The invention relates to the technical field of marine gas hydrate resource development engineering, in particular to an indoor experimental device and method for evaluating the mutual coupling relationship between the shakeout process and mechanical parameters of hydrate-containing loose sediments. The device comprises a high-pressure reaction kettle, a thermostatic control system, a triaxial pressurizing system, a confining pressure control system, a pore pressure injection system and a shakeout parameter test system, wherein the confining pressure control system, the pore pressure injection system and the triaxial pressurizing system are connected with the high-pressure reaction kettle; and the shakeout parameter test system is connected with the outlet end of the high-pressure reaction kettle. Through measurement of the mutual coupling relationship between shakeout parameters, such as the shakeout amount, the shakeout grain size and the shakeout speed of the hydrate sediments, under the actual temperature, pressure and stress conditions, and triaxial mechanical parameters, such as the stress-strain curve, the shear strength, the Yong modulus and the cohesion, a support is provided for forecasting the related relationship between the shakeout parameters and the mechanical parameters of a hydrate-containing reservoir, and a new concept is provided for probing into the shakeout mechanism of the natural gas hydrate reservoir.