13results about How to "Has inhibitory activity" patented technology

The invention provides liquorice seed oil as well as a preparation method and application thereof, and relates to the field of vegetable oil extraction. The preparation method of the licorice seed oil comprises the following steps: crushing licorice seeds to obtain licorice seed powder; extracting the licorice seed powder with n-hexane, and concentrating under reduced pressure to obtain crude oil; and refining the crude oil to obtain the licorice seed oil. The invention further provides application of the liquorice seed oil in preparation of anti-tumor or anti-cancer drugs, preparation of health-care foods or drugs with anti-inflammatory activity and preparation of health-care foods or drugs with anti-oxidation activity. The method is of great significance to utilization and popularization of liquorice seed resources.

The invention provides bacillus velezensis SFT4 with an antibacterial function and application thereof, and belongs to the technical field of microbe application, the bacillus velezensis SFT4 has a good inhibition effect on Erpex lacteus, Aspergillus pallidum, Clostridium perfringens, Staphylococcus aureus, Micrococcus luteus and the like, has a certain inhibition effect on salmonella, and can be used for preparing the bacillus velezensis SFT4. The invention provides a bacillus velezensis SFT4 and a metabolite thereof, provides a microecological preparation containing the bacillus velezensis SFT4 and the metabolite thereof, and provides a use method of the microecological preparation, the microecological preparation is composed of the bacillus velezensis SFT4, lactobacillus reuteri, lactobacillus casei and lactobacillus plantarum, and the microecological preparation is applied to the livestock and poultry industry. The microecological preparation can effectively prevent and treat clostridium perfringens and escherichia coli, can be prepared into a feed additive for use, can be directly fed through a drinking water line, and is not easy to block the drinking water feeding line.

Provided are a method for producing a triazine derivative having a virus proliferation inhibitory action and a formulation for oral administration containing the triazine derivative.

The invention discloses an application of Lycobetaine in the preparation of an SHMT2 protein targeted inhibitor. According to the invention, 11 candidate compounds are obtained by adopting a molecular docking technology, and a CCK-8 cell viability experiment shows that the anti-proliferative activity of Lycobetaine on non-small cell lung cancer A549 and H1299 cells is superior to that of a standard SHMT2 inhibitor SHIN1. A Western blot result shows that the expression of the SHMT2 is down-regulated by the Lycobetaine in a dose-dependent manner, and the SHMT1 is not influenced. A gene knockout experiment shows that the anti-proliferative activity of the Lycobetaine depends on the expression of the SHMT2. In-vitro experiments and organoid models show that Lycobetaine significantly inhibits tumor growth and induces structural collapse and volume reduction of tumor organoids. The Lycobetaine can be used as an SHMT2 protein targeted inhibitor, and is applied to tumor treatment.

The invention provides a glycyrrhetinic acid derivative, a pharmaceutical composition and application of the glycyrrhetinic acid derivative and relates to the technical field of pharmaceutical chemistry, a main framework of the prepared glycyrrhetinic acid derivative is glycyrrhetinic acid with carbamido, and the glycyrrhetinic acid derivative with the carbamido is obtained by modifying the 3-site, 11-site, 18-site and 30-site of the glycyrrhetinic acid and modifying the 3-site, 11-site, 18-site and 30-site of the glycyrrhetinic acid. Therefore, the compound has nanomole-level inhibitory activity on soluble epoxide hydrolase. On the basis of 18alpha / 18beta-glycyrrhetinic acid, different ureido substituents are introduced to the 30th site, the activity difference between the different substituents is small, but when the different ureido substituents are connected to the 20th site of the 18alpha / 18beta-glycyrrhetinic acid, the inhibition effect of the 18alpha / 18beta-glycyrrhetinic acid on soluble epoxide hydrolase is greatly reduced. The glycyrrhetinic acid derivative prepared by the invention has an efficient inhibition effect on soluble epoxide hydrolase, so that the inhibition effect on inflammation can be realized by inhibiting the soluble epoxide hydrolase, and the glycyrrhetinic acid derivative has a good application prospect.

