30 results about "Bergapten" patented technology

The invention relates to novel bacterial QS (quorum sensing) inhibitors and an antibacterial application thereof. Two coumarin compounds including psoralen and bergapten are obtained through separation and identification from fig leaves. Experiments prove for the first time that the compounds have activity of inhibiting Chromobacterium violaceum and pseudomonas aeruginosa QS systems and cannot produce survival pressure to pathogenic bacteria which further produce drug resistance, thereby being novel antibacterial compounds. The novel bacterial QS inhibitors and the antibacterial application thereof have the advantages that raw materials are easily available, a preparation method is easy to implement, and drug resistance and toxic actions are avoided, so that the coumarin compounds have potential to be developed into lead compounds for novel antibacterial drugs.

The invention belongs to the technical field of medical care, and particularly relates to a hypertensive healthcare drug pillow. The hypertensive healthcare drug pillow comprises a pillow body and a drug bag arranged in the pillow body, wherein the drug bag contains liquid medicine,and the liquid medicine comprises, by weight, angelica sinensis, notopterygium, bergapten, radix aconiti preparata, black aconite, rhizoma chuanxiong red peony roots, flos carthami, lumbricus, resina draconis, calamendiol, juncos, asarum, cassia twig, salviae miltiorrhizae, saposhnicovia divaricata, semen raphani, clematis chinensis, olibanum, myrrh and ornel; a heat conduction oil coil pipe is arranged in the drug bag. The liquid medicine in the drug pillow is gentle in medicine property and has no side effects, hypertension can be treated in the sleeping process of a hypertensive, time and efforts of the patient do not need to be wasted, and the drug pillow can prevent and cure the hypertension for long-term use.

The invention provides a fragrance essence with bacteriostatic efficacy components and a preparation method thereof. The fragrance essence with bacteriostasis effect is prepared from acetaldehyde, hydroxycitronellal, pinene, sabinene, beta-myrcene, limonene, leaf alcohol, ligustral, benzaldehyde, linalool, Bergapten, caryophyllene, linalyl acetate, beta fenchyl alcohol, anthemene, Neryl propionate, Florol, benzyl acetate, geranyl acetate, citronellyl acetate, nerol, methyl salicylate, ethyl salicylate, ethyl salicylate, Beta Damascone, phenethyl alcohol, allyl amyl glycolate, ionone, methyl anthranilate, watermelon ketone, Ambrox, Methyl dihydrojasmonate, isoeugenol, thyme oil, eugenol and the like. The fragrant raw materials used are convenient in sources, and the obtained essence has thefragrance characteristics of fresh fragrance, flower fragrance, fruit fragrance and pungent fragrance, and also has the fresh feeling of forests and nature, the overall fragrance is fine and smooth,and the fragrance essence has bacteriostatic effect.

The invention discloses a HPLC finger-print detection method of Heracleum souliei. The finger-print has multiple peaks, good resolution, good repeatability and high precision, and thereby provides an effective guarantee for comprehensive monitor of Heracleum souliei quality. By means of an extraction method and a chromatogram condition of the finger-print detection method, contents of two active components psoralen and bergapten in Heracleum souliei can also be detected, so that quality of Heracleum souliei can be controlled from more aspects according to the invention.

The invention discloses a selenium-fortified anticancer high-quality camellia oil. The camellia oil is prepared from, by weight, 110-120 parts of camellia seed oil, 45-50 parts of fig leaves, 5-7 parts of selenocystein, 6-8 parts of amino acid zinc, 11-12 parts of Nata, 0.2-0.3 part of pure soda ash and an appropriate amount of water. According to the selenium-fortified anticancer high-quality camellia oil, camellia seed oil superfine powder modified by the fig leaves is subjected to squeezing multiple times to prepare the crude camellia oil, and the anticancer effect of the oil is synergetically enhanced through anticancer active substances such as psoralen, benzaldehyde, bergapten, polysaccharide and selenium which are rich in the leaves of figs.

