The invention provides a method for detecting coumarin series compounds, which comprises the following steps that: ultra high-efficiency liquid chromatography and tandem mass spectrometry detection are carried out to a sample, so as to determine the types and the content of coumarin series compounds contained in the sample. The coumarin series compounds comprise one or more types in vinegar Glass coumarin, dicoumarol, 6-methoxy-7-hydroxy coumarin, 7-hydroxycoumarin, 8-hydroxy-psoralen, 4-methyl-7-hydroxy coumarin, 6,7-dimethoxy coumarin, coumarin, 7-methoxy coumarin, dihydro coumarin, psoralen, psoralen, 8-methoxypsoralen, 7-methyl, 5-methoxypsoralen, 4-methyl-7-ethoxyl coumarin, 4-methyl-7-diethylamino coumarin, 2', 4,8-trimethyl psoralen, imperatorin, isoimperatorin, columbianadin and cyclocoumarol. The method of the invention can complete the analysis and the detection of 22 coumarin series compounds within 4 min.