to make the alcohol content reach 75%-85%, let stand for 10-20 hours, filter, recover the ethanol from the filtrate, concentrate and dry to obtain the Cynomorium extract.

[0038] In one possible implementation, the preparation process of the agent for improving male erectile function and sperm quality includes the following steps:

[0039] Step 1: Mix the Epimedium extract, Cistanche deserticola extract, Lycium barbarum extract, Cuscuta chinensis extract, Cynomorium songaricum extract, maca powder, and raspberry extract evenly according to the formula ratio to obtain a mixed powder;

[0040] Step 2: Add lycopene, L-carnitine, and B vitamins to an appropriate amount of cooking oil, stir well, and obtain the oil phase;

[0041] Step 3: Add the mixed powder to the oil phase and stir thoroughly to ensure the raw materials are fully mixed. Then add appropriate excipients, such as microcrystalline cellulose and starch, to make a soft material.

[0042] Step 4: Pelletize the soft material using a granulator, dry it, and granulate it.

[0043] Step 5: Compress the granulated granules into tablets to obtain tablet formulations; or fill them into capsules to obtain capsule formulations.

[0044] In specific applications of this invention, the icariin content in the Epimedium extract is not less than 60%. This involves reflux extraction with 8-12 times the volume of 60%-80% ethanol 2-3 times, each time for 1-2 hours. The extracts are combined and concentrated under reduced pressure, then purified using a macroporous adsorption resin column. Elution is performed with 30%-50% ethanol, and the eluent is collected, concentrated under reduced pressure, and dried. Ethanol reflux extraction can fully dissolve the active ingredient icariin in Epimedium. Multiple extractions can improve the extraction rate and ensure the full dissolution of icariin. Reduced pressure concentration reduces the volume of the extract, facilitating subsequent processing. Macroporous adsorption resin column purification utilizes the selective adsorption and elution characteristics of the resin for different components to remove impurities and improve the purity of icariin, thereby ensuring that the icariin content in the extract is not less than 60%, providing an effective ingredient guarantee for the formulation.

[0045] The total content of echinacoside and verbascoside in the extract of Cistanche deserticola is not less than 45%. The preparation method involves pulverizing Cistanche deserticola into coarse powder, soaking it in 10-15 times its volume of water for 2-4 hours, then decocting it 2-3 times, each time for 1.5-2.5 hours. The decoctions are combined, filtered, and concentrated to a relative density of 1.15-1.25 (60℃). Ethanol is added to achieve an alcohol content of 70%-80%, and the mixture is allowed to stand for 12-24 hours. The decoction is then filtered, the ethanol is recovered from the filtrate, and the solution is concentrated and dried. Water decoction is a traditional Chinese medicine extraction method that allows the effective components of Cistanche deserticola, such as echinacoside and verbascoside, to fully dissolve in water. Multiple decoctions can improve extraction efficiency. After filtration to remove impurities, concentrating the extract increases the concentration of effective components. Adding ethanol to achieve a certain alcohol content utilizes the difference in solubility of different components in ethanol to precipitate some impurities, further purifying the extract and ensuring that the total content of echinacoside and verbascoside is not less than 45%.

[0046] The content of Lycium barbarum polysaccharides in the Lycium barbarum extract is not less than 35%. The preparation process involves taking Lycium barbarum, adding 6-10 times the amount of water, and using ultrasonic-assisted extraction with an ultrasonic power of 200-400W for 30-60 minutes. Extraction is repeated 2-3 times. The extracts are combined, filtered, and the filtrate is concentrated to a relative density of 1.05-1.15 (60℃). Then, ethanol is added to achieve an alcohol content of 60%-70%. The mixture is allowed to stand for 8-16 hours, filtered, and the ethanol is recovered from the filtrate. The extract is then concentrated and dried to obtain the Lycium barbarum extract. Ultrasonic-assisted extraction utilizes the cavitation, mechanical, and thermal effects of ultrasound to accelerate the release and dissolution of the effective component, Lycium barbarum polysaccharides, within the Lycium barbarum cells, thus improving extraction efficiency. Compared to traditional water extraction, a higher extraction rate can be obtained in a shorter time, and multiple extractions ensure the full dissolution of Lycium barbarum polysaccharides. Subsequent concentration and alcohol precipitation steps are similar to those for Cistanche deserticola extract. Impurities are precipitated with ethanol to improve the purity of Lycium barbarum polysaccharides, ensuring a content of not less than 35%.