The invention provides a traditional Chinese medicine for treating chronic endometritis and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine is prepared from the following medicinal materials: centipeda minima, glycosmis pentaphylla, phlomis umbrosa, aster ageratoides, alnus tinctoria, vitex negundo linn root, bergapten, long pepper root, dyebark evodia fruit root leaf, micromeria biflora benth, russula nigricans, little platanthera, vicia sativa, lance asiabell root and podocarp fruit. The traditional Chinese medicine provided by the invention has an accurate curative effect on chronic endometritis, and is small in toxic or side effect, short in treatment course and not easy to recur.

The invention discloses medicine for the treatment of spleen insufficiency damp-aggregating type chloasma and a preparation method thereof. The medicine for the treatment of spleen insufficiency damp-aggregating type chloasma is composed of medicine for oral use and medicine for external use, wherein the medicine for oral use comprises asparagus, ginseng, astragalus, poria cocos, polyporus umbellatus, atractylodes macrocephala koidz, rhizoma alismatis, liquidambar formosana hance, oroxylum indicum vent, rhizoma cimicifugae, rhizoma cimicifugae, chaenomeles sinensis koehne, rhizoma atractylodis, semen lablab album, bilobate grewia, marrow honey-suckle, sculpins, medicated leaven and wild angelica dahurica; the medicine for external use comprises powder on the surface of a dried persimmon, katsumade galangal seeds, costusroots, citrus, pericarpium arecae, cortex mori radicis, ginger peel, perilla leaves, radix platycodi, radix cyathulae, feather cockscomb seed, butterflybush flower, rice-grain sprout, rhizoma nardostachyos, snow pears, illigera cordata rootss, berchemia sinica, bergapten and nakedflower beautyberry branchlet and leaves. The medicine for the treatment of spleen insufficiency damp-aggregating type chloasma and the preparation method thereof have the advantages that the medicine for the treatment of spleen insufficiency damp-aggregating type chloasma has effects on tonifying the spleen and supplementing qi, clearing damp and removing chloasma, regulating the middle warmer and resolving damp, soothing the liver and harmonizing the stomach, clearing damp and promoting dieresis, warming yang, eliminating water and glorifying the face, activating collateral and removing chloasma, and promoting blood circulation to remove blood stasis, and the main function is the treatment of the spleen insufficiency damp-aggregating type chloasma; the treatment effect is good, the toxic and side effects are small, and the spleen insufficiency damp-aggregating type chloasma is not prone to reoccurring.

The invention discloses application of bergapten in preparation of drugs for treating colorectal cancer and belongs to the technical field of medicines. According to the application of the bergapten in the preparation of the drugs for treating the colorectal cancer, disclosed by the invention, through administrating the bergapten of different concentrations to SW1116, LoVo, SW1116 / 5-Fu and LoVo / 5-Fu of the human colorectal cancer for intervention, drug resistance of the bergapten to human colorectal cancer cells 5-Fu and influence on EBI3 / STAT3 signal channels are observed, and thus, an experiment basis is provided for the bergapten in treatment of a liver cancer as an antitumor drug.

The invention relates to a method for preparing a radix angelicae pubescentis extract with a pine wood nematode killing activity and an application thereof. The method comprises the following steps: taking dry radix angelicae pubescentis powder; extracting with absolute ethyl alcohol under room temperature; performing reduced pressure distillation and concentration on the extracting solution, thereby obtaining a brown rough extract; extracting a rough ethyl alcohol extract with ethyl acetate-water extracting solution for three times, merging with ethyl acetate phase; reducing the pressure and distilling, thereby obtaining the radix angelicae pubescentis extract with higher pine wood nematode killing activity; utilizing the separating methods, such as column chromatography and recrystallization, to separate four coumarins compounds with obvious pine wood nematode killing activity, namely cnidium lactone, columbianadin, bergapten and xanthotoxin, from the radix angelicae pubescentis extract. The radix angelicae pubescentis extract in the concentration of 1mg / mL has a 95.27% correcting death rate for the pine wood nematode after 72 hours. The invention has the advantages of simple operation method, convenience in raw material resource, low cost, high efficiency, low toxicity, safety and environmental protection. The radix angelicae pubescentis has a developing potential at the aspect of controlling the pine wood nematode and can be applied to a natural preparation for killing the pine wood nematode.