This invention provides compounds useful as active ingredients in pharmaceutical compositions for the treatment of pancreatic cancer. The inventors studied compounds useful as active ingredients in pharmaceutical compositions for the treatment of pancreatic cancer and discovered that 4-aminoquinazoline compounds possess excellent G12D mutant KRAS inhibitory activity, making them suitable for use as therapeutic agents for pancreatic cancer, thus completing this invention. The 4-aminoquinazoline compound or its salt of this invention can be used as a therapeutic agent for pancreatic cancer.

This invention discloses an antimicrobial peptide, HlHepcidin, derived from *Hemibarbus labeo*, and its application in regulating fish gut microbiota and preventing *Aeromonas hydrophila* infection. The antimicrobial peptide comprises the amino acid sequence QSHLSLCRYCCNCCRNKGCGYCCKF shown in SEQ ID NO:1, or a functional variant retaining antimicrobial activity and / or fish gut microbiota regulation activity. This invention further provides a nucleic acid molecule encoding the peptide, a recombinant expression vector, engineered bacteria or host cells, a preparation method, a composition containing the antimicrobial peptide, and its applications. The antimicrobial peptide exhibits inhibitory activity against various aquaculture-related bacteria and can be used to restore the diversity and community composition of fish gut microbiota after *Aeromonas hydrophila* infection. The antimicrobial peptide or composition can be prepared as a feed additive, bath agent, water treatment agent, spray, injection, or other aquaculture product, thereby providing a green technology solution for the prevention and control of bacterial diseases in fish and reducing antibiotic use.

The present invention discloses a sesquiterpene lactone compound extracted and separated from wild horsetail, and a method and application thereof, wherein the structural formula thereof is shown in formula (I). The sesquiterpene lactone compound is extracted and separated from dried wild horsetail by ethanol reflux extraction, ethyl acetate extraction, silica gel column chromatography, C18 reverse phase chromatography separation and other steps, and is a new sesquiterpene lactone compound with a new structure and pharmacological activity, which can be used in the preparation of anti-lung cancer drugs, and provides a reliable basis for the preparation of new anti-cancer drugs and the medicinal research of sesquiterpene lactone substances. #imgabs0#

The application discloses a donkey skin oligopeptide, and an application thereof. The amino acid sequence of the donkey skin oligopeptide is selected from Glu-Thr-Trp-Arg or Ala-Tyr-Phe-Pro-Lys. The donkey skin oligopeptide disclosed by the application has alpha-glucosidase and alpha-amylase inhibitory activity, can assist in reducing blood sugar, has very important significance for developing medicines with blood sugar reducing function, and can be used for preparing alpha-glucosidase, alpha-amylase inhibitors and anti-type 2 diabetes drugs.

The invention belongs to the technical field of medicines, and particularly relates to application of a myrtle ketone derivative in preparation of an antibacterial drug and the antibacterial drug. A novel myrtle ketone derivative is synthesized, the myrtle ketone derivative has inhibitory activity on gram-positive bacteria, and a compound 27 is the most effective DNA (deoxyribonucleic acid) gyrase and Topo IV inhibitor. Biological activity determination shows that the compound 27 not only has the advantage of rapid sterilization on methicillin-resistant staphylococcus aureus, but also has low toxicity, is not easy to induce bacterial drug resistance, and shows a synergistic effect with first-line antibacterial drugs such as ofloxacin, amikacin, cefpiramide and ceftazidime; this makes it a potential candidate for novel antibacterial agents.

This invention provides a benzothiadiazine 1,1-dioxide compound, its preparation method, and its applications. The general structural formula of the benzothiadiazine 1,1-dioxide compound is shown in Formula (I), or its isomers, or pharmaceutically acceptable salts, esters, or prodrugs thereof. The benzothiadiazine 1,1-dioxide compound of this invention has a novel structure, can selectively inhibit HDAC6 enzyme, has a strong protective effect on nerve cells, low toxicity, and low potential cardiotoxicity, and is expected to be used as a neuroprotective agent for the treatment of neurodegenerative diseases.

The present invention provides an oligonucleotide or a modified sequence thereof for treating diseases related to PCSK9. 80 small interfering RNA (siRNA) sequences were designed for the PCSK9 mRNA sequence and were modified alternately. Cell experiment results show that some unmodified or modified siRNA sequences have a significant inhibitory effect on PCSK9 gene expression and can be used to develop drugs for treating and / or preventing diseases related to PCSK9 gene expression.