[0047] The content of hyperoside in the dodder seed extract is not less than 25%. The preparation steps are as follows: wash the dodder seed material, add 8-12 times the amount of 50%-70% ethanol, heat and reflux for 1.5-2.5 hours, extract twice, combine the extracts, concentrate under reduced pressure to a relative density of 1.12-1.22 (60℃), purify using membrane separation technology with a membrane pore size of 0.1-0.5μm, collect the permeate, concentrate and dry to obtain the dodder seed extract.

[0048] Ethanol reflux extraction is suitable for extracting hyperoside from Cuscuta chinensis. Appropriate ethanol concentration and extraction time ensure the full dissolution of the active ingredient. Reduced pressure concentration removes some solvent, increasing the extract concentration. Membrane separation technology utilizes the selective permeability of membranes to separate the active ingredient from impurities based on differences in molecular size and shape. Membrane pore sizes of 0.1-0.5 μm effectively remove large molecular impurities, improving the purity of hyperoside and ensuring its content is not less than 25%.

[0049] The total flavonoid content in the Cynomorium songaricum extract is no less than 30%. The preparation method involves taking Cynomorium songaricum, adding 10-15 times the amount of water, and extracting 2-3 times at 80-100℃, each extraction lasting 1-2 hours. The extracts are combined, filtered, and the filtrate is concentrated to a relative density of 1.18-1.28 (60℃). Ethanol is added to achieve an alcohol content of 75%-85%, and the mixture is allowed to stand for 10-20 hours. After filtration, the ethanol is recovered from the filtrate, and the extract is concentrated and dried to obtain the Cynomorium songaricum extract. Water extraction at higher temperatures (80-100℃) better dissolves the total flavonoid active ingredients in Cynomorium songaricum. Multiple extractions can increase the extraction rate. After filtration to remove impurities, the extract is concentrated to increase its concentration. Adding ethanol to achieve a certain alcohol content allows some impurities to precipitate, improving the purity of the total flavonoids and ensuring a content of no less than 30%.

[0050] Epimedium extract, Cistanche deserticola extract, Lycium barbarum extract, Cuscuta chinensis extract, Cynomorium songaricum extract, maca powder, and raspberry extract were mixed evenly according to the formula ratio to obtain a mixed powder. Each extract and raw material was accurately weighed according to the formula ratio and thoroughly mixed to ensure uniform dispersion of all components, providing a homogeneous raw material base for subsequent formulation preparation and ensuring that the content of each component in each tablet or capsule meets the requirements.

[0051] Lycopene, L-carnitine, and B vitamins were added to an appropriate amount of edible oil and stirred until homogeneous to obtain the oil phase. Lycopene, L-carnitine, and B vitamins have good solubility in edible oil. Adding them to the edible oil and stirring ensures that these components are evenly dispersed in the oil phase, facilitating subsequent mixing with the powder and improving the stability and bioavailability of the formulation.

[0052] The mixed powder is added to the oil phase and stirred thoroughly to ensure complete mixing of the raw materials. Then, appropriate excipients, such as microcrystalline cellulose and starch, are added to form a soft material. Alternatively, the mixed powder is added to the oil phase and stirred thoroughly to ensure full contact and mixing of the components in the oil phase with the mixed powder, forming a homogeneous mixture. Microcrystalline cellulose and starch excipients are then added. These excipients possess good filling, binding, and disintegration properties, and can adjust the hardness and plasticity of the soft material to make it suitable for subsequent granulation processes.

[0053] The soft material is granulated into granules using a granulator, then dried and sized. The granulator can produce granules of uniform size from the soft material, improving the flowability and uniformity of the formulation. The drying process removes moisture from the granules, preventing the formulation from deteriorating during storage. Sizing further ensures that the granules are more uniform in size, removing excessively large or small granules and guaranteeing the quality of the formulation.

[0054] The granules are either compressed into tablets or filled into capsules. Compressing involves pressing the granules under pressure to form tablets with a specific shape and hardness, making them easy to take and store. Filling capsules involves encapsulating the granules in a shell, which protects the drug components, masks unpleasant odors, and provides convenient administration. Both dosage forms can be chosen based on specific needs and can effectively improve male sexual function and sperm quality.

[0055] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0056] The present invention and its embodiments have been described above. This description is not restrictive, and the accompanying drawings are only one embodiment of the present invention; the actual structure is not limited thereto. In conclusion, if those skilled in the art are inspired by this description and design similar structures and embodiments without departing from the spirit of the invention, such designs should fall within the protection scope of the present invention.