The present invention provides laminaria japonica sugar and a preparation method thereof. The laminaria japonica sugar is prepared from laminaria japonica, celery, carrots, pumpkins, orange peels, dragon fruit peels, citrus fruit juice and mango juice as raw materials. The laminaria japonica has characteristics of being low in calorie, moderate in proteins and high in minerals; the celery is rich nutrition, and the stems and leaves contain apiin, bergapten, organic acids, carotene, vitamin C, carbohydrates, and volatile oil containing a special smell of butylphthalide derivatives; the carrots are rich in vitamins, can stimulate skin metabolism, and can enable the skin to be delicate and smooth; and the pumpkins contain human body beneficial ingredients of polysaccharides, amino acids, active protein carotenoids, a variety of trace elements, etc. Therefore, the prepared laminaria japonica sugar is rich in nutrient, improves and expands the nutritional efficacies of the laminaria japonica, and is liable to be absorbed by human body, convenient to eat and carry, and good in taste.

The invention discloses a composition for treating rhinitis, which comprises the following material components in parts by weight: 55-75 parts of pyroligneous liquor, 15-35 parts of disodium octoborate tetrahydrate, 12-25 parts of sodium lactate, 8-20 parts of bergapten and 20-40 parts of pure water. The composition disclosed by the invention can be used by spraying or dripping steam fog into a nose, has the characteristics of good curative effect, high cure rate, few toxic or side effects, convenient use and the like, is capable of expelling wind and removing cold, promoting the restoration of consciousness and conditioning qi, relieving swelling and pain, repairing the lesion tissue of the mucosa of the nasal cavity as well as promoting blood circulation to remove blood stasis, and is suitable for people at all ages.

The present invention discloses a blood lipid lowering compound based on miichthys miiuy swimming bladder polypeptides and a preparation method thereof. The compound comprises the following ingredients in parts by weight: 80-95 parts of the miichthys miiuy swimming bladder polypeptides, 10-15 parts of radix notoginseng total saponins, 0.0001-0.0002 part of guaiacol, 1-10 parts of fish oil, 0.5-2 parts of vitamin C and 0.0002-0.0006 part of bergapten. Beneficial effects are as follows: the prepared compound is green and safe, free of toxic and side effects, low in molecular weight, easy for absorption and high in utilization rates, at the same time can supplement needs of users for amino acids, etc., lowers blood pressure, at the same time increases blood flow volumes of coronary arteries and brain blood vessels, improves blood microcirculation of heart and brain tissues, can effectively reduce contents of serum cholesterols and low density lipoproteins in human body, and reduces incidence of cardiovascular diseases. The preparation method uses a biological enzymolysis, and is simple in steps, high in efficiency and low in costs.

The invention relates to the technical field of traditional Chinese medicines, and in particular relates to a pharmaceutical composition for treating a stomach cold. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 4-8 parts of cassia twig, 8-18 parts of Chinese mosla herb, 10-20 parts of bergapten, 8-20 parts of radix cynanchi panicullati, 10-20 parts of pogostemon cablin, 15-30 parts of chrysoidine, 5-10 parts of pericarpium arecae, 3-6 parts of aspongopus and 10-20 parts of pericarpium arecae. The pharmaceutical composition for treating the stomach cold is capable of quickly and effectively treating the stomach gold, and is not easy to recur and free of toxic or side effect.

