The invention belongs to the technical field of wastewater treatment and in particular relates to an oil and gas field fracturing flow-back fluid centralized treatment process. The oil and gas field fracturing flow-back fluid centralized treatment process comprises the following steps: 1, collecting fracturing flow-back fluid into an adjusting tank, carrying out homogenizing and quantity equalizing treatment on the fracturing flow-back fluid, and enabling the fracturing flow-back fluid to enter a sand settling and oil removal tank to be subjected to sand settling and oil removal; 2, lifting effluent of the adjusting tank into a coagulation/air floatation tank, adding a flocculating agent, and removing floating oil and suspended matters through flocculation and air floatation; 3, enabling effluent of the air floatation tank to enter a primary oxidation unit, adding sodium hypochlorite, and primarily oxidizing and decomposing macromolecular organic compounds; 4, enabling effluent of a primary oxidation tank to enter a Fenton oxidation tower, and deeply oxidizing and decomposing by adopting a Fenton oxidizing agent; 5, enabling effluent of the Fenton oxidation tower to enter a sedimentation tank; and 6, enabling effluent of the sedimentation tank to enter an activated coke filtration and adsorption tank to be subjected to filtration and adsorption treatment, various indexes of effluent of the activated coke filtration and adsorption tank can reach the standard, and the effluent of the activated coke filtration and adsorption tank can be discharged or recycled. The oil and gas field fracturing flow-back fluid centralized treatment process is applicable to treatment of fracturing flow-back fluid in unconventional oil and gas field fracturing mining of petroleum, natural gas, shale gas and coal bed gas.