Claims

1. A preparation for improving male erectile function and sperm quality, characterized in that, include: This preparation is made from the following raw materials in parts by weight: 30-50 parts of Epimedium extract, 20-40 parts of Cistanche deserticola extract, 15-30 parts of Lycium barbarum extract, 18-35 parts of Cuscuta chinensis extract, 10-25 parts of Cynomorium songaricum extract, 8-20 parts of maca powder, 6-18 parts of raspberry extract, 0.5-2 parts of lycopene, 1-3 parts of L-carnitine, and 0.3-1 parts of B vitamins (a mixture of vitamin B1, vitamin B2, vitamin B6, and vitamin B12 in a mass ratio of 1:1:2:0.5).

2. The preparation for improving male erectile function and sperm quality according to claim 1, characterized in that, The content of icariin in the epimedium extract is not less than 60%. The epimedium extract is prepared by the following method: take epimedium medicinal material, add 8-12 times the amount of 60%-80% ethanol, reflux extract 2-3 times, 1-2 hours each time, combine the extracts, concentrate under reduced pressure to a relative density of 1.10-1.20 (60℃), then purify by passing through a macroporous adsorption resin column, elute with 30%-50% ethanol, collect the eluent, concentrate under reduced pressure and dry to obtain the extract.

3. The preparation for improving male erectile function and sperm quality according to claim 1, characterized in that, The total content of echinacoside and verbascoside in the Cistanche deserticola extract is not less than 45%. The preparation method of the Cistanche deserticola extract is as follows: Cistanche deserticola is pulverized into coarse powder, 10-15 times the amount of water is added, and the mixture is soaked for 2-4 hours. Then, it is decocted 2-3 times, each time for 1.5-2.5 hours. The decoctions are combined, filtered, and the filtrate is concentrated to a relative density of 1.15-1.25 (60℃). Ethanol is added to make the alcohol content reach 70%-80%. The mixture is allowed to stand for 12-24 hours, filtered, and the ethanol is recovered from the filtrate. The filtrate is then concentrated and dried to obtain the final product.

4. The preparation for improving male erectile function and sperm quality according to claim 1, characterized in that, The content of wolfberry polysaccharides in the wolfberry extract is not less than 35%. The preparation process of the wolfberry extract is as follows: take wolfberries, add 6-10 times the amount of water, use ultrasonic-assisted extraction, ultrasonic power is 200-400W, extraction time is 30-60 minutes, extract 2-3 times, combine the extracts, filter, concentrate the filtrate to a relative density of 1.05-1.15 (60℃), then add ethanol to make the alcohol content reach 60%-70%, let stand for 8-16 hours, filter, recover ethanol from the filtrate, concentrate and dry to obtain wolfberry extract.

5. The preparation for improving male erectile function and sperm quality according to claim 1, characterized in that, The dodder extract contains no less than 25% hyperoside. The preparation steps of the dodder extract are as follows: wash the dodder herb, add 8-12 times the amount of 50%-70% ethanol, heat and reflux for 1.5-2.5 hours, extract twice, combine the extracts, concentrate under reduced pressure to a relative density of 1.12-1.22 (60℃), purify using membrane separation technology with a membrane pore size of 0.1-0.5μm, collect the permeate, concentrate and dry to obtain the dodder extract.

6. The preparation for improving male erectile function and sperm quality according to claim 1, characterized in that, The total flavonoid content in the Cynomorium extract is not less than 30%. The preparation method of the Cynomorium extract is as follows: take Cynomorium medicinal material, add 10-15 times the amount of water, extract 2-3 times at 80-100℃, each extraction time is 1-2 hours, combine the extracts, filter, concentrate the filtrate to a relative density of 1.18-1.28 (60℃), add ethanol to make the alcohol content reach 75%-85%, let stand for 10-20 hours, filter, recover the ethanol from the filtrate, concentrate and dry to obtain Cynomorium extract.

7. A preparation process for an agent for improving male erectile function and sperm quality according to any one of claims 1-6, characterized in that, Includes the following steps: Step 1: Mix the Epimedium extract, Cistanche deserticola extract, Lycium barbarum extract, Cuscuta chinensis extract, Cynomorium songaricum extract, maca powder, and raspberry extract evenly according to the formula ratio to obtain a mixed powder; Step 2: Add lycopene, L-carnitine, and B vitamins to an appropriate amount of cooking oil, stir well, and obtain the oil phase; Step 3: Add the mixed powder to the oil phase and stir thoroughly to ensure the raw materials are fully mixed. Then add appropriate excipients, such as microcrystalline cellulose and starch, to make a soft material. Step 4: Pelletize the soft material using a granulator, dry it, and granulate it. Step 5: Compress the granulated granules into tablets to obtain tablet formulations; or fill them into capsules to obtain capsule formulations.

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