2results about How to "Antagonistic" patented technology

This invention discloses a biomimetic nanozyme and its application in the preparation of tumor therapeutic drugs, belonging to the field of pharmaceutical technology. The biomimetic nanozyme of this invention comprises a shell and a core encapsulated within the shell. The shell is a T cell membrane, and the core is a manganese oxide nanozyme with an average Mn valence state of +3 to +4. This invention uses manganese oxide nanozyme, which exhibits optimal oxidase-like activity, as the core material for anti-tumor treatment. By encapsulating it with a T cell membrane, it can induce immunogenic cell death through OXD catalysis, activate the cGAS-STING pathway and T cell-mediated tumor killing function, and antagonize the effect of PD-L1 elevation, thus overcoming the defect of STING activation-induced PD-L1 overexpression impairing T cell function.

The application discloses a bacillus velezensis for preventing and treating sugarcane leaf blight, which is bacillus velezensi NN02 with a preservation number of CGMCC No. 37628. The application also discloses application of the bacillus velezensi for preventing and treating sugarcane leaf blight, cabbage black spot and guava stem base rot. The bacillus velezensi NN02 for preventing and treating sugarcane leaf blight is separated from healthy mulberry variety Guiyou 12 branches, has antagonistic effect on sugarcane leaf blight and can effectively prevent and treat sugarcane leaf blight.