The invention discloses a pharmaceutical composition for repairing scars. The pharmaceutical composition is prepared from the following raw materials: hirudin, dexamethasone, metronidazole, vitamin E,tanshinone II, forsythin, citric acid, allicin, bergapten, pearl powder, octadecadienoic acid, sodium tartrate, hexadecanoic acid, lignin, ethyl octadecanoate, sodium tetraborate, hydroxyethyl cellulose, folic acid, a lubricant and mixed glycosides. The pharmaceutical composition disclosed by the invention has a good curative effect and is convenient to smear; the pharmaceutical composition has the effects of promoting blood circulation and removing blood stasis, clearing away heat and detoxifying and stopping itch and pain; the pharmaceutical composition can be used for effectively repairingthe scars and prompting skin regeneration; furthermore, when normal skin is coated with the pharmaceutical composition, the skin can become fine and smooth and has elasticity.

The invention relates to a preparation method for separating high-purity bergapten and psoralen from ficus carica by using a high speed countercurrent chromatography method. The method comprises the following steps of: (1) preparing a proper solvent system, and standing still for layering to obtain an upper phase and a lower phase; (2) selecting the upper phase as a fixed phase and the lower phase as a flowing phase; filling a countercurrent chromatograph column with the fixed phase, and regulating the rotating speed of a host to be 600-1,000rpm; pumping the flowing phase into the column with a flowing speed of 0.5-5.0ml / min, and after dynamic balance of the whole system is established, introducing the sample through a sample introduction valve; and (3) receiving a target ingredient according to an ultraviolet spectrum of a detector, and then concentrating and crystallizing to obtain the finished product. The method is suitable for the preparation of various types of high speed countercurrent chromatographs as well as bergapten and psoralen of various contents and has the characteristics of large separation quantity, high recovery rate and simpleness and convenience for operation.

The invention discloses a medicine composition for pre-operative regulation of pelvic abscess and a preparation method thereof. The medicine composition is mainly prepared from triamterene, tinidazole, ursolic acid, aucubin, luteolin, chlorogenic acid, total glucoside of paeony, polygalic acid, glutathione powder, tribulus terrestris saponins superfine powder, mangiferin, bergapten, amino acid and mannitol. The medicine composition is prepared from multiple effective ingredients in a reasonable proportion, has the effects of diminishing inflammation, inhibiting bacteria, diminishing swelling, eliminating pus, clearing heat, removing dampness, enhancing body immunity and regulating physical constitution, and is used for providing pre-operative assistant treatment for pelvic abscess patients requiring operating treatment, so that on the one hand, patient pain can be alleviated and symptoms can be reduced, and on the other hand, the probability of infection during the operation can be reduced, the operation difficulty can be reduced in an assistant way, and thus a good operation effect can be achieved.

The invention discloses a novel antistatic and sterilization fiber treatment material and a preparation method thereof. The novel antistatic and sterilization fiber treatment material is prepared from the following components in parts by weight: 50-60 parts of polyethylene glycol, 5-8 parts of 2-ethyl hexyl ester of epoxidized soybean oil, 3-5 parts of hydroxymethyl cellulose, 2-4 parts of dihydrocarveol, 1-3 parts of polyethylene wax, 1-3 parts of dicalcium phosphate dihydrate, 1-2 parts of polymethylcyclotetrasiloxane, 0.5-2 parts of quininic acid, 0.5-1 part of polydimethylsiloxane diquaternary ammonium salt, 0.5-1 part of 4-guanidyl-1-butanol and 0.02-0.08 part of bergapten. The invention further provides a preparation method of the antistatic and sterilization fiber treatment material.

The invention discloses an application of bergapten in preparation of an HIV-1 latent infection reversal agent. According to the research by the inventor of the invention, the bergapten is found to have the capacity of activating an HIV-1 latent infection cell model in vitro and not to show obvious cytotoxicity at 400 [mu]M. Different from obvious increase of CD25 and CD69 expression quantities caused by a positive control drug, namely Prostratin, the expression quantities of CD25 and CD69 in human peripheral blood cells treated by the bergapten are not obviously changed, and no side effects of T cell activation is caused. The bergapten is expected to provide a new way and means for induced activation and final elimination of HIV latent infection viruses.

The invention discloses an externally-used gel preparation for treating erythromelalgia and a preparation method of the externally-used preparation. The externally-used gel preparation is mainly prepared from components in parts by weight as follows: 2-4 parts of promethazine hydrochloride, 1.1-1.5 parts of paeonol, 0.3-1.2 parts of diphenhydramine hydrochloride, 0.1-0.42 parts of an alpha adrenergic receptor stimulant, 0.5-1.3 parts of ursolic acid, 0.6-0.7 parts of diclofenac sodium, 1.2-2.0 parts of bergapten, 1.5-3.4 parts of magnesium sulfate, 0.1-0.7 parts of chavicol, 0.12-0.25 parts of naringin, 0.8-2.0 parts of eucalyptol, 20-34 parts of a gel matrix, 0.03-0.06 parts of an antioxidant, 0.02-0.04 parts of a preservative and 0.05-0.1 parts of a solubilizer. The externally-used gel preparation for treating erythromelalgia has the functions of shrinking blood vessels and reducing the vascular permeability, can also relieve pain and resist inflammation and bacteria and can remarkably relieve redness, swelling, heat and pain of lower limbs in a short period of time; the externally-used gel preparation which is locally applied is prepared from the medicines, the absorption and utilization rate of the preparation is high, the safety is also higher, and clinical experiments show that the externally-used gel preparation has a good curative effect.

The invention discloses application of bergapten in treatment of depression, and belongs to the technical field of medicines. The invention provides a natural medicine bergapten for preventing and treating depression by regulating inflammatory response for the first time, and the depression symptom is remarkably improved. The bergapten enables the immobility time of lipopolysaccharide (LPS)-induced anti-depression mice in a tail suspension test and a forced swimming test to be obviously reduced; the sweet water preference percentage is increased, and the autonomous activity is enhanced; and the action mechanism is related to the neuroinflammatory response mediated by the activation of depression mouse microglial cells. The invention provides a new way for improving the current depression treatment method. According to the scheme, new use of old medicines can be realized, and the time from medicine discovery to clinical transformation can be greatly shortened.

The invention discloses a Chinese herbal medicine combination capable of activating blood circulation, moistening skin and removing wrinkles. The Chinese herbal medicine combination is prepared from pokeberry roots, radix polygonati officinalis, bergapten, Ligusticum wallichii, felwort, giant typhonium rhizome, pistia stratiotes, flos magnoliae, Miwu flowers, tuguagen series, white gourd kernels and alkanet. The Chinese herbal medicine combination is made from pure natural plant essence, is remarkable in wrinkle removing effect, and enables skin to be glossy, red, tender, plump, smooth and tight.

The invention provides sunscreen cooling gel and preparation method thereof. The sunscreen cooling gel is prepared from the following raw materials in parts by weight: 10-50 parts of tinosorb, 13 parts of bergapten, 12 parts of hyaluronic acid, 1 part of carbomer 940, 12 parts of almond glycerides, 8 parts of xanthophyll, 0.3 part of ethyl p-hydroxybenzoate, 3 parts of titanium dioxide and 2 partsof zinc oxide. The sunscreen cooling gel is physically sunscreen, the components are scientifically proportioned and synergistically play a role, and the sunscreen cooling gel has a good sunscreen effect, broad-spectrum protection, no phototoxicity or photoallergic reaction, no degradation product and good light stability, is only distributed on the surface of skin, is not prone to forming aggregates or crystals to block pores, and has excellent spreadability, so that the skin is moistened and not dry.

The invention provides a pharmaceutical composition which comprises an effective dose of bergapten and pharmaceutically acceptable carriers or excipients, and the pharmaceutical composition can be used for preventing and / or treating bone loss.

The present invention discloses a blood lipid lowering compound based on miichthys miiuy swimming bladder polypeptides and a preparation method thereof. The compound comprises the following ingredients in parts by weight: 80-95 parts of the miichthys miiuy swimming bladder polypeptides, 10-15 parts of radix notoginseng total saponins, 0.0001-0.0002 part of guaiacol, 1-10 parts of fish oil, 0.5-2 parts of vitamin C and 0.0002-0.0006 part of bergapten. Beneficial effects are as follows: the prepared compound is green and safe, free of toxic and side effects, low in molecular weight, easy for absorption and high in utilization rates, at the same time can supplement needs of users for amino acids, etc., lowers blood pressure, at the same time increases blood flow volumes of coronary arteries and brain blood vessels, improves blood microcirculation of heart and brain tissues, can effectively reduce contents of serum cholesterols and low density lipoproteins in human body, and reduces incidence of cardiovascular diseases. The preparation method uses a biological enzymolysis, and is simple in steps, high in efficiency and low in costs.

The invention relates to a preparation method for separating high-purity bergapten and psoralen from ficus carica by using a high speed countercurrent chromatography method. The method comprises the following steps of: (1) preparing a proper solvent system, and standing still for layering to obtain an upper phase and a lower phase; (2) selecting the upper phase as a fixed phase and the lower phase as a flowing phase; filling a countercurrent chromatograph column with the fixed phase, and regulating the rotating speed of a host to be 600-1,000rpm; pumping the flowing phase into the column with a flowing speed of 0.5-5.0ml / min, and after dynamic balance of the whole system is established, introducing the sample through a sample introduction valve; and (3) receiving a target ingredient according to an ultraviolet spectrum of a detector, and then concentrating and crystallizing to obtain the finished product. The method is suitable for the preparation of various types of high speed countercurrent chromatographs as well as bergapten and psoralen of various contents and has the characteristics of large separation quantity, high recovery rate and simpleness and convenience for operation.

The invention relates to a method for preparing a radix angelicae pubescentis extract with a pine wood nematode killing activity and an application thereof. The method comprises the following steps: taking dry radix angelicae pubescentis powder; extracting with absolute ethyl alcohol under room temperature; performing reduced pressure distillation and concentration on the extracting solution, thereby obtaining a brown rough extract; extracting a rough ethyl alcohol extract with ethyl acetate-water extracting solution for three times, merging with ethyl acetate phase; reducing the pressure and distilling, thereby obtaining the radix angelicae pubescentis extract with higher pine wood nematode killing activity; utilizing the separating methods, such as column chromatography and recrystallization, to separate four coumarins compounds with obvious pine wood nematode killing activity, namely cnidium lactone, columbianadin, bergapten and xanthotoxin, from the radix angelicae pubescentis extract. The radix angelicae pubescentis extract in the concentration of 1mg / mL has a 95.27% correcting death rate for the pine wood nematode after 72 hours. The invention has the advantages of simple operation method, convenience in raw material resource, low cost, high efficiency, low toxicity, safety and environmental protection. The radix angelicae pubescentis has a developing potential at the aspect of controlling the pine wood nematode and can be applied to a natural preparation for killing the pine wood nematode.

The invention discloses a medicine for treating glaucoma and a preparation method of the medicine. The medicine is mainly prepared from angelica sinensis, rhizoma atractylodis macrocephalae, fructus forsythia, radix glehniae, selfheal, earthworms, ruddle, fructus evodiae, concha haliotidis, white peony root, wolfberry fruits, plantain herb, divaricate saposhnikovia root, rhizoma arisaematis, bergapten, schisandra chinensis, glossy privet fruits, semen lepidii, wild chrysanthemum flowers, rhizoma phragmitis, scutellaria baicalensis, cacumen biotae, sanguisorba officinalis, sophora japonica, fructus viticis, Chinese yam, nacre and uncaria rhynchophylla at a certain weight ratio. The medicine has the functions of clearing the liver, removing stasis, tonifying the spleen, harmonizing the stomach, dispelling wind and heat, clearing the brain and eyes, nourishing the kidneys and tonifying the liver, and is fast to take effect, good in curative effect and free of relapse when being applied to treatment of the glaucoma.